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ClinicalTrials.gov public records Last synced Oct 3, 2026, 6:54 PM EDT

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Showing 25–48 of 58 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Hot water therapy Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Hot Water Immersion on Heart Rate Variability and Glucose

NCT06193291
View directory record Official record
Conditions
Glucose Tolerance, HRV
Interventions
Feet heating, Calf heating
Procedure
Lead sponsor
San Diego State University
Other
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 8, 2024 · Synced Oct 3, 2026, 6:54 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Influence of Wet Clothing on Thermal Protection

NCT05409937
View directory record Official record
Conditions
Low Body Temperatures
Interventions
Water-saturated Improved Hot Weather Combat Uniform, Water-saturated Army Combat Uniform, Water-saturated Army Combat Uniform + Silk Weights
Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 49 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 27, 2023 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional Results available

Pilot Study for Investigating the Effect of the Bruder Eye Hydrating Compress on Contact Lens Discomfort in Contact Lens Wearers

NCT02848222
View directory record Official record
Conditions
Contact Lens Discomfort, Dry Eye Disease, Meibomian Gland Dysfunction
Interventions
Bruder Moist Heat Compress, Washcloth
Device · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 17, 2018 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Chamomile Intake on Blood Coagulation Tests in Healthy Volunteers

NCT05006378
View directory record Official record
Conditions
Coagulation Disorder
Interventions
Chamomile Tea, Chamomile Extract Capsule, Placebo Capsule
Dietary Supplement
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Feb 10, 2022 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Passive Heat Therapy on Oxygen Consumption and Cardiovascular Fitness in Adults

NCT04026126
View directory record Official record
Conditions
Heart Failure, Heart Diseases, Cardiovascular Diseases, Endothelial Dysfunction
Interventions
Heat Therapy Treatment
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
50 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 17, 2022 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Crossover Trial to Examine the Efficacy of a Powder to Improve Sleep Quality and Performance

NCT07183735
View directory record Official record
Conditions
Sleep, Sleep Disorder
Interventions
BEAM Dream Powder, Placebo Control
Dietary Supplement
Lead sponsor
Beam
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Sep 19, 2025 · Synced Oct 3, 2026, 6:54 PM EDT
Recruiting Not applicable Interventional

Randomized Evaluation of Natural Extract for Menopausal Wellness (RENEW)

NCT07834463
View directory record Official record
Conditions
Menopause, Hot Flashes
Interventions
Shatavari (Asparagus racemosus) Extract, Placebo
Dietary Supplement · Other
Lead sponsor
India Glycols Ltd
Industry
Eligibility
45 Years to 60 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Port Richey, Florida
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Oct 3, 2026, 6:54 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Hot Flashes and Neurovascular Function in Women

NCT05193968
View directory record Official record
Conditions
Hot Flashes, Menopause, Vasomotor System; Labile
Interventions
Sympathoexcitatory stressors, Sodium Nitroprusside, Acetylcholine, Terbutaline, Norepinephrine
Other · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years to 60 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 3, 2026, 6:54 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

IEEM-Heat and Heart Failure

NCT06961929
View directory record Official record
Conditions
Heart Failure, Hyperthermia
Interventions
Control Trial, Water-saturated T-shirt trial, Skin-Wetting Trial
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
45 Years and older
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic Study of GSK2881078 and Study to Evaluate the Effect of CYP3A4 Inhibition on PK of GSK2881078

NCT02567773
View directory record Official record
Conditions
Cachexia
Interventions
GSK2881078, Placebo, Itraconazole
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 75 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 6, 2017 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Phase 2 Interventional

Preventing Sexual Dysfunction With Aromatase Inhibitors

NCT01603303
View directory record Official record
Conditions
Breast Cancer
Interventions
Questionnaires, Education Materials, Luvena, Hyalo-Gyn, Vaginal Lubricant, Interactive Internet-Based Website, Telephone Counseling.
Behavioral · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 18, 2017 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Food Form and Fitness on Appetite and Digestion.

