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ClinicalTrials.gov public records Last synced Oct 11, 2026, 8:44 AM EDT

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Showing 25–48 of 55 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: High-intensity focused ultrasound (HIFU) Clear all
Not listed Not applicable Interventional

A Multicenter Clinical Study of the Sonablate®450 for the TreAtment of Locally Recurrent Prostate Cancer With HIFU (STAR Trial)

NCT00772317
View directory record Official record
Conditions
Recurrent Prostate Cancer
Interventions
High Intensity Focused Ultrasound
Device
Lead sponsor
SonaCare Medical
Industry
Eligibility
40 Years to 85 Years · Male only
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2021
U.S. locations
14
States / cities
Los Angeles, California • Washington D.C., District of Columbia • Naples, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 10, 2019 · Synced Oct 11, 2026, 8:44 AM EDT
Completed Not applicable Interventional

Safety and Feasibility of MR-Guided High Intensity Focused Ultrasound (MR-HIFU) Ablation of Osteoid Osteoma in Children

NCT02349971
View directory record Official record
Conditions
Osteoid Osteoma
Interventions
MR-HIFU
Device
Lead sponsor
Children's National Research Institute
Other
Eligibility
Up to 25 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 11, 2022 · Synced Oct 11, 2026, 8:44 AM EDT
Completed Early Phase 1 Interventional

Ultrasound-Guided Photoselective Vaporization of the Prostate

NCT02346500
View directory record Official record
Conditions
Benign Prostatic Hyperplasia
Interventions
Transrectal Ultrasound
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
40 Years to 85 Years · Male only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 18, 2018 · Synced Oct 11, 2026, 8:44 AM EDT
Not yet recruiting Not applicable Interventional

High Intensity Focused Ultrasound (HIFU) Ablation for Treatment of Prostate Tissue in Bladder Outlet Obstruction

NCT07194187
View directory record Official record
Conditions
Bladder Outlet Obstruction, BPH
Interventions
High Intensity Focused Ultrasound
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
45 Years to 80 Years · Male only
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 11, 2026, 8:44 AM EDT
Terminated Phase 2 Interventional Results available

High Resolution, 18F-PSMA PET-MRI Before Prostate Cancer HIFU or Radical Prostatectomy

NCT04461509
View directory record Official record
Conditions
Prostatic Neoplasms, Genital Neoplasms, Male, Urogenital Neoplasms, Neoplasms by Site, Neoplasms, Genital Diseases, Male, Prostatic Disease
Interventions
18F-PSMA
Drug
Lead sponsor
Alessandro D'Agnolo
Other
Eligibility
18 Years and older · Male only
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Oct 11, 2026, 8:44 AM EDT
Terminated Phase 1 Interventional

Focused Ultrasound Ablation and PD-1 Antibody Blockade in Advanced Solid Tumors

NCT04116320
View directory record Official record
Conditions
Melanoma, Breast Cancer, Merkel Cell Carcinoma, Squamous Cell Cancer, Non Small Cell Lung Cancer, Cervical Cancer, Urothelial Carcinoma, Ovarian Cancer, Hepatocellular Carcinoma, Small-cell Lung Cancer, Microsatellite Instability High, Gastric Cancer, Esophageal Cancer
Interventions
Echopulse, Poly ICLC, Standard of Care PD-1 Therapy
Device · Drug
Lead sponsor
Craig L Slingluff, Jr
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Oct 11, 2026, 8:44 AM EDT
Active, not recruiting Phase 2 Interventional

MR-HIFU Treatment of Painful Osteoid Osteoma

NCT04658771
View directory record Official record
Conditions
Osteoid Osteoma
Interventions
MR-HIFU treatment
Device
Lead sponsor
Children's National Research Institute
Other
Eligibility
0 Years to 30 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 11, 2025 · Synced Oct 11, 2026, 8:44 AM EDT
Recruiting No phase listed Observational

