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ClinicalTrials.gov public records Last synced Nov 5, 2026, 1:52 AM EST

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Showing 1–24 of 56 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: High Definition transcranial Direct Current Stimulation Clear all

Conditions: Traumatic Brain Injury, Word Finding Difficulty, Acquired Brain Injury, Cognitive Change
Interventions: Active Transcranial direct current stimulation, Sham Transcranial direct current stimulation; Device
Lead sponsor: The University of Texas at Dallas; Other
Eligibility: 18 Years to 85 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 2
States / cities: Dallas, Texas

Conditions: Cocaine Use Disorder
Interventions: High Definition Transcranial Direct Current Stimulation; Device
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Posterior Cortical Atrophy
Interventions: HD-tDCS sessions, Sham HD-tDCS sessions, HD-tDCS sessions - Open-label (after randomized treatment); Device
Lead sponsor: University of Michigan; Other
Eligibility: 50 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Anxiety and Fear
Interventions: active tDCS, sham tDCS; Device
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 55 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Multiple Sclerosis, Relapsing-remitting Multiple Sclerosis (RRMS)
Interventions: High Definition transcranial Direct Current Stimulation, Sham High Definition transcranial Direct Current Stimulation; Device
Lead sponsor: The University of Texas at Dallas; Other
Eligibility: 18 Years to 64 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Richardson, Texas

Conditions: Cognitive Change
Interventions: Stimulation via Soterix Medical or Neuroelectrics noninvasive brain stimulation systems; Other
Lead sponsor: Tufts University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 1,500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Mild Cognitive Impairment, Dementia of Alzheimer Type
Interventions: 1 mA HD-tDCS, 2 mA HD-tDCS, 3 mA HD-tDCS, Sham; Device
Lead sponsor: University of Michigan; Other
Eligibility: 50 Years and older
Enrollment: 233 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Cognitive Ability, General
Interventions: Cognitive Training - 48 sessions, Fitness, Active Control, active tDCS, sham tDCS, Cognitive Training - 20 sessions; Behavioral · Device
Lead sponsor: University of Illinois at Urbana-Champaign; Other
Eligibility: 18 Years to 44 Years
Enrollment: 521 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: Urbana, Illinois

Conditions: Major Depressive Disorder
Interventions: Active - HD tDCS, Sham - HD tDCS, Active - Conventional tDCS, Sham - Conventional tDCS; Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 55 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Stroke, Aphasia
Interventions: Targeted Transcranial Direct Current Stimulation, Active Control Transcranial Direct Current Stimulation, Phonologic-Focused Speech Therapy, Semantic-Focused Speech Therapy; Device · Behavioral
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 18 Years to 85 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Mild Cognitive Impairment
Interventions: Active frontal, Active parietal, Sham; Device
Lead sponsor: The University of Texas at Dallas; Other
Eligibility: 40 Years to 90 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Richardson, Texas

Conditions: Cancer-related Fatigue, Neuromodulation
Interventions: Active tDCS + elbow flexion exercise, Sham tDCS + elbow flexion exercise; Device · Drug
Lead sponsor: Kessler Foundation; Other
Eligibility: 40 Years to 80 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: West Orange, New Jersey

Conditions: SCHIZOPHRENIA 1 (Disorder), Schizo Affective Disorder
Interventions: transcranial direct current stimulation, Sham stimulation; Device
Lead sponsor: Nathan Kline Institute for Psychiatric Research; Other
Eligibility: 18 Years to 55 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Orangeburg, New York

Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: Transcranial Direct Current Stimulation, Sham transcranial direct current stimulation; Device
Lead sponsor: The University of Texas at Dallas; Other
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Richardson, Texas

Conditions: Spinal Cord Injury, Tetraplegia
Interventions: transcranial direct current stimulation, peripheral nerve somatosensory stimulation, sham transcranial direct current stimulation; Other
Lead sponsor: Shepherd Center, Atlanta GA; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Depression
Interventions: Transcranial Direct Current Stimulation, Sham Transcranial Direct Current Stimulation; Device
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Mild Cognitive Impairment, Memory Disorders, Memory Loss
Interventions: HD-tDCS combined with CT, sham HD-tDCS combined with CT; Device
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 50 Years to 90 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Primary Progressive Aphasia
Interventions: HD-tDCS, Sham; Device
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 45 Years and older
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Tinnitus, Subjective
Interventions: Transcranial Direct Current Stimulation; Device
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Memory Disorders, Word Finding Difficulty
Interventions: High Definition Transcranial Direct Current Stimulation, Sham High Definition Transcranial Direct Current Stimulation; Device
Lead sponsor: The University of Texas at Dallas; Other
Eligibility: 45 Years to 78 Years
Enrollment: 93 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Chronic Aphasia
Interventions: HD-tDCS (Soterix Medical, Active), HD-tDCS (Soterix Medical, Sham); Device
Lead sponsor: Soterix Medical; Industry
Eligibility: 25 Years to 75 Years
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Chapel Hill, North Carolina

Conditions: Down Syndrome
Interventions: High definition transcranial direct current stimulation; Device
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 45 Years
Enrollment: 5 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Logopenic Progressive Aphasia, Primary Progressive Aphasia
Interventions: High-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment, Sham + "Repeat After Me" (RAM) Treatment; Device
Lead sponsor: Johns Hopkins University; Other
Eligibility: 50 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Acute Ischemic Stroke
Interventions: High-definition Cathodal Transcranial Direct Current Stimulation (HD C-tDCS), Sham tDCS; Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 3
States / cities: Los Angeles, California • Baltimore, Maryland • Durham, North Carolina

Search by objective public record fields.

Treating Civilian Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation (ciTBI-HDtDCS)

Open-label Feasibility Trial of HD-tDCS During Cognitive Behavioral Therapy for Cocaine Use Disorder

Testing Personalized High-Definition Transcranial Direct Current Stimulation (HD-tDCS) as a Treatment of Posterior Cortical Atrophy

Modulating Context Generalization Through Transcranial Direct Current Stimulation

Treatment of Memory Retrieval Impairments in MS With HDtDCS to the LIFG in a Placebo Controlled Trial

Cerebral Excitability and Cognitive Performance

Stimulation to Improve Memory

INSIGHT, A Comprehensive, Multidisciplinary Brain Training System

Transcranial Direct Current Stimulation in Major Depression

Effects of Transcranial Direct Current Stimulation (tDCS) on Language

Investigating HD-tDCS in Improving Word Finding and Memory Retrieval in Individuals With MCI

tDCS for Cancer-Related Fatigue and Weakness

Non-invasive Brain Stimulation Using Tdcs of the Third (of Many) Visual Pathways

Treatment of Cognitive Deficits in Multiple Sclerosis With High-Definition Transcranial Direct Current Stimulation

Conditioning Neural Circuits to Improve Upper Extremity Function

MRI-Guided High-Definition Transcranial Direct Current Stimulation (tDCS) for Depression

A Study of HD-tDCS and Cognitive Training to Improve Cognitive Function in MCI

HDtDCS in Logopenic Variant PPA: Effects on Language and Neural Mechanisms

MRI Study of High Definition Transcranial Electrical Stimulation in Chronic Tinnitus (MRI HDtES-T)

Treatment of Memory Disorders in Gulf War Illness With High Definition Transcranial Direct Cortical Stimulation

Targeted Electrotherapy for Aphasia Stroke Rehabilitation (TEASER) - Phase II Multi-Center Study

Feasibility and Dose Tolerability of HD-tDCS in Healthy Adults and Children With Down Syndrome

Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA

Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke