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ClinicalTrials.gov public records Last synced Oct 22, 2026, 2:26 PM EDT

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Showing 1–24 of 61 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Heart Rate Variability- Biofeedback Clear all
Completed Not applicable Interventional

Mental Stress Ischemia: Biofeedback Study

NCT02657382
View directory record Official record
Conditions
Cardiovascular Disease, Coronary Artery Disease
Interventions
Heart Rate Variability (HRV) Biofeedback (BF), Mental Stress Protocol
Behavioral · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
4
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 14, 2020 · Synced Oct 22, 2026, 2:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Heart Focused Movement Effects on Cardiometabolic Risk

NCT05687240
View directory record Official record
Conditions
Cardiometabolic Risk Factors
Interventions
Qigong/Tai Chi, Heart rate variability biofeedback
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
55 Years to 85 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 12, 2024 · Synced Oct 22, 2026, 2:26 PM EDT
Completed Not applicable Interventional Results available

Heart Rate Variability Biofeedback for Substance Use Disorder: A Randomized Clinical Trial

NCT05454657
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Heart rate variability biofeedback + treatment as usual, Treatment as usual only
Device · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 26, 2025 · Synced Oct 22, 2026, 2:26 PM EDT
Completed Not applicable Interventional Results available

HRV Biofeedback in Pain Patients

NCT02426476
View directory record Official record
Conditions
Chronic Neuromuscular Pain
Interventions
active heart rate variability biofeedback training, sham HRVB training
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 2, 2021 · Synced Oct 22, 2026, 2:26 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Diaphragmatic Breathing and Heart Rate Variability Training for Improving Hypertension in Fragile X Associated Tremor/Ataxia

NCT03816540
View directory record Official record
Conditions
Hypertension, FXTAS
Interventions
HRV and respiratory coherence biofeedback
Device
Lead sponsor
University of California, Davis
Other
Eligibility
50 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Oct 22, 2019 · Synced Oct 22, 2026, 2:26 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Restorative Neurophysiology: Backing up and Restoring the Brain (BandR)

NCT07252011
View directory record Official record
Conditions
Adults With Variability in Their Mood
Interventions
Transcranial alternating current stimulation (tACS), Neuro/biofeedback, Recall, Physiological stimulation
Device · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Oct 22, 2026, 2:26 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Caring Relationships Expression Study

NCT05627687
View directory record Official record
Conditions
Caregiver Burden, Anxiety, Stress
Interventions
Heart Rate Variability Biofeedback, Music Listening Control
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 12, 2024 · Synced Oct 22, 2026, 2:26 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Feasibility of Heart Rate Variability Biofeedback With In-patient Pregnant Women

NCT02119936
View directory record Official record
Conditions
Maternal Stress, Maternal Anxiety, Maternal Health Services
Interventions
Heart Rate Variability Biofeedback Tool
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 19, 2018 · Synced Oct 22, 2026, 2:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cardiac Autonomic Function in Women with Microvascular Coronary Dysfunction

NCT01568177
View directory record Official record
Conditions
Microvascular Coronary Dysfunction
Interventions
Mental Stress Testing, Peripheral Arterial Tonometry (PAT) Testing, Heart Rate Variability (HRV), RESPeRATE Breathing Trial, SPECT cardiac scan with 123I-mIBG and Myoview
Behavioral · Other · Procedure
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 22, 2026, 2:26 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Prospective Trial of Behavioral Therapy for Chronic Cough

NCT03235466
View directory record Official record
Conditions
Cough
Interventions
Voice Therapy, Voice Therapy and Heart Rate Variability Biofeedback, Heart Rate Variability Biofeedback
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 90 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Dec 4, 2020 · Synced Oct 22, 2026, 2:26 PM EDT
Recruiting Phase 2Phase 3 Interventional

The Many Roads to Trauma Recovery: A Clinical Trial Comparing Empirically Supported Treatments for Veterans With Co-Morbid Posttraumatic Stress and Substance Use Disorder Symptoms

NCT07756723
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Substance Use Disorder (SUD)
Interventions
Trauma Informed Heart Rate Variability Biofeedback, Present Centered Therapy
Behavioral
Lead sponsor
Coatesville VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Coatesville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 22, 2026, 2:26 PM EDT
Completed Phase 1Phase 2 Interventional

Arthritis Ease Study

NCT05721352
View directory record Official record
Conditions
Knee Osteoarthritis, Chronic Pain, Kinesiophobia
Interventions
Virtual Reality Nature scene plus heart rate variability biofeedback phone application
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
45 Years to 74 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 23, 2024 · Synced Oct 22, 2026, 2:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Cognitive Behavioral Stress Intervention for Women Who Smoke

