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ClinicalTrials.gov public records Last synced Oct 27, 2026, 2:46 PM EDT

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Showing 1–24 of 70 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Ice application Clear all
Terminated Not applicable Interventional Accepts healthy volunteers

FDM for Subacute and Chronic Extremity Pain in the ED

NCT04555239
View directory record Official record
Conditions
Myofascial Pain, Chronic Pain, Extremities Disorders, Osteopathic Manipulation
Interventions
Fascial Distortion Model (FDM), Standard Care
Procedure · Other
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
4
States / cities
Christiansburg, Virginia • Lexington, Virginia • Roanoke, Virginia + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2022 · Synced Oct 27, 2026, 2:46 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Ice as an Adjunct for Local Anesthesia During Anorectal Surgeries

NCT04000191
View directory record Official record
Conditions
Anesthesia, Local
Interventions
MAC, Perianal ice application
Procedure · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 27, 2026, 2:46 PM EDT
Completed Not applicable Interventional Results available

Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases

NCT02511678
View directory record Official record
Conditions
Pain, Neoplasm Metastasis, Bone Metastasis of Diverse Origins
Interventions
Cryoablation
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
7
States / cities
Los Angeles, California • Atlanta, Georgia • Boston, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2021 · Synced Oct 27, 2026, 2:46 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Pain Alleviating Strategies During Allergy Shots

NCT04181632
View directory record Official record
Conditions
Immunotherapy, Allergy
Interventions
Buzzy Bee with Ice pack, Buzzy Bee without Ice pack, Shot Blocker
Device
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
4 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 29, 2023 · Synced Oct 27, 2026, 2:46 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Utility of Intermittent Cryo-Compression Versus Traditional Icing Following Arthroscopic Rotator Cuff Repair

NCT05095909
View directory record Official record
Conditions
Rotator Cuff Injuries, Cryotherapy Effect
Interventions
Cryo-compression, Cryo-therapy
Device · Other
Lead sponsor
Allina Health System
Other
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Plymouth, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 27, 2026, 2:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neural Control of Kidney Blood Flow During Exercise in African American Adults

NCT03981640
View directory record Official record
Conditions
Healthy
Interventions
Acute exercise, Cold pressor test, Mental stress test
Other
Lead sponsor
University of Massachusetts, Boston
Other
Eligibility
18 Years to 35 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 27, 2026, 2:46 PM EDT
Recruiting Not applicable Interventional

Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

NCT04996628
View directory record Official record
Conditions
Chronic Pancreatitis, Chronic Pain
Interventions
Quantitative Sensory Test 1, Quantitative Sensory Test 2, Quantitative Sensory Test 3
Diagnostic Test
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
3
States / cities
Indianapolis, Indiana • Baltimore, Maryland • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 27, 2026, 2:46 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Electrical Stimulation of Human Myocytes in Microgravity

NCT03665051
View directory record Official record
Conditions
Sarcopenia
Interventions
Muscle Tissue Biopsy, Maximal Oxygen Consumption (V02max)
Procedure · Other
Lead sponsor
AdventHealth Translational Research Institute
Other
Eligibility
20 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Oct 27, 2026, 2:46 PM EDT
Not listed Not applicable Interventional

Effects of Talocrural Joint Mobilizations in the Treatment of Subacute Lateral Ankle Sprains

NCT01117909
View directory record Official record
Conditions
Ankle Sprain
Interventions
Mobilization therapy in addition to standard therapy, Sham intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 30, 2011 · Synced Oct 27, 2026, 2:46 PM EDT
Completed Not applicable Interventional

Emergency Department Digital Pain Self-Management Intervention to Improve Acute Low Back Pain Outcomes

NCT06360341
View directory record Official record
Conditions
Low Back Pain, Mechanical, Acute Pain
Interventions
Emergency Department Digital Pain Self-Management Intervention (EDPSI), Routine Discharge Care
Behavioral · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 27, 2025 · Synced Oct 27, 2026, 2:46 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Role of Adenosine in the Release of VEGF and Cytokines

NCT00580905
View directory record Official record
Conditions
Inflammation
Interventions
Adenosine, Sodium Nitroprusside
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 60 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2017
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 28, 2018 · Synced Oct 27, 2026, 2:46 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Nasal Compression Device Study for Epistaxis

NCT05789264
View directory record Official record
Conditions
Epistaxis Nosebleed
Interventions
Nasal Compression Device, Routine Care
Device · Diagnostic Test
Lead sponsor
NasaClip
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 22, 2023 · Synced Oct 27, 2026, 2:46 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)

