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Showing 1–20 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Focal Cryoablation Clear all
Active, not recruiting Not applicable Interventional

Multi-center Clinical Study to Evaluate the C2 CryoBalloon Focal Ablation System

NCT02514525
View directory record Official record
Conditions
Barrett Esophagus
Interventions
CryoBalloon Ablation System
Device
Lead sponsor
Pentax Medical
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
11
States / cities
Orange, California • Sarasota, Florida • Chicago, Illinois + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2025 · Synced Sep 10, 2026, 5:54 PM EDT
Completed Phase 3 Interventional Results available

A Clinical Study of the Arctic Front Cryoablation Balloon for the Treatment of Paroxysmal Atrial Fibrillation

NCT00523978
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
Arctic Front® Cryoablation Catheter, Flecainide or Sotalol or Propafenone
Device · Drug
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years to 75 Years
Enrollment
245 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
23
States / cities
Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 19 more
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Sep 10, 2026, 5:54 PM EDT
Recruiting No phase listed Observational

International REgistry of COnservative or Radical Treatment of Localized Kidney Tumors

NCT05363657
View directory record Official record
Conditions
Kidney Cancer
Interventions
Partial Nephrectomy (PN), Radical Nephrectomy (RN), Ablation therapy (AT), Active Surveillance (AS)
Procedure · Diagnostic Test
Lead sponsor
Azienda Ospedaliero-Universitaria Careggi
Other
Eligibility
18 Years and older
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
7
States / cities
Los Angeles, California • San Diego, California • Stanford, California + 4 more
Source: ClinicalTrials.gov public record
Updated May 5, 2022 · Synced Sep 10, 2026, 5:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Randomized Trial of HIFU vs. Cryo for Prostate Cancer

NCT06929065
View directory record Official record
Conditions
Prostate Cancer, Prostate Cancer Stage I, Prostate Cancer Stage II, High Intensity Focused Ultrasound, HIFU, Cryoablation
Interventions
HIFU vs Cryoablation
Procedure
Lead sponsor
Kaiser Permanente
Other
Eligibility
40 Years to 80 Years · Male only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 14, 2025 · Synced Sep 10, 2026, 5:54 PM EDT
Completed Phase 2 Interventional

Cryosurgery in Treating Patients With Liver Cancer or Liver Metastases

NCT00002655
View directory record Official record
Conditions
Liver Cancer, Metastatic Cancer
Interventions
cryosurgery
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 1999
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 21, 2013 · Synced Sep 10, 2026, 5:54 PM EDT
Terminated Phase 2 Interventional

Unilateral Nerve-Sparing Cryoablation for Low-Risk, Clinically Localized, Unilateral Prostate Cancer

NCT02459912
View directory record Official record
Conditions
Prostate Cancer
Interventions
Unilateral Nerve-Sparing Cryoablation of the Prostate, Precise Cryoablation System with IceRod Needles
Procedure · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
40 Years to 69 Years · Male only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Mineola, New York
Source: ClinicalTrials.gov public record
Updated Feb 5, 2019 · Synced Sep 10, 2026, 5:54 PM EDT
Recruiting Phase 2 Interventional

An Evidence-Based Focal Cryotherapy Protocol for Focal Ablation of Intermediate Risk Prostate Cancer

NCT05454488
View directory record Official record
Conditions
Prostate Cancer
Interventions
Focal Cryoablation, Standard of Care, Quality-of-life Questionnaires
Drug · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Male only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Sep 10, 2026, 5:54 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Compare Ultrasound Assisted Cold Therapy and Lidocaine Injection to Treat Morton's Neuroma

NCT02838758
View directory record Official record
Conditions
Intermetatarsal Neuroma
Interventions
Cryoablation, Lidocaine, Saline
Device · Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 5, 2018 · Synced Sep 10, 2026, 5:54 PM EDT
Recruiting Not applicable Interventional

Improving Cryoablation Efficacy With BARRigel Rectal Spacing (ICE-BARR)

NCT07567027
View directory record Official record
Conditions
Prostate Cancer (Diagnosis), Transperineal Cryoablation
Interventions
Barrigel Injectable Gel, Cryoablation
Device · Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
40 Years to 95 Years · Male only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 10, 2026, 5:54 PM EDT
Terminated Early Phase 1 Interventional

Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer

NCT00499733
View directory record Official record
Conditions
Cancer
Interventions
cyclophosphamide, Cryoablation
Drug · Device
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Other
Eligibility
18 Years to 120 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 17, 2019 · Synced Sep 10, 2026, 5:54 PM EDT
Not listed Not applicable Interventional

Focal US-guided Cryo-ablation Using DynaCAD / UroNAV Preplanning / Guidance of Intermediate Risk Prostate Cancer

NCT04656678
View directory record Official record
Conditions
Prostate Cancer, Prostate Disease
Interventions
Cryo-ablation Using DynaCAD / UroNAV preplanning / guidance
Device
Lead sponsor
Northwell Health
Other
Eligibility
45 Years and older · Male only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
3
States / cities
Lake Success, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Sep 10, 2026, 5:54 PM EDT
Recruiting No phase listed Observational

MRI-Guided Cryoablation for Focal Native Prostate Cancer

NCT04797039
View directory record Official record
Conditions
Primary Malignant Neoplasm of Prostate (Diagnosis)
Interventions
MR guided cryoablation
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
30 Years to 100 Years · Male only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 10, 2026, 5:54 PM EDT
Completed Phase 2 Interventional

Study of Focal Cryoablation in Low-Risk Prostate Cancer

NCT00774436
View directory record Official record
Conditions
Prostate Cancer
Interventions
focal cryotherapy
Procedure
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
21 Years and older · Male only
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 28, 2019 · Synced Sep 10, 2026, 5:54 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Focal Therapy for Localized Prostate Cancer

NCT06270043
View directory record Official record
Conditions
Prostate Cancer
Interventions
Focal Therapy
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Male only
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2034
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Feb 25, 2024 · Synced Sep 10, 2026, 5:54 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Effect of CryoBalloon Focal Ablation System on Human Esophageal Epithelium

NCT02534233
View directory record Official record
Conditions
Barrett's Esophagus, Esophageal Squamous Dysplasia, Esophageal Cancer
Interventions
CryoBalloon
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Sep 10, 2026, 5:54 PM EDT
Terminated Not applicable Interventional Results available

Feasibility Study of Prostate Tumor Localization for Focal Cryoablation of Prostate Carcinoma

NCT00851682
View directory record Official record
Conditions
Prostate Cancer
Interventions
MRI scan
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
20 Years to 85 Years · Male only
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 30, 2018 · Synced Sep 10, 2026, 5:54 PM EDT
Completed Not applicable Interventional Results available

CellFX Comparison to Cryosurgery in Cutaneous Non-Genital Common Warts

NCT04738734
View directory record Official record
Conditions
Warts, Warts Hand, Verruca
Interventions
CellFX System Device, Cryosurgery Liquid Nitrogen Sprayer
Device
Lead sponsor
Pulse Biosciences, Inc.
Industry
Eligibility
22 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
10
States / cities
Scottsdale, Arizona • Beverly Hills, California • Greenwood Village, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Nov 23, 2023 · Synced Sep 10, 2026, 5:54 PM EDT
Completed Not applicable Interventional Results available

Cryovagotomy Diabetes Trial

NCT04276051
View directory record Official record
Conditions
Diabetes Type 2, Diabetes Mellitus, Obesity
Interventions
Cryoablation of the Vagus Nerve, Lifestyle Intervention
Device · Behavioral
Lead sponsor
Emory University
Other
Eligibility
22 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
5
States / cities
Atlanta, Georgia • Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 7, 2023 · Synced Sep 10, 2026, 5:54 PM EDT
Recruiting Not applicable Interventional

Focal Ablation With Focal Cryotherapy or HIFU for the Treatment of Men With Localized Prostate Cancer

NCT06178354
View directory record Official record
Conditions
Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage IIIA Prostate Cancer AJCC v8, Stage IIIB Prostate Cancer AJCC v8
Interventions
Cryosurgery, High-Intensity Focused Ultrasound Ablation, Survey Administration
Procedure · Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older · Male only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 10, 2026, 5:54 PM EDT
Completed Not applicable Interventional

Prostate Conformal Cryotherapy

NCT00877682
View directory record Official record
Conditions
Prostate Cancer
Interventions
Cryoablation
Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
Male only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 30, 2018 · Synced Sep 10, 2026, 5:54 PM EDT