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ClinicalTrials.gov public records Last synced Oct 22, 2026, 3:57 PM EDT

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Showing 1–24 of 78 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Heart Rate Variability (HRV) Clear all
Completed Not applicable Interventional

Mental Stress Ischemia: Biofeedback Study

NCT02657382
View directory record Official record
Conditions
Cardiovascular Disease, Coronary Artery Disease
Interventions
Heart Rate Variability (HRV) Biofeedback (BF), Mental Stress Protocol
Behavioral · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
4
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 14, 2020 · Synced Oct 22, 2026, 3:57 PM EDT
Not listed Phase 1Phase 2 Interventional Accepts healthy volunteers

The Effect of Acupuncture on Blood Pressure and Heart Rate Variability (HRV)

NCT00724763
View directory record Official record
Conditions
Hypertension
Interventions
acupuncture, sham needle treatment
Device
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
20 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2008
U.S. locations
1
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 30, 2008 · Synced Oct 22, 2026, 3:57 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Foundational Programs to Combat Clinician Stress

NCT07220421
View directory record Official record
Conditions
Burnout, Professional, Stress, Psychological, Stress, Physiological, Psychological Well-Being, Mind-Body Therapies, Work Related Stress
Interventions
Sudarshan Kriya Yoga (SKY) Breathing and Sahaj Meditation, Health Education Program (HEP)
Behavioral · Other
Lead sponsor
Lancaster General Hospital
Other
Eligibility
25 Years to 70 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
6
States / cities
Boston, Massachusetts • Plainsboro, New Jersey • Lancaster, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Oct 22, 2026, 3:57 PM EDT
Completed No phase listed Observational

Novel Real-world Methods in Social Drinkers and AUD

NCT05155176
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Abuse, Alcohol Use Disorder
Interventions
Intensive Day Monitoring
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
54 participants
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Oct 22, 2026, 3:57 PM EDT
Completed Not applicable Interventional Results available

HRV Biofeedback in Pain Patients

NCT02426476
View directory record Official record
Conditions
Chronic Neuromuscular Pain
Interventions
active heart rate variability biofeedback training, sham HRVB training
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 2, 2021 · Synced Oct 22, 2026, 3:57 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Diaphragmatic Breathing and Heart Rate Variability Training for Improving Hypertension in Fragile X Associated Tremor/Ataxia

NCT03816540
View directory record Official record
Conditions
Hypertension, FXTAS
Interventions
HRV and respiratory coherence biofeedback
Device
Lead sponsor
University of California, Davis
Other
Eligibility
50 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Oct 22, 2019 · Synced Oct 22, 2026, 3:57 PM EDT
Completed Not applicable Interventional

Autonomic Recalibration

NCT06603168
View directory record Official record
Conditions
Chronic Pain (Back / Neck), Autonomic Dysregulation
Interventions
Autonomic Recalibration Treatment
Other
Lead sponsor
Edward Via Virginia College of Osteopathic Medicine
Other
Eligibility
21 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 22, 2026, 3:57 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Caring Relationships Expression Study

NCT05627687
View directory record Official record
Conditions
Caregiver Burden, Anxiety, Stress
Interventions
Heart Rate Variability Biofeedback, Music Listening Control
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 12, 2024 · Synced Oct 22, 2026, 3:57 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Feasibility of Heart Rate Variability Biofeedback With In-patient Pregnant Women

NCT02119936
View directory record Official record
Conditions
Maternal Stress, Maternal Anxiety, Maternal Health Services
Interventions
Heart Rate Variability Biofeedback Tool
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 19, 2018 · Synced Oct 22, 2026, 3:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cardiac Autonomic Function in Women with Microvascular Coronary Dysfunction

NCT01568177
View directory record Official record
Conditions
Microvascular Coronary Dysfunction
Interventions
Mental Stress Testing, Peripheral Arterial Tonometry (PAT) Testing, Heart Rate Variability (HRV), RESPeRATE Breathing Trial, SPECT cardiac scan with 123I-mIBG and Myoview
Behavioral · Other · Procedure
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 22, 2026, 3:57 PM EDT
Recruiting No phase listed Observational

HRV Variation in Rheumatoid Arthritis

NCT07878975
View directory record Official record
Conditions
Rheumatoid Arthritis (RA)
Interventions
Oura Ring
Device
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 22, 2026, 3:57 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effects of Intramuscular (IM) Oxytocin on Pupil Diameter and Heart Rate Variability (HRV)

NCT04105998
View directory record Official record
Conditions
Chronic Pain Due to Injury
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 66 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 10, 2022 · Synced Oct 22, 2026, 3:57 PM EDT
Not listed Phase 1 Interventional

