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ClinicalTrials.gov public records Last synced Oct 4, 2026, 8:06 PM EDT

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Showing 49–72 of 140 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Flavored tobacco Clear all
Completed Not applicable Interventional Results available

Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace

NCT05110872
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Cigarette flavor restricted and e-cigarette flavor restricted, Cigarette flavor restricted and e-cigarette flavor unrestricted, Cigarette flavor unrestricted and e-cigarette flavor restricted, Cigarette flavor unrestricted and e-cigarette flavor unrestricted
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Assess Tobacco-related Biomarkers of Exposure in Smokers Using myBlu E-cigarettes

NCT04019626
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Continue-smoking, myblu Tobacco 2.5%, myblu Tobacco 4.0%, myblu Honeymoon 2.5%, myblu Honeymoon 4.0%, JUUL 5%
Other
Lead sponsor
Fontem Ventures BV
Industry
Eligibility
21 Years to 65 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD231005 Nicotine Pouch Biomarkers of Exposure

NCT06303115
View directory record Official record
Conditions
Tobacco Use, Smoking
Interventions
Nicotine Pouch P1312914, 4 mg nicotine, Nicotine Pouch P1312915, 8 mg nicotine, Nicotine Pouch P1013215, 8 mg nicotine, Nicotine Pouch P1013218, 10 mg nicotine, Nicotine Pouch P1012919, 12 mg nicotine, Smoking Abstinence, Continued UB cigarette smoking
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
5
States / cities
Bentonville, Arkansas • Lexington, Kentucky • Springfield, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 11, 2025 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Menthol and Mint Experimental Tobacco Marketplace (ETM) Study

NCT04879225
View directory record Official record
Conditions
Cigarette Smoking, Vaping
Interventions
Tobacco e-liquids, Menthol and Tobacco e-liquids, Mint, Menthol and Tobacco e-liquids, All e-liquid flavors
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Not applicable Interventional Results available

E-cigarettes for Harm Reduction in Adults With Asthma

NCT05278065
View directory record Official record
Conditions
Smoking, Asthma, Electronic Cigarette Use, Cigarette Smoking
Interventions
Nicotine
Other
Lead sponsor
Brown University
Other
Eligibility
21 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Establishing the Effect of Flavor on the Addictive Potential of Electronic Cigarettes

NCT03905928
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Nicotine Containing ECIG with tobacco flavor, Nicotine Containing ECIG with Strawberry Vanilla Flavor, Placebo ECIG with Tobacco Flavor, Placebo ECIG with Strawberry Vanilla Flavor
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 60 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 22, 2025 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cigarette and E-cigarette Nicotine Content in an Electronic Tobacco Marketplace (ETM)

NCT05320887
View directory record Official record
Conditions
Tobacco Use
Interventions
Normal Nicotine Content Vape with all flavor e-liquids, Normal nicotine content vape with tobacco e-liquids, Low nicotine content vape with all flavor e-liquids, Low nicotine content vape with tobacco e-liquids
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 9, 2024 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Consumer Perceptions of Waterpipe Tobacco Packaging and Digital Marketing Claims

NCT05439421
View directory record Official record
Conditions
Waterpipe Tobacco Smoking
Interventions
Package/Advertisement With Claim, Package/Advertisement Without Claim
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 29 Years
Enrollment
1,507 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Oct 4, 2026, 8:06 PM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers Results available

Biomarkers of Exposure and Effect in Standardized Research E-cigarette (SREC) Users

NCT04003805
View directory record Official record
Conditions
Smoking, Cigarette
Interventions
Standardized Research E-cigarette (SREC)
Drug
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Understanding the Impact of Cartridge-Based Electronic Cigarettes and Generated Aerosols on Cardiopulmonary Health

NCT05199480
View directory record Official record
Conditions
E-Cig Use
Interventions
Tobacco flavored liquid type 1, Tobacco flavored liquid type 2
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years and older
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterization of Product Use in Smokers Switching From Cigarettes to a RELX Electronic Nicotine Delivery System

NCT04708106
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, RELX ENDS Tobacco and Menthol Flavors
Other
Lead sponsor
Cheerain HK Limited
Industry
Eligibility
22 Years to 65 Years
Enrollment
194 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
5
States / cities
Bentonville, Arkansas • Lexington, Kentucky • Springfield, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2021 · Synced Oct 4, 2026, 8:06 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Consumer Assessment of Tobacco Flavor and Odor

