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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: HD-tDCS Clear all
Completed Not applicable Interventional

Transcranial Direct Current Stimulation in Major Depression

NCT03556124
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Active - HD tDCS, Sham - HD tDCS, Active - Conventional tDCS, Sham - Conventional tDCS
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 55 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 30, 2020 · Synced Sep 26, 2026, 5:13 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Explosive Synchronization of Brain Network Activity in Chronic Pain

NCT04606095
View directory record Official record
Conditions
Fibromyalgia, Healthy Volunteers
Interventions
EEG, Neuroimaging EEG/fMRI (Aim 1), HD-tDCS treatments, Sham HD-tDCS treatments, Neuroimaging EEG/fMRI (Aim 3)
Diagnostic Test · Device
Lead sponsor
University of Michigan
Other
Eligibility
19 Years to 74 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 9, 2026 · Synced Sep 26, 2026, 5:13 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Non Invasive Brain Stimulation for PTSD

NCT02442843
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD)
Interventions
Active tDCS, Sham tDCS
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 88 Years · Male only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Sep 26, 2026, 5:13 AM EDT
Recruiting Not applicable Interventional

Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease

NCT05326451
View directory record Official record
Conditions
Huntington Disease
Interventions
active tDCS
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Sep 26, 2026, 5:13 AM EDT
Completed Not applicable Interventional Results available

Targeted High-definition Transcranial Direct Current Stimulation (HD-tDCS) for Reducing Post-stroke Movement Impairments

NCT05174949
View directory record Official record
Conditions
Stroke
Interventions
Transcranial direct current stimulation (high-definition)
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 90 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Sep 26, 2026, 5:13 AM EDT
Completed Not applicable Interventional Results available

Stimulation to Improve Memory

NCT03875326
View directory record Official record
Conditions
Mild Cognitive Impairment, Dementia of Alzheimer Type
Interventions
1 mA HD-tDCS, 2 mA HD-tDCS, 3 mA HD-tDCS, Sham
Device
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 26, 2026, 5:13 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA

NCT03887481
View directory record Official record
Conditions
Logopenic Progressive Aphasia, Primary Progressive Aphasia
Interventions
High-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment, Sham + "Repeat After Me" (RAM) Treatment
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 26, 2026, 5:13 AM EDT
Recruiting Phase 2 Interventional

Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

NCT05446584
View directory record Official record
Conditions
Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Amnestic Mild Cognitive Impairment, Mild Traumatic Brain Injury, Concussion, Brain
Interventions
High Definition Transcranial Direct Current Stimulation
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
55 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Sep 26, 2026, 5:13 AM EDT
Completed Phase 1 Interventional

High Definition Cathodal Transcranial Direct Current Stimulation for Treatment of Refractory Partial Onset Epilepsy

NCT02264652
View directory record Official record
Conditions
Epilepsy
Interventions
HD Transcranial Direct Stimulation
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
9 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
2
States / cities
Boston, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 25, 2018 · Synced Sep 26, 2026, 5:13 AM EDT
Completed Not applicable Interventional

Transcranial Direct Current Stimulation (tDCS) Therapy in Major Depression

NCT04507243
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Active - HD tDCS, Sham - HD tDCS
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 29, 2024 · Synced Sep 26, 2026, 5:13 AM EDT
Completed Not applicable Interventional

Exploration of Parameters of Transcranial Direct Current Stimulation (tDCS) in Chronic Pain

NCT01402960
View directory record Official record
Conditions
Chronic Pain
Interventions
High Definition Transcranial Direct Current Stimulation (HD-tDCS)
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Sep 26, 2026, 5:13 AM EDT
Not yet recruiting Not applicable Interventional

Optimal Targeted High-definition Transcranial Direct Current Stimulation for Reducing Post-stroke Upper Limb Motor Impairments

NCT07599774
View directory record Official record
Conditions
Hemiparetic Stroke
Interventions
High-definition transcranial direct stimulation: sham, High-definition transcranial direct stimulation: optimal, Modified constraint-induced movement therapy
Device · Behavioral
Lead sponsor
Carle Foundation Hospital
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 26, 2026, 5:13 AM EDT
Completed Not applicable Interventional Results available

