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Conditions: Rheumatic Disease
Interventions: Methotrexate, Sulfasalazine, Hydroxychloroquine, Leflunomide, Azathioprine, Mycophenolate, Cyclosporine, Tacrolimus, Etanercept, Adalimumab, Golimumab, Certolizumab, Infliximab, Rituximab, Belimumab, Tocilizumab, Anakinra, Canakinumab, Abatacept, Secukinumab, Ixekizumab, Bimekizumab, Ustekinumab, Guselkumab, Risankizumab, Tofacitinib, Upadacitinib; Drug · Biological
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Osteoarthritis, Avascular Necrosis, Traumatic Arthritis
Interventions: Aequalis Pyrocarbon Humeral Head; Device
Lead sponsor: Stryker Trauma and Extremities; Industry
Eligibility: 22 Years and older
Enrollment: 157 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2022
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Arthroplasties, Knee Replacement
Interventions: Depuy total knee implant, Triathlon total knee implant; Device
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 75 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Hip Arthritis, Hip Disease, Hip Fractures, Hip Injuries, Hip Pain Chronic
Interventions: RingLoc Bipolar Acetabular Cup, Endo II Femoral Head; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 116 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Falls Church, Virginia

Conditions: Femoral Neck Fractures
Interventions: Hip Hemiarthroplasty; Procedure
Lead sponsor: Mayo Clinic; Other
Eligibility: 65 Years and older
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Shoulder Arthroplasty, Positive C. Acnes Culture
Interventions: Povidone-Iodine, Hydrogen Peroxide, Xperience Antimicrobial Wash, Bacterial Cultures, Shoulder Arthroplasty; Device · Diagnostic Test · Procedure
Lead sponsor: Henry Ford Health System; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Proximal Femoral Metastases
Interventions: long-stem cemented hemiarthroplasty (LSCH), intramedullary nailing (IMN), questionnaires; Procedure · Behavioral
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 73 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2027
U.S. locations: 6
States / cities: Grand Rapids, Michigan • New York, New York • Rochester, New York + 3 more

Conditions: Femoral Neck Fractures
Interventions: Arthroplasty, Internal Fixation; Procedure
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 60 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 8
States / cities: Los Angeles, California • New Haven, Connecticut • Gainesville, Florida + 5 more

Conditions: Osteoarthritis (OA) of the Knee
Interventions: Periarticular Injection, Adductor Canal Block, Bupivacaine-Meloxicam; Drug
Lead sponsor: Henry Ford Health System; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Grosse Pointe Farms, Michigan

Conditions: Unilateral Primary Osteoarthritis of Knee, Primary Osteoarthritis of Knee Nos
Interventions: Placebo TENS, Active TENS; Device
Lead sponsor: Barbara A Rakel; Other
Eligibility: 30 Years to 100 Years
Enrollment: 317 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Hip Dysplasia, Cerebral Palsy
Interventions: Proximal Femoral Resection Arthroplasty, Subtrochanteric Valgus Osteotomy; Procedure
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 7 Years to 21 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 5
States / cities: Phoenix, Arizona • Miami, Florida • Boston, Massachusetts + 2 more

Conditions: Staphylococcal Infections, Methicillin-resistant Staphylococcus Aureus
Interventions: Daptomycin, Vancomycin; Drug
Lead sponsor: Mountain Home Research & Education Corporation; Other
Eligibility: 18 Years to 90 Years
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 2
States / cities: Johnson City, Tennessee • Mountain Home, Tennessee

Conditions: Osteoarthritis of the Shoulder, Avascular Necrosis, Traumatic Arthritis
Interventions: Aequalis Pyrocarbon Humeral Head; Device
Lead sponsor: Stryker Trauma and Extremities; Industry
Eligibility: 22 Years and older
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 8
States / cities: Denver, Colorado • Fort Lauderdale, Florida • New Orleans, Louisiana + 5 more

Conditions: Bone Cement Implantation Syndrome
Interventions: Administration of general anaesthesia, Neuraxial Analgesia; Procedure
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Acute Hip Fractures
Interventions: Tranexamic Acid, Placebo; Drug · Other
Lead sponsor: Carilion Clinic; Other
Eligibility: 65 Years and older
Enrollment: 113 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Femoral Neck Fractures
Interventions: Hip arthroplasty, Internal fixation; Procedure
Lead sponsor: University of Southern California; Other
Eligibility: 60 Years and older
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 20
States / cities: Irvine, California • Los Angeles, California • Miami, Florida + 15 more

