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Showing 1–24 of 41 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Hyperoxia Clear all
Recruiting Phase 4 Interventional Accepts healthy volunteers

Retinal Blood Flow and Autoregulation

NCT05344274
View directory record Official record
Conditions
Glaucoma
Interventions
Indocyanine Green Angiography, Isocapnic Oxygen, Ocular Imaging with Optical Coherence Tomography (OCT) and Adaptive Optics (AO)
Diagnostic Test · Biological
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 88 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
4
States / cities
Baltimore, Maryland • Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Sep 5, 2026, 7:35 PM EDT
Withdrawn Phase 4 Interventional

Oxygen Therapy for Retinal Ischemia

NCT03730779
View directory record Official record
Conditions
Retinal Ischemia
Interventions
Hyperoxia
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 8, 2020 · Synced Sep 5, 2026, 7:35 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Chemoreflex and Baroreflex Alterations Causing Postural Tachycardia Syndrome With Orthostatic Hyperpnea and Hypocapnia

NCT05923840
View directory record Official record
Conditions
Postural Orthostatic Tachycardia Syndrome, Hypocapnia, Hyperventilation
Interventions
Chemoreflex Testing, Baroreflex testing, Orthostatic stress testing
Diagnostic Test
Lead sponsor
New York Medical College
Other
Eligibility
15 Years to 39 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Hawthorne, New York
Source: ClinicalTrials.gov public record
Updated Jun 27, 2023 · Synced Sep 5, 2026, 7:35 PM EDT
Completed Phase 1 Interventional Results available

Reoxygenation After Cardiac Arrest II (REOX II Study)

NCT02698826
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Protocol for rapid FiO2 optimization
Other
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
5
States / cities
Indianapolis, Indiana • Boston, Massachusetts • Jackson, Mississippi + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 28, 2022 · Synced Sep 5, 2026, 7:35 PM EDT
Recruiting Not applicable Interventional

Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis

NCT04368039
View directory record Official record
Conditions
Psychosis, Schizophrenia, First-episode Psychosis
Interventions
Normobaric Oxygen, Placebo
Device
Lead sponsor
Nicholas Breitborde
Other
Eligibility
15 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 5, 2026, 7:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

HYPEROXIA Responses and ROS

NCT05958303
View directory record Official record
Conditions
Cerebrovascular Disorders
Interventions
Antioxidant Cocktail, Placebo
Dietary Supplement · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 40 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 5, 2026, 7:35 PM EDT
Recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Sleep Disordered Breathing With Opioid Use

NCT05589753
View directory record Official record
Conditions
Sleep Apnea, Opioid Use, Sleep Disordered Breathing
Interventions
Hyperoxia, Acetazolamide
Other · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 5, 2026, 7:35 PM EDT
Completed No phase listed Observational

Genes Associated With Bronchopulmonary Dysplasia and Retinopathy of Prematurity

NCT01780155
View directory record Official record
Conditions
Bronchopulmonary Dysplasia, Retinopathy of Prematurity, Prematurity, Pulmonary Disease
Interventions
Not listed
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
Not listed
Enrollment
1,068 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Research Triangle Park, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Sep 5, 2026, 7:35 PM EDT
Not listed No phase listed Observational

Intraoperative Hyperoxia and MINS

NCT04540276
View directory record Official record
Conditions
Hyperoxia, Myocardial Infarction, Myocardial Injury
Interventions
Inspiratory oxygen fraction
Drug
Lead sponsor
University Hospital Bispebjerg and Frederiksberg
Other
Eligibility
18 Years and older
Enrollment
7,700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Sep 5, 2026, 7:35 PM EDT
Not listed Not applicable Interventional

Intraoperative Oxygen Concentration and Neurocognition After Cardiac Surgery

NCT02591589
View directory record Official record
Conditions
Hyperoxia, Normoxic, Delirium
Interventions
Normoxic oxygenation, Hyperoxic oxygenation
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 22, 2020 · Synced Sep 5, 2026, 7:35 PM EDT
Completed No phase listed Observational Results available

Pilot Study of Targeted Normoxia in Critically Ill Trauma Patients

NCT03789396
View directory record Official record
Conditions
Trauma, Critical Illness, Oxygen Toxicity
Interventions
Targeted Normoxia (oxygen saturation 90-96%), Usual Care Oxygenation
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 109 Years
Enrollment
572 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 14, 2024 · Synced Sep 5, 2026, 7:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Targeting the Carotid Bodies to Reduce Disease Risk Along the Diabetes Continuum

