- Conditions
- Sleep Apnea, Spinal Cord Injury
- Interventions
- Acute episodic hypoxia, Supplemental oxygen, Trazodone, Placebo, Sham
- Procedure · Drug
- Lead sponsor
- John D. Dingell VA Medical Center
- Federal
- Eligibility
- 18 Years to 89 Years
- Enrollment
- 100 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2017 – 2027
- U.S. locations
- 1
- States / cities
- Detroit, Michigan
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- Conditions
- Ventilatory Depression, Opioid Intoxication, Opioid Toxicity
- Interventions
- Ventilatory chemosensitivity
- Diagnostic Test
- Lead sponsor
- Duke University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 10 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2019
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
- Conditions
- Sleep Apnea, Healthy, Vasoconstriction, Vasodilation
- Interventions
- Hypoxic exposure, modified Oxford test, Oral Bosentan 62.5 mg, Hypoxic ventilatory response test
- Other · Drug
- Lead sponsor
- University of Missouri-Columbia
- Other
- Eligibility
- 18 Years to 45 Years
- Enrollment
- 54 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2016 – 2021
- U.S. locations
- 2
- States / cities
- Columbia, Missouri • Rochester, Missouri