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ClinicalTrials.gov public records Last synced Oct 21, 2026, 10:37 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 41 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Hyperoxia Clear all
Recruiting Phase 4 Interventional Accepts healthy volunteers

Retinal Blood Flow and Autoregulation

NCT05344274
View directory record Official record
Conditions
Glaucoma
Interventions
Indocyanine Green Angiography, Isocapnic Oxygen, Ocular Imaging with Optical Coherence Tomography (OCT) and Adaptive Optics (AO)
Diagnostic Test · Biological
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 88 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
4
States / cities
Baltimore, Maryland • Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Oct 21, 2026, 10:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Supplemental Oxygen on Maximal Oxygen Consumption in Patients With Chronic Obstructive Pulmonary Disease

NCT01294033
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
Fractional inspired oxygen (FiO2) 0.21, Fractional inspired oxygen 0.28
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2017 · Synced Oct 21, 2026, 10:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

HYPEROXIA Responses and ROS

NCT05958303
View directory record Official record
Conditions
Cerebrovascular Disorders
Interventions
Antioxidant Cocktail, Placebo
Dietary Supplement · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 40 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 21, 2026, 10:37 AM EDT
Completed Not applicable Interventional

Hyperoxia on Ventilation During Recovery From General Anesthesia

NCT05922020
View directory record Official record
Conditions
Ventilatory Depression, Postoperative Respiratory Failure
Interventions
Oxygen gas
Other
Lead sponsor
Stanford University
Other
Eligibility
20 Years to 90 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 13, 2024 · Synced Oct 21, 2026, 10:37 AM EDT
Terminated Not applicable Interventional

Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis

NCT04368039
View directory record Official record
Conditions
Psychosis, Schizophrenia, First-episode Psychosis
Interventions
Normobaric Oxygen, Placebo
Device
Lead sponsor
Nicholas Breitborde
Other
Eligibility
15 Years to 35 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 21, 2026, 10:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Targeting the Carotid Bodies to Reduce Disease Risk Along the Diabetes Continuum

NCT05219994
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Hyperoxia Exposure, Normoxia Exposure
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 27, 2023 · Synced Oct 21, 2026, 10:37 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Risk of Oxygen During Cardiac Surgery Trial

NCT02361944
View directory record Official record
Conditions
Cardiac Surgery
Interventions
Oxygen - normoxia, Oxygen - hyperoxia
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
213 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Oct 21, 2026, 10:37 AM EDT
Active, not recruiting Not applicable Interventional

Low Tidal Volume Ventilation With Hyperoxia Avoidance During Cardiopulmonary Bypass (The FOCUS Trial)

NCT04978636
View directory record Official record
Conditions
Cardiac Surgery
Interventions
Continuous low-tidal volume ventilation with using FiO2 of 0.21, Continuous low tidal volume ventilation with using FiO2 of 1.0, Apnea During CPB
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
5,502 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Oct 21, 2026, 10:37 AM EDT
Recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Sleep Disordered Breathing With Opioid Use

NCT05589753
View directory record Official record
Conditions
Sleep Apnea, Opioid Use, Sleep Disordered Breathing
Interventions
Hyperoxia, Acetazolamide
Other · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 21, 2026, 10:37 AM EDT
Terminated Not applicable Interventional

DAMP-Mediated Innate Immune Failure and Pneumonia After Trauma - the Harvard-Longwood (HALO) Campus Area Consortium

NCT03993002
View directory record Official record
Conditions
Respiratory Failure
Interventions
Normoxia with Normocarbia, Normoxia with Hypercarbia, Hyperoxia with Normocarbia, Hyperoxia with Hypercarbia
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 18, 2022 · Synced Oct 21, 2026, 10:37 AM EDT
Not listed No phase listed Observational

Intraoperative Hyperoxia and MINS

NCT04540276
View directory record Official record
Conditions
Hyperoxia, Myocardial Infarction, Myocardial Injury
Interventions
Inspiratory oxygen fraction
Drug
Lead sponsor
University Hospital Bispebjerg and Frederiksberg
Other
Eligibility
18 Years and older
Enrollment
7,700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Oct 21, 2026, 10:37 AM EDT
Terminated Not applicable Interventional Results available

The Role of Hyperoxia in Acute Ischemic Stroke

NCT03904017
View directory record Official record
Conditions
Stroke, Acute
Interventions
Oxygen, placebo
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
Aurora, Colorado • Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Oct 21, 2026, 10:37 AM EDT
Terminated Not applicable Interventional

Computer-assisted Oxygen Therapy Weaning in Critically Ill Children

NCT03550469
View directory record Official record
Conditions
Hyperoxia, Hypoxia
Interventions
Computer-assisted Oxygen Weaning
Device
Lead sponsor
Stanford University
Other
Eligibility
Up to 2 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 29, 2022 · Synced Oct 21, 2026, 10:37 AM EDT
Recruiting Not applicable Interventional

