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ClinicalTrials.gov public records Last synced Oct 24, 2026, 7:07 AM EDT

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Showing 1–24 of 54 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Hypoxic exposure Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Intermittent Hypoxia and Inspiratory Threshold Loading to Enhance Inspiratory Muscle Function

NCT03029559
View directory record Official record
Conditions
Intermittent Hypoxia
Interventions
Intermittent Hypoxia, Inspiratory Threshold Loading, Sham Intermittent Hypoxia
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 20, 2019 · Synced Oct 24, 2026, 7:07 AM EDT
Completed Not applicable Interventional

Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea

NCT03736382
View directory record Official record
Conditions
Obstructive Sleep Apnea, Spinal Cord Injuries
Interventions
Mild intermittent hypoxia, Sham protocol, Continuous positive airway pressure (CPAP)
Other
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 60 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
2
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 24, 2026, 7:07 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effect of an H1 Receptor Antagonist on Exercise Performance in Hypoxia

NCT03192488
View directory record Official record
Conditions
Hypoxia, Altitude
Interventions
Cetirizine, Placebo oral capsule, Hypoxia
Drug · Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 35 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Oct 24, 2026, 7:07 AM EDT
Completed No phase listed Observational

Prematurity-Related Ventilatory Control

NCT03464396
View directory record Official record
Conditions
Respiratory Control in Premature Infants
Interventions
Bedside Physiology study, Carotid Body Function Test, Room Air Challenge, Hypoxia Challenge Test, Effects of Nasal Cannula Flow, Magnetic Resonance Imaging, Echocardiogram, Blood Sample
Other · Diagnostic Test
Lead sponsor
Washington University School of Medicine
Other
Eligibility
1 Day to 28 Days
Enrollment
177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 31, 2023 · Synced Oct 24, 2026, 7:07 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Impact of Hypoxia on Resting and Exertional Right Ventricular Performance

NCT05272514
View directory record Official record
Conditions
Ventricular Dysfunction, Right, Hypoxia
Interventions
Hypoxia
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Oct 24, 2026, 7:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia

NCT02482571
View directory record Official record
Conditions
Brain Hypoxia
Interventions
Mild Hypoxia
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 19, 2019 · Synced Oct 24, 2026, 7:07 AM EDT
Recruiting Not applicable Interventional

IHT for Mild Cognitive Impairment

NCT05495087
View directory record Official record
Conditions
Mild Cognitive Impairment, Memory Impairment
Interventions
IHT Treatment, Sham-IHT Control
Device · Other
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
55 Years to 79 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 24, 2026, 7:07 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

NCT06417177
View directory record Official record
Conditions
Aging, Menopause, Hypoxia, Vasodilation
Interventions
Placebo, Propranolol, Gemtesa
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 70 Years · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 24, 2026, 7:07 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Healthy Little Eyes

NCT05971446
View directory record Official record
Conditions
Hypoxic-Ischemic Encephalopathy, Neonatal Encephalopathy, Encephalopathy
Interventions
Visual Evoked Potential (VEP), Electroretinogram (ERG)
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
Up to 36 Months
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2029
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 24, 2026, 7:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Overnight Low Oxygen Exposure on Energy Balance

NCT04151927
View directory record Official record
Conditions
Resting Metabolic Rate, Appetite, Heart Rate Variability
Interventions
Normobaric Hypoxia, Normobaric Normoxia
Device
Lead sponsor
Florida State University
Other
Eligibility
20 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Nov 29, 2021 · Synced Oct 24, 2026, 7:07 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia

NCT05256069
View directory record Official record
Conditions
Vasodilation, Hypoxia
Interventions
Propranolol Pill, Placebo
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 45 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Oct 24, 2026, 7:07 AM EDT
Completed Not applicable Interventional Results available

Intermittent Hypoxia to Enhance Motor Function After Spinal Cord Injury

NCT03071393
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Hypoxia via Hypoxico Hyp-123, Sham via Hypoxico Hyp-123
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
Gainesville, Florida • Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 18, 2023 · Synced Oct 24, 2026, 7:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Wireless Disposable SpO2 Sensor Hypoxia Testing

