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Showing 1–19 of 19 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Fluoride Varnish Treatment Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers

Medical Management of Caries in the Primary Dentition Using Silver Nitrate

NCT02604134
View directory record Official record
Conditions
Dental Caries
Interventions
Prophylaxis, Fluoride varnish, Silver Nitrate
Procedure · Drug
Lead sponsor
Arwa Owais
Other
Eligibility
2 Years to 11 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Sep 22, 2026, 6:11 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

LT Comparative Effectiveness of 2 Caries Treatments

NCT07213661
View directory record Official record
Conditions
Dental Caries
Interventions
A "simple medical strategy" consisting of silver diamine fluoride (SDF), A "typical dental strategy" consisting of atraumatic restorative treatment (ART) with glass ionomer cement + Fluoride Varnish (FV)
Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
62 Years and older
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Sep 22, 2026, 6:11 AM EDT
Active, not recruiting Not applicable Interventional

Post-Radiation Oral Health in Underserved Head and Neck Cancer Patients

NCT07556367
View directory record Official record
Conditions
Head and Neck Cancer, Head and Neck Carcinoma, Head and Neck Neoplasms
Interventions
Surveys, Saliva Collection, Intra-oral photographs, Fluoride Varnish Treatment, Interview (Participant)
Other · Procedure · Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 22, 2026, 6:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cold Plasma for Dental Restoration and Caries Prevention

NCT01529606
View directory record Official record
Conditions
Dental Restoration, Caries
Interventions
Composite restoration and tooth cleaning, Plasma treatment
Other · Procedure
Lead sponsor
Nanova, Inc
Industry
Eligibility
18 Years to 35 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 15, 2020 · Synced Sep 22, 2026, 6:11 AM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Building Adaptive School-based Interventions for Caries

NCT07265830
View directory record Official record
Conditions
Dental Caries
Interventions
Silver Diamine Fluoride (38%), Glass Ionomer Sealant, Fluoride Varnishes, Hygiene Intervention
Device · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
5 Years to 13 Years
Enrollment
1,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Glenwood Springs, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Sep 22, 2026, 6:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

In Vivo Comparison of Salivary Fluoride Levels Following the Application of Different 5% NaF Varnishes

NCT01629290
View directory record Official record
Conditions
Dental Caries
Interventions
Enamel Pro, Duraphat, Vanish, Placebo
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 21, 2017 · Synced Sep 22, 2026, 6:11 AM EDT
Completed Not applicable Interventional Results available

Resin Infiltration to Arrest Early Tooth Decay

NCT01584024
View directory record Official record
Conditions
Dental Caries
Interventions
Resin infiltration, Sham treatment
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 24 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
West Point, New York
Source: ClinicalTrials.gov public record
Updated Feb 11, 2019 · Synced Sep 22, 2026, 6:11 AM EDT
Withdrawn Not applicable Interventional

Lesion Progression of Approximal Caries After Resin Infiltration

NCT02191943
View directory record Official record
Conditions
Proximal Caries
Interventions
Duraphat, Icon approximal caries infiltration kit
Device
Lead sponsor
DMG Dental Material Gesellschaft mbH
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 25, 2015 · Synced Sep 22, 2026, 6:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study of Treatments Used for White Spot Lesions After Orthodontic Treatment.

NCT01059058
View directory record Official record
Conditions
Tooth Demineralization
Interventions
MI Paste Plus, PreviDent Fluoride Varnish, Normal Home Care
Procedure
Lead sponsor
University of Washington
Other
Eligibility
12 Years to 20 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 16, 2015 · Synced Sep 22, 2026, 6:11 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Early Caries Lesion Management Observational Study

NCT04933331
View directory record Official record
Conditions
Initial Caries, Arrested Dental Caries, Cavitated Caries, Dental Caries, Dental Caries in Children
Interventions
Curodont Repair Fluoride Plus, Silver Diamine Fluoride, Glass Ionomer Sealant, Fluoride varnish, Fluoride toothpaste
Drug · Device
Lead sponsor
CareQuest Institute for Oral Health
Other
Eligibility
4 Years and older
Enrollment
744 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
4
States / cities
Dothan, Alabama • Westborough, Massachusetts • Bend, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 23, 2023 · Synced Sep 22, 2026, 6:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CAMBRA - PBRN Caries Management By Risk Assessment In A Practice-Based Research Network

NCT01176396
View directory record Official record
Conditions
Dental Caries
Interventions
Caries prevention active intervention, control treatment
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
12 Years to 65 Years
Enrollment
460 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 9, 2020 · Synced Sep 22, 2026, 6:11 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Fluoride Varnish Randomized Clinical Trial

NCT00066963
View directory record Official record
Conditions
Dental Caries
Interventions
Fluoride Varnish
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Months to 36 Months
Enrollment
376 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 8, 2022 · Synced Sep 22, 2026, 6:11 AM EDT
Terminated Not applicable Interventional Results available

Clinical Trial Proximal Caries Infiltration and Detection

NCT01796106
View directory record Official record
Conditions
Caries,Dental
Interventions
Resin infiltration, Fluoride varnish & Oral hygiene instruction
Device
Lead sponsor
DMG Dental Material Gesellschaft mbH
Industry
Eligibility
6 Years to 13 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 18, 2023 · Synced Sep 22, 2026, 6:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Older Adult Effectiveness of 2 Treatments

NCT03916926
View directory record Official record
Conditions
Dental Caries
Interventions
A "simple medical strategy" consisting of silver diamine fluoride (SDF), B "typical dental strategy" consisting of atraumatic restorative treatment (ART) with glass ionomer cement + Fluoride varnish (FV)
Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
62 Years and older
Enrollment
568 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Sep 22, 2026, 6:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride

NCT03770286
View directory record Official record
Conditions
Dental Caries in Children, Dental Caries Class II, Dental Caries
Interventions
5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
Device
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
3 Years to 12 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 22, 2026, 6:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Fissure Caries Inhibition Study With Solea CO2-9.3μm Short-pulsed Laser

NCT02357979
View directory record Official record
Conditions
Dental Caries
Interventions
Laser, Fluoride
Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Sep 22, 2026, 6:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Fluoride Varnish for Treatment of White Spot Lesions

NCT01500187
View directory record Official record
Conditions
White Spot Lesions
Interventions
Vanish Varnish, Pediagel
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
12 Years to 16 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Sep 22, 2026, 6:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Effectiveness of School-based Caries Prevention

NCT03442309
View directory record Official record
Conditions
Dental Caries, Quality of Life
Interventions
Silver Diamine Fluoride, Fluoride Varnishes, Glass Ionomer
Device
Lead sponsor
NYU College of Dentistry
Other
Eligibility
5 Years to 12 Years
Enrollment
7,418 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Sep 22, 2026, 6:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Effectiveness of Treatments to Prevent Dental Caries

NCT03448107
View directory record Official record
Conditions
Dental Caries
Interventions
Silver Diamine Fluoride, Fluoride Varnishes, Glass Ionomer
Device
Lead sponsor
NYU College of Dentistry
Other
Eligibility
5 Years to 12 Years
Enrollment
3,345 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Sep 22, 2026, 6:11 AM EDT