NCT04358315
View directory record Official record
Conditions
Current Vaper, Healthy Subject
Interventions
Behavioral Intervention, Questionnaire Administration
Behavioral · Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

The Interaction of Flavor With Nicotine Form in Adult Smokers

NCT04262817
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine form, E-cigarette experimental flavor
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 26, 2023 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Predictors and Consequences of Combustible Cigarette Smokers' Switch to Standardized Research E-Cigarettes

NCT03277495
View directory record Official record
Conditions
Tobacco Use
Interventions
Brief behavioral counseling
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
21 Years and older
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Not applicable Interventional Results available

Free-Base Nicotine or Nicotine Salt e-Liquids in Current E-Cigarette Smokers, PeloPET Study

NCT05455086
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Cigarette Smoking, Computed Tomography, Positron Emission Tomography, Questionnaire Administration
Behavioral · Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 50 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 24, 2025 · Synced Oct 4, 2026, 8:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Social Media Influences on Engagement and Susceptibility to Non-combustible Tobacco Product Use Among Youth and Young Adults (AYA)

NCT07721883
View directory record Official record
Conditions
Perceptions of Tobacco Products
Interventions
Each intervention will be a picture of a social media post. The posts will vary (in a 3X2 factorial design) the type of flavor described and whether concealability is described.
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
14 Years to 17 Years
Enrollment
4,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Not applicable Interventional Results available

A Test of Short and Long Term Naturalistic Outcomes of Smokers Who Sample Smokeless Tobacco

NCT01509586
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Potentially Reduced Exposure Product (PREP): a smokeless, spit-free tobacco product
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
19 Years and older
Enrollment
1,236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 12, 2023 · Synced Oct 4, 2026, 8:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Attitudes and Perceptions Attitudes and Smoking Perceptions in the Real Environment -II

NCT06668350
View directory record Official record
Conditions
Cigarillo Flavor
Interventions
Smoking outcomes
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 34 Years
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 17, 2025 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD210903: A Study to Determine Subject Puffing Patterns of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Ambulatory Setting

NCT05307822
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Interventions
Non-combusted cigarette variant 42001401, Non-combusted cigarette variant 42001399, Non-combusted cigarette variant 40007386, Non-combusted cigarette variant 42001402
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years and older
Enrollment
194 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
7
States / cities
Sandy Springs, Georgia • Lexington, Kentucky • Charlotte, North Carolina + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 27, 2023 · Synced Oct 4, 2026, 8:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers

NCT06264154
View directory record Official record
Conditions
Smoking, Tobacco Use, Cigarette Smoking, E-Cig Use
Interventions
E-cigarettes
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years and older
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Phase 1 Interventional Results available

Effects of E-cigarette Flavors on Youth TCORS 2.0

NCT03634839
View directory record Official record
Conditions
Nicotine Use Disorder
Interventions
Flavoring Agents, Nicotine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 20 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 9, 2024 · Synced Oct 4, 2026, 8:06 PM EDT
Terminated Not applicable Interventional Results available

Impact of Cigarette and E-cigarette Flavors on Adult Smoking Behavior

NCT04009850
View directory record Official record
Conditions
Tobacco Use
Interventions
Cigarette Brand Switching, E-cigarette Flavor
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 8, 2024 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Phase 1Phase 2 Interventional

Acute Nicotine Gum and Tinnitus Loudness in Non-Smoking Adults

NCT07772089
View directory record Official record
Conditions
Tinnitus, Chronic Subjective Tinnitus
Interventions
Nicotine polacrilex gum 4 mg, Placebo gum
Drug · Other
Lead sponsor
San Diego State University
Other
Eligibility
18 Years to 80 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 4, 2026, 8:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assess Biomarkers of Tobacco Exposure and Nicotine Pharmacokinetics in Smokers After a 5-Day In-Clinic Confinement Switch to an Electronic Cigarette or Nicotine Gum

NCT02323438
View directory record Official record
Conditions
Smoking
Interventions
Usual Brand Cigarette, Electronic Cigarette #1, Electronic Cigarette #2, Leading U.S. Nicotine Gum
Other
Lead sponsor
R.J. Reynolds Vapor Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 1, 2018 · Synced Oct 4, 2026, 8:06 PM EDT