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ClinicalTrials.gov public records Last synced Oct 21, 2026, 4:19 PM EDT

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Showing 217–240 of 310 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: IOL Clear all
Completed Phase 4 Interventional

Efficacy of Topical Cyclosporine Versus Tears for Improving Visual Outcomes Following Multifocal IOL Implantation

NCT00349583
View directory record Official record
Conditions
Cataract, Dry Eye
Interventions
Topical Cyclosporine, Tears
Drug
Lead sponsor
Innovative Medical
Industry
Eligibility
50 Years and older
U.S. locations
1
States / cities
Rockville Centre, New York
Source: ClinicalTrials.gov public record
Updated Jun 1, 2007 · Synced Oct 21, 2026, 4:19 PM EDT
Completed Not applicable Interventional Results available

RxSight Light Adjustable Lens and Light Delivery Device New Enrollment Study

NCT05202808
View directory record Official record
Conditions
Aphakia, Cataract
Interventions
Light Adjustable lens (LAL) and Light Delivery Device (LDD), Control IOL
Device
Lead sponsor
RxSight, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
14
States / cities
Fayetteville, Arkansas • Chico, California • Largo, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2025 · Synced Oct 21, 2026, 4:19 PM EDT
Completed Phase 4 Interventional

Comparison of Postoperative Visual Acuity and Spectacle Independence Between the Tecnis Multifocal Intraoculer Lens (IOL) and the Crystalens Accommodating IOL

NCT01275118
View directory record Official record
Conditions
Cataract
Interventions
Tecnis Multifocal IOL, crystalens Accommodating IOL
Device
Lead sponsor
Mark Packer, MD, FACS
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 28, 2014 · Synced Oct 21, 2026, 4:19 PM EDT
Completed No phase listed Observational Results available

AcrySof® Bilateral PanOptix(R) Spectacle Freedom and Patient Satisfaction Study

NCT04126187
View directory record Official record
Conditions
Cataract
Interventions
Panoptix
Device
Lead sponsor
Gainesville Eye Associates
Other
Eligibility
40 Years and older
Enrollment
30 participants
Timeline
2020 – 2021
U.S. locations
1
States / cities
Gainesville, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Oct 21, 2026, 4:19 PM EDT
Completed Not applicable Interventional

I-ZIP Ocular Bandage Pivotal Study

NCT00774228
View directory record Official record
Conditions
Cataract
Interventions
I-ZIP Ocular Bandage, Oasis 24 Hour Soft Shield Collagen Corneal Shield
Device
Lead sponsor
Ocular Therapeutix, Inc.
Industry
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 29, 2021 · Synced Oct 21, 2026, 4:19 PM EDT
Terminated No phase listed Interventional Results available

A Clinical Study to Evaluate The Safety and Effectiveness of The RxSight Light Adjustable Lens (LAL) In Subjects Desiring an Extended Depth of Focus

NCT04177771
View directory record Official record
Conditions
Aphakia, Cataract, Presbyopia
Interventions
Light Adjustable lens (LAL) and Light Delivery Device (LDD) - Pre-COVID Population, SofPort LI61AO IOL, Tecnis ZCB00 or ZTC150 IOL
Device
Lead sponsor
RxSight, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Fayetteville, Arkansas
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Oct 21, 2026, 4:19 PM EDT
Completed No phase listed Observational

Trifocal Intraocular Lens (IOL) Aberrometry Outcomes

NCT04196569
View directory record Official record
Conditions
Cataract
Interventions
Alcon Trifocal and Trifocal Toric Intraocular Lenses
Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 15, 2022 · Synced Oct 21, 2026, 4:19 PM EDT
Completed Phase 2 Interventional

Methotrexate, Cyclophosphamide, and Etoposide Phosphate Given With Osmotic Blood-Brain Barrier Disruption Plus Dexamethasone and Cytarabine in Treating Patients With Primary CNS Lymphoma

NCT00074178
View directory record Official record
Conditions
Lymphoma
Interventions
filgrastim, pegfilgrastim, cyclophosphamide, cytarabine, dexamethasone, etoposide phosphate, methotrexate
Biological · Drug
Lead sponsor
OHSU Knight Cancer Institute
Other
Eligibility
16 Years to 75 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2006
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 21, 2017 · Synced Oct 21, 2026, 4:19 PM EDT
Completed Phase 1 Interventional

Lenalidomide Plus Rituximab for Recurrent/Refractory CNS and Intraocular Lymphoma

NCT01542918
View directory record Official record
Conditions
Recurrent/Refractory CNS, Intraocular Lymphoma
Interventions
Lenalidomide, Rituximab
Drug
Lead sponsor
James Rubenstein
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 11, 2020 · Synced Oct 21, 2026, 4:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Study of a UV-Absorbing Acrylic Posterior Chamber Intraocular Lens

NCT00625313
View directory record Official record
Conditions
Aphakia
Interventions
HMY Model YA-60BB IOL
Device
Lead sponsor
Hoya Surgical Optics, Inc.
Industry
Eligibility
21 Years and older
Enrollment
617 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Chino Hills, California
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 21, 2026, 4:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Post-approval Follow-up Study of the IC-8 Apthera Intraocular Lens (IOL)

NCT05758883
View directory record Official record
Conditions
Cataract, Presbyopia
Interventions
Not listed
Lead sponsor
AcuFocus, Inc.
Industry
Eligibility
22 Years and older
Enrollment
196 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
20
States / cities
Tucson, Arizona • Bakersfield, California • Laguna Hills, California + 17 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Oct 21, 2026, 4:19 PM EDT
Completed Phase 2 Interventional

Iontophoretic Delivery of EGP-437 in Patients Who Have Undergone Cataract Surgery

NCT03180255
View directory record Official record
Conditions
Cataract, Anterior Chamber Inflammation, Pain, Postoperative
Interventions
Dexamethasone phosphate, Placebo
Combination Product · Other
Lead sponsor
Eyegate Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 21, 2018 · Synced Oct 21, 2026, 4:19 PM EDT
Completed Phase 1 Interventional

Arsenic Trioxide in Treating Patients With Advanced Hematologic Cancer

NCT00003395
View directory record Official record
Conditions
Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
Interventions
arsenic trioxide
Drug
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
17 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2000
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 25, 2013 · Synced Oct 21, 2026, 4:19 PM EDT
Completed No phase listed Observational

User Acceptability Evaluation of Pseudophakic Patients Previously Implanted With the TECNIS Odyssey IOL

NCT06005675
View directory record Official record
Conditions
Cataracts
Interventions
Intervention
Device
Lead sponsor
Johnson & Johnson Surgical Vision, Inc.
Industry
Eligibility
Not listed
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
4
States / cities
Bakersfield, California • Venice, Florida • Mt. Pleasant, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2025 · Synced Oct 21, 2026, 4:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Blue Light Intraocular Lenses (IOLs) and Photostress

NCT00710996
View directory record Official record
Conditions
Cataract
Interventions
Not listed
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Feb 2, 2010 · Synced Oct 21, 2026, 4:19 PM EDT
Completed Not applicable Interventional Results available

Clinical Assessment of Visual Function With the Acrysof ReSTOR Multifocal IOL

NCT00759096
View directory record Official record
Conditions
Visual Acuity
Interventions
RESTOR IOL Model SA60D3
Device
Lead sponsor
Alcon Research
Industry
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Dec 5, 2023 · Synced Oct 21, 2026, 4:19 PM EDT
Completed Not applicable Interventional Results available

Randomized Contralateral Clinical Trial With Single-piece (SN60WF) vs. Three Piece (MA60AC) AcrySof Intraocular Lenses (IOLs) on Development of Posterior Chamber Opacification (PCO).

NCT00758745
View directory record Official record
Conditions
Cataract
Interventions
Model SN60WF, Model MA60AC
Device
Lead sponsor
Alcon Research
Industry
Eligibility
50 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 19, 2014 · Synced Oct 21, 2026, 4:19 PM EDT
Completed Not applicable Interventional

A Comparative Pilot Study Of High-Order Aberrations With Aspheric IOL Models SN60WF and ZCB00

NCT01105585
View directory record Official record
Conditions
Cataracts
Interventions
Tecnis 1-piece Aspheric Acrylic (ZCB00) IOL, AcrySof Natural IQ (SN60WF) IOL
Device
Lead sponsor
Alcon Research
Industry
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Nov 29, 2012 · Synced Oct 21, 2026, 4:19 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Clinical Investigation of Expanded Designs of a Multifocal IOL

NCT01714635
View directory record Official record
Conditions
Cataract
Interventions
Tecnis Multifocal Intraocular Lens, Monofocal Intraocular Lens
Device
Lead sponsor
Abbott Medical Optics
Industry
Eligibility
18 Years and older
Enrollment
445 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
17
States / cities
Tucson, Arizona • Rogers, Arkansas • Bakersfield, California + 14 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2015 · Synced Oct 21, 2026, 4:19 PM EDT
Not listed No phase listed Observational

Intraocular Lens Power Calculation After Laser Refractive Surgery Based on Optical Coherence Tomography

NCT00532051
View directory record Official record
Conditions
Cataract
Interventions
OCT measurements
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
690 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 12, 2024 · Synced Oct 21, 2026, 4:19 PM EDT
Completed Not applicable Interventional Results available

ACRYSOF® Toric NATURAL T9 Intraocular Lens (IOL)

NCT00967473
View directory record Official record
Conditions
Bilateral Cataract
Interventions
ACRYSOF® Single-Piece NATURAL Toric IOL Model SN60T9 and Model SN60T8.
Device
Lead sponsor
Alcon Research
Industry
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Oct 21, 2026, 4:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Patient Satisfaction in Post-LASIK Patients With Presbyopia-Correcting IOLs vs. Post-Lasik Patients With Monofocal IOLs

NCT04134507
View directory record Official record
Conditions
Patient Satisfaction
Interventions
Not listed
Lead sponsor
Bucci Laser Vision Institute
Other
Eligibility
Not listed
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Wilkes-Barre, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 17, 2020 · Synced Oct 21, 2026, 4:19 PM EDT
Completed Not applicable Interventional

MULTICENTER, DOUBLE-ARM, PATIENT AND ASSESSOR-MASKED, PROSPECTIVE, RANDOMIZED CLINICAL TRIAL TO COMPARE VISUAL PERFORMANCE OF NEGATIVE AND NEUTRAL ASPHERIC MONOFOCAL INTRAOCULAR LENSES

NCT07385014
View directory record Official record
Conditions
Cataract, Presbyopia
Interventions
Neutral Aspheric Monofocal IOL, Negative Aspheric Monofocal IOL
Device
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 95 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Oct 21, 2026, 4:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Patient Perception of Visual Distortions

NCT02203747
View directory record Official record
Conditions
Cataract, Astigmatism
Interventions
Administration of patient self-assessment
Other
Lead sponsor
Abbott Medical Optics
Industry
Eligibility
22 Years and older
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Santa Ana, California
Source: ClinicalTrials.gov public record
Updated Dec 22, 2015 · Synced Oct 21, 2026, 4:19 PM EDT