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ClinicalTrials.gov public records Last synced Oct 15, 2026, 3:24 PM EDT

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Showing 721–744 of 851 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Hormone Replacement Therapy (HRT) Clear all
Recruiting Phase 1 Interventional

A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of DNL952 in Adult Participants With Late-Onset Pompe Disease

NCT07354724
View directory record Official record
Conditions
Late-onset Pompe Disease
Interventions
DNL952
Drug
Lead sponsor
Denali Therapeutics Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
4
States / cities
Irvine, California • St Louis, Missouri • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Phase 4 Interventional

Replagal Enzyme Replacement Therapy for Adults With Fabry Disease

NCT00097890
View directory record Official record
Conditions
Fabry Disease
Interventions
Replagal (Agalsidase Alfa), Replagal
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Male only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Phase 2 Interventional Results available

Gender Differences in Response to Nicotine Replacement Therapy and De-Nicotinized Cigarettes

NCT00960778
View directory record Official record
Conditions
Nicotine Dependence
Interventions
nicotine patch (Nicoderm Committed Quitter (CQ), Habitrol), denicotinized cigarettes (Quest 3 cigarettes)
Drug · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 60 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 23, 2018 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Disease Management for Smoking Cessation

NCT00440115
View directory record Official record
Conditions
Smoking Cessation
Interventions
High intensity disease management, Low intensity disease management, Comparison group, Bupropion
Behavioral · Drug
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jun 7, 2017 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Phase 3 Interventional Results available

Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation

NCT01406223
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Bupropion, Nicotine patches, Placebo varenicline, Placebo bupropion, Placebo patch
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years
Enrollment
282 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Durham, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 14, 2017 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Phase 2Phase 3 Interventional

Omega-3 Fatty Acid Deficiency Replacement in Early Schizophrenia

NCT00585390
View directory record Official record
Conditions
Schizophrenia, Fatty Acid Deficiency
Interventions
Omega-3 Fatty Acids, Olive oil placebo, EPA fish oil concentrate; DHA fish oil concentrate, Placebo
Dietary Supplement · Other · Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
8 Years to 25 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 2, 2011 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tobacco Treatment for Employable Californians, Total IMPACT Study

NCT02478697
View directory record Official record
Conditions
Tobacco Dependence
Interventions
ProChange ExpertSystem
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
3
States / cities
Menlo Park, California • San Francisco, California • San Rafael, California
Source: ClinicalTrials.gov public record
Updated Mar 20, 2024 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Phase 4 Interventional Results available

Post-Discharge Smoking Cessation Strategies: Helping HAND 4

NCT03603496
View directory record Official record
Conditions
Smoking Cessation
Interventions
Transitional Tobacco Care Management (TTCM), eReferral to State Tobacco Quitline (QL), Nicotine replacement therapy
Behavioral · Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
1,416 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
3
States / cities
Boston, Massachusetts • Pittsburgh, Pennsylvania • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 5, 2022 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Growth Hormone, Cardiovascular Risk, and Visceral Adiposity

NCT00131378
View directory record Official record
Conditions
Obesity
Interventions
Nutropin AQ growth hormone, Placebo Growth Hormone
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 11, 2016 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Treatment of Smoking Lapses and Relapses

NCT01807871
View directory record Official record
Conditions
Smoking Cessation
Interventions
nicotine patch, experimental use, nicotine patch, labeled use
Drug
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
701 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 13, 2017 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Early Phase 1 Interventional

Effects of Nicotine Replacement and Repeated Cue Exposure on Cigarette Craving

NCT01329614
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Cue Extinction Training, Nicotine Replacement Therapy, Cue Extinction Therapy, Progressive Muscle Relaxation
Behavioral · Drug
Lead sponsor
Columbia University
Other
Eligibility
21 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 15, 2024 · Synced Oct 15, 2026, 3:24 PM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Treating Adults at Risk for Weight Gain With Interactive Technology

NCT01199185
View directory record Official record
Conditions
Smoking, Body Weight
Interventions
Smoking Cessation, Smoking Cessation plus Weight Loss
Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 35 Years
Enrollment
330 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 18, 2013 · Synced Oct 15, 2026, 3:24 PM EDT
Completed No phase listed Observational

Wound Complications in Head and Neck Surgery

NCT03134976
View directory record Official record
Conditions
Hypothyroidism; Surgery, Head and Neck Cancer, Wound Heal, Laryngeal Cancer, Laryngeal Fistula
Interventions
Levothyroxine
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 1, 2020 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Changing the Default for Tobacco Treatment

