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ClinicalTrials.gov public records Last synced Oct 2, 2026, 1:51 PM EDT

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Showing 25–48 of 80 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Hip and Knee Joint Replacement Clear all
Completed Phase 4 Interventional Results available

Apixaban Pharmacokinetics in Bariatric Patients (APB)

NCT02406885
View directory record Official record
Conditions
Bariatric Surgery, Obesity
Interventions
Apixaban
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 22, 2020 · Synced Oct 2, 2026, 1:51 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Prophylaxis Against DVTs After Primary Hip and Knee Replacement Surgery

NCT00767559
View directory record Official record
Conditions
Pulmonary Embolism
Interventions
warfarin, Fondaparinux:
Drug
Lead sponsor
The New England Baptist Hospital
Other
Eligibility
20 Years and older
Enrollment
330 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 26, 2011 · Synced Oct 2, 2026, 1:51 PM EDT
Enrolling by invitation Not applicable Interventional

Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression

NCT05640336
View directory record Official record
Conditions
Periprosthetic Joint Infection
Interventions
Single Debridement, Antibiotics and Implant Retention, Planned Double Debridement, Antibiotics and Implant Retention
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
490 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2032
U.S. locations
2
States / cities
Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Oct 2, 2026, 1:51 PM EDT
Completed Not applicable Interventional Results available

Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA)

NCT02197273
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis, Shoulder
Interventions
Liposomal bupivacaine, Standard of care analgesia
Drug
Lead sponsor
OhioHealth
Other
Eligibility
18 Years and older
Enrollment
211 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 21, 2016 · Synced Oct 2, 2026, 1:51 PM EDT
Completed Not applicable Interventional Results available

Effect of Gabapentin Enacarbil on Opioid Consumption and Pain Scores

NCT02840240
View directory record Official record
Conditions
Pain
Interventions
Gabapentin enacarbil, Placebo
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Oct 2, 2026, 1:51 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Continuous Postoperative Pulse Oximetry in Patients Presenting for Total Hip and Total Knee Replacement

NCT01189565
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Not listed
Lead sponsor
Medical University of South Carolina
Other
Eligibility
19 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 22, 2013 · Synced Oct 2, 2026, 1:51 PM EDT
Terminated Not applicable Interventional

Total Joint Arthroplasty (TJA) Weight Loss Study

NCT05156762
View directory record Official record
Conditions
Osteoarthritis, Hip, Osteoarthritis, Knee, Obesity, Morbid
Interventions
Bariatric surgery, Medical weight loss, Patient research surveys, Total joint arthroplasty (TJA), Usual standard of care
Procedure · Behavioral · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 2, 2026, 1:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Does Fluid Replacement From Preoperative NPO Status Improve Postoperative Recovery

NCT02638623
View directory record Official record
Conditions
Osteoarthritis
Interventions
Lactated Ringer, Placebo
Drug
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2020 · Synced Oct 2, 2026, 1:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Meditation and Opioid Consumption in Total Joint Replacement Patients Undergo Primary Total Hip and Knee Replacement

NCT05669066
View directory record Official record
Conditions
Arthropathy of Knee, Osteo Arthritis Knee, Osteonecrosis, Meditation, Knee Osteoarthritis, Knee Disease, Knee Injuries, Opioid Use, Opioid Dependence, Opioid Use Disorder
Interventions
Mindful meditation
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 30, 2022 · Synced Oct 2, 2026, 1:51 PM EDT
Completed Not applicable Interventional

Brief Nurse-led Mindfulness Based Intervention

NCT04800354
View directory record Official record
Conditions
Pain, Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Nurse-led Mindfulness Based Intervention, Nurse-led Pain Psychoeducation
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 11, 2022 · Synced Oct 2, 2026, 1:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Incorporating Patient-Reported Outcomes Into Shared Decision Making With Patients With Osteoarthritis of the Hip or Knee

NCT04805554
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Joint Insights decision aid
Other
Lead sponsor
University of Texas at Austin
Other
Eligibility
45 Years to 89 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jan 5, 2024 · Synced Oct 2, 2026, 1:51 PM EDT
Completed Phase 4 Interventional

Tranexamic Acid in Revision Total Joint Arthroplasty

NCT02877381
View directory record Official record
Conditions
Revision Total Knee Arthroplasty, Revision Total Hip Arthroplasty, Acute Blood Loss Anemia
Interventions
Revision Total Knee Arthroplasty (TKA), Revision Total Hip Arthroplasty (THA)
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
3
States / cities
Chicago, Illinois • Rochester, Minnesota • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 22, 2021 · Synced Oct 2, 2026, 1:51 PM EDT
Completed Phase 4 Interventional Results available

