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Showing 25–46 of 22 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: HBOT Clear all
Completed Phase 2 Interventional

Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury

NCT00170352
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Hyperbaric Oxygen Treatment (HBOT), Enhanced Oxygen Treatment (Enhanced FiO2)
Procedure
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
16 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 27, 2015 · Synced Sep 10, 2026, 2:29 PM EDT
Not yet recruiting Not applicable Interventional

Effect of HBOT on Femoral Head Avascular Necrosis (AVN)

NCT06931301
View directory record Official record
Conditions
Osteonecrosis, Avascular Necrosis
Interventions
Hyperbaric Oxygen Therapy
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2035
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 10, 2026, 2:29 PM EDT
Completed Phase 1 Interventional

Hyperbaric Oxygen Therapy (HBOT) in Chronic Traumatic Brain Injury (TBI)/Post Concussion Syndrome (PCS) and TBI/Post-Traumatic Stress Disorder (PTSD)

NCT00760734
View directory record Official record
Conditions
TBI (Traumatic Brain Injury), Post Concussion Syndrome, Post Traumatic Stress Disorder, Chronic Post Traumatic Stress Disorder
Interventions
Low pressure hyperbaric oxygen therapy
Drug
Lead sponsor
Paul G. Harch, M.D.
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Sep 10, 2026, 2:29 PM EDT
Completed Phase 1 Interventional

Hyperbaric Oxygen Treatment (HBOT) During Methadone Tapering

NCT05924022
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Hyperbaric Oxygen Treatment Full, Hyperbaric Oxygen Treatment Sham, Hyperbaric Oxygen Treatment Partial Pressure
Combination Product
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 10, 2026, 2:29 PM EDT
Active, not recruiting Phase 4 Interventional

Hyperbaric Oxygen Therapy for Soft Tissue Sarcoma Pilot Study

NCT03144206
View directory record Official record
Conditions
Sarcoma, Hyperbaric Oxygen Therapy
Interventions
Hyperbaric oxygen
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 10, 2026, 2:29 PM EDT
Completed Phase 2 Interventional Results available

Hyperbaric Oxygen Therapy for Lung Transplantation

NCT02363959
View directory record Official record
Conditions
Disorder Related to Lung Transplantation, Central Airway Stenosis, Airway Exudative Plaques, Airway Complications Post-Lung Transplantation
Interventions
Hyperbaric Oxygen Therapy, Endobronchial Biopsy of Airway Epithelium
Drug · Procedure
Lead sponsor
Duke University
Other
Eligibility
18 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 10, 2026, 2:29 PM EDT
Active, not recruiting Not applicable Interventional

EXHIT ENTRE Implementation Trial of High Intensity Versus Low Intensity Strategy

NCT04921787
View directory record Official record
Conditions
Substance Use Disorders, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
Interventions
Low Intensity, High Intensity
Other
Lead sponsor
Gavin Bart
Other
Eligibility
Not listed
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
4
States / cities
Boston, Massachusetts • Minneapolis, Minnesota • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 10, 2026, 2:29 PM EDT
Recruiting Not applicable Interventional

Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)

NCT05987852
View directory record Official record
Conditions
Ulcerative Colitis
Interventions
Hyperbaric Oxygen Therapy, Sham Hyperbaric Air
Device · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 85 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
13
States / cities
Birmingham, Alabama • Los Angeles, California • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 10, 2026, 2:29 PM EDT
Completed Not applicable Interventional

Use of Hyperbaric Oxygen Therapy to Treat COVID-19 Patients With Respiratory Distress

NCT04800120
View directory record Official record
Conditions
Covid19
Interventions
Hyperbaric Oxygen Therapy
Other
Lead sponsor
Steward St. Elizabeth's Medical Center of Boston, Inc.
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Taunton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 1, 2023 · Synced Sep 10, 2026, 2:29 PM EDT
Recruiting Phase 2 Interventional

Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy

NCT07214415
View directory record Official record
Conditions
TBI Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder, Post Concussive Syndrome
Interventions
Hyperbaric Oxygen Therapy
Drug
Lead sponsor
Summit Hyperbarics and Wellness
Other
Eligibility
18 Years to 75 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boise, Idaho
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 10, 2026, 2:29 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Chronic Radiation Cystitis and Effect of Hyperbaric Oxygen Therapy on Patient Reported Outcomes and Urine Inflammatory Biomarkers

NCT07368647
View directory record Official record
Conditions
Radiation Cystitis, Urinary Tract Infection (Diagnosis)
Interventions
Hyperbaric Oxygen Therapy
Other
Lead sponsor
Rachel A. Moses
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 10, 2026, 2:29 PM EDT
Terminated Not applicable Interventional