NCT02721082
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Opt Out Treatment Program, Nicotine Replacement Therapy, Opt In Treatment Program
Behavioral · Drug
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Dec 1, 2022 · Synced Oct 15, 2026, 3:24 PM EDT
Not listed Phase 1 Interventional

Safety and TDM of Continuous Infusion Vancomycin Through Continuous Renal Replacement Therapy Solution

NCT02663596
View directory record Official record
Conditions
Pediatric Continuous Renal Replacement Therapy, Dialysis, Renal Failure
Interventions
Vancomycin
Drug
Lead sponsor
Drexel University
Other
Eligibility
Not listed
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 15, 2026, 3:24 PM EDT
Active, not recruiting Phase 1 Interventional

Renal Allograft Tolerance Through Mixed Chimerism - SMC/MGH

NCT04540380
View directory record Official record
Conditions
Renal Failure
Interventions
Rituximab, Fludarabine, Cyclophosphamide, Thymic irradiation and Siplizumab, Combined bone marrow and kidney transplant
Drug · Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 15, 2026, 3:24 PM EDT
Withdrawn Not applicable Interventional

Developing and Pilot Testing a Remote Smoking Cessation Digital Therapeutic for Individuals With Serious Mental Illness

NCT05031416
View directory record Official record
Conditions
Smoking Cessation
Interventions
LTQ
Combination Product
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 4, 2025 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Phase 2 Interventional

Reduction of Smoking in Cardiac Disease Patients

NCT00469885
View directory record Official record
Conditions
Cardiovascular Disease, Tobacco Use Disorder
Interventions
Nicotine replacement, Motivational counseling
Drug · Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
2
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Oct 15, 2026, 3:24 PM EDT
Not listed Not applicable Interventional

Hemofiltration in Burns: RESCUE (Randomized Controlled Evaluation of Hemofiltration in Adult Burn Patients With Septic Shock and Acute Renal Failure)

NCT01213914
View directory record Official record
Conditions
Burns, Hemofiltration, Kidney Failure, Acute, Shock, Septic
Interventions
An FDA approved continuous renal replacement device, Control Group
Device · Other
Lead sponsor
American Burn Association
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
9
States / cities
Phoenix, Arizona • Washington D.C., District of Columbia • Tampa, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 6, 2018 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Not applicable Interventional

Web-Delivered Acceptance & Commitment Therapy for Smokers With Bipolar Disorder

NCT02750904
View directory record Official record
Conditions
Smoking, Bipolar Disorder
Interventions
Experimental plus Nicotine Replacement Therapy, Control plus Nicotine Replacement Therapy
Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
4
States / cities
Palo Alto, California • Denver, Colorado • Bedford, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2019 · Synced Oct 15, 2026, 3:24 PM EDT
Withdrawn Phase 4 Interventional

Opioids and Smoking Cessation

NCT03857139
View directory record Official record
Conditions
Smoking, Smoking Cessation, Smoking, Tobacco, Opioid Use, Opioid Abuse
Interventions
Nicotine patch
Drug
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 20, 2022 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Not applicable Interventional

Clinical Trial of an Automated Smartphone Based Smoking Cessation Treatment

NCT02930200
View directory record Official record
Conditions
Smoking Cessation
Interventions
Treatment as Usual, QuitGuide, Smart-T
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 20, 2019 · Synced Oct 15, 2026, 3:24 PM EDT
Completed Phase 2 Interventional Results available

Effects of Testosterone Replacement on Pain Sensitivity and Pain Perception

NCT00351819
View directory record Official record
Conditions
Pain, Hypogonadism
Interventions
AndroGel, Placebo
Drug · Other
Lead sponsor
Boston University
Other
Eligibility
18 Years to 100 Years · Male only
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2017 · Synced Oct 15, 2026, 3:24 PM EDT
Completed No phase listed Observational

Prevalence of Antibodies to Selected Porcine Viruses in Patients With Cystic Fibrosis Receiving Porcine-derived Pancreatic Enzyme Replacement Therapy

NCT01858519
View directory record Official record
Conditions
Cystic Fibrosis
Interventions
Not listed
Lead sponsor
AbbVie
Industry
Eligibility
2 Years to 99 Years
Enrollment
1,310 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
47
States / cities
Anchorage, Alaska • Little Rock, Arkansas • Long Beach, California + 41 more
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Oct 15, 2026, 3:24 PM EDT