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Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Hypocaloric diet Clear all
Recruiting Not applicable Interventional

Role of Race in Nutritional Approach in Men on ADT

NCT06682390
View directory record Official record
Conditions
Prostate Cancer Metastatic Disease
Interventions
Hypocaloric anti-inflammatory diet
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Male only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Weight Loss and Cognitive Function in Adults

NCT03685305
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Hypocaloric diet with hunger reduction strategy, Hypocaloric diet without hunger reduction strategy
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
50 Years to 75 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Not applicable Interventional

Noninvasive Neuromodulation of the Prefrontal Cortex in Subjects With Obesity

NCT02953353
View directory record Official record
Conditions
Obesity
Interventions
Active transcranial direct current stimulation (tDCS), Hypocaloric diet, Sham transcranial direct current stimulation (tDCS)
Device · Other
Lead sponsor
University of Sao Paulo
Other
Eligibility
20 Years to 40 Years · Female only
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 21, 2021 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Obesity, Weight Loss, and Cardiovascular Disease Risk

NCT00186459
View directory record Official record
Conditions
Obesity
Interventions
Hypocaloric diet of varying macronutrient composition
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2017
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 3, 2024 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study of Serum Markers for Cardiovascular Risk in Obese Youth and Impact of Lifestyle and Medication Intervention

NCT00139477
View directory record Official record
Conditions
Obesity
Interventions
Metformin, Dietary modification with caloric restriction, Establishment of exercise protocol
Drug · Behavioral
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
7 Years to 18 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2011
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 17, 2023 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Phase 4 Interventional

Improving Beta Cell Function in Mexican American Women With Prediabetes

NCT02488057
View directory record Official record
Conditions
Pre-Diabetes
Interventions
Liraglutide, Weight loss
Drug · Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
4
States / cities
Los Angeles, California • Torrance, California • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Not applicable Interventional

Use of MCT Oil for Enhancement of Weight Loss in Obese Patients

NCT00207272
View directory record Official record
Conditions
Obesity, Weight Loss
Interventions
1170-1870 kcal/day liquid diet, Gastric bypass surgery, Biopsy.visceral adipose tissue, Biopsy.omental adipose tissue, Biopsy. subcutaneous abdominal adipose tissue, Blood sample
Behavioral · Procedure
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 25, 2008 · Synced Sep 3, 2026, 6:58 PM EDT
Not listed Not applicable Interventional

Effect of Modified Time-restricted Feeding in Preventing Progression of Non-Alcoholic Fatty Liver Disease (NAFLD).

NCT03848390
View directory record Official record
Conditions
Non-Alcoholic Fatty Liver Disease
Interventions
Conventional diet, Modified Time-restricted Feeding, Physical activity, Restricted consumption of sweetened beverages
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
8 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 14, 2019 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Optimizing Body Composition for Function in Older Adults

NCT00315146
View directory record Official record
Conditions
Obesity, Overweight With Indications for Weight Loss
Interventions
Pioglitazone, Resistance exercise training to maximize muscle power, Hypocaloric diet, Placebo
Drug · Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
65 Years to 79 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Sep 3, 2026, 6:58 PM EDT
Terminated Phase 2 Interventional

Effects of Caloric Restriction Alone Versus Postoperative Caloric Restriction Following Bariatric Surgery on Glucose Metabolism in Patients With Diabetes Mellitus

NCT01083108
View directory record Official record
Conditions
Obesity, Bariatric Surgery, Morbid Obesity, Diabetes Mellitus Type 2, Diet Therapy
Interventions
Roux-en-Y Gastric Bypass, Caloric Restriction
Other
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 60 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
3
States / cities
Baltimore, Maryland • Bethesda, Maryland • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Phase 1Phase 2 Interventional

Use of MCT Oil for Enhancement of Weight Loss and Glycemic Control in Obese Diabetic Patients

NCT00207233
View directory record Official record
Conditions
Obesity, Type 2 Diabetes Mellitus
Interventions
MCT oil hypocaloric liquid diet, LCT hypocaloric liquid diet, Subcutaneous abdominal adipose tissue biopsy
Behavioral · Procedure
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 24, 2011 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Not applicable Interventional

Bariatric Surgery And Adipose Inflammation Dysfunction and Type 2 Diabetes Mellitus

NCT01882036
View directory record Official record
Conditions
Type 2 Diabetes Mellitus, Insulin Resistance
Interventions
Gastric Bypass w/ matched hypocaloric diet, Hypocaloric diet
Procedure · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 70 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 13, 2023 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Phase 4 Interventional

A Phase IV, Multi-Center, Open-Label Trial of Sibutramine in Combination With a Hypocaloric Diet in Obese and Overweight Thai Subjects.