NCT03077945
View directory record Official record
Conditions
Smoking, Cigarette, Smoking Cessation, Stress, Stress, Emotional, Stress Reaction
Interventions
heart rate variability biofeedback and cognitive reappraisal, control tasks
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 14, 2018 · Synced Oct 22, 2026, 2:26 PM EDT
Terminated Not applicable Interventional

Impact of a Biofeedback Intervention on Microbiome, Metabolome, and Clinical Outcomes in Pediatric IBD (Study 2)

NCT04296110
View directory record Official record
Conditions
IBD
Interventions
Biofeedback, Music Relaxation Therapy
Behavioral · Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
8 Years to 17 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 15, 2024 · Synced Oct 22, 2026, 2:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Minority Health Through Biofeedback and Stress Reduction

NCT07172152
View directory record Official record
Conditions
Cardiovascular Disease Risk Reduction, Chronic Stress, Anxiety, Emotional Regulation, Hypertension Prevention, Health Disparities
Interventions
HRV Biofeedback Training
Behavioral
Lead sponsor
Amelia Saul, PhD, CTRS, BCB
Other
Eligibility
18 Years to 35 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 22, 2026, 2:26 PM EDT
Completed Not applicable Interventional

Heartmath Migraine Study

NCT04077658
View directory record Official record
Conditions
Migraine
Interventions
HeartMath, Waitlist Control
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older · Male only
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 24, 2020 · Synced Oct 22, 2026, 2:26 PM EDT
Enrolling by invitation Not applicable Interventional

App-based Breathing Program for Migraine Relief

NCT07297901
View directory record Official record
Conditions
Migraine, Heart Rate Variability (HRV), Autonomic Nervous System, Headache (Migraine), Headache, Chronic Pain, mHealth, Breathing
Interventions
Baseline Survey, Heart rate variability biofeedback, Sham Control Group
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 22, 2026, 2:26 PM EDT
Recruiting Not applicable Interventional

Heart Rate Variability and Inflammatory Bowel Disease

NCT06537258
View directory record Official record
Conditions
Inflammatory Bowel Diseases
Interventions
Biofeedback Enhanced Treatment
Behavioral
Lead sponsor
Emory University
Other
Eligibility
13 Years to 18 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
3
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 22, 2026, 2:26 PM EDT
Completed Not applicable Interventional Results available

The Care After Life-threatening Medical Events Study

NCT04589559
View directory record Official record
Conditions
Cardiac Arrest, Fear
Interventions
Heart Rate Variability Biofeedback Training
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 19, 2022 · Synced Oct 22, 2026, 2:26 PM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Heart Rate Variability Biofeedback Following Traumatic Brain Injury

NCT05913505
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
OSC-
Behavioral
Lead sponsor
Brigham Young University
Other
Eligibility
18 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Provo, Utah
Source: ClinicalTrials.gov public record
Updated Jun 22, 2023 · Synced Oct 22, 2026, 2:26 PM EDT
Completed Not applicable Interventional

Coherence Training for Military Personnel

NCT01599598
View directory record Official record
Conditions
Stress
Interventions
Progressive Muscle Relaxation, Coherence Advantage
Behavioral
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
Not listed
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2016 · Synced Oct 22, 2026, 2:26 PM EDT
Recruiting Phase 2Phase 3 Interventional

Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms

NCT07071350
View directory record Official record
Conditions
Autonomic Nervous System Disease, Concussive Injury, Mild Traumatic Brain Injury, Post Traumatic Stress Disorder, Persistent Post Concussion Syndrome
Interventions
HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI), Quantitative Sleep Measures, Patient Global Impression of Change (PGIC), Cognitive Performance/NIH Toolbox Cognitive Battery, Pain Interference/TBI-QoL Pain Interference Short-Form, Patient Health Questionnaire-9 (PHQ-9), PTSD Checklist for DSM-5 (PCL-5), HRV Biofeedback (HRV-B), Psychoeducational (Edu) Comparator Intervention
Other · Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Oct 22, 2026, 2:26 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Using Heart Rate Variability Biofeedback to Improve Attention and Memory in PTSD+ Combat Veterans

NCT00625105
View directory record Official record
Conditions
PTSD
Interventions
Biofeedback
Behavioral
Lead sponsor
William Jennings Bryan Dorn VA Medical Center
Federal
Eligibility
20 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 7, 2014 · Synced Oct 22, 2026, 2:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Changing Impulsivity With Mindful Breathing Therapy to Reduce Problem Drinking

NCT02527720
View directory record Official record
Conditions
Problem Drinking
Interventions
Mindfulness Therapy
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 30 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 13, 2019 · Synced Oct 22, 2026, 2:26 PM EDT