NCT06211530
View directory record Official record
Conditions
SpO2, Peripheral Oxygen Saturation Measurement
Interventions
SpO2 Sensor Testing
Device
Lead sponsor
GE Healthcare
Industry
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Louisville, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Oct 24, 2026, 7:07 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Measuring Brain Activity of School Age Children

NCT03407729
View directory record Official record
Conditions
Perinatal Hypoxia, Dopamine, Neurobehavioral Manifestations
Interventions
Magnetic Resonance Imaging, Cognitive Performance Testing
Other
Lead sponsor
Case Western Reserve University
Other
Eligibility
8 Years to 15 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 10, 2022 · Synced Oct 24, 2026, 7:07 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Repetitive Acute Intermittent Hypoxia for Spinal Cord Repair

NCT03433599
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Repeated exposure to acute Intermittent Hypoxia (rAIH), Normal Room Air, Upper-limb Training by Research Staff, Lower-limb Training by Research Staff
Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 30, 2022 · Synced Oct 24, 2026, 7:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exercise Induced Plasma Volume Expansion Lowers Cardiovascular Strain

NCT05800808
View directory record Official record
Conditions
Cardiac Output, Stroke Volume
Interventions
High Intensity Intervals, Moderate Exercise
Procedure
Lead sponsor
California Baptist University
Other
Eligibility
18 Years to 38 Years · Male only
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Riverside, California
Source: ClinicalTrials.gov public record
Updated Apr 6, 2023 · Synced Oct 24, 2026, 7:07 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury

NCT02922894
View directory record Official record
Conditions
Sleep Apnea, Spinal Cord Injury
Interventions
Acute episodic hypoxia, Supplemental oxygen, Trazodone, Placebo, Sham
Procedure · Drug
Lead sponsor
John D. Dingell VA Medical Center
Federal
Eligibility
18 Years to 89 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 24, 2026, 7:07 AM EDT
Recruiting Not applicable Interventional

Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog

NCT06614309
View directory record Official record
Conditions
Long COVID
Interventions
Acute Placebo Visit, Acute Progressive Carbon Dioxide, Acute Intermittent Hypoxia, Training: Progressive Carbon Dioxide Ramping, Training: Intermittent Hypoxic Exposure, Training: Placebo Control
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 5, 2026 · Synced Oct 24, 2026, 7:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Mild Hypobaric Hypoxia on Sleep and Post-sleep Performance

NCT00498563
View directory record Official record
Conditions
Altitude, Hypoxia, Environmental Sleep Disorder
Interventions
altitude exposure in hypobaric chamber
Procedure
Lead sponsor
Oklahoma State University Center for Health Sciences
Other
Eligibility
30 Years to 60 Years · Male only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 24, 2015 · Synced Oct 24, 2026, 7:07 AM EDT
Completed Not applicable Interventional

Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury

NCT06520358
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Acute Intermittent Hypoxia (AIH), Task specific Airway Protection Training, Sham AIH
Other · Behavioral
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 9, 2026 · Synced Oct 24, 2026, 7:07 AM EDT
Recruiting Not applicable Interventional

Combination Therapy to Improve SCI Recovery.

NCT05563103
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Daily acute intermittent hypoxia, Room air (SHAM), Walking + tSTIM, Walking + Sham transcutaneous spinal stimulation (tSHAM)
Other
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 20, 2026 · Synced Oct 24, 2026, 7:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of 2-Week Nightly Moderate Hypoxia on Glucose Tolerance in Individuals With Type 2 Diabetes

NCT02513641
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Hypoxico Altitude Training Systems
Device
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
20 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
2
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Oct 12, 2020 · Synced Oct 24, 2026, 7:07 AM EDT
Recruiting Phase 1Phase 2 Interventional

Intermittent Hypoxia-initiated Plasticity in Humans: A Multi-pronged Therapeutic Approach to Treat Sleep Apnea and Overlapping Co-morbidities

NCT05558501
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Mild Intermittent Hypoxia, Sham MIH
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
30 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Oct 24, 2026, 7:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Physiological Effects of Acute and Ramp Simulated Altitude Exposure During Simulated Flight Tasks

NCT05867719
View directory record Official record
Conditions
Altitude Hypoxia
Interventions
Hypoxic breathing conditions
Other
Lead sponsor
University of Texas, El Paso
Other
Eligibility
18 Years to 40 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 24, 2026, 7:07 AM EDT