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Showing 1–24 of 30 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Hyperoxia/oxygen Clear all
Recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Sleep Disordered Breathing With Opioid Use

NCT05589753
View directory record Official record
Conditions
Sleep Apnea, Opioid Use, Sleep Disordered Breathing
Interventions
Hyperoxia, Acetazolamide
Other · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 3, 2026, 8:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Unmasking Right Ventricular and Pulmonary Derangements With Exercise and Oxygen in Early Stage Cardiopulmonary Diseases

NCT03911856
View directory record Official record
Conditions
Cardiopulmonary Disease
Interventions
Echocardiography, Pulmonary Gas Exchange
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 11, 2024 · Synced Sep 3, 2026, 8:02 AM EDT
Active, not recruiting Phase 3 Interventional

Strategy to Avoid Excessive Oxygen in Major Burn Patients

NCT04534972
View directory record Official record
Conditions
Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
Interventions
Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 120 Years
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
6
States / cities
Birmingham, Alabama • Aurora, Colorado • Cincinnati, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Sep 3, 2026, 8:02 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Risk of Oxygen During Cardiac Surgery Trial

NCT02361944
View directory record Official record
Conditions
Cardiac Surgery
Interventions
Oxygen - normoxia, Oxygen - hyperoxia
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
213 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 31, 2024 · Synced Sep 3, 2026, 8:02 AM EDT
Recruiting Phase 2 Interventional

Hyperbaric Oxygen Brain Injury Treatment Trial

NCT02407028
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Hyperbaric oxygen (1.5 ATA, no NBH), Hyperbaric oxygen (2.0 ATA, no NBH), Hyperbaric oxygen (2.5 ATA, no NBH), Hyperbaric oxygen (1.5 ATA + NBH), Hyperbaric oxygen (2.0 ATA + NBH), Hyperbaric oxygen (2.5 ATA + NBH), Normobaric Hyperoxia (NBH), Usual Care
Drug · Other
Lead sponsor
Gaylan Rockswold
Other
Eligibility
16 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2029
U.S. locations
10
States / cities
San Diego, California • West Palm Beach, Florida • Iowa City, Iowa + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Sep 3, 2026, 8:02 AM EDT
Not listed Phase 2Phase 3 Interventional Accepts healthy volunteers

A Dosing Study of Hyperbaric Oxygen Therapy (HBOT) on Epigenetic Aging

NCT05297019
View directory record Official record
Conditions
Aging
Interventions
Hyperbaric Oxygen Therapy
Procedure
Lead sponsor
TruDiagnostic
Industry
Eligibility
40 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Florham Park, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 11, 2023 · Synced Sep 3, 2026, 8:02 AM EDT
Completed Phase 1 Interventional Results available

Reoxygenation After Cardiac Arrest II (REOX II Study)

NCT02698826
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Protocol for rapid FiO2 optimization
Other
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
5
States / cities
Indianapolis, Indiana • Boston, Massachusetts • Jackson, Mississippi + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 28, 2022 · Synced Sep 3, 2026, 8:02 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Retinal Blood Flow and Autoregulation

NCT05344274
View directory record Official record
Conditions
Glaucoma
Interventions
Indocyanine Green Angiography, Isocapnic Oxygen, Ocular Imaging with Optical Coherence Tomography (OCT) and Adaptive Optics (AO)
Diagnostic Test · Biological
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 88 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
4
States / cities
Baltimore, Maryland • Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Sep 3, 2026, 8:02 AM EDT
Completed Phase 2Phase 3 Interventional

Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior

NCT05767385
View directory record Official record
Conditions
Congenital Heart Disease in Children, Hypoxia, Neurodevelopmental Disorders, Complex Congenital Heart Disease
Interventions
Single Arm, Neonatal Neurobehavioral Scale
Procedure
Lead sponsor
University of Utah
Other
Eligibility
0 Years to 52 Years · Female only
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
5
States / cities
San Francisco, California • Washington D.C., District of Columbia • Scarborough, Maine + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Sep 3, 2026, 8:02 AM EDT
Withdrawn Phase 4 Interventional

Oxygen Therapy for Retinal Ischemia

NCT03730779
View directory record Official record
Conditions
Retinal Ischemia
Interventions
Hyperoxia
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 8, 2020 · Synced Sep 3, 2026, 8:02 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Predictors of Opioid-Induced Respiratory Depression (OIRD)

NCT02473354
View directory record Official record
Conditions
Respiratory Depression
Interventions
Remifentanil, Oxygen, Carbon dioxide
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Sep 3, 2026, 8:02 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Sleep Apnea in Elderly

