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Showing 1–24 of 34 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Grapefruit Clear all
Withdrawn Phase 3 Interventional Accepts healthy volunteers

A Study to Evaluate the Efficacy of Xlear vs. Placebo for Acute COVID-19 Infection

NCT04858620
View directory record Official record
Conditions
Covid19
Interventions
Xlear Nasal Spray, Placebo
Drug
Lead sponsor
Larkin Community Hospital
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 15, 2023 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

CYP3A4 Activity and Mineral Homeostasis

NCT02019875
View directory record Official record
Conditions
Vitamin D and Calcium Homeostasis
Interventions
Rifampin, Clarithromycin, Grapefruit Juice, Placebo
Drug · Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 60 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 18, 2023 · Synced Sep 4, 2026, 4:07 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

DHB Supplement Interaction Study

NCT02257879
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Not listed
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
18 Years to 60 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2020
U.S. locations
1
States / cities
Research Triangle Park, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Loperamide Grapefruit Juice Interaction PK Trial

NCT00806299
View directory record Official record
Conditions
Drug Interaction
Interventions
Loperamide / Red Grapefruit Juice, Loperamide/ White Grapefruit Juice, Loperamide / Pink Grapefruit Juice
Drug
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years to 59 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Oct 5, 2011 · Synced Sep 4, 2026, 4:07 PM EDT
Active, not recruiting Phase 2 Interventional

Ivosidenib for Patients With Clonal Cytopenia of Undetermined Significance and Mutations in IDH1

NCT05030441
View directory record Official record
Conditions
Clonal Cytopenia of Undetermined Significance
Interventions
Ivosidenib
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2030
U.S. locations
2
States / cities
St Louis, Missouri • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Phase 1 Interventional

Rapamycin With Grapefruit Juice for Advanced Malignancies

NCT00375245
View directory record Official record
Conditions
Tumors, Neoplasm Metastasis
Interventions
Rapamycin (sirolimus), Grapefruit Juice
Drug · Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 16, 2014 · Synced Sep 4, 2026, 4:07 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Fruit Juices on Hormone Metabolism

NCT02187328
View directory record Official record
Conditions
Cortisol
Interventions
Grapefruit juice, Apple juice
Other
Lead sponsor
Benedictine University
Other
Eligibility
18 Years to 60 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Lisle, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 10, 2014 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study Examing The Effect of Grapefruit Juice On The Blood And Urine Samples of Study Drug And Its By Product And Safety

NCT00645216
View directory record Official record
Conditions
Obesity
Interventions
CP-945,598
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 55 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 9, 2009 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Nitrate-rich Fruit and Vegetable Supplement on Blood Pressure

NCT03486145
View directory record Official record
Conditions
High Blood Pressure, Flow Mediated Dilation
Interventions
fruit and vegetable juice supplement, Placebo
Dietary Supplement
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 40 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 2, 2018 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Grapefruit or Grapefruit Juice on Anthropometry, Dietary Intakes, Appetite, and Metabolic Profile in Overweight and Obese Young and Middle-Aged Adults

NCT00581074
View directory record Official record
Conditions
Obesity
Interventions
diet (grapefruit or grapefruit juice)
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
21 Years to 50 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 26, 2011 · Synced Sep 4, 2026, 4:07 PM EDT
Terminated Phase 2 Interventional Results available

Sorafenib in Children and Young Adults With Recurrent or Progressive Low-Grade Astrocytomas

NCT01338857
View directory record Official record
Conditions
neurofibromatosis1 (NF1), Recurrent or Progressive Optic Pathway Gliomas (OPG), Recurrent or Progressive Low-grade Glioma
Interventions
Sorafenib (Nexavar)
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
2 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 16, 2017 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Impact of Grapefruit Juice on the Response to Clopidogrel

NCT00817999
View directory record Official record
Conditions
Healthy
Interventions
Grapefruit juice, Clopidogrel 75 mg/day, Clopidogrel 300 mg
Dietary Supplement · Drug
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 40 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 30, 2012 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Novel Supplement on Glycemic Variability Measured by Continuous Glucose Monitoring

