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Showing 1–24 of 151 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: High nicotine Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Consumer Perceptions of Waterpipe Tobacco Packaging and Digital Marketing Claims

NCT05439421
View directory record Official record
Conditions
Waterpipe Tobacco Smoking
Interventions
Package/Advertisement With Claim, Package/Advertisement Without Claim
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 29 Years
Enrollment
1,507 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 18, 2024 · Synced Sep 10, 2026, 4:06 AM EDT
Completed Not applicable Interventional Results available

Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Short Laryngologic Surgery

NCT03091179
View directory record Official record
Conditions
Laryngologic Surgical Procedures
Interventions
THRIVE, Endotracheal tube
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Sep 10, 2026, 4:06 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Equitable Smoking Relapse Prevention

NCT05625685
View directory record Official record
Conditions
Tobacco Use Disorder, Tobacco Dependence
Interventions
Quitbuddy, Control, SDoH Augmentation, SDoH Control
Other
Lead sponsor
Bryan W. Heckman
Other
Eligibility
21 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Sep 10, 2026, 4:06 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Behind the Wheel (BTW) Smartphone Application

NCT05554614
View directory record Official record
Conditions
High-risk Driving Events
Interventions
BTW app with reward-based feedback, BTW app with situational supervised driving practice, Sham BTW app
Behavioral
Lead sponsor
Motao Zhu
Other
Eligibility
15 Years to 17 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 18, 2025 · Synced Sep 10, 2026, 4:06 AM EDT
Not yet recruiting Not applicable Interventional

Effects of Tobacco Abuse Liability-dependent Taxes in the ETM

NCT07042373
View directory record Official record
Conditions
Cigarette Smoking Behavior
Interventions
Control, Product Category Score, Product Category Rank, Product Tiers
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Sep 10, 2026, 4:06 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes

NCT04038515
View directory record Official record
Conditions
Nicotine, E-liquid Flavors
Interventions
Nicotine 0 mg/mL, Nicotine 6 mg/mL, Nicotine 12 mg/mL, Nicotine 24 mg/mL, 'Menthol' flavor, 'Menthol/Mint' flavor, 'Green Apple' flavor, 'Watermelon' flavor, 'Unflavored'
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 30 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 4, 2024 · Synced Sep 10, 2026, 4:06 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Vaping High vs. Low Nicotine E-Liquid

NCT04047836
View directory record Official record
Conditions
Cardiovascular Risk Factor, Nicotine Dependence
Interventions
Low Nicotine E-Liquid, Medium or High Nicotine E-Liquid
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2023 · Synced Sep 10, 2026, 4:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Text Message Intervention for Alcohol Use and Sexual Violence in College Students

NCT05065918
View directory record Official record
Conditions
Alcohol Use, Unspecified, Sexual Violence, Sexual Assault
Interventions
sexual violence and alcohol use harm reduction text message content, alcohol use reduction content
Behavioral
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 24 Years
Enrollment
183 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Sep 10, 2026, 4:06 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Acute Pharmacokinetic and Pharmacodynamic Effects of "Tobacco-Free" Oral Nicotine Pouches in Smokers

NCT05335915
View directory record Official record
Conditions
Nicotine Withdrawal, Nicotine Addiction, Drug Effect
Interventions
Nicotine, Cigarette
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years and older
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 10, 2026, 4:06 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

MicroRNA Correlates of Childhood Maltreatment and Suicidality

NCT04923685
View directory record Official record
Conditions
Major Depressive Disorder, Suicidal Ideation
Interventions
Trier Social Stress Test
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 60 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
2
States / cities
Birmingham, Alabama • Huntsville, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 10, 2026, 4:06 AM EDT
Recruiting Not applicable Interventional

Effects of Novel E-cigarette Constituents on Adults TCORS 3.0

NCT05932745
View directory record Official record
Conditions
Nicotine Use Disorder
Interventions
E-liquid coolant (No WS-3) for non-menthol (1), E-liquid coolant (No WS-3) for low (0.1%) menthol (1), E-liquid coolant (No WS-3) for high (2.0%) menthol (1), E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2), E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2), E-liquid coolant (Low [0.1%] WS-3) for high (2.0%) menthol (2), E-liquid coolant (High [2.0%] WS-3) for non-menthol (3), E-liquid coolant (High [2.0%] WS-3) for low (0.1%) menthol (3), E-liquid coolant (High [2.0%] WS-3) for high (2.0%) menthol (3), E-liquid coolant (Low [0.1%] WS-23) for non-menthol (4), E-liquid coolant (Low [0.1%] WS-23) for low (0.1%) menthol (4), E-liquid coolant (Low [0.1%] WS-23) for high (2.0%) menthol (4), E-liquid coolant (High [2.0%] WS-23) for non-menthol (5), E-liquid coolant (High [2.0%] WS-23) for low (0.1%) menthol (5), E-liquid coolant (High [2.0%] WS-23) for high (2.0%) menthol (5), E-liquid coolant (4% WS-23) for non-menthol (6), E-liquid coolant (4% WS-23) for low (0.1%) menthol (6), E-liquid coolant (4% WS-23) for high (2.0%) menthol (6)
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 10, 2026, 4:06 AM EDT
Completed Not applicable Interventional

Machine-Generated Mortality Estimates and Nudges to Promote Advance Care Planning Discussion Among Cancer Patients