NCT00234988
View directory record Official record
Conditions
Obesity
Interventions
sibutramine hydochloride monohydrate
Drug
Lead sponsor
Abbott
Industry
Eligibility
18 Years to 65 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
North Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 14, 2008 · Synced Sep 3, 2026, 6:58 PM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Effect of Metformin, a Drug Used to Treat Diabetes, vs Placebo

NCT05949008
View directory record Official record
Conditions
NIDDM, Obesity
Interventions
Metformin Extended Release (ER) Oral Tablet, Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Changing Dietary Fat on Weight Loss

NCT02953158
View directory record Official record
Conditions
Overweight
Interventions
Haas Avocado, Dietary Counseling
Other · Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
20 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 1, 2020 · Synced Sep 3, 2026, 6:58 PM EDT
Enrolling by invitation Not applicable Interventional

Evaluating Benefit of Peptide Based Diet in Obese HEN Patients

NCT05080699
View directory record Official record
Conditions
Obesity
Interventions
Peptamen Intense VHP, Nestlé Health Science, Switzerland
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Phase 3 Interventional

VIsceral Fat Reduction Assessed by CT-scan On RImonabAnt

NCT00299325
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
Rimonabant, Placebo (for Rimonabant), Mild hypocaloric diet
Drug · Other
Lead sponsor
Sanofi
Industry
Eligibility
35 Years to 70 Years
Enrollment
254 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 5, 2016 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Weight Loss With Exenatide Treatment

NCT01590433
View directory record Official record
Conditions
Obesity
Interventions
Exenatide, Placebo, Dietary counseling
Drug · Behavioral
Lead sponsor
Jody Dushay
Other
Eligibility
18 Years to 70 Years · Female only
Enrollment
249 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 22, 2021 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fat Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance

NCT00830999
View directory record Official record
Conditions
Cardiovascular Diseases
Interventions
Positive energy balance, Energy balance with exercise, Negative energy balance, Negative energy balance with exercise, Energy balance
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
21 Years to 50 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 20, 2013 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Phase 4 Interventional Results available

Cardiovascular Effects of GLP-1 Receptor Activation

NCT03101930
View directory record Official record
Conditions
Obesity, PreDiabetes
Interventions
Liraglutide, Sitagliptin, hypocaloric diet, Placebos, Exendin (9-39)
Drug · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
329 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 17, 2022 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Changes in Food Reinforcement During Obesity Treatment

NCT00200291
View directory record Official record
Conditions
Obesity
Interventions
hypocaloric, low-fat diet
Behavioral
Lead sponsor
The Miriam Hospital
Other
Eligibility
21 Years to 70 Years · Female only
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 19, 2012 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Not applicable Interventional Results available

Exercise Intolerance in Elderly Patients With Diastolic Heart Failure

NCT00959660
View directory record Official record
Conditions
Heart Failure, Diastolic, Obesity
Interventions
Exercise, Dietary Intervention, Diet and exercise, Attention Control
Behavioral · Dietary Supplement · Other
Lead sponsor
Wake Forest University
Other
Eligibility
60 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 14, 2019 · Synced Sep 3, 2026, 6:58 PM EDT
Completed Phase 2 Interventional Results available

Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid

NCT03648996
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Hyperuricemia
Interventions
Low-fructose diet, isocaloric, Allopurinol, Placebo, Low-fructose, hypocaloric
Other · Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
40 Years to 75 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Sep 3, 2026, 6:58 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function

NCT06776081
View directory record Official record
Conditions
Obesity, Weight Loss
Interventions
Weight loss without pharmacotherapy
Other
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
40 Years and older
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Sep 3, 2026, 6:58 PM EDT