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Showing 1–24 of 92 matching trials from the live ClinicalTrials.gov search.
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Completed Not applicable Interventional Accepts healthy volunteers

Does the Addition of Manual Therapy Techniques Increase Gastrocnemius/Soleus Length More Than Stretching Alone?

NCT01856972
View directory record Official record
Conditions
Muscle Tightness
Interventions
Instrument Assisted Soft Tissue Mobilization, Rearfoot joint mobilization, Static stretching/ROM exercises
Procedure · Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
12 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 10, 2014 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Not applicable Interventional

A Study Examining Changes in Pain After Manual Therapy in People With Achilles Tendon Pain

NCT06134856
View directory record Official record
Conditions
Achilles Tendinopathy, Ankle Strain, Achilles Tendon Pain, Achilles Tendonitis
Interventions
Ankle mobilization, Sham treatment
Procedure
Lead sponsor
Philadelphia College of Osteopathic Medicine
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Suwanee, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Sep 25, 2026, 7:56 PM EDT
Active, not recruiting Not applicable Interventional

Osteopathic Manipulation Makes a Neuropsychological Difference

NCT04058431
View directory record Official record
Conditions
Cognitive Change, Musculoskeletal Pain
Interventions
Osteopathic Manipulative Treatment, Control- No Intervention
Other
Lead sponsor
Midwestern University
Other
Eligibility
40 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
1
States / cities
Downers Grove, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Sep 25, 2026, 7:56 PM EDT
Not listed Not applicable Interventional

Prescriptive Mobilization Versus a Pragmatic Mobilization

NCT01940744
View directory record Official record
Conditions
Mechanical Low Back Pain
Interventions
Prescriptive Mobilization, Pragmatic Mobilization
Procedure
Lead sponsor
Walsh University
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
3
States / cities
Des Moines, Iowa • North Canton, Ohio • Youngstown, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 12, 2013 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Not applicable Interventional Results available

Patient Response to Spinal Manipulation - Pilot Study

NCT01562756
View directory record Official record
Conditions
Low Back Pain
Interventions
HVLA-SM
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
21 Years to 65 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 30, 2017 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Not applicable Interventional Results available

Manual Cervical Distraction: Measuring Chiropractic Delivery for Neck Pain Clinical Trial

NCT01765751
View directory record Official record
Conditions
Neck Pain, Pain in Arm, Unspecified
Interventions
Manual Cervical Distraction
Procedure
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
18 Years to 70 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 3, 2018 · Synced Sep 25, 2026, 7:56 PM EDT
Not yet recruiting Not applicable Interventional

The Immediate Effects of First Rib Mobilization on Pain and Range of Motion in Patients With Shoulder Pain

NCT07064772
View directory record Official record
Conditions
Shoulder Pain
Interventions
First Rib Mobilization, Sham Comparator
Other
Lead sponsor
Andrews University
Other
Eligibility
18 Years to 75 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Annville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Phase 2 Interventional

Thrust Manipulation Versus Non-Thrust Manipulation

NCT01438203
View directory record Official record
Conditions
Mechanical Low Back Pain
Interventions
Thrust manipulation, Non-thrust manipulation
Procedure
Lead sponsor
Walsh University
Other
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
North Canton, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 4, 2012 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Not applicable Interventional Results available

Effect of Spinal Manipulation on Sensorimotor Functions in Back Pain Patients

NCT00830596
View directory record Official record
Conditions
Low Back Pain
Interventions
HVLA-SM, LVVA-SM, Sham Intervention
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
21 Years to 65 Years
Enrollment
221 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 24, 2017 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Manual Therapy on Shoulder Function

NCT04513535
View directory record Official record
Conditions
Musculoskeletal Manipulations, Shoulder, Range of Motion, Muscle Strength, Surface Electromyography
Interventions
Thoracic Manipulation, Cervical Manipulation, glenohumeral posterior glide mobilization, Sleeper stretch
Other
Lead sponsor
University of Hartford
Other
Eligibility
18 Years to 55 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
West Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 22, 2021 · Synced Sep 25, 2026, 7:56 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Impact of Practitioner and Instructional Set on Subject Perceptions and Expectations of Cervical Spine Manipulation