Nutritional Supplements on Blood Pressure 2008

NCT00609570
View directory record Official record
Conditions
Hypertension
Interventions
NanoGreens, Whey protein, Calcium pills
Dietary Supplement
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
20 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
2
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 28, 2008 · Synced Oct 22, 2026, 3:57 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Parasympathetic Augmentation Via Respiratory Training for Patients With Systolic Heart Failure

NCT05223751
View directory record Official record
Conditions
Diastolic Heart Failure
Interventions
Meo Health Breathing and humming exercises
Behavioral
Lead sponsor
Lancaster General Hospital
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Lancaster, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Oct 22, 2026, 3:57 PM EDT
Recruiting Phase 2Phase 3 Interventional

The Many Roads to Trauma Recovery: A Clinical Trial Comparing Empirically Supported Treatments for Veterans With Co-Morbid Posttraumatic Stress and Substance Use Disorder Symptoms

NCT07756723
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Substance Use Disorder (SUD)
Interventions
Trauma Informed Heart Rate Variability Biofeedback, Present Centered Therapy
Behavioral
Lead sponsor
Coatesville VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Coatesville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 22, 2026, 3:57 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Monitoring Heart Rate Variability for the Early Detection of Pancreatic Cancer

NCT04400903
View directory record Official record
Conditions
Pancreatic Ductal Adenocarcinoma, Stage I Pancreatic Cancer AJCC v8, Stage IA Pancreatic Cancer AJCC v8, Stage IB Pancreatic Cancer AJCC v8
Interventions
Activity Monitor, Quality-of-Life Assessment, Questionnaire Administration
Device · Other
Lead sponsor
OHSU Knight Cancer Institute
Other
Eligibility
50 Years to 75 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
3
States / cities
Omaha, Nebraska • New York, New York • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 22, 2022 · Synced Oct 22, 2026, 3:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study of Osteopathic Manipulative Medicine on the Autonomic Nervous System

NCT02193373
View directory record Official record
Conditions
Osteopathic Manual Manipulation of Neurovascular Regulation
Interventions
Osteopathic Manual Medicine, Sham
Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
20 Years to 50 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Jul 5, 2019 · Synced Oct 22, 2026, 3:57 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Validation of Ejection Fraction and Cardiac Output Using Biostrap Wristband

NCT05279066
View directory record Official record
Conditions
Heart Failure
Interventions
Biostrap Wristband
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 15, 2022 · Synced Oct 22, 2026, 3:57 PM EDT
Withdrawn No phase listed Observational

Using WHOOP Fitness Band to Measure Heart Health Variability Before and After Surgery

NCT07097168
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Not listed
Lead sponsor
Tufts Medical Center
Other
Eligibility
20 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Oct 22, 2026, 3:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Cognitive Behavioral Stress Intervention for Women Who Smoke

NCT03077945
View directory record Official record
Conditions
Smoking, Cigarette, Smoking Cessation, Stress, Stress, Emotional, Stress Reaction
Interventions
heart rate variability biofeedback and cognitive reappraisal, control tasks
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 14, 2018 · Synced Oct 22, 2026, 3:57 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Wearable Technology to Evaluate Hyperglycemia and HRV in DMD

NCT06124196
View directory record Official record
Conditions
Duchenne Muscular Dystrophy
Interventions
wearable technology
Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
10 Years and older · Male only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2031
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 22, 2026, 3:57 PM EDT
Terminated Not applicable Interventional

Impact of a Biofeedback Intervention on Microbiome, Metabolome, and Clinical Outcomes in Pediatric IBD (Study 2)

NCT04296110
View directory record Official record
Conditions
IBD
Interventions
Biofeedback, Music Relaxation Therapy
Behavioral · Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
8 Years to 17 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 15, 2024 · Synced Oct 22, 2026, 3:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Minority Health Through Biofeedback and Stress Reduction

NCT07172152
View directory record Official record
Conditions
Cardiovascular Disease Risk Reduction, Chronic Stress, Anxiety, Emotional Regulation, Hypertension Prevention, Health Disparities
Interventions
HRV Biofeedback Training
Behavioral
Lead sponsor
Amelia Saul, PhD, CTRS, BCB
Other
Eligibility
18 Years to 35 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 22, 2026, 3:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Stress, EEG, ECG, and Chiropractic

NCT05245409
View directory record Official record
Conditions
Stress
Interventions
Chiropractic adjustment using an activator
Other
Lead sponsor
Life University
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 2, 2024 · Synced Oct 22, 2026, 3:57 PM EDT