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Showing 1–24 of 49 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Hybrid Closed Loop System Clear all
Completed Not applicable Interventional

A Study of an Automated Insulin Delivery System in Adult Participants With Type 1 Diabetes Mellitus

NCT03849612
View directory record Official record
Conditions
Type 1 Diabetes Mellitus
Interventions
AID System, Insulin Lispro
Device · Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Walnut Creek, California
Source: ClinicalTrials.gov public record
Updated Apr 24, 2019 · Synced Sep 11, 2026, 8:45 AM EDT
Recruiting Not applicable Interventional

A Randomized Parallel Clinical Trial of AIDANET, an Automated Insulin Delivery Algorithm, in Fully Closed-Loop Vs Hybrid Closed-Loop Mode In Adults With Type 1 Diabetes (AIDANET At Home)

NCT07039617
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
AIDANET + FCL, AIDANET + HCL, AIDANET in FCL-HCL-mixed mode, Automated Insulin Delivery (AID) (usual care)
Device · Other
Lead sponsor
Sue Brown
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Not applicable Interventional Results available

Two Way Crossover Closed Loop MPC vs Control IQ

NCT05799781
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
MPC closed-loop system, t:slim X2 pump with Dexcom G6 CGM and Control IQ
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Portland, Oregon • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Not applicable Interventional Results available

Safety Evaluation of the Advanced Hybrid Closed Loop (AHCL) System

NCT03959423
View directory record Official record
Conditions
Type 1 Diabetes Mellitus
Interventions
AHCL insulin pump system
Device
Lead sponsor
Medtronic MiniMed, Inc.
Industry
Eligibility
7 Years to 75 Years
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
17
States / cities
Little Rock, Arkansas • La Jolla, California • Torrance, California + 13 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Sep 11, 2026, 8:45 AM EDT
Recruiting Not applicable Interventional

Insulin Delivery With Self-Adjusting Closed-Loop and Behavioral Glycemic Control Enhanced by Prediction

NCT07507708
View directory record Official record
Conditions
Type 1 Diabetes (T1D)
Interventions
Automated Insulin Delivery (AID), AIDANET + Fully Closed Loop (FCL), AIDANET + Anticipatory Closed Loop (ACL)
Device
Lead sponsor
Sue Brown
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 11, 2026, 8:45 AM EDT
Withdrawn No phase listed Observational

Hybrid Closed-Loop Insulin Delivery System in Type 1 Diabetes Candidates for a Living Donor Kidney Transplant

NCT03494010
View directory record Official record
Conditions
Diabetes, Type 1
Interventions
Observation
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 8, 2021 · Synced Sep 11, 2026, 8:45 AM EDT
Withdrawn Not applicable Interventional

Technology Knowledge Optimization in Type 1 Diabetes (TeKnO T1D): Parents

NCT05300022
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
TeKnO T1D: Parents
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
8 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Not applicable Interventional Results available

Evaluation of the Advanced Hybrid Closed Loop (AHCL) System in Type 1 Adults and Pediatrics Utilizing Lyumjev®

NCT05325294
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
MiniMed 780G System
Device
Lead sponsor
Medtronic MiniMed, Inc.
Industry
Eligibility
7 Years to 80 Years
Enrollment
244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
19
States / cities
Palo Alto, California • San Diego, California • Aurora, Colorado + 15 more
Source: ClinicalTrials.gov public record
Updated Jan 14, 2025 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Not applicable Interventional Results available

Safety Evaluation of the Hybrid Closed Loop (HCL) System in Pediatric Subjects With Type 1 Diabetes

NCT02660827
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
Insulin Pump
Device
Lead sponsor
Medtronic MiniMed, Inc.
Industry
Eligibility
2 Years to 13 Years
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
10
States / cities
Escondido, California • Palo Alto, California • Torrance, California + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2022 · Synced Sep 11, 2026, 8:45 AM EDT
Not yet recruiting Phase 2 Interventional

Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes Who Are Using Hybrid Closed Loop (HCL) Systems

NCT07616206
View directory record Official record
Conditions
Type 1 Diabetes (T1D)
Interventions
Cadisegliatin 800 mg QD, Placebo
Drug
Lead sponsor
vTv Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Not applicable Interventional

Insulet Artificial Pancreas Evaluating Meal Performance and Moderate Exercise (IDE2)

NCT03064906
View directory record Official record
Conditions
Type 1 Diabetes Mellitus
Interventions
Insulet AP (artificial pancreas) System
Device
Lead sponsor
Insulet Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
3
States / cities
Palo Alto, California • Walnut Creek, California • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 11, 2018 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Phase 3 Interventional Results available

Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 Diabetes

NCT04233034
View directory record Official record
Conditions
Type1 Diabetes
Interventions
HCL, verapamil 120mg tablet, non-HCL, placebo
Device · Drug
Lead sponsor
Jaeb Center for Health Research
Other
Eligibility
7 Years to 17 Years
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
6
States / cities
Palo Alto, California • Aurora, Colorado • New Haven, Connecticut + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 26, 2024 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Not applicable Interventional Results available