NCT03984773
View directory record Official record
Conditions
Oncology
Interventions
Nudge
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Sep 10, 2026, 4:06 AM EDT
Completed Not applicable Interventional

The Impact of Innovative Tax Proposals on Purchase Patterns

NCT05370313
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Market Price Condition (control), Tobacco Parity Tax Condition, Nicotine-Content Tax Condition, Harm-Reduction Tax Condition, Modified Risk Tobacco Product (MRTP) Tax Condition
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
285 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Buffalo, New York • Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Sep 10, 2026, 4:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tobacco Product Susceptibility and Substitutability by Rurality and Alcohol Use

NCT07010601
View directory record Official record
Conditions
Alcohol Use, E-cigarette Use, Cigarette Use
Interventions
Experimental Tobacco Marketplace, Hypothetical Novel Nicotine Product Purchase Tasks
Behavioral
Lead sponsor
Mark J Rzeszutek, PhD
Other
Eligibility
21 Years and older
Enrollment
737 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Sep 10, 2026, 4:06 AM EDT
Completed Early Phase 1 Interventional

Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids

NCT06602492
View directory record Official record
Conditions
Healthy, Nicotine Addiction, Electronic Cigarette Use
Interventions
Lower nicotine e-liquid, Higher nicotine eliquid
Drug
Lead sponsor
Rochester Institute of Technology
Other
Eligibility
21 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 26, 2024 · Synced Sep 10, 2026, 4:06 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults

NCT06395415
View directory record Official record
Conditions
Electronic Nicotine Delivery Systems, Tobacco Products, Cigarette Smoking
Interventions
EQUIP, Standard Care
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 26 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 10, 2026, 4:06 AM EDT
Active, not recruiting Not applicable Interventional

The Precision CAD Trial

NCT04755413
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Medical/Behavioral therapy, Standard of Care, Registry
Other
Lead sponsor
Emory University
Other
Eligibility
21 Years to 90 Years
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
5
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Sep 10, 2026, 4:06 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Nicotine Pouch Characteristics on Perceptions and Behavior

NCT06597435
View directory record Official record
Conditions
Nicotine Pouch Self-Administration
Interventions
Nicotine pouch
Other
Lead sponsor
University of Southern California
Other
Eligibility
21 Years to 35 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Sep 10, 2026, 4:06 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

The Villainous Vape: Advancing Vaping Prevention Among Adolescents Through a Comic Book

NCT07737080
View directory record Official record
Conditions
Vaping Behaviors
Interventions
Health Impacts of E-cigarettes, Mind Matters: The Body's Response to Nicotine, Tobacco, and Vaping, The Villainous Vape
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
12 Years to 17 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 10, 2026, 4:06 AM EDT
Recruiting Not applicable Interventional

Improving Mental Health Treatment for Individuals in Crisis Interacting With the Criminal-Legal System

NCT06564948
View directory record Official record
Conditions
Suicide Risk, Psychiatric Disorders
Interventions
Treatment as usual (TAU), FSJS, FSJS+Navigator Intervention
Other
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
18 Years to 100 Years
Enrollment
1,040 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 10, 2026, 4:06 AM EDT
Completed Not applicable Interventional

HIV Prevention and Trauma Treatment in Men Who Have Sex With Men and Who Have a History of Sexual Abuse

NCT00797654
View directory record Official record
Conditions
Risk Reduction
Interventions
Information-motivation-behavior skills and cognitive processing therapy, Pre and Post HIV-Test Counseling
Behavioral
Lead sponsor
Fenway Community Health
Other
Eligibility
18 Years and older · Male only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 8, 2016 · Synced Sep 10, 2026, 4:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Risk Communication in African American Smokers

NCT04084561
View directory record Official record
Conditions
Lung Cancer
Interventions
HRHA, LRLA, HRLA, LRHA
Behavioral
Lead sponsor
Temple University
Other
Eligibility
18 Years and older
Enrollment
166 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
2
States / cities
New York, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 17, 2023 · Synced Sep 10, 2026, 4:06 AM EDT
Completed Not applicable Interventional Results available

Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth

NCT05458895
View directory record Official record
Conditions
E-cigarette Use
Interventions
ECIG lab session 1, ECIG lab session 2, ECIG lab session 3, ECIG lab session 4, ECIG lab session 5, ECIG lab session 6, ECIG lab session 7, ECIG lab session 8
Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 25 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Sep 10, 2026, 4:06 AM EDT
Active, not recruiting Phase 3 Interventional

Testing the Addition of Atezolizumab to Combination Chemotherapy or Atezolizumab Alone for Metastatic Colon or Rectal Cancer, the COMMIT Study

NCT02997228
View directory record Official record
Conditions
Metastatic Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v7
Interventions
Atezolizumab, Bevacizumab, Biospecimen Collection, Computed Tomography, Fluorouracil, Leucovorin, Magnetic Resonance Imaging, Oxaliplatin, Positron Emission Tomography, Quality-of-Life Assessment, Questionnaire Administration
Drug · Biological · Procedure + 1 more
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
445
States / cities
Kingman, Arizona • Jonesboro, Arkansas • Anaheim, California + 346 more
Source: ClinicalTrials.gov public record
Updated Sep 7, 2026 · Synced Sep 10, 2026, 4:06 AM EDT