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Showing 1–24 of 66 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Imaginal Exposure Condition Clear all
Completed Not applicable Interventional Results available

Integrated Treatment for Posttraumatic Stress Disorder and Substance Abuse in Young Adults

NCT02667119
View directory record Official record
Conditions
Substance Use Disorder, Posttraumatic Stress Disorder
Interventions
Prolonged Exposure with Contingency Management, Standard Care
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 25 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
3
States / cities
Farmington, Connecticut • Hartford, Connecticut • New Britain, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Sep 7, 2026, 9:31 PM EDT
Terminated Not applicable Interventional Results available

Imaginal Exposure & D-Cycloserine (DCS) for Posttraumatic Stress Disorder (PTSD)

NCT00875342
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
DCS, Placebo
Drug · Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 70 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 15, 2021 · Synced Sep 7, 2026, 9:31 PM EDT
Recruiting Not applicable Interventional

Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD

NCT06285708
View directory record Official record
Conditions
PTSD, Suicidal Ideation, Suicide, Attempted, Trauma, Psychological
Interventions
Prolonged exposure
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Phase 2 Interventional Results available

Prolonged Exposure for Post Traumatic Stress Disorder (PTSD) With/Without Yohimbine

NCT01031979
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Yohimbine, Placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 45 Years · Male only
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 6, 2018 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Not applicable Interventional

Outcomes After Spinal Cord Injury (OASIS)

NCT03624218
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Spinal Cord Injuries
Interventions
Prolonged Exposure Therapy
Behavioral
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Not applicable Interventional

In-Home Exposure Therapy for Veterans With Post Traumatic Stress Disorder (PTSD)

NCT03110302
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Prolonged exposure
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 13, 2019 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Phase 3 Interventional

Individual PE vs Couples' CBT for Combat-Related Posttraumatic Stress Disorder

NCT02336971
View directory record Official record
Conditions
PTSD, Marital Relationship
Interventions
CBCT for PTSD, Prolonged Exposure
Behavioral
Lead sponsor
Toronto Metropolitan University
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
3
States / cities
Fort Hood, Texas • Fort Sam Houston, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced Sep 7, 2026, 9:31 PM EDT
Recruiting Not applicable Interventional

Mechanisms Underlying the Efficacy of Prolonged Exposure

NCT05663151
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Prolonged Exposure Therapy for Posttraumatic Stress Disorder
Behavioral
Lead sponsor
VA Boston Healthcare System
Federal
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 7, 2025 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Brief Treatment for Posttraumatic Stress Disorder

NCT03033602
View directory record Official record
Conditions
PTSD
Interventions
written exposure therapy, CPT, cognitive only
Behavioral
Lead sponsor
Boston VA Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
169 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
2
States / cities
Killeen, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 23, 2023 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Not applicable Interventional Results available

Integrated CBT-I and PE on Sleep and PTSD Outcomes (Impact Study)

NCT02774642
View directory record Official record
Conditions
Posttraumatic Stress Disorders, Chronic Insomnia
Interventions
CBTI-PE, Hygiene-PE
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
19 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2024 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Not applicable Interventional Results available

Imaginal Exposure for Hoarding Disorder

NCT03734705
View directory record Official record
Conditions
Hoarding Disorder
Interventions
Imaginal Exposure Writing, Neutral Writing
Behavioral · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Sep 7, 2026, 9:31 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

General Psychological Distress, PTSD, and Co-Morbidities in Healthcare Workers Consequent to Occupational Trauma

NCT04626050
View directory record Official record
Conditions
Post-traumatic Stress Disorder, Moral Injury
Interventions
Medical Music, Narrative Writing, Prolonged Exposure Therapy, Interpersonal Psychotherapy
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Not applicable Interventional Results available

Comparing Virtual Reality Exposure Therapy to Prolonged Exposure

NCT01459705
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic Stress Disorder
Interventions
Prolonged Exposure Therapy (PE), Virtual Reality Exposure Therapy (VRET), Waitlist
Behavioral
Lead sponsor
National Center for Telehealth and Technology
Federal
Eligibility
18 Years to 65 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 13, 2015 · Synced Sep 7, 2026, 9:31 PM EDT
Recruiting Not applicable Interventional

