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ClinicalTrials.gov public records Last synced Oct 23, 2026, 8:42 PM EDT

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Showing 553–576 of 8,263 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: IMPROVED Clear all
Suspended Not applicable Interventional

NHLBI and Cook Trans-Atrial Intra-Pericardial Tricuspid Annuloplasty (TRAIPTA) Early Feasibility Study

NCT06479824
View directory record Official record
Conditions
Tricuspid Valve Insufficiency
Interventions
TRAIPTA (Trans-Atrial Intra-Pericardial Tricuspid Annuloplasty)
Device
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
21 Years to 100 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
2
States / cities
Atlanta, Georgia • Roslyn, New York
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Individualized Preoperative Rehabilitation Pilot

NCT02082223
View directory record Official record
Conditions
Quality of Life, Complex Gastrointestinal Surgery
Interventions
Interventions to improve preop QOL/resilience deficits
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 99 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 28, 2018 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Phase 2 Interventional Results available

Curcumin and Cholecalciferol in Treating Patients With Previously Untreated Stage 0-II Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT02100423
View directory record Official record
Conditions
Contiguous Stage II Small Lymphocytic Lymphoma, Noncontiguous Stage II Small Lymphocytic Lymphoma, Stage 0 Chronic Lymphocytic Leukemia, Stage I Chronic Lymphocytic Leukemia, Stage I Small Lymphocytic Lymphoma, Stage II Chronic Lymphocytic Leukemia
Interventions
curcumin, cholecalciferol, laboratory biomarker analysis, pharmacological study
Drug · Dietary Supplement · Other
Lead sponsor
Paolo Caimi, MD
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 12, 2024 · Synced Oct 23, 2026, 8:42 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

HELIOS Advanced: Human Oocyte Illumination to Enhance Development

NCT07425080
View directory record Official record
Conditions
IVF Outcomes
Interventions
Photobiomodulation
Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 48 Years · Female only
Enrollment
270 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Not applicable Interventional

CAREGIVER: A Trial to Improve the Burden and Distress of Caring for Persons With Decompensated Cirrhosis

NCT04205396
View directory record Official record
Conditions
Caregivers
Interventions
Written emotional disclosure, Resilience training, No treatment
Behavioral · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 15, 2022 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Not applicable Interventional

Neuromodulation of Central Sensory Integration to Improve Postural Control

NCT06610617
View directory record Official record
Conditions
Survivorship, Quality of Life, Cognitive Deficits, Mild
Interventions
transcranial direct current stimulation (tDCS), Sham tDCS
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years to 85 Years · Female only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Oct 23, 2026, 8:42 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Mirror Illusion Training and Cross-education

NCT05084690
View directory record Official record
Conditions
Exercise Therapy, Weight Lifting
Interventions
Unilateral resistance training, Illusionary mirror visual feedback
Other
Lead sponsor
Texas Christian University
Other
Eligibility
18 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
2
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Oct 20, 2021 · Synced Oct 23, 2026, 8:42 PM EDT
Active, not recruiting Not applicable Interventional

Leveraging Technology to Improve Medication Adherence in Youth With Kidney or Liver Transplant

NCT05613010
View directory record Official record
Conditions
Transplant;Failure,Kidney, Transplant; Failure, Liver, Adherence, Medication, Adherence, Patient, Adherence, Treatment
Interventions
mHealth Messaging Intervention Group
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
13 Years to 25 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Developing and Evaluating Culturally Relevant Interventions to Improve Breast Cancer Screening

NCT05665660
View directory record Official record
Conditions
Breast Cancer
Interventions
CARE, CARE + COACH
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
Female only
Enrollment
323 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Whiteriver, Arizona
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Randomized Trial of Intensive Motivational Interviewing (IMI) to Improve Drinking Outcomes Among Women

NCT02272023
View directory record Official record
Conditions
Alcohol Use Disorders
Interventions
Intensive Motivational Interviewing, Single session of Motivational Interviewing
Behavioral
Lead sponsor
Public Health Institute, California
Other
Eligibility
18 Years and older · Female only
Enrollment
215 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Lafayette, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2019 · Synced Oct 23, 2026, 8:42 PM EDT
Recruiting Not applicable Interventional

Inpatient Use of Personal Continuous Glucose Monitor (CGM) to Improve Diabetes Mellitus Control

NCT07006480
View directory record Official record
Conditions
Diabetes Mellitus
Interventions
Real time CGM data monitoring, Insulin dose adjustment based on glucometer and CGM glucose data trends, Share CGM data on admission and on discharge from the hospital
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Piloting Use of Multi-Level Pregnancy Tests in Remote Abortion Services

NCT03207880
View directory record Official record
Conditions
Medical Abortion, Complete or Unspecified, Without Complication
Interventions
Multi-level pregnancy test
Device
Lead sponsor
Gynuity Health Projects
Other
Eligibility
Up to 50 Years · Female only
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 27, 2018 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Promoting Early Detection of Melanoma During the Mammography Experience

