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ClinicalTrials.gov public records Last synced Oct 22, 2026, 10:05 AM EDT

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Showing 1–24 of 46 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: HD Transcranial Direct Stimulation Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Investigating Transcranial Direct Current Stimulation (tDCS) in Accelerating Learning in a Healthy Older Population

NCT03467698
View directory record Official record
Conditions
Associative Memory in Healthy Subjects
Interventions
Active tDCS, Sham tDCS
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
55 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Oct 22, 2026, 10:05 AM EDT
Active, not recruiting Not applicable Interventional

HD-tDCS for Phonological Impairment in Aphasia

NCT06010030
View directory record Official record
Conditions
Aphasia, Stroke
Interventions
Targeted Transcranial Direct Current Stimulation, Speech Therapy
Device · Behavioral
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2033
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Noninvasive Brain Stimulation in Mild Cognitive Impairment and Dementia

NCT05270408
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment, Dementia
Interventions
Active Transcranial direct current stimulation (STARStim 8), Sham Transcranial direct current stimulation (STARStim 8)
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
50 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 5, 2025 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Noninvasive Brain Stimulation on Memory in Individuals With Mild Cognitive Impairment and History of Brain Injury

NCT04504630
View directory record Official record
Conditions
Amnestic Mild Cognitive Impairment, Traumatic Brain Injury, Mild Traumatic Brain Injury
Interventions
High Definition Transcranial Direct Current Stimulation, Sham HD-tDCS
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
50 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Stimulation to Improve Memory

NCT03875326
View directory record Official record
Conditions
Mild Cognitive Impairment, Dementia of Alzheimer Type
Interventions
1 mA HD-tDCS, 2 mA HD-tDCS, 3 mA HD-tDCS, Sham
Device
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 2, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional

NEUROBALANCE Training to Improve Postural Control in Individuals With Traumatic Brain Injury

NCT06584591
View directory record Official record
Conditions
Traumatic Brain Injury, TBI, Diffuse Axonal Brain Injury, Brain Injuries, Traumatic
Interventions
Combined (Robotic balance training and high-definition transcranial direct current stimulation), Standard of Care Balance Training
Device · Other
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Oct 22, 2026, 10:05 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Electrical Stimulation on Verbal Learning in Typical and Atypical Alzheimer's Disease

NCT04122001
View directory record Official record
Conditions
Alzheimer Disease, Early Onset, Atypical Alzheimer's Disease, Logopenic Progressive Aphasia
Interventions
Active, in-person HD-tDCS or active remote tDCS, Sham, Word List Learning Intervention (WordLLI)
Device · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
45 Years to 85 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Treating Word Finding Difficulties in Traumatic Brain Injury With HD-tDCS

NCT06840808
View directory record Official record
Conditions
Traumatic Brain Injury, Cognitive Change, Word Finding Difficulty, Acquired Brain Injury
Interventions
Active Transcranial direct current stimulation, Sham Transcranial direct current stimulation
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 85 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Targeted Noninvasive Brain Stimulation (T-NIBS) to Improve Hand Motor Functions in Acquired Brain Injury

NCT04057105
View directory record Official record
Conditions
Upper Extremity Dysfunction, Traumatic Brain Injury
Interventions
Active High-definition Transcranial Direct Current Stimulation (HD-tDCS), MusicGlove
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 21, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Active, not recruiting Not applicable Interventional

Targeted HD-tDCS to Improve Upper Limb Rehabilitation in SCI

NCT05589415
View directory record Official record
Conditions
Spinal Cord Injuries, Spinal Cord Diseases
Interventions
High-definition Transcranial Direct Current Stimulation, Conventional Transcranial Direct Current Stimulation
Device
Lead sponsor
University of Texas Rio Grande Valley
Other
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Harlingen, Texas
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional

Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease

NCT05326451
View directory record Official record
Conditions
Huntington Disease
Interventions
active tDCS
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional

Open-label Feasibility Trial of HD-tDCS During Cognitive Behavioral Therapy for Cocaine Use Disorder

NCT07829263
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
High Definition Transcranial Direct Current Stimulation
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Withdrawn Not applicable Interventional

Investigating HD-tDCS in Improving Word Finding and Memory Retrieval in Individuals With MCI

NCT03446508
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Active frontal, Active parietal, Sham
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
40 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2022 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 1 Interventional

Open Label Treatment With tDCS for Parkinson's and Related Disorders for Improvement of Speech, Gait and Mood

NCT02104401
View directory record Official record
Conditions
Parkinson's Disease
Interventions
tDCS
Device
Lead sponsor
Georgetown University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 20, 2014 · Synced Oct 22, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional

Neuromodulation-Enhanced Use of RObotic BALANCE Training to Improve Balance Function in Individuals With Stroke

NCT07113041
View directory record Official record
Conditions
Stroke, Stroke (CVA) or Transient Ischemic Attack, Stroke Ischemic, Stroke Gait Rehabilitation, Balance Deficits
Interventions
Combined (Robotic balance training and high-definition transcranial direct current stimulation), Standard of Care Balance Training
Device · Other
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 21, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

HDtDCS in Logopenic Variant PPA: Effects on Language and Neural Mechanisms

NCT03805659
View directory record Official record
Conditions
Primary Progressive Aphasia
Interventions
HD-tDCS, Sham
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
45 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 11, 2024 · Synced Oct 22, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Psychobiological Responses Following Exercise and Brain Stimulation

NCT06874595
View directory record Official record
Conditions
Psychological
Interventions
Cycling exercise at 65% of HRR for 20 minutes followed by HD-tDCS (exercise + HD-tDCS), Cycling exercise at 65% of HRR exercise followed by sham HD-tDCS (exercise + sham tDCS), No exercise followed by HD-tDCS (no exercise + HD-tDCS)., State Anxiety Inventory, Visual Analog Scale for Anxiety
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 50 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Single-arm, Open-label, Phase II Trial of HD-tDCS in Fibromyalgia Patients

NCT01842009
View directory record Official record
Conditions
Fibromyalgia, Chronic Pain
Interventions
High Definition transcranial Direct Current Stimulation
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 24, 2020 · Synced Oct 22, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional

Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury

NCT05236010
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
rTMS, HD-tDCS, Attention Process Training
Device · Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years to 59 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
5
States / cities
Minneapolis, Minnesota • Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 2 Interventional Results available

Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS

NCT04046991
View directory record Official record
Conditions
Primary Progressive Aphasia
Interventions
high-definition transcranial direct current stimulation, modified constraint-induced language therapy
Device · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
45 Years to 80 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Transcranial Direct Current Stimulation (tDCS) Therapy in Major Depression

NCT04507243
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Active - HD tDCS, Sham - HD tDCS
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Oct 22, 2026, 10:05 AM EDT
Completed No phase listed Observational

Targeted Noninvasive Brain Stimulation to Improve Hand Dexterity in Stroke Patients

NCT04058288
View directory record Official record
Conditions
Stroke
Interventions
High-definition Transcranial Direct Current Stimulation
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 12, 2023 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility and Dose Tolerability of HD-tDCS in Healthy Adults and Children With Down Syndrome

NCT02481765
View directory record Official record
Conditions
Down Syndrome
Interventions
High definition transcranial direct current stimulation
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 45 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 11, 2020 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

INSIGHT, A Comprehensive, Multidisciplinary Brain Training System

NCT02780739
View directory record Official record
Conditions
Cognitive Ability, General
Interventions
Cognitive Training - 48 sessions, Fitness, Active Control, active tDCS, sham tDCS, Cognitive Training - 20 sessions
Behavioral · Device
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years to 44 Years
Enrollment
521 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated May 23, 2016 · Synced Oct 22, 2026, 10:05 AM EDT