HIFU for Focal Ablation of Prostate Tissue: An Observational Study

NCT03620786
View directory record Official record
Conditions
Prostate Cancer
Interventions
Sonablate HIFU device
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
40 Years to 85 Years · Male only
Enrollment
100 participants
Timeline
2018 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Oct 11, 2026, 8:44 AM EDT
Withdrawn Not applicable Interventional

High-Intensity Focused Ultrasound in Treating Participants With Intermediate and High-risk Prostate Cancer

NCT03514927
View directory record Official record
Conditions
Prostate Cancer Stage I AJCC V6, Prostate Cancer Stage II, Prostate Cancer Stage III
Interventions
Contrast-Enhanced Ultrasound, High-Intensity Focused Ultrasound, Laboratory Biomarker Analysis, Multiparametric Magnetic Resonance Imaging, Radical Prostatectomy
Procedure · Device · Other
Lead sponsor
University of Southern California
Other
Eligibility
40 Years and older · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 22, 2019 · Synced Oct 11, 2026, 8:44 AM EDT
Suspended Phase 1Phase 2 Interventional

High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain

NCT00637364
View directory record Official record
Conditions
Pain, Pancreatic Adenocarcinoma, Ductal Adenocarcinoma
Interventions
High intensity focused ultrasound, HIFU
Procedure
Lead sponsor
CMED HIFU Development Corporation
Industry
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2008
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 13, 2009 · Synced Oct 11, 2026, 8:44 AM EDT
Completed Phase 1 Interventional

Ultrasound in Treating Patients With Prostate Cancer Confined to the Prostate

NCT00030290
View directory record Official record
Conditions
Prostate Cancer
Interventions
high-intensity focused ultrasound ablation
Procedure
Lead sponsor
Focus Surgery
Industry
Eligibility
40 Years to 80 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 10, 2013 · Synced Oct 11, 2026, 8:44 AM EDT
Recruiting Phase 2 Interventional

High Intensity Focused Ultrasound in Prostate Cancer

NCT06402357
View directory record Official record
Conditions
Prostate Cancer
Interventions
Focal One high intensity focused ultrasound device
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older · Male only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 11, 2026, 8:44 AM EDT
Withdrawn Phase 1 Interventional

HIFU Hyperthermia With Liposomal Doxorubicin (DOXIL) for Relapsed or Refractory Pediatric and Young Adult Solid Tumors

NCT02557854
View directory record Official record
Conditions
Rhabdomyosarcoma, Neuroblastoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Desmoid
Interventions
Doxorubicin HCl liposomal injection, Philips Sonalleve MR-HIFU Hyperthermia
Drug · Device
Lead sponsor
Theodore Laetsch
Other
Eligibility
1 Year to 40 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 19, 2019 · Synced Oct 11, 2026, 8:44 AM EDT
Withdrawn Not applicable Interventional

Robotic Telesurgery in Urology

NCT07541066
View directory record Official record
Conditions
Prostate Cancer
Interventions
High-Intensity Focused Ultrasound (HIFU) robotic device
Procedure
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years and older · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Oct 11, 2026, 8:44 AM EDT
Completed Phase 2 Interventional

MRI-Guided Ultrasound Energy in Treating Patients With Stage I, Stage II, or Stage IIIA Breast Cancer

NCT00008437
View directory record Official record
Conditions
Breast Cancer
Interventions
high-intensity focused ultrasound ablation
Device
Lead sponsor
InSightec
Industry
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 2, 2012 · Synced Oct 11, 2026, 8:44 AM EDT
Completed Phase 2 Interventional Results available

High Resolution PET-MRI Before Prostate Cancer HIFU

NCT03263780
View directory record Official record
Conditions
Prostate Cancer
Interventions
18F-Fluciclovine
Drug
Lead sponsor
Timothy J. Daskivich
Other
Eligibility
18 Years and older · Male only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 21, 2021 · Synced Oct 11, 2026, 8:44 AM EDT
Recruiting Not applicable Interventional

