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ClinicalTrials.gov public records Last synced Oct 20, 2026, 4:22 PM EDT

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Showing 1–24 of 165 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Hydroxocobalamin Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Misoprostol Versus Dilapan-S for Cervical Preparation

NCT00835731
View directory record Official record
Conditions
Cervical Ripening
Interventions
misoprostol, Dilapan-S, vitamin B-12
Drug · Device
Lead sponsor
Planned Parenthood League of Massachusetts
Other
Eligibility
18 Years and older · Female only
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 23, 2017 · Synced Oct 20, 2026, 4:22 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Lactoferrin-enriched Whey on Iron Status in Females

NCT06232642
View directory record Official record
Conditions
Serum Ferritin
Interventions
Lactoferrin, iron and B12 in Whey Protein, Lactoferrin, Iron and B12 in Rice Protein, Lactoferrin, Iron and B12 in Maltrodextrin
Dietary Supplement
Lead sponsor
Utah State University
Other
Eligibility
18 Years to 30 Years · Female only
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Phase 3 Interventional

Vitamin Therapy for Prevention of Stroke

NCT00004734
View directory record Official record
Conditions
Stroke, Cerebral Infarction, Myocardial Infarction
Interventions
pyridoxine, cyanocobalamin, folic acid multivitamin
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
35 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2004
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 24, 2005 · Synced Oct 20, 2026, 4:22 PM EDT
Not listed Not applicable Interventional

Vitamin B6, B12, Folic Acid and Exercise in Parkinson's Disease

NCT01238926
View directory record Official record
Conditions
Parkinson's Disease
Interventions
PD vitamin supplementation, PD exercise intervention, PD vitamin + exercise
Dietary Supplement · Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
50 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Nov 11, 2010 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Not applicable Interventional Results available

VITATOPS: A Study of VITAmins TO Prevent Stroke

NCT00097669
View directory record Official record
Conditions
Stroke, Transient Ischemic Attack
Interventions
Active VITATOPS Tablet (folic acid 2mg, B6 25mg , B12 500ug) or placebo, Placebo
Drug · Other
Lead sponsor
VITATOPS
Government
Eligibility
Not listed
Enrollment
8,164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2009
U.S. locations
4
States / cities
New York, New York • Abington, Pennsylvania • Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 25, 2020 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Not applicable Interventional

Randomized Study of Folic Acid Therapy for Hyperhomocysteinemia in Patients With End Stage Renal Disease Receiving Hemodialysis

NCT00004495
View directory record Official record
Conditions
End Stage Renal Disease, Hyperhomocysteinemia
Interventions
cyanocobalamin, folic acid, pyridoxine
Drug
Lead sponsor
Georgetown University
Other
Eligibility
21 Years to 89 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2000
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 25, 2015 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Phase 1 Interventional

Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)

NCT01381354
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Progressive exercise, Neuromuscular electrical stimulation delivered using the electrical therapy device EMPI 300 PV, Modified paleolithic diet, Omega 3 fatty acids, Full Spectrum vitamin, Essential - hydroxytyrosol, Maltodextrin fiber supplement, Mineral boost (magnesium), Niacinamide, Methyl B12, Taurine, creatine, thiamine, riboflavin, N acetylcysteine, alpha lipoic acid, L acetyl carnitine, methyl folate, coenzyme Q, meditation, self massage, learning, Coconut oil
Other · Device · Dietary Supplement + 1 more
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 26, 2018 · Synced Oct 20, 2026, 4:22 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Assessment of Vitamin B12 Bioavailability From Egg

NCT01366937
View directory record Official record
Conditions
Bioavailability of Vitamin B12 From Chicken Eggs
Interventions
Not listed
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Aug 4, 2011 · Synced Oct 20, 2026, 4:22 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Metformin Use and Vitamin B12 Deficiency

NCT01136512
View directory record Official record
Conditions
Vitamin B12 Deficiency, Type 2 Diabetes Mellitus
Interventions
Not listed
Lead sponsor
Northwell Health
Other
Eligibility
20 Years to 80 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Staten Island, New York
Source: ClinicalTrials.gov public record
Updated Jul 31, 2013 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Phase 1 Interventional

Open Label Study: Treatment of ALS Fatigue With PolyMVA

NCT04557410
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis
Interventions
PolyMVA
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
Not listed
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated May 27, 2021 · Synced Oct 20, 2026, 4:22 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

An Exploratory, Randomized, Blinded, Placebo-Controlled Trial of Folic Acid and L-methylfolate in Parkinson's Disease

NCT00853879
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Folic Acid, Vitamin B6, Vitamin B12, B6, B12, L-methylfolate, B6, B12, Placebo
Dietary Supplement
Lead sponsor
Northwell Health
Other
Eligibility
30 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated May 15, 2015 · Synced Oct 20, 2026, 4:22 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Néevo®/NéevoDHA® P.L.U.S. Program (Progress Through Learning, Understand & Support)

