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Showing 1–24 of 72 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: High and low salt diets Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Natriuretic Peptide System in African-Americans.

NCT02730780
View directory record Official record
Conditions
Healthy, Prehypertension
Interventions
Low-Salt Diet, High-Salt Diet
Dietary Supplement
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Sep 29, 2026, 8:02 PM EDT
Not yet recruiting Not applicable Interventional

Di-PKD: A Pilot Trial of Dietary Intervention in Patients With Autosomal Dominant Polycystic Kidney Disease

NCT06786260
View directory record Official record
Conditions
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Interventions
Interventional Diet
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Dietary Salt Intake and Vascular Function

NCT00590512
View directory record Official record
Conditions
Healthy
Interventions
High sodium, Low sodium
Dietary Supplement
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
133 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 28, 2013 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Not applicable Interventional Results available

Dietary Salt in Rheumatoid Arthritis

NCT03649178
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
salt
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 29, 2026, 8:02 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Vascular Effects of High-Salt After Preeclampsia

NCT06749418
View directory record Official record
Conditions
Preeclampsia, Preeclampsia Postpartum
Interventions
Eplerenone
Drug
Lead sponsor
Anna Stanhewicz, PhD
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Role of COX-2 Inhibition in Salt Sensitivity of Blood Pressure

NCT00624559
View directory record Official record
Conditions
Hypertension
Interventions
celecoxib (Celebrex), Placebo
Drug · Other
Lead sponsor
University of Delaware
Other
Eligibility
22 Years to 50 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jan 5, 2012 · Synced Sep 29, 2026, 8:02 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Lysine-specific Demethylase 1 and Salt-sensitivity in Humans

NCT03029806
View directory record Official record
Conditions
Healthy Subjects
Interventions
Aldosterone response to AngII LS, Renal blood flow response to salt, Vascular Stiffness
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
25 Years to 45 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Cheese Consumption and Human Microvascular Function

NCT03376555
View directory record Official record
Conditions
Microvascular Dysfunction
Interventions
Low sodium no cheese, Low sodium cheese, High sodium no cheese, High sodium cheese
Dietary Supplement
Lead sponsor
Lacy Alexander
Other
Eligibility
55 Years to 75 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 3, 2025 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dietary Salt in Postural Tachycardia Syndrome

NCT01547117
View directory record Official record
Conditions
Postural Orthostatic Tachycardia Syndrome
Interventions
Blood Volume, Total Blood Volume, Exercise Capacity Test - Bicycle, Posture Study
Radiation · Procedure
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 50 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 21, 2022 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Not applicable Interventional Results available

Mi Propio Camino Intervention RCT for Blood Pressure Medication Adherence

NCT04585594
View directory record Official record
Conditions
Hypertension, Medication Adherence
Interventions
Mi Propio Camino (MPC), Habilidades para Controlar la Presion (HCP; Skills for Blood Pressure Control)
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
511 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Not applicable Interventional

Improving Blood Pressure Control Through the myBPmyLife mHealth Application

NCT05154929
View directory record Official record
Conditions
Hypertension
Interventions
Dietary and physical activity JITAI delivered through the myBPmyLife app, Control Group
Behavioral · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
608 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Ann Arbor, Michigan • Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 19, 2024 · Synced Sep 29, 2026, 8:02 PM EDT
Not yet recruiting Not applicable Interventional

Beta-2 Adrenergic Receptor Polymorphic Variants: An Endotype of Salt Sensitive Hypertension (Beta2AR).

NCT07832942
View directory record Official record
Conditions
Genetics in Hypertension
Interventions
low sodium diet, high sodium diet, renal plasma flow, SIEA collection
Other · Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 50 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Sep 29, 2026, 8:02 PM EDT
Recruiting Phase 4 Interventional

DiEtary Sodium Intake Effects on Ertugliflozin-induced Changes in GFR, reNal Oxygenation and Systemic Hemodynamics: the DESIGN Study, a Randomized, Placebo-controlled, Cross-over Study With Ertugliflozin in People With Type 2 Diabetes

NCT06983054
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
ertugliflozine, low salt diet, placebo, high salt diet
Drug · Behavioral
Lead sponsor
Amsterdam UMC, location VUmc
Other
Eligibility
18 Years to 85 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated May 20, 2025 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets.

