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ClinicalTrials.gov public records Last synced Oct 17, 2026, 7:35 AM EDT

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Showing 1–24 of 162 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Fluoride Toothpaste Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Three Toothpastes for the Prevention and Reduction of White Spot Lesions

NCT03440996
View directory record Official record
Conditions
White Spot Lesion, Orthodontic Treatment, Decalcification; Teeth
Interventions
Clinpro™ 5000, Clinpro™ Tooth Crème, MI-Paste Plus
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
12 Years to 60 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity

NCT02832375
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
stannous fluoride, sodium monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
242 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated May 25, 2017 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste

NCT07419685
View directory record Official record
Conditions
Dental Caries
Interventions
Negative Control Toothpaste, Active Comparator, Test Toothpaste
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Noblesville, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease

NCT02750943
View directory record Official record
Conditions
Gingivitis
Interventions
Stannous Fluoride, Sodium Monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
253 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 26, 2017 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Four-Week Oral Malodor and Clinical Safety for a Concentrated Cosmetic Mouthwash

NCT06479096
View directory record Official record
Conditions
Oral Malodor
Interventions
Brush / Espresso Mild Prototype, Brush / Espresso Intense Prototype, Brush / Fresh Breath Oral Rinse, Brush / Hydroalcohol
Other
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years to 99 Years
Enrollment
166 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Oct 17, 2026, 7:35 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study to Assess the Efficacy of an Experimental Mouthwash Used With a Marketed Whitening Toothpaste on Stain Build-up

NCT07836998
View directory record Official record
Conditions
Tooth Discoloration
Interventions
Whitening Toothpaste, Experimental Mouthwash, Regular Fluoride Toothpaste
Drug · Device
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Not applicable Interventional Results available

Trial of Acupuncture for Radiation-Induced Xerostomia in Head and Neck Cancer

NCT02589938
View directory record Official record
Conditions
Radiation-Induced Xerostomia, Head and Neck Cancer, Radiation Toxicity, Oral Complications of Chemotherapy and Head/Neck Radiation
Interventions
Standard Oral Hygiene, Standard Oral Hygiene + True Acupuncture, Standard Oral Hygiene + Sham Acupuncture
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2022
U.S. locations
36
States / cities
Burbank, California • San Francisco, California • San Jose, California + 26 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Caries Prevention Products & Dentinal Hypersensitivity

NCT02136576
View directory record Official record
Conditions
Hypersensitivity
Interventions
Sensodyne, Crest Cavity Protection & MI Paste Plus, Clinpro 5000
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 10, 2020 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Not applicable Interventional Results available

A Real-World Evidence Study to Evaluate Oral Health Related Quality of Life Using an Anti-Sensitivity Toothpaste

NCT04964063
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Potassium Nitrate + Sodium Fluoride
Other
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
655 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jan 22, 2024 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

To Evaluate Efficacy and Tolerability of Sodium Bicarbonate Toothpaste and Its Effect on Opportunistic or Resistant Organisms

NCT02207400
View directory record Official record
Conditions
Oral Hygiene
Interventions
Sodium bicarbonate and sodium fluoride, Sodium fluoride
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
246 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 31, 2018 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Anti-caries Potential of a Sodium Monofluorophosphate and Calcium Sodium Phosphosilicate Dentifrice

NCT01657877
View directory record Official record
Conditions
Caries
Interventions
Calcium sodium phosphosilicate, Sodium monoflurophosphate, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 1, 2014 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Stannous Fluoride Dentifrice for Control of Oral Malodor

NCT07425509
View directory record Official record
Conditions
Oral Malodor (Halitosis)
Interventions
Sodium Fluoride Dentifrice, Stannous Fluoride Toothpaste (SnF)
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Pilot Study to Evaluate a Method for Plaque When Comparing Stannous Fluoride Toothpaste to a Regular Dentifrice

NCT02543060
View directory record Official record
Conditions
Plaque, Gingivitis
Interventions
stannous fluoride toothpaste, cavity protection toothpaste
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 6, 2017 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Arginine Plaque Metabolism Pilot Clinical Study

NCT06954779
View directory record Official record
Conditions
Plaque, Dental
Interventions
Colgate Cavity Protection, TOM's Superior Sensitivity Relief Toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated May 2, 2025 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis.

NCT06244303
View directory record Official record
Conditions
Gingivitis, Plaque
Interventions
manual Tooth Brush + Colgate Total TP (0.454% SnF, 1100 ppm F), manual toothbrush + Colgate dental cream
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Costa Mesa, California
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Oct 17, 2026, 7:35 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Early Caries Lesion Management Observational Study

NCT04933331
View directory record Official record
Conditions
Initial Caries, Arrested Dental Caries, Cavitated Caries, Dental Caries, Dental Caries in Children
Interventions
Curodont Repair Fluoride Plus, Silver Diamine Fluoride, Glass Ionomer Sealant, Fluoride varnish, Fluoride toothpaste
Drug · Device
Lead sponsor
CareQuest Institute for Oral Health
Other
Eligibility
4 Years and older
Enrollment
744 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
4
States / cities
Dothan, Alabama • Westborough, Massachusetts • Bend, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 24, 2023 · Synced Oct 17, 2026, 7:35 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Novel Dental Gel as an Adjunct to Scaling and Root Planing

NCT05384132
View directory record Official record
Conditions
Periodontal Diseases, Gingival Diseases, Gingival Pocket, Gum Bleed, Plaque, Dental
Interventions
SRP + Livfresh Dental Gel, SRP + standard flouride dentifrice
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 85 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Efficacy of a Toothpaste on Hypersensitivity Reduction

NCT01040169
View directory record Official record
Conditions
Hypersensitivity
Interventions
Arginine/Calcium Carbonate, Mint Prophy paste - Fluoride free
Device
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 10, 2013 · Synced Oct 17, 2026, 7:35 AM EDT
Completed No phase listed Observational

Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque

NCT04006483
View directory record Official record
Conditions
Dental Plaque
Interventions
Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
2,359 participants
Timeline
2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 18, 2023 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Study to Evaluate the Anti-sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers

NCT06359028
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Stannous fluoride toothpaste, Crest cavity protection toothpaste
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 24, 2025 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion

NCT07442136
View directory record Official record
Conditions
Enamel Erosion
Interventions
New Toothpaste Containing SnF, Fluoride Toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste

NCT06300866
View directory record Official record
Conditions
Gingivitis, Plaque, Dental
Interventions
Test, Control
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 8, 2024 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluation of the Fluoride Dose Response Using In Situ Caries Model

NCT04763044
View directory record Official record
Conditions
Caries
Interventions
0 ppm F, 250 ppm F as MFP, 1100 ppm as MFP, 2800 ppm F as MFP, 1100 ppm SnF2
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Oct 17, 2026, 7:35 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children

NCT04750902
View directory record Official record
Conditions
Dental Caries
Interventions
0.24% Sodium Fluoride Dentifrice, 1.5% Arginine Dentifrice, 4.0% Arginine Dentifrice, 8.0% Arginine Dentifrice
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
10 Years to 14 Years
Enrollment
2,025 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
8
States / cities
Loma Linda, California • Gainesville, Florida • Indianapolis, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 17, 2026, 7:35 AM EDT