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Showing 1–24 of 28 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Functional Endoscopic Sinus Surgery Clear all
Completed Not applicable Interventional Results available

Balloon Sinus Dilation In Office or OR

NCT00939393
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
FESS instruments with or without balloon treatment, Balloon Sinuplasty
Device
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Independence, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 11, 2024 · Synced Sep 7, 2026, 7:27 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Management of Pediatric Chronic Rhinosinusitis in Asthmatic Children

NCT03336671
View directory record Official record
Conditions
Chronic Sinusitis, Adenoid Disease - Chronic
Interventions
Endoscopic Sinus surgery, Adenoidectomy
Procedure
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
6 Years to 12 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Sep 7, 2026, 7:27 PM EDT
Completed Phase 3 Interventional Results available

A Clinical Evaluation of a Steroid-Coated Sinus Stent When Used Following Functional Endoscopic Sinus Surgery in Patients With Chronic Sinusitis

NCT01253577
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
Sinus Stent with drug coating, Non Coated Sinus Stent
Device
Lead sponsor
Intersect ENT
Industry
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
11
States / cities
Fresno, California • Colorado Springs, Colorado • Chicago, Illinois + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 21, 2015 · Synced Sep 7, 2026, 7:27 PM EDT
Completed Phase 4 Interventional Results available

Postoperative Pain and Functional Patient Outcomes After Functional Endoscopic Sinus Surgery

NCT00927888
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Bupivacaine Block, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 70 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 18, 2016 · Synced Sep 7, 2026, 7:27 PM EDT
Completed Not applicable Interventional Results available

Prospective Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline Absorption

NCT02453841
View directory record Official record
Conditions
Adenoidectomy, Functional Endoscopic Sinus Surgery (FESS), Turbinate Surgery
Interventions
Oxymetazoline
Drug
Lead sponsor
Richard Cartabuke
Other
Eligibility
2 Years to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 17, 2018 · Synced Sep 7, 2026, 7:27 PM EDT
Completed Phase 2 Interventional Results available

Effectiveness of Antibiotic Delivery Via Bio-absorbable Sponge

NCT01222832
View directory record Official record
Conditions
Paranasal Sinus Disease
Interventions
Bacitracin
Drug
Lead sponsor
Steward St. Elizabeth's Medical Center of Boston, Inc.
Other
Eligibility
18 Years and older
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Brighton, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Sep 7, 2026, 7:27 PM EDT
Withdrawn Not applicable Interventional

Pilot Study To Evaluate A Pharmacologically Active Nasal Sponge Following Endoscopic Sinus Surgery

NCT00705354
View directory record Official record
Conditions
Sinusitis, Chronic Sinusitis
Interventions
Bacitracin, Nasopore sponge soaked with saline
Drug · Procedure
Lead sponsor
Lahey Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Burlington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2012 · Synced Sep 7, 2026, 7:27 PM EDT
Completed Phase 4 Interventional Results available

Prophylactic Antibiotics After Functional Endoscopic Sinus Surgery: a Randomized, Double-blind Placebo Controlled Trial

NCT01919411
View directory record Official record
Conditions
Sinusitis
Interventions
Amoxicillin-Potassium Clavulanate, Placebo
Drug
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 24, 2020 · Synced Sep 7, 2026, 7:27 PM EDT
Terminated Phase 4 Interventional

Study of the Use of LUMA Lightwire

NCT00705237
View directory record Official record
Conditions
Sinusitis
Interventions
Functional Endoscopic Sinus Surgery with Balloon Dilatation
Procedure
Lead sponsor
Lahey Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Burlington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 17, 2009 · Synced Sep 7, 2026, 7:27 PM EDT
Completed Phase 1Phase 2 Interventional

Functional Endoscopic Sinus Surgery Study

NCT03970655
View directory record Official record
Conditions
Chronic Rhinosinusitis (Diagnosis)
Interventions
Bupivacaine or Ropivacaine with epinephrine plus dexamethasone - Group 1, Bupivacaine or Ropivacaine with epinephrine plus dexamethasone - Group 2
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 90 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 7, 2026, 7:27 PM EDT
Not listed Phase 3 Interventional

Acetaminophen Given Per Os and Intravenous in Sinus Surgery

NCT03295214
View directory record Official record
Conditions
Acetaminophen
Interventions
Acetaminophen
Drug
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Sep 7, 2026, 7:27 PM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of the Steroid-Eluting Sinexus Intranasal Splint When Used Following Functional Endoscopic Sinus Surgery (FESS) in Patients With Chronic Sinusitis

NCT00912405
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
Steroid-Eluting Sinexus Intranasal Splint
Device
Lead sponsor
Intersect ENT
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Apr 19, 2015 · Synced Sep 7, 2026, 7:27 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Topical Irrigation Therapy for CRS