Hybrid Closed Loop Insulin Delivery System in Hypoglycemia

NCT03215914
View directory record Official record
Conditions
Type1diabetes, Hypoglycemia Unawareness, Nocturnal Hypoglycemia, Hypoglycemia Night, Hypoglycemia
Interventions
MiniMed 670G system
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
25 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
3
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Not applicable Interventional

Supporting Parents of Young Children With Type 1 Diabetes in Closed-Loop System

NCT03354286
View directory record Official record
Conditions
Type 1 Diabetes Mellitus
Interventions
Developmental & Technological Demands, Distress Reduction, Nutrition, Set Point, & C:I Ratio, Hypoglycemia management, Minimal Intervention
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
2 Years to 6 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 24, 2019 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Phase 4 Interventional Results available

Evaluation of Fiasp® (Fast Acting Insulin Aspart) in 670G Hybrid Closed-Loop Therapy

NCT03554486
View directory record Official record
Conditions
Diabetes Mellitus, Type 1
Interventions
Fiasp, Novolog
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 17, 2021 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Not applicable Interventional

A Study of an Automated Insulin Delivery System in Adult Participants With Type 1 Diabetes Mellitus During Meal Challenges

NCT03848767
View directory record Official record
Conditions
Type 1 Diabetes Mellitus
Interventions
AID System, Insulin Lispro
Device · Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Renton, Washington
Source: ClinicalTrials.gov public record
Updated Apr 22, 2019 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Not applicable Interventional Results available

Multi-center Trial in Adult and Pediatric Patients With Type 1 Diabetes Using Hybrid Closed Loop System and Control at Home

NCT02748018
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
670G and 770G Insulin Pump, Subject's Current Diabetes Therapy
Device
Lead sponsor
Medtronic MiniMed, Inc.
Industry
Eligibility
2 Years to 80 Years
Enrollment
959 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
25
States / cities
La Jolla, California • Palo Alto, California • Sacramento, California + 21 more
Source: ClinicalTrials.gov public record
Updated Aug 18, 2025 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Not applicable Interventional Results available

Hybrid Closed Loop Pivotal Trial in Type 1 Diabetes

NCT02463097
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
Insulin Pump
Device
Lead sponsor
Medtronic MiniMed, Inc.
Industry
Eligibility
14 Years to 75 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
9
States / cities
Escondido, California • Palo Alto, California • Aurora, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2019 · Synced Sep 11, 2026, 8:45 AM EDT
Completed No phase listed Observational

Impact of Hybrid Closed-Loop Systems on Sleep and Psychosocial Outcomes in Youth With T1D and Their Parents

NCT04431947
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
2 Years to 17 Years
Enrollment
46 participants
Timeline
2020 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 24, 2022 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Not applicable Interventional Results available

Pregnancy Intervention With a Closed-Loop System (PICLS) Study

NCT03774186
View directory record Official record
Conditions
Type 1 Diabetes Mellitus, Pregnancy in Diabetes
Interventions
Hybrid closed-loop therapy, Sensor-augmented pump therapy
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Aurora, Colorado • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced Sep 11, 2026, 8:45 AM EDT
Recruiting Not applicable Interventional

Starting Technology in At Risk Type 1 Diabetes Study

NCT06453928
View directory record Official record
Conditions
Diabetes Mellitus, Type 1
Interventions
Hybrid Closed Loop Insulin Pump System
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
3
States / cities
Santa Monica, California • Sylmar, California • Torrance, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Not applicable Interventional

Insulet Artificial Pancreas Free-Living IDE3

NCT03216460
View directory record Official record
Conditions
Type1 Diabetes Mellitus
Interventions
Insulet automated glucose control system
Device
Lead sponsor
Insulet Corporation
Industry
Eligibility
2 Years to 85 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
3
States / cities
Palo Alto, California • Denver, Colorado • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 1, 2019 · Synced Sep 11, 2026, 8:45 AM EDT
Recruiting Not applicable Interventional

Using Simplified Meal Boluses Versus Carbohydrate Counting in Adolescents With Hybrid Closed Loop Systems

NCT06575790
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
Simple Meal Bolusing, Carbohydrate counting
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
14 Years to 26 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Sep 11, 2026, 8:45 AM EDT
Completed Not applicable Interventional Results available

Overnight Closed Loop Study in U.S.

NCT01857973
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
Hybrid Closed Loop
Device
Lead sponsor
Medtronic MiniMed, Inc.
Industry
Eligibility
2 Years to 75 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
6
States / cities
Escondido, California • Aurora, Colorado • New Haven, Connecticut + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2019 · Synced Sep 11, 2026, 8:45 AM EDT