Mechanisms Underlying Efficacy of Prolonged Exposure

NCT05788302
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Prolonged Exposure
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

fMRI Predictors of Treatment Response in Posttraumatic Stress Disorder (PTSD)

NCT01576510
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD)
Interventions
Prolonged Exposure (PE)
Behavioral
Lead sponsor
Research Foundation for Mental Hygiene, Inc.
Other
Eligibility
18 Years to 60 Years
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 23, 2014 · Synced Sep 7, 2026, 9:31 PM EDT
Recruiting Not applicable Interventional

Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center

NCT06210711
View directory record Official record
Conditions
Traumatic Injury, PTSD, Posttraumatic Stress Disorder
Interventions
Treatment as Usual, Brief Prolonged Exposure Therapy
Behavioral
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
3
States / cities
Dallas, Texas • Temple, Texas • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Phase 2 Interventional Results available

Combined Treatment for Generalized Anxiety Disorder (GAD)

NCT00620776
View directory record Official record
Conditions
Generalized Anxiety Disorder
Interventions
Cognitive Behavioral Therapy, Venlafaxine XR
Behavioral · Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 15, 2017 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Virtual Reality System for Anxiety and OCD

NCT03636022
View directory record Official record
Conditions
Anxiety, Obsessive-Compulsive Disorder
Interventions
VR System, Control
Other
Lead sponsor
Minnesota HealthSolutions
Industry
Eligibility
7 Years to 17 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 7, 2026, 9:31 PM EDT
Recruiting Not applicable Interventional

Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder

NCT06740487
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder
Interventions
Traditional Exposure Therapy (ET) Treatment, Stepwise Augmented Reality (AR) Component with Traditional Exposure Treatment for Nonresponders
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Not applicable Interventional Results available

Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic Disorder

NCT04293341
View directory record Official record
Conditions
Major Depressive Disorder, Posttraumatic Stress Disorder, Panic Disorder and Agoraphobia
Interventions
Transdiagnostic Behavior Therapy, Cognitive Processing Therapy for PTSD, Cognitive Behavioral Therapy for MDD, Cognitive Behavioral Therapy for Panic Disorder
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prospective Cohort Study of Accelerated Resolution Therapy (ART) for Treatment of Military Psychological Trauma

NCT02030522
View directory record Official record
Conditions
Post-traumatic Stress Disorder (PTSD)
Interventions
Accelerated Resolution Therapy (ART)
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
8
States / cities
Clearwater, Florida • Holiday, Florida • Jupiter, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2020 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Not applicable Interventional

Exposure Therapy for Active Duty Soldiers With Post Traumatic Stress Disorder

NCT01193725
View directory record Official record
Conditions
Stress Disorders, Post Traumatic
Interventions
Prolonged Exposure Therapy (PE), Virtual Reality Exposure Therapy (VRET), Waitlist
Behavioral
Lead sponsor
National Center for Telehealth and Technology
Federal
Eligibility
18 Years to 65 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Apr 13, 2015 · Synced Sep 7, 2026, 9:31 PM EDT
Recruiting Phase 2 Interventional

MDMA-Assisted Massed Exposure Therapy for PTSD

NCT07288151
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
3,4-Methylenedioxymethamphetamine (MDMA), Placebo, Massed Prolonged Exposure (PE)
Drug · Behavioral
Lead sponsor
Emory University
Other
Eligibility
21 Years to 70 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Sep 7, 2026, 9:31 PM EDT
Completed Not applicable Interventional Results available

A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD

NCT00371176
View directory record Official record
Conditions
Combat Disorders, Stress Disorders, Post-Traumatic
Interventions
Exposure therapy, D-Cycloserine, Placebo pill
Behavioral · Drug · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 3, 2014 · Synced Sep 7, 2026, 9:31 PM EDT