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Showing 1–17 of 17 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Fluorides, Topical Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

LT Comparative Effectiveness of 2 Caries Treatments

NCT07213661
View directory record Official record
Conditions
Dental Caries
Interventions
A "simple medical strategy" consisting of silver diamine fluoride (SDF), A "typical dental strategy" consisting of atraumatic restorative treatment (ART) with glass ionomer cement + Fluoride Varnish (FV)
Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
62 Years and older
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Sep 6, 2026, 1:53 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Medical Management of Caries in the Primary Dentition Using Silver Nitrate

NCT02604134
View directory record Official record
Conditions
Dental Caries
Interventions
Prophylaxis, Fluoride varnish, Silver Nitrate
Procedure · Drug
Lead sponsor
Arwa Owais
Other
Eligibility
2 Years to 11 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Sep 6, 2026, 1:53 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Fluoride Administered and Retained After Topical Fluoride Varnish

NCT01754831
View directory record Official record
Conditions
Healthy
Interventions
Fluoride varnish
Device
Lead sponsor
University of Washington
Other
Eligibility
12 Months to 15 Months
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 6, 2018 · Synced Sep 6, 2026, 1:53 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Pharmacokinetics of Advantage Arrest

NCT04184271
View directory record Official record
Conditions
Dental Caries
Interventions
38% silver diamine fluoride
Drug
Lead sponsor
Advantage Silver Dental Arrest, LLC
Industry
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 25, 2021 · Synced Sep 6, 2026, 1:53 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of a Low-fluoride Anticaries Toothpaste

NCT01094210
View directory record Official record
Conditions
Tooth Abnormality
Interventions
Fluorides, Topical
Drug
Lead sponsor
Indiana Nanotech, LLC
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 24, 2015 · Synced Sep 6, 2026, 1:53 PM EDT
Terminated Not applicable Interventional Results available

Clinical Trial Proximal Caries Infiltration and Detection

NCT01796106
View directory record Official record
Conditions
Caries,Dental
Interventions
Resin infiltration, Fluoride varnish & Oral hygiene instruction
Device
Lead sponsor
DMG Dental Material Gesellschaft mbH
Industry
Eligibility
6 Years to 13 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 18, 2023 · Synced Sep 6, 2026, 1:53 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Pharmacokinetics of Advantage Arrest in Children

NCT04186663
View directory record Official record
Conditions
Dental Caries
Interventions
Silver Diamine Fluoride
Drug
Lead sponsor
Advantage Silver Dental Arrest, LLC
Industry
Eligibility
3 Years to 13 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Sep 6, 2026, 1:53 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride

NCT03770286
View directory record Official record
Conditions
Dental Caries in Children, Dental Caries Class II, Dental Caries
Interventions
5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
Device
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
3 Years to 12 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 6, 2026, 1:53 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Topical Rapamycin Therapy to Alleviate Cutaneous Manifestations of Tuberous Sclerosis Complex (TSC) and Neurofibromatosis I (NF1)

NCT01031901
View directory record Official record
Conditions
Tuberous Sclerosis, Neurofibromatoses, Angiofibroma, Neurofibroma
Interventions
Skincerity, Skincerity plus sirolimus/rapamycin, Skinercity plus sirolimus/rapamycin
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
13 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 26, 2012 · Synced Sep 6, 2026, 1:53 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Safety Evaluation of Advantage Anti-Caries Varnish

NCT02645617
View directory record Official record
Conditions
Dental Caries
Interventions
Varnish
Drug
Lead sponsor
Advantage Dental Services, LLC
Industry
Eligibility
36 Months to 60 Months
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 20, 2020 · Synced Sep 6, 2026, 1:53 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Glass Ionomer Sealant and Fluoride Varnish Study to Prevent Early Childhood Caries

NCT01129440
View directory record Official record
Conditions
Dental Caries
Interventions
Fluoride Varnish, Glass Ionomer Sealant
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
2 Years to 3 Years
Enrollment
597 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
San Ysidro, California
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Sep 6, 2026, 1:53 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Older Adult Effectiveness of 2 Treatments

NCT03916926
View directory record Official record
Conditions
Dental Caries
Interventions
A "simple medical strategy" consisting of silver diamine fluoride (SDF), B "typical dental strategy" consisting of atraumatic restorative treatment (ART) with glass ionomer cement + Fluoride varnish (FV)
Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
62 Years and older
Enrollment
568 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Sep 6, 2026, 1:53 PM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Effectiveness Silver Diamine Fluoride Versus Sodium Fluoride in Arresting Caries Around Crown Margins in Older Adults

NCT04255251
View directory record Official record
Conditions
Caries Roots, Flouride Varnish, Caries; Dentin, Caries Arrested
Interventions
Silver Diammine Fluoride, Fluoride Varnishes
Drug
Lead sponsor
University of New England
Other
Eligibility
65 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Oct 4, 2021 · Synced Sep 6, 2026, 1:53 PM EDT
Completed Early Phase 1 Interventional

SDF Application in Oral Cancer Patients to Prevent Dental Caries

NCT05403125
View directory record Official record
Conditions
Dental Caries
Interventions
silver diamine fluoride, 38%, Sodium fluoride gel, 5000 PPM
Device
Lead sponsor
Texas A & M University Baylor College Of Dentistry
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Sep 6, 2026, 1:53 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Improve Diabetic Glucose Control

NCT06890676
View directory record Official record
Conditions
Periodontitis, Gingivitis, Periodontal Disease, Periodontal Infections, Oral Infections, Periapical Infections, Pneumonia, Diabetes
Interventions
Comprehensive Oral Evaluation, Intraoral Complete Radiographic Series, • Teledentistry-synchronous and asynchronous, Periodontal Therapy, Periodontal Maintenance Procedure, Application of Caries Arresting Medicament, Oral Hygiene Assistance, Referral for Treatment of Acute Oral Infection
Other · Procedure
Lead sponsor
Missouri Department of Health and Senior Services
Other
Eligibility
60 Years to 100 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Jefferson City, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 25, 2025 · Synced Sep 6, 2026, 1:53 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Stopping Cavities Study: Diammine Silver Fluoride

NCT02536040
View directory record Official record
Conditions
Dental Caries
Interventions
38% diammine silver fluoride, Water
Drug · Other
Lead sponsor
Advantage Dental Services, LLC
Industry
Eligibility
24 Months to 60 Months
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Redmond, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 22, 2020 · Synced Sep 6, 2026, 1:53 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Pharmacokinetics of Advantage Arrest in Healthy Children 13-Months to 13-Years of Age

NCT05670743
View directory record Official record
Conditions
Dental Caries in Children
Interventions
38% silver diamine fluoride
Drug
Lead sponsor
Advantage Silver Dental Arrest, LLC
Industry
Eligibility
13 Months to 13 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 5, 2024 · Synced Sep 6, 2026, 1:53 PM EDT