NCT05832463
View directory record Official record
Conditions
Healthy
Interventions
Carbohydrate blocking supplement (CBS), Placebo capsule
Dietary Supplement
Lead sponsor
dōTERRA International
Industry
Eligibility
18 Years to 65 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Pleasant Grove, Utah
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Not applicable Interventional

Visual-OLfactory Training in Participants With COVID-19 Resultant Loss of Smell

NCT04710394
View directory record Official record
Conditions
Anosmia, Covid19, Ageusia, Hyposmia, Hypogeusia, SARS-CoV-2 Infection, COVID-19 Pandemic
Interventions
Smell Training
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 70 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 20, 2022 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Not applicable Interventional

Transporter Mediated Uptake of Montelukast

NCT00513760
View directory record Official record
Conditions
Asthma
Interventions
Grapefruit juice, Orange Juice, Gatorade
Dietary Supplement
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
15 Years to 18 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 9, 2025 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Grapefruit Feeding Trial in Healthy, Overweight Adults

NCT01452841
View directory record Official record
Conditions
Weight Loss, Obesity, Cardiovascular Risk Factors
Interventions
Grapefruit, Control
Other
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 16, 2011 · Synced Sep 4, 2026, 4:07 PM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

Evaluation of the Efficacy of Xylitol Nasal Spray Against SARS-CoV-2

NCT04610801
View directory record Official record
Conditions
Covid19
Interventions
Nasal Spray
Drug
Lead sponsor
Larkin Community Hospital
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 15, 2023 · Synced Sep 4, 2026, 4:07 PM EDT
Terminated Phase 2 Interventional Results available

Oral LBH589 in Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL)

NCT01090973
View directory record Official record
Conditions
Non-Hodgkin's Lymphoma
Interventions
LBH589
Drug
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 15, 2013 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

The Effect of Low Furanocoumarin Grapefruit Hybrid Juice Consumption on Midazolam Pharmacokinetics

NCT02117869
View directory record Official record
Conditions
Pharmacokinetics
Interventions
Low furanocoumarin hybrid grapefruit juice, Regular grapefruit juice, Water (control)
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 9, 2015 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Buprenorphine Disposition and CYP3A

NCT01576575
View directory record Official record
Conditions
Healthy
Interventions
Buprenorphine Control, Buprenorphine + Rifampin, Buprenorphine + Grapefruit juice, Buprenorphine + Ketoconazole
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 21, 2020 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

A Drug-Food Interaction Study Between Colchicine and Grapefruit Juice

NCT00984009
View directory record Official record
Conditions
Pharmacokinetics
Interventions
Colchicine, Grapefruit Juice
Drug · Other
Lead sponsor
Mutual Pharmaceutical Company, Inc.
Industry
Eligibility
18 Years to 45 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Nov 20, 2011 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Human Lycopene and Beta-cryptoxanthin Absorption From Citrus Fruit

NCT02348164
View directory record Official record
Conditions
Bioavailability of Carotenoids
Interventions
Pink grapefruit first followed by tangerines two weeks later, Tangerines first followed by pink grapefruit two weeks later
Other
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jan 27, 2015 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Phase 1 Interventional

A Pilot Study of the Grapefruit Flavonoid Naringenin for HCV Infection

NCT01091077
View directory record Official record
Conditions
Hepatitis C Virus, HCV Infection, Chronic HCV, Hepatitis C
Interventions
Naringenin
Dietary Supplement
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 22, 2015 · Synced Sep 4, 2026, 4:07 PM EDT
Completed Phase 2 Interventional

Phase II Trial of LBH589 in Refractory Colorectal Cancer

NCT00690677
View directory record Official record
Conditions
Colorectal Cancer
Interventions
LBH589
Drug
Lead sponsor
Swedish Medical Center
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 17, 2012 · Synced Sep 4, 2026, 4:07 PM EDT