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ClinicalTrials.gov public records Last synced Sep 5, 2026, 10:51 PM EDT

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Showing 1–24 of 163 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: IC Green Clear all
Recruiting Phase 4 Interventional Accepts healthy volunteers

Retinal Blood Flow and Autoregulation

NCT05344274
View directory record Official record
Conditions
Glaucoma
Interventions
Indocyanine Green Angiography, Isocapnic Oxygen, Ocular Imaging with Optical Coherence Tomography (OCT) and Adaptive Optics (AO)
Diagnostic Test · Biological
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 88 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
4
States / cities
Baltimore, Maryland • Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Sep 5, 2026, 10:51 PM EDT
Recruiting Not applicable Interventional

UHFUS Characterization of Normal Lymphatic Anatomy

NCT07677839
View directory record Official record
Conditions
Breast Cancer
Interventions
Indocyanine green (ICG) solution injection, Ultra-High Frequency Ultrasound
Procedure · Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2036
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 5, 2026, 10:51 PM EDT
Not yet recruiting No phase listed Observational

Tumor-Lymph Node Mapping

NCT07054944
View directory record Official record
Conditions
Pediatric Solid Tumors, Rhabdomyosarcoma, Sarcoma, Germ Cell Tumor
Interventions
ICG (Indocyanine Green)
Diagnostic Test
Lead sponsor
University of Rochester
Other
Eligibility
1 Month to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 5, 2026, 10:51 PM EDT
Withdrawn Phase 4 Interventional

A Study to Evaluate Indocyanine Green Lymphangiography to Improve Lymphadenectomy in Gastric Cancer Patients

NCT04591028
View directory record Official record
Conditions
Gastric Cancer
Interventions
Indocyanine green
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 18, 2023 · Synced Sep 5, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Determining the Sensitivity of Sentinel Lymph Nodes Identified With Robotic Fluorescence Imaging

NCT01673022
View directory record Official record
Conditions
Endometrial Cancer, Cervical Cancer
Interventions
IC Green
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older · Female only
Enrollment
430 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
7
States / cities
Mobile, Alabama • Indianapolis, Indiana • Edgewood, Kentucky + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2018 · Synced Sep 5, 2026, 10:51 PM EDT
Recruiting Phase 1Phase 2 Interventional

Bronchial NIR Image-guided Resection

NCT03097575
View directory record Official record
Conditions
Sentinel Lymph Node
Interventions
ICG Intervention, Near Infrared Imaging
Drug · Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Sep 5, 2026, 10:51 PM EDT
Not yet recruiting Phase 2 Interventional

Bacterial Decolonization Plus Intraoperative Angiography for Soft Tissue Sarcomas Receiving Preoperative Radiotherapy (CONCERTO)

NCT06712433
View directory record Official record
Conditions
Sarcoma,Soft Tissue
Interventions
2% intranasal mupirocin ointment, 4% chlorhexidine gluconate body cleanser
Drug
Lead sponsor
Adam Olson
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 5, 2026, 10:51 PM EDT
Completed Not applicable Interventional

Correlation Study of Imaging Data Acquired During CABG With Data Acquired in the Cath Lab

NCT02138305
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
ComboMap XT Guidewire, 'SPY' NIRF During CABG
Device · Procedure
Lead sponsor
East Carolina University
Other
Eligibility
18 Years to 80 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Sep 5, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Lymph Node Mapping in Patients With Endometrial Cancer

NCT01818739
View directory record Official record
Conditions
Endometrial Cancer
Interventions
sentinel lymph node detection, indocyanine green solution, isosulfan blue, sentinel lymph node biopsy
Procedure · Drug
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years to 85 Years · Female only
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
2
States / cities
New Haven, Connecticut • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Sep 5, 2026, 10:51 PM EDT
Recruiting Phase 1 Interventional

ICG Fluorescence in Knee Arthroscopy Study

NCT07793266
View directory record Official record
Conditions
To Assess the Feasibility, Visualization Capability, and Optimal Dosing of ICG Fluorescence Imaging for Intraoperative Assessment of Knee Tissue Perfusion
Interventions
Intravenous administration of indocyanine green (SPY Agent Green) 2 mL of SPY Agent Green (5.0 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 3 mL of SPY Agent Green (7.5 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 4 mL of SPY Agent Green (10 mg dose), Intravenous administration of indocyanine green (SPY Agent Green)5 mL of SPY Agent Green (12.5 mg dose)
Combination Product
Lead sponsor
Henry Ford Health System
Other
Eligibility
14 Years to 89 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 5, 2026, 10:51 PM EDT
Completed Not applicable Interventional

Indocyanine Green and Near-infrared Fluorescence Imaging to Detect Sentinel Lymph Nodes in Patients With Endometrial Cancer

NCT02131558
View directory record Official record
Conditions
Endometrial Cancer, Sentinel Lymph Node Detection
Interventions
ICG Dye
Procedure
Lead sponsor
Lahey Clinic
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Burlington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced Sep 5, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Fluorescent Evaluation of Colorectal Anastamoses

NCT01424293
View directory record Official record
Conditions
Rectal Neoplasms, Colon Neoplasms, Diverticulitis
Interventions
Indocyanine Green, The SPY® Intraoperative Imaging System
Device
Lead sponsor
Maimonides Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jul 12, 2021 · Synced Sep 5, 2026, 10:51 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

SPY Fluorescence Imaging Systems and Indocyanine Green to Determine the Percentage of Successful Critical Anatomy Recognition in Laparoscopic Cholecystectomy Surgeries.

