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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:17 AM EST

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Showing 1–24 of 31 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Hypoglossal nerve stimulation Clear all

Conditions: Obstructive Sleep Apnea
Interventions: aura6000 System; Device
Lead sponsor: ImThera Medical, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 138 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2023
U.S. locations: 14
States / cities: Chula Vista, California • Los Angeles, California • San Diego, California + 11 more

Conditions: Obstructive Sleep Apnea
Interventions: MAD, HGNS; Device
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Obstructive Sleep Apnea, Sleep Disordered Breathing
Interventions: Tonsillectomy, HGNS; Procedure · Device
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Obstructive Sleep Apnea
Interventions: Upper airway stimulation (Inspire Medical Systems, Inc.); Device
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Obstructive Sleep Apnea
Interventions: Genio™ system; Device
Lead sponsor: Nyxoah S.A.; Industry
Eligibility: 22 Years to 75 Years
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2028
U.S. locations: 16
States / cities: Birmingham, Alabama • Boca Raton, Florida • Tampa, Florida + 12 more

Conditions: Obstructive Sleep Apnea
Interventions: Inspire Hypoglossal Nerve Stimulation System; Device
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Obstructive Sleep Apnea
Interventions: Grass S88 Muscle Stimulator; Device
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Obstructive Sleep Apnea
Interventions: Mandibular advancement device (MAD); Device
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 70 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Obstructive Sleep Apnea, Comorbid Insomnia and Sleep Apnea, Insomnia
Interventions: Digital Cognitive Behavioral Therapy (CBT-i)-COAST; Device
Lead sponsor: Thomas Kaffenberger; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Obstructive Sleep Apnea, Sleep-disordered Breathing
Interventions: Combination device and drug: Unilateral hypoglossal nerve stimulation & atomoxetine-plus-oxybutynin (HGNS+AtoOxy), Unilateral hypoglossal nerve stimulation (HGNS), active comparator condition, Atomoxetine-plus-oxybutynin (80/5 mg) (AtoOxy), active comparator condition, Placebo; placebo comparator condition; Other · Device · Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 79 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Obstructive Sleep Apnea
Interventions: Inspire Upper Airway Stimulation System; Device
Lead sponsor: Inspire Medical Systems, Inc.; Industry
Eligibility: 22 Years and older
Enrollment: 929 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2017
U.S. locations: 15
States / cities: Palo Alto, California • St. Petersburg, Florida • Tampa, Florida + 12 more

Conditions: Sleep Apnea, Sleep Apnea, Obstructive, Sleep Apnea Syndromes, Sleep Disorder
Interventions: Hypoglossal nerve stimulation; Device
Lead sponsor: Invicta Medical Inc.; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Obstructive Sleep Apnea
Interventions: HGNS Treatment; Device
Lead sponsor: Apnex Medical, Inc.; Industry
Eligibility: 21 Years to 70 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 4
States / cities: San Francisco, California • Indianapolis, Indiana • Minneapolis, Minnesota + 1 more

Conditions: Obstructive Sleep Apnea
Interventions: Inspire therapy, No intervention; Device · Other
Lead sponsor: Inspire Medical Systems, Inc.; Industry
Eligibility: Not listed
Enrollment: 5,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2025
U.S. locations: 53
States / cities: Birmingham, Alabama • Mesa, Arizona • Phoenix, Arizona + 43 more

Conditions: Obstructive Sleep Apnea, Obstructive Sleep Apnea of Adult
Interventions: No HGNS therapy (HGNS-off); Device
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Obstructive Sleep Apnea
Interventions: Inspire® UAS System; Device
Lead sponsor: Inspire Medical Systems, Inc.; Industry
Eligibility: 22 Years and older
Enrollment: 127 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2025
U.S. locations: 14
States / cities: Birmingham, Alabama • Los Angeles, California • Miami, Florida + 9 more