Use of the Neurolyser XR for the Treatment of Low Back Pain Related to Sacroiliitis

NCT06053255
View directory record Official record
Conditions
Sacroiliitis
Interventions
High-intensity focused ultrasound for Sacroiliitis using the Neurolyser XR
Device
Lead sponsor
FUSMobile Inc.
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Oct 11, 2026, 8:44 AM EDT
Not listed Phase 2Phase 3 Interventional

Ablatherm Integrated Imaging High Intensity Focused Ultrasound for the Indication of Low Risk, Localized Prostate Cancer

NCT00295802
View directory record Official record
Conditions
Prostate Cancer
Interventions
Integrated Imaging High Intensity Focused Ultrasound, Endocare CRYOcare Cryosurgical and Galil Medical CRYO-HIT Systems (cryotherapy)
Device
Lead sponsor
EDAP TMS S.A.
Industry
Eligibility
50 Years and older · Male only
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2014
U.S. locations
14
States / cities
Arcadia, California • Aurora, Colorado • Ocala, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2014 · Synced Oct 11, 2026, 8:44 AM EDT
Completed Not applicable Interventional

Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound

NCT02078011
View directory record Official record
Conditions
Breast Fibroadenoma
Interventions
High Intensity Focused Ultrasound
Device
Lead sponsor
David R. Brenin, MD
Other
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 7, 2018 · Synced Oct 11, 2026, 8:44 AM EDT
Recruiting Not applicable Interventional

Single-Port Transvesical Partial Prostatectomy Versus High Intensity Focused Ultrasound

NCT05610852
View directory record Official record
Conditions
Prostate Adenocarcinoma, Prostate Cancer
Interventions
Transvesical Single Port Robotic Partial Prostatectomy, High-intensity focused ultrasound (HIFU)
Procedure
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
19 Years and older · Male only
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 11, 2026, 8:44 AM EDT
Not yet recruiting Phase 3 Interventional

Multiparametric Ultrasound for the Diagnosis of Clinically Significant Prostate Cancer

NCT06024772
View directory record Official record
Conditions
Prostate Carcinoma
Interventions
ultiparametric Magnetic Resonance Imaging, Perflutren lipid microsphere, Transrectal Ultrasound, Biopsy of Prostate
Procedure · Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older · Male only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 11, 2026, 8:44 AM EDT
Terminated Phase 1 Interventional

A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric Refractory Solid Tumors

NCT02536183
View directory record Official record
Conditions
Pediatric Cancer, Solid Tumors, Rhabdomyosarcoma, Ewing Sarcoma, Soft Tissue Sarcomas, Osteosarcoma, Neuroblastoma, Wilms Tumor, Hepatic Tumor, Germ Cell Tumors
Interventions
Magnetic resonance high intensity focused ultrasound, Lyso-thermosensitive liposomal doxorubicin
Device · Drug
Lead sponsor
AeRang Kim
Other
Eligibility
Up to 30 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 29, 2023 · Synced Oct 11, 2026, 8:44 AM EDT
Recruiting No phase listed Observational

Ablative Therapy in the Management of Prostate Cancer

NCT03492424
View directory record Official record
Conditions
Prostate Cancer
Interventions
cryotherapy
Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older · Male only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2039
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Oct 11, 2026, 8:44 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Safety and Effectiveness Evaluation of the High-intensity Focused Ultrasound Device for Lifting Lax Submental and Neck Tissue

NCT07229430
View directory record Official record
Conditions
Skin Laxity (Submental and Neck), Facial Skin Laxity, Submental Tissue Laxity
Interventions
ULTRAFORMER MPT PLUS, Ulthera System
Device
Lead sponsor
CLASSYS Inc.
Industry
Eligibility
30 Years to 65 Years
Enrollment
273 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
5
States / cities
Los Angeles, California • Charlotte, North Carolina • Wilmington, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 11, 2026, 8:44 AM EDT