NCT03057327
View directory record Official record
Conditions
Melanoma (Skin Cancer)
Interventions
Improve awareness of checking moles, Comparator
Behavioral · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 70 Years · Female only
Enrollment
560 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 9, 2017 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Not applicable Interventional

Michigan Split-belt Treadmill Training Program to Improve Acute Knee Biomechanics After ACL Reconstruction

NCT06529679
View directory record Official record
Conditions
ACL, ACL Injury
Interventions
Split-belt Training, Tied-Belt Training
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 45 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Phase 3 Interventional

Evaluation of Oral Simethicone With Low Volume Polyethylene Glycol Bowel Preparation During Colonoscopy

NCT03410524
View directory record Official record
Conditions
Colonoscopy
Interventions
Simethicone Solution, Water
Drug
Lead sponsor
University of Nevada, Reno
Other
Eligibility
18 Years to 80 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
2
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated Dec 12, 2018 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee

NCT02449369
View directory record Official record
Conditions
Unilateral Knee Arthroplasty
Interventions
Preop acetaminophen IV, Preop orphenadrine IV, Postop oral oxycodone & acetaminophen, Postop hydromorphone IV, Postop oral orphenadrine, Postop oral oxycodone, Postop acetaminophen IV, Postop orphenadrine IV
Drug
Lead sponsor
AdventHealth
Other
Eligibility
18 Years to 85 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Winter Park, Florida
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Oct 23, 2026, 8:42 PM EDT
Withdrawn Not applicable Interventional

Pathophysiologic Study to Understand and Possibly Treat Nocturia

NCT05298384
View directory record Official record
Conditions
Nocturia
Interventions
Compression stockings
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 110 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 26, 2024 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effectiveness of Direct-to-Patient Outreach on Colorectal Cancer Screening Within a Low Income and Diverse Population

NCT01385579
View directory record Official record
Conditions
Malignant Neoplasm of Large Intestine
Interventions
Care manager outreach
Other
Lead sponsor
Northwestern University
Other
Eligibility
50 Years to 80 Years
Enrollment
202 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 6, 2014 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Phase 1Phase 2 Interventional

Effectiveness of Collaborative Services in Primary Care for Treating Children With Behavior Disorders

NCT00600470
View directory record Official record
Conditions
Attention Deficit and Disruptive Behavior Disorders
Interventions
Doctor-office collaborative care (DOCC) management, Treatment as usual (TAU)
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
5 Years to 12 Years
Enrollment
858 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 1, 2015 · Synced Oct 23, 2026, 8:42 PM EDT
Recruiting Not applicable Interventional

Move and Snooze: Adding Insomnia Treatment to an Exercise Program to Improve Pain Outcomes in Older Adults With Knee Osteoarthritis

NCT06580561
View directory record Official record
Conditions
Knee Osteoarthritis, Insomnia
Interventions
Personalized exercise coaching, Cognitive behavioral therapy for Insomnia
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Not applicable Interventional

Supporting Parents of Young Children With Type 1 Diabetes in Closed-Loop System

NCT03354286
View directory record Official record
Conditions
Type 1 Diabetes Mellitus
Interventions
Developmental & Technological Demands, Distress Reduction, Nutrition, Set Point, & C:I Ratio, Hypoglycemia management, Minimal Intervention
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
2 Years to 6 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Oct 23, 2026, 8:42 PM EDT
Terminated Phase 2 Interventional Results available

Proof-of-concept Trial of Apraglutide in Acute Graft Versus Host Disease (aGVHD)

NCT05415410
View directory record Official record
Conditions
GVHD
Interventions
Apraglutide
Drug
Lead sponsor
VectivBio AG
Industry
Eligibility
12 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
5
States / cities
Stanford, California • Iowa City, Iowa • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Oct 23, 2026, 8:42 PM EDT
Recruiting Not applicable Interventional

Technology Assisted Collaborative Care Intervention to Improve Patient-centered Outcomes in Dialysis Patients

NCT06978127
View directory record Official record
Conditions
Chronic Kidney Disease Requiring Hemodialysis
Interventions
Technology Assisted Stepped Collaborative Care, Usual Care Arm
Behavioral · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
424 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
2
States / cities
Albuquerque, New Mexico • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 23, 2026, 8:42 PM EDT
Completed Phase 1 Interventional

Pancreatic Islet Cell Transplantation - A Novel Approach to Improve Islet Quality and Engraftment

NCT00530686
View directory record Official record
Conditions
Islet Cell Transplantation, Type 1 Diabetes
Interventions
Islet cell transplantation
Drug
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 24, 2017 · Synced Oct 23, 2026, 8:42 PM EDT