NCT01358552
View directory record Official record
Conditions
Pregnancy
Interventions
Néevo®/ NéevoDHA®
Other
Lead sponsor
Pamlab, Inc.
Industry
Eligibility
18 Years to 39 Years · Female only
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated May 1, 2013 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of a Multi-vitamin Supplement in Adult Females

NCT03828097
View directory record Official record
Conditions
Health, Subjective
Interventions
Experimental supplement, Placebo
Dietary Supplement
Lead sponsor
Auburn University
Other
Eligibility
21 Years to 40 Years · Female only
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 28, 2020 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Not applicable Interventional

Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly

NCT00212147
View directory record Official record
Conditions
Avitaminosis, Delirium, Dementia, Amnestic, Cognitive Disorders
Interventions
General anesthesia with nitrous oxide, General anesthesia without nitrous oxide
Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
60 Years and older
Enrollment
444 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
2
States / cities
Brooklyn, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 8, 2022 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Not applicable Interventional

A Nutritional Intervention for Diabetic Neuropathy

NCT01690962
View directory record Official record
Conditions
Diabetic Neuropathy
Interventions
Vegan diet and vitamin B12 supplement, Vitamin B12 supplement
Other · Dietary Supplement
Lead sponsor
Physicians Committee for Responsible Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Sep 4, 2014 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study on Hydroxocobalamin Given to Healthy Individual to Monitor Symptoms

NCT07469189
View directory record Official record
Conditions
Hydroxocobalamin Adverse Reaction
Interventions
Hydroxocobalamin
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 20, 2026, 4:22 PM EDT
Not listed Not applicable Interventional

B Vitamin Supplementation to Chiropractic Management of Chronic LBP: Pilot Clinical Trial (VCLBP)

NCT06576739
View directory record Official record
Conditions
Recurrent Low Back Pain
Interventions
Spinal Manipulation
Procedure
Lead sponsor
University of Western States
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 29, 2024 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Phase 3 Interventional

Alimta® Versus Its Combination With Carboplatin in Advanced Non-small-cell Lung Cancer in Patients Performance Status 2

NCT01836575
View directory record Official record
Conditions
Non Small Cell Lung Carcinoma
Interventions
Pemetrexed, Carboplatin
Drug
Lead sponsor
Instituto Nacional de Cancer, Brazil
Government
Eligibility
18 Years and older
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Miami Beach, Florida
Source: ClinicalTrials.gov public record
Updated Apr 22, 2013 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Phase 3 Interventional

Homocysteine Study (HOST)

NCT00032435
View directory record Official record
Conditions
End Stage Renal Disease, Renal Failure
Interventions
PAL-40 Active, PAL-40 Placebo
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
21 Years and older
Enrollment
2,003 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
36
States / cities
Birmingham, Alabama • Menlo Park, California • Palo Alto, California + 33 more
Source: ClinicalTrials.gov public record
Updated Oct 15, 2010 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Trial to Assess the Effects of a Vitamin Shot on Energy Levels

NCT06019858
View directory record Official record
Conditions
Energy, Fatigue, Mood, Weight Loss, Cognition
Interventions
Vitamin Energy Shot
Other
Lead sponsor
Vitamin Energy®
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Aug 31, 2023 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Not applicable Interventional

Effect of High-Dose B-Complex Vitamins on the Symptoms of Schizophrenia

NCT00403247
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
Capsule with folate, Vitamin B12 & pyridoxine, placebo
Dietary Supplement · Other
Lead sponsor
Nathan Kline Institute for Psychiatric Research
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Orangeburg, New York
Source: ClinicalTrials.gov public record
Updated Aug 23, 2007 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Exploratory Investigation of a Supplement to Promote Brain Health

NCT05520424
View directory record Official record
Conditions
Memory Deficits, Cognitive Change, Stress
Interventions
The Daily Supplement
Dietary Supplement
Lead sponsor
Parable
Industry
Eligibility
30 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Apr 3, 2024 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Transdermal Iontophoresis of Vitamin B12 Under Three Different Skin Preparations

NCT04027959
View directory record Official record
Conditions
Macrocytic Anemia With Vitamin B12 Deficiency
Interventions
Vitamin B12
Dietary Supplement
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 14, 2020 · Synced Oct 20, 2026, 4:22 PM EDT
Completed Not applicable Interventional Results available

Vitamins in Nitrous Oxide Study

NCT00655980
View directory record Official record
Conditions
Major Surgery, Coronary Artery Disease
Interventions
Vitamin B12 and folic acid, Nitrous oxide and placebo, standard of care
Drug · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
687 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 1, 2020 · Synced Oct 20, 2026, 4:22 PM EDT