NCT06449287
View directory record Official record
Conditions
Ketogenic Diet, Weight Loss
Interventions
Diet, Blood Draw, Ketone/Glucose Monitoring, Body Composition, Urine Analysis, Neuropsychological Measures - ANAM
Other · Biological · Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
21 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 18, 2024 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Not applicable Interventional Results available

Aldosterone and Glucose Homeostasis

NCT00732160
View directory record Official record
Conditions
Diabetes Mellitus
Interventions
Aldosterone infusion (A), Vehicle Infusion (V), High Sodium Diet (HS), Low Sodium Diet (LS)
Drug · Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 70 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 5, 2017 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Not applicable Interventional Results available

Effects of the Dietary Approaches to Stop Hypertension(DASH) Sodium-restricted Diet in Diastolic Heart Failure

NCT00939640
View directory record Official record
Conditions
Diastolic Heart Failure, Hypertensive Heart Disease
Interventions
DASH/sodium-restricted diet (SRD)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 14, 2019 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Sodium Intake on Calcium Retention in Girls

NCT01564238
View directory record Official record
Conditions
Osteoporosis
Interventions
Low Na diet (1.3 g/d), High sodium diet (3.8 g/d)
Other
Lead sponsor
Purdue University
Other
Eligibility
11 Years to 15 Years · Female only
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2000
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated May 8, 2018 · Synced Sep 29, 2026, 8:02 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Genetic Architecture of Natriuretic Peptides and Blood Pressure Response

NCT07118592
View directory record Official record
Conditions
Hypertension (HTN), Cardiometabolic Diseases
Interventions
Low Salt Diet, High Salt Diet, Saline Infusion
Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 29, 2026, 8:02 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Gut Microbiome, Metabolome, and SSBP

NCT07790900
View directory record Official record
Conditions
Salt-sensitivity of Blood Pressure
Interventions
Dietary sodium
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
50 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Dietary Sodium Intake on Vascular Endothelium

NCT01550315
View directory record Official record
Conditions
Postural Tachycardia Syndrome (POTS)
Interventions
Pulsitile Arterial Tonometry (PAT) Protocol, Calf Blood Flow in Reactive Hyperemia (CBF-RH), Evaluation of Forearm-Mediated Dilation
Procedure · Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 4, 2022 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

CARDIA-Salt Sensitivity of Blood Pressure (SSBP)

NCT04258332
View directory record Official record
Conditions
Salt Sensitivity of Blood Pressure, Hypertension
Interventions
High Salt Diet, Low Salt Diet
Dietary Supplement
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
50 Years to 70 Years
Enrollment
281 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
2
States / cities
Birmingham, Alabama • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Not applicable Interventional

Smartstep Smartphone PAD

NCT03479255
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Smartphone-enabled structured exercise therapy (SE-SET), Standard exercise therapy
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years to 89 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced Sep 29, 2026, 8:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adverse Neurogenic Actions of Dietary Salt

NCT02881515
View directory record Official record
Conditions
Blood Pressure
Interventions
Low Sodium Diet, Medium Sodium Diet, High Sodium Diet
Other
Lead sponsor
University of Delaware
Other
Eligibility
21 Years to 75 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 29, 2026, 8:02 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Prospective Phenotyping of Autonomous Aldosterone Secretion

NCT03484130
View directory record Official record
Conditions
Aldosterone Disorder, Adrenal Gland Disease, Blood Pressure
Interventions
Sodium loaded diet, Restricted sodium diet
Dietary Supplement
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
35 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Sep 29, 2026, 8:02 PM EDT