NCT05006950
View directory record Official record
Conditions
Cholecystitis
Interventions
Stryker1688 Fluorescence imaging system
Device
Lead sponsor
Stryker Endoscopy
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Annapolis, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 18, 2022 · Synced Sep 5, 2026, 10:51 PM EDT
Recruiting Phase 2 Interventional

Fluorescent Intra-operative Tumor Margin Examination

NCT04719156
View directory record Official record
Conditions
Sarcoma
Interventions
Indocyanine green solution administered at 2.0mg/kg., Stryker SPY-PHI Imaging Device
Drug · Device
Lead sponsor
Kurt Weiss
Other
Eligibility
18 Years to 100 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 5, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Proposal for Intraoperative Administration of Intravenous Indocyanine Green to Evaluate Position of the Optic Canal, Position of the Internal Carotid Arteries, Tumor Vascularization, and Vessel Encasement in Endoscopic Endonasal Cranial Base Surgery

NCT03072186
View directory record Official record
Conditions
Skull Base Neoplasms, Skull Neoplasms, Bone Neoplasm, Neoplasms, Bone Diseases, Musculoskeletal Disease
Interventions
near-infrared light nasal endoscope used with ICG
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 25, 2021 · Synced Sep 5, 2026, 10:51 PM EDT
Terminated Phase 3 Interventional

Right to Left Cardiac Shunt Detection

NCT01773252
View directory record Official record
Conditions
Right to Left Shunt, Patent Foramen Ovale, Atrial Septal Defect
Interventions
Flow Detection System
Device
Lead sponsor
Cardiox Corporation
Industry
Eligibility
18 Years and older
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
8
States / cities
Phoenix, Arizona • Los Angeles, California • Aurora, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 12, 2015 · Synced Sep 5, 2026, 10:51 PM EDT
Completed Phase 1 Interventional

NIR-Guided Sentinel Lymph Node Mapping in Melanoma

NCT01121718
View directory record Official record
Conditions
Melanoma
Interventions
ICG Intervention
Drug
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 2, 2017 · Synced Sep 5, 2026, 10:51 PM EDT
Not listed No phase listed Observational

The Use of Indocyanine Green as a Diagnostic Adjunct for Pediatric Solid Malignancies

NCT04492735
View directory record Official record
Conditions
Metastatic Disease, Primary Tumor, Solid Malignancies
Interventions
Not listed
Lead sponsor
Roshni Dasgupta
Other
Eligibility
1 Day to 45 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 29, 2020 · Synced Sep 5, 2026, 10:51 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Vinorelbine in Treating Patients With Advanced Solid Tumors That Have Not Responded to Treatment and Liver Dysfunction

NCT00540982
View directory record Official record
Conditions
Lung Cancer, Unspecified Adult Solid Tumor, Protocol Specific
Interventions
indocyanine green, lidocaine, vinorelbine ditartrate, high performance liquid chromatography, intracellular fluorescence polarization analysis, liquid chromatography, mass spectrometry, pharmacological study
Drug · Other
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years to 120 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2010
U.S. locations
2
States / cities
Duarte, California • Pasadena, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Sep 5, 2026, 10:51 PM EDT
Completed No phase listed Observational

Evaluation of the Association Between Genetic Load and Response to Anti-VEGF Therapy in AMD Patients

NCT01644513
View directory record Official record
Conditions
Age Related Macular Degeneration
Interventions
Not listed
Lead sponsor
Sequenom, Inc.
Industry
Eligibility
55 Years and older
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 11, 2013 · Synced Sep 5, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

The Use of Fluorescent Imaging for Intraoperative Cholangiogram During Laparoscopic Cholecystectomy

NCT01424215
View directory record Official record
Conditions
Cholelithiasis, Cholecystitis, Pancreatitis Biliary, Colic of Gallbladder Without Mention of Cholecystitis
Interventions
Indocyanine Green (ICG)
Drug
Lead sponsor
Maimonides Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2020 · Synced Sep 5, 2026, 10:51 PM EDT
Recruiting Phase 1Phase 2 Interventional

Use of Indocyanine Green (ICG) for the Diagnosis of Biliary Atresia

NCT07513038
View directory record Official record
Conditions
Biliary Atresia
Interventions
Indocyanine Green (ICG)
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
0 Days to 3 Months
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 5, 2026, 10:51 PM EDT
Completed No phase listed Observational

Wound Necrosis in Lower Extremity Surgery

NCT03351387
View directory record Official record
Conditions
Extremity Lower Wounds
Interventions
SPY Intra-operative Angiography
Combination Product
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 16, 2021 · Synced Sep 5, 2026, 10:51 PM EDT
Completed Early Phase 1 Interventional

Novel Application of Indocyanine Green as a Biomarker to Identify Tissue Necrosis in Mastectomy Patients

NCT04145323
View directory record Official record
Conditions
Breast Cancer, Necrosis
Interventions
ICG microangiography
Diagnostic Test
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Sep 5, 2026, 10:51 PM EDT