Conditions: Intracapsular Fracture of Femur, Femoral Neck Fractures, Hip Hemiarthroplasty
Interventions: Bupivacaine liposome, Saline; Drug
Lead sponsor: Maimonides Medical Center; Other
Eligibility: 65 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Post-operative Pain, Acute, Opioid Use
Interventions: Adding Magnesium as an adjuvant to Bupivacaine in the adductor canal block (ACB) for same-day discharge total knee arthroplasty, Adding Buprenorphine as an adjuvant to Bupivacaine in the adductor canal block (ACB) for same-day discharge total knee arthroplasty; Drug
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 100 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Pontiac, Michigan

Conditions: Hallux Rigidus
Interventions: Cartiva Implant, Cheilectomy; Device · Procedure
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 88 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Hallux Limitus, Hallux Rigidus
Interventions: Joint Resection- Keller Procedure, Joint Fusion, Hemi-metallic Joint Implant; Radiation · Procedure
Lead sponsor: American College of Foot and Ankle Surgeons; Other
Eligibility: 21 Years and older
Enrollment: 158 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 6
States / cities: Greeley, Colorado • Des Moines, Iowa • Scituate, Massachusetts + 3 more

Conditions: Hip Fractures, Femoral Neck Fractures
Interventions: Total hip arthroplasty, Hemi-arthroplasty; Device
Lead sponsor: McMaster University; Other
Eligibility: 50 Years and older
Enrollment: 1,495 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Acute Pain
Interventions: Drug: Bupivacaine 0.375% 20 mL, Drug: Bupivacaine 0.375% diluted to 0.1875%; Drug
Lead sponsor: Anna Uskova; Other
Eligibility: 18 Years to 90 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania

Conditions: Degenerative Joint Disease, Osteoarthritis
Interventions: EACA, Placebo arm; Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Arthritis, Arthritis, Degenerative, Rheumatoid Arthritis, Post-traumatic Arthrosis of Other Joints, Shoulder Region, Rotator Cuff Syndrome of Shoulder and Allied Disorders, Fracture, Avascular Necrosis, Joint Instability, Joint Trauma, Dislocation, Shoulder, Pain, Shoulder
Interventions: Integra TITAN™ Total Shoulder Generation 1.0; Device
Lead sponsor: Smith & Nephew, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 2
States / cities: Indianapolis, Indiana • Philadelphia, Pennsylvania

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Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty

Aequalis Pyrocarbon IDE; Replacing the Humeral Head in Hemi-Arthroplasty

Impact of Component Design and Fixation in Total Knee Arthroplasty

MDR - PMCF Study for RingLoc Bipolar Acetabular Cup and Endo II Femoral Heads

Direct Anterior vs. Anterolateral Approach for Hip Arthroplasty After Femoral Neck Fracture in the Senior Population

Post-incision Antimicrobial Wash vs C. Acnes in Shoulder Arthroplasty

A Randomized Trial to Assess Patient Quality of Life and Function After Alternative Surgeries for Pathologic Fractures of the Femur

Minimally Displaced Femoral Neck Fracture Pilot Study

Novel Extended-Release Bupivacaine Polymer for Sustained Pain Relief Following Total Knee Arthroplasty

Effect of TENS for Pain and Function After Total Knee Replacement

A Randomized Control Trial of Hip Dislocation Techniques for Pediatric Patients With Cerebral Palsy

Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Knee, or Shoulder Arthroplasty

Pyrocarbon Clinical Follow-up Study

Relationship Between Anesthetic Regimen and Bone Cement Implantation Syndrome (BCIS)

Tranexamic Acid Use in Acute Hip Fractures

MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)

Hip Fracture Exparel Administration Trial Capsule During Hemiarthroplasty

Are Adductor Canal Blocks With Bupivacaine and Added Magnesium Better at Managing Post-operative Pain Than Bupivacaine and Added Buprenorphine in Patients Undergoing Same-day Discharge Total Knee Arthroplasty?

Surgical Treatment for Great Toe Arthritis

Surgical Treatment for Hallux Rigidus

Comparing Total Hip Arthroplasty and Hemi-Arthroplasty on Secondary Procedures and Quality of Life in Adults With Displaced Hip Fractures

Volume Versus Concentration: Clinical Effectiveness of Single Shot Quadrates Lumborum Block Using Either a High Volume/Low Concentration or Low Volume/High Concentration Injectate for Total Hip Arthroplasty.

Epsilon Aminocaproic Acid (EACA) for the Reduction of Blood Loss in Total Hip Arthroplasty (THA)

Clinical Evaluation of the TITAN™ Total Shoulder System