NCT03509649
View directory record Official record
Conditions
Neck Pain
Interventions
Cervical spine manipulation
Procedure
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Apr 17, 2019 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Phase 2 Interventional

Spinal Manipulation for Treatment of Chronic Headaches

NCT00246350
View directory record Official record
Conditions
Headache Disorders
Interventions
massage, Spinal manipulation
Procedure
Lead sponsor
University of Western States
Other
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 21, 2010 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Not applicable Interventional Results available

Veterans Response to Dosage in Chiropractic Therapy

NCT04087291
View directory record Official record
Conditions
Low Back Pain, Patient Acceptance of Health Care, Veterans Health
Interventions
Chiropractic Care
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
18 Years and older
Enrollment
766 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
4
States / cities
Los Angeles, California • West Haven, Connecticut • Iowa City, Iowa + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 25, 2026, 7:56 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

The Role of Disc Nutrition in the Etiology and Clinical Treatment of Disc Degeneration

NCT04134910
View directory record Official record
Conditions
Back Pain, Intervertebral Disc Degeneration
Interventions
Physical Therapy
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
30 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Lumbopelvic Manipulation on Hip and Knee Neuromuscular Activity

NCT01637480
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Lumbopelvic manipulation
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years to 50 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2015 · Synced Sep 25, 2026, 7:56 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Chiropractic Treatment With Counseling Versus Counseling Alone for Promoting Smoking Cessation

NCT01689168
View directory record Official record
Conditions
Smoking
Interventions
Counseling, Chiropractic adjustment
Behavioral · Procedure
Lead sponsor
Southern California University of Health Sciences
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Whittier, California
Source: ClinicalTrials.gov public record
Updated May 19, 2015 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Not applicable Interventional

Effect of Lower Back Treatment in People With Patellofemoral Pain Syndrome.

NCT01975311
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Lumbopelvic Manipulation, Passive lumbar spine flexion and extension
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years to 50 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2015 · Synced Sep 25, 2026, 7:56 PM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Simulated vs Genuine Manual Chiropractic Adjustments

NCT06931600
View directory record Official record
Conditions
Subluxation
Interventions
Sham adjustment, Chiropractic adjustment
Procedure
Lead sponsor
Life University
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Phase 1Phase 2 Interventional

Cervicogenic Headache Dose-Response

NCT01530321
View directory record Official record
Conditions
Cervicogenic Headache
Interventions
Spinal Manipulation, Light Massage
Other
Lead sponsor
University of Western States
Other
Eligibility
18 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
2
States / cities
Bloomington, Minnesota • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Patient Perceptions Following a Single Session of Simulated or Genuine HVLA Manual Chiropractic Adjustments

NCT06153290
View directory record Official record
Conditions
Subluxation
Interventions
Chiropractic adjustment, Sham adjustment
Procedure
Lead sponsor
Life University
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 26, 2025 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Not applicable Interventional

Hip Manipulation for Improved Strength in Patients With Hip Pain

NCT06655987
View directory record Official record
Conditions
Hip Pain
Interventions
Unrestrained Femoral Internal Rotation (UFIR) manipulation, Sham manipulation
Other
Lead sponsor
Andrews University
Other
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Columbia, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Sep 25, 2026, 7:56 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Validation of CPR for Manipulation for Neck Pain

NCT02287337
View directory record Official record
Conditions
Cervicalgia
Interventions
Manipulation, Exercise
Procedure
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 70 Years
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 21, 2019 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Not applicable Interventional

Cervical and Upper Thoracic Mobilization and Manipulation for Mechanical Neck Pain

NCT02036905
View directory record Official record
Conditions
Neck Pain
Interventions
Cervical and thoracic mobilization, cervical and thoracic manipulation
Other
Lead sponsor
Youngstown State University
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Solon, Ohio • Havertown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 25, 2016 · Synced Sep 25, 2026, 7:56 PM EDT
Completed Not applicable Interventional

Manual Therapy and Exercise in Patients With Cervicogenic Headache

NCT01580280
View directory record Official record
Conditions
Cervicogenic Headache
Interventions
Thrust Manipulation, Non-thrust Mobilization and Exercise
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
18 Years to 65 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Montgomery, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 13, 2014 · Synced Sep 25, 2026, 7:56 PM EDT