NCT05219994
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Hyperoxia Exposure, Normoxia Exposure
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Sep 5, 2026, 7:35 PM EDT
Completed No phase listed Observational

Respiratory Control and Narcotic Effects

NCT04047550
View directory record Official record
Conditions
Ventilatory Depression, Opioid Intoxication, Opioid Toxicity
Interventions
Ventilatory chemosensitivity
Diagnostic Test
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2020 · Synced Sep 5, 2026, 7:35 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Risk of Oxygen During Cardiac Surgery Trial

NCT02361944
View directory record Official record
Conditions
Cardiac Surgery
Interventions
Oxygen - normoxia, Oxygen - hyperoxia
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
213 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 31, 2024 · Synced Sep 5, 2026, 7:35 PM EDT
Recruiting Phase 2 Interventional

Treating Spinal Cord Injury With Early Normobaric Hyperoxia

NCT07465302
View directory record Official record
Conditions
Traumatic Spinal Cord Injuries
Interventions
Normobaric Hyperoxia
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 5, 2026, 7:35 PM EDT
Completed Not applicable Interventional

Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention

NCT06374225
View directory record Official record
Conditions
Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
Interventions
Automated Titration (O2matic)
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
4
States / cities
Aurora, Colorado • Winston-Salem, North Carolina • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 5, 2026, 7:35 PM EDT
Terminated Not applicable Interventional

DAMP-Mediated Innate Immune Failure and Pneumonia After Trauma - the Harvard-Longwood (HALO) Campus Area Consortium

NCT03993002
View directory record Official record
Conditions
Respiratory Failure
Interventions
Normoxia with Normocarbia, Normoxia with Hypercarbia, Hyperoxia with Normocarbia, Hyperoxia with Hypercarbia
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 17, 2022 · Synced Sep 5, 2026, 7:35 PM EDT
Completed Phase 2 Interventional

Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury

NCT00170352
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Hyperbaric Oxygen Treatment (HBOT), Enhanced Oxygen Treatment (Enhanced FiO2)
Procedure
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
16 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 27, 2015 · Synced Sep 5, 2026, 7:35 PM EDT
Completed No phase listed Observational Results available

ED Lung Protective Ventilation to Reduce Complications

NCT02543554
View directory record Official record
Conditions
Mechanical Ventilation, Ventilator-associated Conditions, ARDS
Interventions
lung protective ventilation
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
1,705 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 2, 2018 · Synced Sep 5, 2026, 7:35 PM EDT
Active, not recruiting Phase 3 Interventional

Strategy to Avoid Excessive Oxygen in Major Burn Patients

NCT04534972
View directory record Official record
Conditions
Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
Interventions
Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 120 Years
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
6
States / cities
Birmingham, Alabama • Aurora, Colorado • Cincinnati, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Sep 5, 2026, 7:35 PM EDT
Active, not recruiting Not applicable Interventional

Low Tidal Volume Ventilation With Hyperoxia Avoidance During Cardiopulmonary Bypass (The FOCUS Trial)

NCT04978636
View directory record Official record
Conditions
Cardiac Surgery
Interventions
Continuous low-tidal volume ventilation with using FiO2 of 0.21, Continuous low tidal volume ventilation with using FiO2 of 1.0, Apnea During CPB
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
5,502 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Sep 5, 2026, 7:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Supplemental Oxygen on Maximal Oxygen Consumption in Patients With Chronic Obstructive Pulmonary Disease

NCT01294033
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
Fractional inspired oxygen (FiO2) 0.21, Fractional inspired oxygen 0.28
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 15, 2017 · Synced Sep 5, 2026, 7:35 PM EDT
Completed No phase listed Observational

Reoxygenation After Cardiac Arrest (REOX Study)

NCT01881243
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Not listed
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
5
States / cities
Indianapolis, Indiana • Boston, Massachusetts • Jackson, Mississippi + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 24, 2019 · Synced Sep 5, 2026, 7:35 PM EDT
Not listed Phase 2Phase 3 Interventional Accepts healthy volunteers

A Dosing Study of Hyperbaric Oxygen Therapy (HBOT) on Epigenetic Aging

NCT05297019
View directory record Official record
Conditions
Aging
Interventions
Hyperbaric Oxygen Therapy
Procedure
Lead sponsor
TruDiagnostic
Industry
Eligibility
40 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Florham Park, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 11, 2023 · Synced Sep 5, 2026, 7:35 PM EDT