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ClinicalTrials.gov public records Last synced Oct 19, 2026, 2:34 PM EDT

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Showing 1–24 of 46 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: High energy density Clear all
Completed No phase listed Observational Accepts healthy volunteers

Low Energy Availability, Menstrual Irregularity, and Low Bone Mass

NCT01059968
View directory record Official record
Conditions
Bone Density, Energy Availability
Interventions
Not listed
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
15 Years to 17 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jun 23, 2011 · Synced Oct 19, 2026, 2:34 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Food Reinforcement, Weight Status, and Energy Density

NCT03981172
View directory record Official record
Conditions
Reinforcing Value of Food
Interventions
Daily snack food intake
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Energy and Physical Density Manipulation on Appetite

NCT05408390
View directory record Official record
Conditions
Appetite, Eating Behavior
Interventions
LPD+LED, HPD+LED, LPD+HED, HPD+HED
Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
17 Years to 39 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 24, 2023 · Synced Oct 19, 2026, 2:34 PM EDT
Not yet recruiting Phase 2 Interventional

Relugolix in Combination With Radiation Therapy for Treating Patients With High Risk Prostate Cancer

NCT06129851
View directory record Official record
Conditions
Stage IIC Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8, Stage IV Prostate Cancer AJCC v8
Interventions
Biospecimen Collection, Bone Scan, Brachytherapy, Computed Tomography, Dual X-ray Absorptiometry, External Beam Radiation Therapy, Magnetic Resonance Imaging, PSMA PET Scan, Questionnaire Administration, Relugolix
Procedure · Radiation · Other + 1 more
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older · Male only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Nov 13, 2023 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional

Breakfast Intake and Satiety Hormones

NCT02497859
View directory record Official record
Conditions
Obesity
Interventions
Egg Breakfast (EB), Cereal Breakfast (CB), Weight Loss Counseling, Weight Loss Diet
Behavioral
Lead sponsor
Texas Tech University
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2016 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Energy Density and Portion Size of Milk in Preschool Children

NCT02755558
View directory record Official record
Conditions
Feeding Behaviors
Interventions
Low energy density, High energy density, Small portion, Large portion
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
3 Years to 6 Years
Enrollment
143 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Alternative Dietary Approaches Online to Promote Tracking

NCT05049005
View directory record Official record
Conditions
Diet Quality, Weight Loss
Interventions
Simplified dietary tracking
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 12, 2022 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional Results available

Effect of Varying Proportions of Low and High Energy Dense Foods Over 5 Days in Preschool Children

NCT03242863
View directory record Official record
Conditions
Feeding Behavior
Interventions
Food proportionality
Other
Lead sponsor
Penn State University
Other
Eligibility
3 Years to 5 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healthy Families Healthy Forces Study

NCT02348853
View directory record Official record
Conditions
Overweight, Obesity
Interventions
Healthy Weight for Living (HWL), Current Best Practice (CBP)
Behavioral
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
308 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2020 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional Results available

Evaluation of the Trabecular Metal™ Revision Hip Cup Using Bone Mineral Density (DEXA)

NCT01183260
View directory record Official record
Conditions
Revision, Joint
Interventions
Trabecular Metal Revision Cup, Trabecular Metal Modular Cup
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 7, 2017 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional

The Healthy Eating Choices for Life Program

NCT01096719
View directory record Official record
Conditions
Obesity
Interventions
Standard Behavioral Weight Loss Intervention, Dietary Goal: Reduction in Energy Density of Dietary Intake, Dietary Goal: Reduction of Energy Intake
Behavioral
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
21 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional Results available

Effect of Energy Density Over 5 Days in Preschool Children

NCT03010501
View directory record Official record
Conditions
Feeding Behavior
Interventions
Food Energy Density
Other
Lead sponsor
Penn State University
Other
Eligibility
3 Years to 5 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 11, 2019 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lowering Caloric Density of the Diet

NCT02674971
View directory record Official record
Conditions
Obesity, Feeding Behavior
Interventions
Common components of intervention
Behavioral
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2025
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 19, 2026, 2:34 PM EDT
Terminated Not applicable Interventional

The Influence of Energy Density and Information on Meal Intake in Adults

NCT04404998
View directory record Official record
Conditions
Feeding Behavior
Interventions
Lower Energy Density, Higher Energy Density, Lower Satiation, Higher Satiation
Other
Lead sponsor
Penn State University
Other
Eligibility
20 Years to 55 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 29, 2021 · Synced Oct 19, 2026, 2:34 PM EDT
Recruiting No phase listed Observational

Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass

NCT07132788
View directory record Official record
Conditions
Pulmonary Hypertension
Interventions
blood draw, Short Performance Physical Battery, Grip strength test, Six minute walk test, Chest CT scan, Dual-Energy X-ray Absorptiometry Scan, Activity monitoring, 24 hour diet recall, Echocardiogram, Quality of Life Questionnaire (emPHasis 10), International Physical Activity Questionnaire Short Form (IPAQ-SF)
Diagnostic Test · Radiation · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 19, 2026, 2:34 PM EDT
Recruiting Not applicable Interventional

Pilot Study of Bone Mineral Density Changes During Anti-PD-1 Immunotherapy

NCT07555210
View directory record Official record
Conditions
Breast Cancer (Triple Negative Breast Cancer (TNBC)), Renal Cell Carcinoma (Kidney Cancer), Melanoma (Skin Cancer), Non-Small Cell Lung Cancer, MSI-H/dMMR Rectal Cancer, Squamous Cell Carcinoma Mouth, Invasive Mammary Carcinoma, Classic Hodgkin Lymphoma
Interventions
Dual-Energy X-ray Absorptiometry (DXA), High Resolution peripheral Quantitative Computed Tomography (HRpQCT)
Device
Lead sponsor
Jessica Mezzanotte Sharpe
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional Results available

Effect of Ultra-processed Versus Unprocessed Diets on Energy Metabolism

NCT05290064
View directory record Official record
Conditions
Healthy Diet, Obesity
Interventions
Ultra-processed food, high energy density (UPF HL), Ultra-processed food, both low (UPF LL), Ultra-processed food, both high (UPF HH), Unprocessed food diet (UNF LL)
Other
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 60 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Oct 19, 2026, 2:34 PM EDT
Recruiting Not applicable Interventional

The Combined Effects of Energy Density and Variety on Intake

NCT07663214
View directory record Official record
Conditions
Eating Behaviors
Interventions
Low Variety, High Variety, Low ED, High ED
Other
Lead sponsor
Cornell University
Other
Eligibility
20 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sympathetic Activation in Obesity

NCT04946552
View directory record Official record
Conditions
Obesity, Healthy
Interventions
PET Scan, Mixed Meal Test, Muscle sympathetic nerve activity (MSNA), Oral Glucose Tolerance Test, Body Composition, Percent Body Fat & Percent Body Water (Tanita scale), CT Scan, Body Composition, Percent Body Fat & Percent Body Water (DXA Scan)
Diagnostic Test · Dietary Supplement · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 16, 2024 · Synced Oct 19, 2026, 2:34 PM EDT
Terminated Phase 2 Interventional Results available

Radiofrequency Ablation in Treating Patients With Unresectable Primary or Metastatic Liver Cancer

NCT00019604
View directory record Official record
Conditions
Liver Cancer, Metastatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific
Interventions
computed tomography, magnetic resonance imaging, positron emission tomography, radiofrequency ablation, radionuclide imaging, ultrasound imaging, fludeoxyglucose F 18 (FDG-PET), gadopentetate dimeglumine
Procedure · Radiation
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2009
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 3, 2017 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

High Quality Protein for Assisting With Weight Loss

NCT03085511
View directory record Official record
Conditions
Obesity
Interventions
Egg breakfast (EB), Weight Loss Counseling, Weight Loss Diet, Cereal Breakfast (CB)
Behavioral
Lead sponsor
Texas Tech University
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated May 30, 2019 · Synced Oct 19, 2026, 2:34 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Foods Within a Meal and Food Liking Study

NCT03783507
View directory record Official record
Conditions
Diet Habit, Obesity
Interventions
Order 1, Order 2, Order 3, Order 4
Behavioral
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 35 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Eat Healthy for Families

NCT03394326
View directory record Official record
Conditions
Obesity, Childhood, Energy Density, Diet Quality
Interventions
family-based obesity prevention lifestyle intervention
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
2 Years to 5 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Oct 19, 2026, 2:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Portion Size Influence Intake of Low-Energy-Dense Foods in Preschool-aged Children?

NCT00936507
View directory record Official record
Conditions
Caloric Intake
Interventions
Energy Density/Portion Size
Other
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
3 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 19, 2026, 2:34 PM EDT