NCT02630472
View directory record Official record
Conditions
Rhinitis, Sinusitis
Interventions
Quinine Sulfate, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 12, 2019 · Synced Sep 7, 2026, 7:27 PM EDT
Completed Not applicable Interventional Results available

Randomized Evaluation of Maxillary Antrostomy Versus Ostial Dilation Efficacy Through Long-Term Follow-Up

NCT01525849
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
Balloon Sinus Dilation, Functional Endoscopic Sinus Surgery
Device · Procedure
Lead sponsor
Entellus Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Plymouth, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 23, 2017 · Synced Sep 7, 2026, 7:27 PM EDT
Completed No phase listed Observational

Response Shift in Sinus Surgery Outcomes

NCT01391910
View directory record Official record
Conditions
Chronic Rhinosinusitis
Interventions
Not listed
Lead sponsor
Greg Davis
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 11, 2013 · Synced Sep 7, 2026, 7:27 PM EDT
Completed Phase 4 Interventional Results available

Regional Anesthesia to Reduce Opioid Use Following Functional Endoscopic Sinus Surgery

NCT03757715
View directory record Official record
Conditions
Pain Management
Interventions
Bupivacaine, Dexamethasone
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 30, 2022 · Synced Sep 7, 2026, 7:27 PM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers

Pain Management Following Sinus Surgery

NCT03822962
View directory record Official record
Conditions
Nasal Sinus; Inflammation, Opioid Abuse, Pain, Postoperative
Interventions
Ibuprofen 600Mg Tablet, Standard Regimen | Tylenol
Drug · Other
Lead sponsor
University of Nebraska
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Omaha, Nebraska • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 5, 2023 · Synced Sep 7, 2026, 7:27 PM EDT
Not listed Phase 2 Interventional

GLS-1200 Topical Nasal Spray to Prevent Sinusitis After Endoscopic Sinus Surgery

NCT04060316
View directory record Official record
Conditions
Sinusitis Chronic
Interventions
GLS-1200, Placebo
Drug
Lead sponsor
GeneOne Life Science, Inc.
Industry
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 10, 2023 · Synced Sep 7, 2026, 7:27 PM EDT
Completed Not applicable Interventional Results available

Comparison of Nasal Steroids After FESS in CRSwNP

NCT02194062
View directory record Official record
Conditions
Sinusitis, Nasal Polyps
Interventions
fluticasone nasal spray, Budesonide head upright, Budesonide head forward
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
2
States / cities
New Haven, Connecticut • Stratford, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 7, 2018 · Synced Sep 7, 2026, 7:27 PM EDT
Active, not recruiting Not applicable Interventional

Safety and Effectiveness of TurbAlign™ for Middle Turbinate Medialization After Functional Endoscopic Sinus Surgery

NCT07027267
View directory record Official record
Conditions
Sinus Endoscopic Surgery, Turbinate
Interventions
Implantation of Spirair device into the middle turbinates, TurbAlign
Device
Lead sponsor
Spirair, Inc
Industry
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
5
States / cities
Arlington Heights, Illinois • Chicago, Illinois • Marrero, Louisiana + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 7, 2026, 7:27 PM EDT
Completed Phase 4 Interventional Results available

Are NSAIDs Effective Enough for Postoperative Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty

NCT03605914
View directory record Official record
Conditions
Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty
Interventions
diclofenac, Norco
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 19, 2021 · Synced Sep 7, 2026, 7:27 PM EDT
Completed Not applicable Interventional Results available

The Efficacy of MEDIHONEY® for Chronic Rhinosinusitis With Nasal Polyposis After Functional Endoscopic Sinus Surgery

NCT02562924
View directory record Official record
Conditions
Chronic Sinusitis, Nasal Polyposis
Interventions
MEDIHONEY®, Budesonide, Normal saline sinus rinse, Prednisone, Endoscopic sinus surgery, nasal saline spray
Device · Drug · Procedure
Lead sponsor
University of Vermont Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 15, 2019 · Synced Sep 7, 2026, 7:27 PM EDT
Completed Not applicable Interventional Results available

Auricular Neuromodulation for FESS

NCT06662422
View directory record Official record
Conditions
Functional Endoscopic Sinus Surgery, Vagal Nerve Stimulation, Platelet Activation
Interventions
Spark Biomedical Sparrow Ascent Transcutaneous Auricular Neurostimulation (tAN) System
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 7, 2026, 7:27 PM EDT
Completed Not applicable Interventional Results available

Microcurrent Device (TIVIC Health)

NCT05198518
View directory record Official record
Conditions
Chronic Rhinosinusitis
Interventions
Microcurrent TENS device, Sham Device
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Sep 7, 2026, 7:27 PM EDT