NCT06456268
View directory record Official record
Conditions
ACL, Opioid Use, Cryotherapy Effect, Vibration; Exposure, Pain, Postoperative
Interventions
VibraCool mechanical stimulation and neuromodulatory therapeutic device, Cryocompression (Game Ready, Bregs) device, Standard ice packs
Device
Lead sponsor
Columbia University
Other
Eligibility
Not listed
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 27, 2026, 2:46 PM EDT
Completed No phase listed Observational

Clinical Correlates of Pressure Pain Thresholds in Back and Leg Pain

NCT06653920
View directory record Official record
Conditions
Segmental Dysfunction of the Lumbar Spine, Back Pain, Leg Pain
Interventions
Chiropractic, Exercise, Cryotherapy, Spinalator
Other · Device
Lead sponsor
Leach Chiropractic Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Starkville, Mississippi
Source: ClinicalTrials.gov public record
Updated Oct 22, 2024 · Synced Oct 27, 2026, 2:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Rate of Tissue Temperature Reduction Between Wetted Ice and Game Ready

NCT04019392
View directory record Official record
Conditions
Cryotherapy Effect
Interventions
Game Ready® device, Wetted Ice Bag with Elastic Wrap
Device · Other
Lead sponsor
North Dakota State University
Other
Eligibility
18 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Feb 26, 2020 · Synced Oct 27, 2026, 2:46 PM EDT
Not listed Not applicable Interventional

Quadriceps Function Prior to Anterior Cruciate Ligament Reconstruction

NCT00971451
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament
Interventions
cryotherapy, TENS
Other
Lead sponsor
University of Virginia
Other
Eligibility
15 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 8, 2011 · Synced Oct 27, 2026, 2:46 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury

NCT06841198
View directory record Official record
Conditions
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
Interventions
spinal cord transcutaneous stimulation, Ice testing
Device · Procedure
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 27, 2026, 2:46 PM EDT
Completed Not applicable Interventional Results available

Brief Cognitive Behavioral Therapy for Chronic Pain

NCT03490981
View directory record Official record
Conditions
Chronic Pain, Musculoskeletal Pain
Interventions
Treatment as usual (TAU), Brief Cognitive Behavioral Therapy for Chronic Pain (Brief CBT-CP)
Other · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 79 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Mar 3, 2021 · Synced Oct 27, 2026, 2:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Compex Use With Delayed Onset Muscle Soreness: A Comparison to Other Methods

NCT01967121
View directory record Official record
Conditions
Focus of Study is to Determine Efficacy of Compex
Interventions
Compex unit's Active Recovery® program, Ice application
Device · Other
Lead sponsor
Michigan State University
Other
Eligibility
18 Years to 30 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
East Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 29, 2014 · Synced Oct 27, 2026, 2:46 PM EDT
Completed Phase 4 Interventional Results available

ICE-T Pain Regimen for Total Laparoscopic Hysterectomy

NCT03987022
View directory record Official record
Conditions
Opioid Substitution Treatment
Interventions
Ketorolac, Opioids, Ice Packs, Tylenol, Motrin, Dilaudid Injectable Product, Percocet 5Mg-325Mg Tablet
Drug · Other
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 24, 2025 · Synced Oct 27, 2026, 2:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ice Application for Postoperative Pain

NCT04145791
View directory record Official record
Conditions
Postoperative Pain
Interventions
Ice
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 29, 2024 · Synced Oct 27, 2026, 2:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

United States Pre-Market Tobacco Application Pharmacokinetics

NCT03719391
View directory record Official record
Conditions
Nicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco Smoking
Interventions
Virginia Tobacco flavored JUUL 5% ENDS, Cool Mint flavored JUUL 5% ENDS, Mango flavored JUUL 5% ENDS, Creme Brulee flavored JUUL 5% ENDS, VUSE Solo e-cigarette, Nicorette White Ice Mint 4mg nicotine polacrilex gum, Usual Brand combustible cigarette
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2021 · Synced Oct 27, 2026, 2:46 PM EDT
Completed Not applicable Interventional

Reduction of Pain Caused by Biologic Drugs in Psoriasis

NCT02168244
View directory record Official record
Conditions
Psoriasis, Pain
Interventions
Heating Pack, Ice pack
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
Not listed
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 13, 2016 · Synced Oct 27, 2026, 2:46 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Non-Invasive Bioelectronic Analytics

NCT04100486
View directory record Official record
Conditions
Autonomic Dysfunction, Autonomic Imbalance, Autonomic Nervous System Diseases, Vagus Nerve Autonomic Disorder
Interventions
Standing-Squatting-Standing Test, Deep Breathing Test, Cold Pressor Test, Cold Face Test, Valsalva Maneuver, Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
Other · Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 60 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 27, 2026, 2:46 PM EDT