NCT01070199
View directory record Official record
Conditions
High and Increasing Contribution of Energy From Beverages in the Diet May Enhance Positive Energy Balance and Weight Gain
Interventions
liquid to liquid, liquid to solid, solid to liquid, solid to solid
Behavioral
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 50 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 25, 2011 · Synced Oct 3, 2026, 6:54 PM EDT
Not yet recruiting Phase 3 Interventional

Fezolinetant and Vascular Health and Brain Health

NCT07606664
View directory record Official record
Conditions
Menopause Hot Flashes
Interventions
Placebo, Fezolinetant
Drug
Lead sponsor
Rebecca Thurston
Other
Eligibility
40 Years to 65 Years · Female only
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Chicago, Illinois • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 3, 2026, 6:54 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Heat Waves and the Elderly - Cooling Modalities

NCT05484739
View directory record Official record
Conditions
Aging, Hyperthermia
Interventions
Water Spray, Fan, Water Spray and Fan, Control
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Acute Effects of Coffee on Glucose Metabolism

NCT00950898
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
decaff, caffcoff, caffeine, placebo
Other
Lead sponsor
Brooklyn College of the City University of New York
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Aug 3, 2009 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Feet and Calf Heating on Glucose Tolerance

NCT04232098
View directory record Official record
Conditions
Postprandial Hyperglycemia, Heart Rate Variability
Interventions
Heat to ankle, Heat to calf
Other
Lead sponsor
San Diego State University
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 20, 2024 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Acute Effects of Chamomile Intake on Blood Coagulation Tests in Healthy Volunteers

NCT05272475
View directory record Official record
Conditions
Coagulation Disorder
Interventions
Chamomile Tea, Chamomile Extract Capsule
Dietary Supplement
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jun 10, 2022 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional Results available

Individualized vs. Household MRSA Decolonization

NCT01814371
View directory record Official record
Conditions
Staphylococcal Skin Infection, Abscess, Furunculosis, Staphylococcus Aureus, MRSA Infection
Interventions
2% mupirocin ointment, Bleach Bath (dilute), Hygiene Protocol
Drug · Other · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
Not listed
Enrollment
474 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 21, 2019 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Assessing the Pharmacokinetics and Drug Interaction Liability of Kratom, an Opioid-like Natural Product

NCT04392011
View directory record Official record
Conditions
Interaction Drug Food
Interventions
Midazolam HCl, Dextromethorphan HBr, Kratom
Drug · Dietary Supplement
Lead sponsor
Washington State University
Other
Eligibility
18 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Dec 20, 2023 · Synced Oct 3, 2026, 6:54 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Passive Heat Therapy for Lowering Systolic Blood Pressure and Improving Vascular Function in Mid-life and Older Adults

NCT05300971
View directory record Official record
Conditions
Aging
Interventions
Heat therapy, Thermoneutral water immersion
Other
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
40 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Phytochemicals From Theobroma Cacao on Mental Energy

NCT01651793
View directory record Official record
Conditions
Mental Fatigue
Interventions
Caffeinated cocoa, Cocoa, Caffeine, Placebo
Other
Lead sponsor
University of Georgia
Other
Eligibility
18 Years to 34 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 25, 2018 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional

Study to Warm Up and Cool Down Recreationally Active Males Using Different Protocols.

NCT06874023
View directory record Official record
Conditions
Heat Acclimation and Thermotolerance
Interventions
Passive heating in hot conditions, Active heating + passive heating in hot conditions, Active heating in hot conditions, Active heating at room temperature, Cool vest, Damp neck towel combined with arm cool water immersion, Combination of cooling interventions, Control in thermoneutral room without cooling
Other
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 30 Years · Male only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 13, 2025 · Synced Oct 3, 2026, 6:54 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Evaluating a Potential Pharmacokinetic Kratom-oxycodone Interaction Concurrent With Clinical Endpoints

NCT05846451
View directory record Official record
Conditions
Herbal Interaction
Interventions
Kratom, Oxycodone
Dietary Supplement · Drug
Lead sponsor
Washington State University
Other
Eligibility
21 Years to 45 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Microbiologic Alterations of the Conjunctiva of Hot Tub-soaking Ophthalmologists

NCT03987178
View directory record Official record
Conditions
Conjunctivitis, Bacterial, Keratitis Bacterial
Interventions
Dunk, Exposure to Hot Tub
Behavioral · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 10, 2020 · Synced Oct 3, 2026, 6:54 PM EDT