Conditions: Obstructive Sleep Apnea
Interventions: Hypoglossal Nerve Stimulation (HGNS) System (Apnex Medical ); Device
Lead sponsor: Apnex Medical, Inc.; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 132 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 12
States / cities: Lenexa, Kansas • Topeka, Kansas • Louisville, Kentucky + 9 more

Conditions: Sleep Apnea, Obstructive
Interventions: Not listed
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Timeline: 2022 – 2028
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Obstructive Sleep Apnea
Interventions: Therapeutic HGNS, Subtherapeutic 'Sham' HGNS; Device
Lead sponsor: University of Pennsylvania; Other
Eligibility: 22 Years and older
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Pediatric Obstructive Sleep Apnea, Down Syndrome (DS)
Interventions: Hypoglossal Nerve Stimulation; Device
Lead sponsor: Inspire Medical Systems, Inc.; Industry
Eligibility: 13 Years to 18 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 6
States / cities: Phoenix, Arizona • Orange, California • Tampa, Florida + 3 more

Conditions: Obstructive Sleep Apnea, Premature Ventricular Contraction (PVC), Atrial Fibrillation (AF), Premature Atrial Contraction
Interventions: HGNS Use Randomized Instructions; Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Obstructive Sleep Apnea
Interventions: This is a single arm study, all consented and eligible subjects will be implanted with the Genio® System 2.1; Device
Lead sponsor: Nyxoah Inc.; Industry
Eligibility: 22 Years and older
Enrollment: 229 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2032
U.S. locations: 2
States / cities: Miami, Florida • Summit, New Jersey

Conditions: Sleep Apnea, Snoring
Interventions: Kai Strap; Device
Lead sponsor: Kai Medical, Inc.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: Obstructive Sleep Apnea
Interventions: Hypoglossal Nerve Stimulation (HGNS); Device
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Search by objective public record fields.

Targeted Hypoglossal Neurostimulation Study #3

Obstructive Sleep Apnea Non-PAP Outcomes and Viable Alternatives

Combination Tonsillectomy and Hypoglossal Nerve Stimulation for OSA Patients With Lateral Pharyngeal Collapse

Stimulation Therapy for Apnea: Reporting Thoughts

Dual-sided Hypoglossal neRvE stimulAtion for the treatMent of Obstructive Sleep Apnea (DREAM)

Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea With Complete Concentric Collapse

Ansa Cervicalis and Hypoglossal Nerve Stimulation in OSA

Reducing Obstructive Sleep Apnea After Hypoglossal Nerve Stimulation Through Mandibular Advancement

Does the Timing of Insomnia Therapy (CBT-i) Impact the Usage and Compliance of Upper Airway Stimulation (UAS) Treatment of Obstructive Sleep Apnea (OSA)

Combination Upper-Airway Electrical and Pharmacological Stimulation for Obstructive Sleep Apnea

Stimulation Therapy for Apnea Reduction (Www.theSTARtrial.Com)

Evaluation of Hypoglossal Nerve Stimulation in Humans With Obstructive Sleep Apnea

US Clinical Study of the Apnex Medical Hypoglossal Nerve Stimulation (HGNS) System to Treat Obstructive Sleep Apnea

Adherence and Outcome of Upper Airway Stimulation (UAS) for OSA International Registry

Cardiometabolic Risk Effects of Short-term Cessation of Neurostimulation Therapy

Inspire® Post-Approval Study / Protocol Number 2014-001

Apnex Clinical Study of the Hypoglossal Nerve Stimulation (HGNS®) System to Treat Obstructive Sleep Apnea

Predicting Outcomes in Hypoglossal Nerve Stimulation Therapy With Stimulated Upper Airway Mechanics

Hypoglossal Nerve Stimulation on Cardiovascular Outcomes

Pediatric Down Syndrome Post-Approval Study

Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation

Bi-lateral HGN Therapy in Real-World Patients -Post Approval Research Investigation

Study to Determine Results of Vibratory Stimulus on Subject's Neck

Metabolic Endpoints for Obstructive Sleep Apnea Following Twelfth Cranial Nerve Stimulation