NCT02703220
View directory record Official record
Conditions
Sleep Apnea, Elderly Adults
Interventions
Hyperoxia/oxygen, Acetazolamide, Finasteride
Other · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years to 89 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 3, 2026, 8:02 AM EDT
Active, not recruiting Not applicable Interventional

Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants

NCT04413097
View directory record Official record
Conditions
IVH- Intraventricular Hemorrhage, Extreme Prematurity, Hypoxia Neonatal, Hyperoxia, Respiratory Insufficiency
Interventions
Delayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration
Procedure
Lead sponsor
Sharp HealthCare
Other
Eligibility
22 Weeks to 28 Weeks
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
3
States / cities
Davis, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Sep 3, 2026, 8:02 AM EDT
Completed Not applicable Interventional

Hyperoxia on Ventilation During Recovery From General Anesthesia

NCT05922020
View directory record Official record
Conditions
Ventilatory Depression, Postoperative Respiratory Failure
Interventions
Oxygen gas
Other
Lead sponsor
Stanford University
Other
Eligibility
20 Years to 90 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Sep 3, 2026, 8:02 AM EDT
Active, not recruiting Phase 3 Interventional

Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients

NCT04534959
View directory record Official record
Conditions
Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
Interventions
Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 120 Years
Enrollment
6,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
8
States / cities
Birmingham, Alabama • Denver, Colorado • Cincinnati, Ohio + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Sep 3, 2026, 8:02 AM EDT
Not listed No phase listed Observational

Intraoperative Hyperoxia and MINS

NCT04540276
View directory record Official record
Conditions
Hyperoxia, Myocardial Infarction, Myocardial Injury
Interventions
Inspiratory oxygen fraction
Drug
Lead sponsor
University Hospital Bispebjerg and Frederiksberg
Other
Eligibility
18 Years and older
Enrollment
7,700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Sep 3, 2026, 8:02 AM EDT
Terminated Not applicable Interventional

Computer-assisted Oxygen Therapy Weaning in Critically Ill Children

NCT03550469
View directory record Official record
Conditions
Hyperoxia, Hypoxia
Interventions
Computer-assisted Oxygen Weaning
Device
Lead sponsor
Stanford University
Other
Eligibility
Up to 2 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 28, 2022 · Synced Sep 3, 2026, 8:02 AM EDT
Not listed Not applicable Interventional

Intraoperative Oxygen Concentration and Neurocognition After Cardiac Surgery

NCT02591589
View directory record Official record
Conditions
Hyperoxia, Normoxic, Delirium
Interventions
Normoxic oxygenation, Hyperoxic oxygenation
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 22, 2020 · Synced Sep 3, 2026, 8:02 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Neuroimaging During Pure Oxygen Breathing

NCT03268590
View directory record Official record
Conditions
Hyperoxia, Hypoxia, Brain, Neurobehavioral Manifestations
Interventions
Oxygen
Drug
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years to 60 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 12, 2019 · Synced Sep 3, 2026, 8:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Supplemental Oxygen on Maximal Oxygen Consumption in Patients With Chronic Obstructive Pulmonary Disease

NCT01294033
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
Fractional inspired oxygen (FiO2) 0.21, Fractional inspired oxygen 0.28
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 15, 2017 · Synced Sep 3, 2026, 8:02 AM EDT
Recruiting Not applicable Interventional

Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis

NCT04368039
View directory record Official record
Conditions
Psychosis, Schizophrenia, First-episode Psychosis
Interventions
Normobaric Oxygen, Placebo
Device
Lead sponsor
Nicholas Breitborde
Other
Eligibility
15 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 3, 2026, 8:02 AM EDT
Completed Phase 2 Interventional

Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury

NCT00170352
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Hyperbaric Oxygen Treatment (HBOT), Enhanced Oxygen Treatment (Enhanced FiO2)
Procedure
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
16 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 27, 2015 · Synced Sep 3, 2026, 8:02 AM EDT
Completed No phase listed Observational

Reoxygenation After Cardiac Arrest (REOX Study)

NCT01881243
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Not listed
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
5
States / cities
Indianapolis, Indiana • Boston, Massachusetts • Jackson, Mississippi + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 24, 2019 · Synced Sep 3, 2026, 8:02 AM EDT
Terminated Not applicable Interventional Results available

The Role of Hyperoxia in Acute Ischemic Stroke

NCT03904017
View directory record Official record
Conditions
Stroke, Acute
Interventions
Oxygen, placebo
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
Aurora, Colorado • Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Sep 3, 2026, 8:02 AM EDT