Hyperbaric Oxygen for COVID-19 Patients With Moderate to Severe Hypoxemia

NCT04619719
View directory record Official record
Conditions
Covid19
Interventions
Hyperbaric Oxygen Therapy (HBOT)
Device
Lead sponsor
Legacy Health System
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
3
States / cities
Bozeman, Montana • Mineola, New York • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 8, 2023 · Synced Sep 10, 2026, 2:29 PM EDT
Completed Phase 2 Interventional Results available

mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms

NCT01611194
View directory record Official record
Conditions
Traumatic Brain Injury With Brief Loss of Consciousness, Post-Concussion Syndrome
Interventions
Hyperbaric oxygen (HBO2) at 1.5 atms, Sham control 1.2 atms
Drug
Lead sponsor
U.S. Army Medical Research and Development Command
Federal
Eligibility
18 Years to 65 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
5
States / cities
Colorado Springs, Colorado • Fort Carson, Colorado • Jacksonville, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 20, 2018 · Synced Sep 10, 2026, 2:29 PM EDT
Withdrawn Not applicable Interventional

Hyperbaric Oxygen Therapy (HBOT) as a Treatment for COVID-19 (COVID-19) Infection

NCT04343183
View directory record Official record
Conditions
COVID-19
Interventions
Hyperbaric Oxygen Therapy
Device
Lead sponsor
Ochsner Health System
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 11, 2023 · Synced Sep 10, 2026, 2:29 PM EDT
Completed Phase 4 Interventional Results available

Pseudoephedrine Prophylaxis for Prevention of Middle Ear Barotrauma in Hyperbaric Oxygen Therapy

NCT04332211
View directory record Official record
Conditions
Barotrauma;Ear
Interventions
Hyperbaric Oxygen Therapy, Pseudoephedrine 60 MG, Placebo oral tablet
Procedure · Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Sep 10, 2026, 2:29 PM EDT
Terminated Not applicable Interventional Results available

An Evaluation of Hyperbaric Treatments for Children With Cerebral Palsy

NCT00290186
View directory record Official record
Conditions
Cerebral Palsy, Cerebral Palsy, Spastic
Interventions
Hyperbaric Oxygen Treatment, Hyperbaric Air Treatment
Device
Lead sponsor
Dayton Children's Hospital
Other
Eligibility
3 Years to 8 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
2
States / cities
Dayton, Ohio • Wpafb, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 27, 2014 · Synced Sep 10, 2026, 2:29 PM EDT
Not listed Phase 2Phase 3 Interventional Accepts healthy volunteers

A Dosing Study of Hyperbaric Oxygen Therapy (HBOT) on Epigenetic Aging

NCT05297019
View directory record Official record
Conditions
Aging
Interventions
Hyperbaric Oxygen Therapy
Procedure
Lead sponsor
TruDiagnostic
Industry
Eligibility
40 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Florham Park, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 11, 2023 · Synced Sep 10, 2026, 2:29 PM EDT
Completed Not applicable Interventional Results available

A Proof-of-principle Study of HBO-SRS for Brain Metastases

NCT01850563
View directory record Official record
Conditions
Brain Metastases
Interventions
Hyperbaric oxygen given at 2.4 ATA for 30 minutes immediately prior to SRS - HBOT for 30 minutes - SRS without prior HBO
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Feb 7, 2022 · Synced Sep 10, 2026, 2:29 PM EDT
Completed Not applicable Interventional

Effect of Hyperbaric Therapy on Markers of Oxidative Stress in Children With Autism

NCT00263367
View directory record Official record
Conditions
Autism, Oxidative Stress
Interventions
Hyperbaric Oxygen
Other
Lead sponsor
The International Child Development Resource Center
Other
Eligibility
5 Years to 12 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated Jun 21, 2011 · Synced Sep 10, 2026, 2:29 PM EDT
Completed Phase 2 Interventional

Hyperbaric Oxygen Therapy for Ulcerative Colitis Flares

NCT03494764
View directory record Official record
Conditions
Colitis, Ulcerative
Interventions
Hyperbaric Oxygen Therapy
Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
8
States / cities
La Jolla, California • San Diego, California • Baltimore, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2021 · Synced Sep 10, 2026, 2:29 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Stem Cell Quantification In Peripheral Blood After Hyperbaric Oxygen Therapy Treatments

NCT01740908
View directory record Official record
Conditions
Changes in Peripheral Blood Population Numbers and Type.
Interventions
Hyperbaric Oxygen Treatment
Other
Lead sponsor
Restorix Research Institute, LLLP
Other
Eligibility
18 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Anacortes, Washington
Source: ClinicalTrials.gov public record
Updated Dec 3, 2012 · Synced Sep 10, 2026, 2:29 PM EDT
Not listed Phase 3 Interventional

Hyperbaric Oxygen Treatment to Treat Mild Traumatic Brain Injury (mTBI)/Persistent Post-Concussion Syndrome (PPCS)

NCT02089594
View directory record Official record
Conditions
Post-Concussion Syndrome, Traumatic Brain Injury
Interventions
Hyperbaric Oxygen, No Hyperbaric Oxygen
Drug
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Sep 10, 2026, 2:29 PM EDT