HDtDCS in Logopenic Variant PPA: Effects on Language and Neural Mechanisms

NCT03805659
View directory record Official record
Conditions
Primary Progressive Aphasia
Interventions
HD-tDCS, Sham
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
45 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 10, 2024 · Synced Sep 26, 2026, 5:13 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Multimodal Investigation of Neural Plasticity

NCT06453980
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
sham tDCS, active tDCS
Device
Lead sponsor
University of Michigan
Other
Eligibility
60 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 26, 2026, 5:13 AM EDT
Completed Not applicable Interventional

Treating Word Finding Difficulties in Traumatic Brain Injury With HD-tDCS

NCT06840808
View directory record Official record
Conditions
Traumatic Brain Injury, Cognitive Change, Word Finding Difficulty, Acquired Brain Injury
Interventions
Active Transcranial direct current stimulation, Sham Transcranial direct current stimulation
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 85 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 26, 2026, 5:13 AM EDT
Completed Not applicable Interventional

Single-arm, Open-label, Phase II Trial of HD-tDCS in Fibromyalgia Patients

NCT01842009
View directory record Official record
Conditions
Fibromyalgia, Chronic Pain
Interventions
High Definition transcranial Direct Current Stimulation
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Sep 26, 2026, 5:13 AM EDT
Completed Not applicable Interventional

Treatment of Memory Disorders in Gulf War Illness With High Definition Transcranial Direct Cortical Stimulation

NCT03542383
View directory record Official record
Conditions
Memory Disorders, Word Finding Difficulty
Interventions
High Definition Transcranial Direct Current Stimulation, Sham High Definition Transcranial Direct Current Stimulation
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
45 Years to 78 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 26, 2026, 5:13 AM EDT
Recruiting Not applicable Interventional

Testing Personalized High-Definition Transcranial Direct Current Stimulation (HD-tDCS) as a Treatment of Posterior Cortical Atrophy

NCT07191327
View directory record Official record
Conditions
Posterior Cortical Atrophy
Interventions
HD-tDCS sessions, Sham HD-tDCS sessions, HD-tDCS sessions - Open-label (after randomized treatment)
Device
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 26, 2026, 5:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

INSIGHT, A Comprehensive, Multidisciplinary Brain Training System

NCT02780739
View directory record Official record
Conditions
Cognitive Ability, General
Interventions
Cognitive Training - 48 sessions, Fitness, Active Control, active tDCS, sham tDCS, Cognitive Training - 20 sessions
Behavioral · Device
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years to 44 Years
Enrollment
521 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated May 22, 2016 · Synced Sep 26, 2026, 5:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Patient Centered-Rehabilitation ver111090.1

NCT03034954
View directory record Official record
Conditions
Cognitive Change
Interventions
Active HD-tDCS, Sham HD-tDCS
Device
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 15, 2018 · Synced Sep 26, 2026, 5:13 AM EDT
Recruiting Not applicable Interventional

Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in Vivo)

NCT05769348
View directory record Official record
Conditions
Chronic Migraine
Interventions
HD-tDCS Active Protocol, HD-tDCS Sham Protocol
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 26, 2026, 5:13 AM EDT
Active, not recruiting Not applicable Interventional

Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation

NCT05368350
View directory record Official record
Conditions
Primary Progressive Aphasia, Apraxia of Speech
Interventions
high-definition transcranial direct current stimulation (HD-tDCS)
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 26, 2026, 5:13 AM EDT
Completed Not applicable Interventional Results available

A Study of HD-tDCS and Cognitive Training to Improve Cognitive Function in MCI

NCT04246164
View directory record Official record
Conditions
Mild Cognitive Impairment, Memory Disorders, Memory Loss
Interventions
HD-tDCS combined with CT, sham HD-tDCS combined with CT
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
50 Years to 90 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 26, 2026, 5:13 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Brain-stimulation on Metamemory Monitoring and Control

NCT03693729
View directory record Official record
Conditions
Healthy
Interventions
HD-tDCS
Device
Lead sponsor
Brooklyn College of the City University of New York
Other
Eligibility
18 Years to 35 Years
Enrollment
216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jul 9, 2020 · Synced Sep 26, 2026, 5:13 AM EDT