PO vs. IV Acetaminophen Given Perioperatively for 24 hr Post-op Pain Control Following Total Hip or Knee Replacement

NCT02244619
View directory record Official record
Conditions
Post-op Pain
Interventions
Oral acetaminophen, IV acetaminophen
Drug
Lead sponsor
Kettering Health Network
Other
Eligibility
18 Years and older
Enrollment
515 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Kettering, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 24, 2017 · Synced Oct 2, 2026, 1:51 PM EDT
Completed Phase 3 Interventional Results available

Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement

NCT01094886
View directory record Official record
Conditions
Arthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Thromboembolism
Interventions
Rivaroxaban
Drug
Lead sponsor
Ortho-McNeil Janssen Scientific Affairs, LLC
Industry
Eligibility
18 Years to 99 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
5
States / cities
Denver, Colorado • Hollywood, Florida • Tamarac, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2017 · Synced Oct 2, 2026, 1:51 PM EDT
Recruiting No phase listed Observational

A Prospective Total Joint Surgery Registry to Monitor Short- and Long-Term Clinical Outcomes

NCT06687109
View directory record Official record
Conditions
Osteoarthritis
Interventions
Total Knee Arthroplasty, Total Hip Arthroplasty
Procedure
Lead sponsor
Spokane Joint Replacement Center
Other
Eligibility
18 Years and older
Enrollment
10,000 participants
Timeline
2020 – 2030
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 2, 2026, 1:51 PM EDT
Terminated Not applicable Interventional

DexCom Hospital Study-CGM Directed Insulin Delivery

NCT05504785
View directory record Official record
Conditions
Type 2 Diabetes, Hip Osteoarthritis, Knee Osteoarthritis
Interventions
DexCom G6 continuous glucose monitor
Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
30 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 17, 2022 · Synced Oct 2, 2026, 1:51 PM EDT
Withdrawn Phase 1Phase 2 Interventional

Bacteriophage Therapy in Patients With Prosthetic Joint Infections

NCT04787250
View directory record Official record
Conditions
Prosthetic Joint Infection
Interventions
Phage Therapy, Two-Stage Exchange Arthroplasty
Biological · Procedure
Lead sponsor
Adaptive Phage Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 4, 2022 · Synced Oct 2, 2026, 1:51 PM EDT
Completed Not applicable Interventional Results available

Functional Movement Retraining After Hip Replacement

NCT01878175
View directory record Official record
Conditions
Arthroplasty, Replacement, Hip
Interventions
Functional Movement Retraining
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
19 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
2
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Oct 2, 2026, 1:51 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Stability Plus - Outcomes From Extended Continuum of Care

NCT00756483
View directory record Official record
Conditions
Arthroplasty
Interventions
Not listed
Lead sponsor
Stability Plus, LLC
Industry
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 22, 2008 · Synced Oct 2, 2026, 1:51 PM EDT
Completed Phase 1 Interventional

Pharmacokinetics of Apixaban in Patients Undergoing Pancreaticoduodenectomy

NCT04191928
View directory record Official record
Conditions
Pancreas Cancer, DVT, Pulmonary Embolism
Interventions
Apixaban
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 23, 2021 · Synced Oct 2, 2026, 1:51 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Prineo Sensitivity Dressing Study

NCT06011603
View directory record Official record
Conditions
Allergic Reaction, Wound Complication
Interventions
Prineo dressing
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
303 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 2, 2026, 1:51 PM EDT
Terminated Not applicable Interventional

Health Partner Evaluation at Princeton

NCT03386786
View directory record Official record
Conditions
Total Knee Arthroplasty; Total Hip Arthroplasty
Interventions
Health Partner, Standard Care
Behavioral
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years and older
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Plainsboro, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 2, 2020 · Synced Oct 2, 2026, 1:51 PM EDT
Active, not recruiting Not applicable Interventional

A Randomized Trial to Assess Patient Quality of Life and Function After Alternative Surgeries for Pathologic Fractures of the Femur

NCT02164019
View directory record Official record
Conditions
Proximal Femoral Metastases
Interventions
long-stem cemented hemiarthroplasty (LSCH), intramedullary nailing (IMN), questionnaires
Procedure · Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2027
U.S. locations
6
States / cities
Grand Rapids, Michigan • New York, New York • Rochester, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Oct 2, 2026, 1:51 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

HealthEast Community Hip and Knee Replacement Registry

NCT02692092
View directory record Official record
Conditions
Bone Fracture
Interventions
Not listed
Lead sponsor
HealthEast Care System
Other
Eligibility
18 Years and older
Enrollment
200,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1991 – 2091
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 26, 2018 · Synced Oct 2, 2026, 1:51 PM EDT