The Effect of Hyperoxia on Ventilation During Recovery From General Anesthesia

NCT05379673
View directory record Official record
Conditions
Ventilatory Depression, Postoperative Respiratory Failure
Interventions
Oxygen Gas for Inhalation
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 21, 2026, 10:37 AM EDT
Completed No phase listed Observational Results available

Pilot Study of Targeted Normoxia in Critically Ill Trauma Patients

NCT03789396
View directory record Official record
Conditions
Trauma, Critical Illness, Oxygen Toxicity
Interventions
Targeted Normoxia (oxygen saturation 90-96%), Usual Care Oxygenation
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 109 Years
Enrollment
572 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 15, 2024 · Synced Oct 21, 2026, 10:37 AM EDT
Withdrawn Phase 4 Interventional

Oxygen Therapy for Retinal Ischemia

NCT03730779
View directory record Official record
Conditions
Retinal Ischemia
Interventions
Hyperoxia
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Oct 21, 2026, 10:37 AM EDT
Recruiting Phase 2 Interventional

Hyperbaric Oxygen Brain Injury Treatment Trial

NCT02407028
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Hyperbaric oxygen (1.5 ATA, no NBH), Hyperbaric oxygen (2.0 ATA, no NBH), Hyperbaric oxygen (2.5 ATA, no NBH), Hyperbaric oxygen (1.5 ATA + NBH), Hyperbaric oxygen (2.0 ATA + NBH), Hyperbaric oxygen (2.5 ATA + NBH), Normobaric Hyperoxia (NBH), Usual Care
Drug · Other
Lead sponsor
Gaylan Rockswold
Other
Eligibility
16 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2029
U.S. locations
10
States / cities
San Diego, California • West Palm Beach, Florida • Iowa City, Iowa + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Oct 21, 2026, 10:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Neuroimaging During Pure Oxygen Breathing

NCT03268590
View directory record Official record
Conditions
Hyperoxia, Hypoxia, Brain, Neurobehavioral Manifestations
Interventions
Oxygen
Drug
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years to 60 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 13, 2019 · Synced Oct 21, 2026, 10:37 AM EDT
Not listed Not applicable Interventional

Effectiveness of Vaporous Hyperoxia Therapy (VHT) in the Treatment of Chronic Diabetic Foot Ulcers

NCT04210609
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Vaporous Hyperoxia Therapy
Device
Lead sponsor
Vaporox
Industry
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
3
States / cities
Castle Rock, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 11, 2021 · Synced Oct 21, 2026, 10:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acute Effects of Supplemental Oxygen on Memory Testing in Healthy Adult Volunteers

NCT06555484
View directory record Official record
Conditions
Cognition
Interventions
Cross Over Assignment Supplemental Oxygen and Supplemental Air
Device
Lead sponsor
Inogen Inc.
Industry
Eligibility
22 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 31, 2025 · Synced Oct 21, 2026, 10:37 AM EDT
Not listed Not applicable Interventional

Intraoperative Oxygen Concentration and Neurocognition After Cardiac Surgery

NCT02591589
View directory record Official record
Conditions
Hyperoxia, Normoxic, Delirium
Interventions
Normoxic oxygenation, Hyperoxic oxygenation
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 23, 2020 · Synced Oct 21, 2026, 10:37 AM EDT
Completed Phase 1 Interventional Results available

Reoxygenation After Cardiac Arrest II (REOX II Study)

NCT02698826
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Protocol for rapid FiO2 optimization
Other
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
5
States / cities
Indianapolis, Indiana • Boston, Massachusetts • Jackson, Mississippi + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 29, 2022 · Synced Oct 21, 2026, 10:37 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Chemoreflex and Baroreflex Alterations Causing Postural Tachycardia Syndrome With Orthostatic Hyperpnea and Hypocapnia

NCT05923840
View directory record Official record
Conditions
Postural Orthostatic Tachycardia Syndrome, Hypocapnia, Hyperventilation
Interventions
Chemoreflex Testing, Baroreflex testing, Orthostatic stress testing
Diagnostic Test
Lead sponsor
New York Medical College
Other
Eligibility
15 Years to 39 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Hawthorne, New York
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Oct 21, 2026, 10:37 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Time Outside Target Oxygen Saturation Range in Preterm Infants and Long Term Outcomes and Preterm Infants

NCT00845624
View directory record Official record
Conditions
Retinopathy of Prematurity
Interventions
Not listed
Lead sponsor
University of Virginia
Other
Eligibility
1 Day to 12 Months
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 15, 2012 · Synced Oct 21, 2026, 10:37 AM EDT