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Showing 1–24 of 109 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: In Vivo Exposure Therapy Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Trauma Management Therapy and Prolonged Exposure Therapy

NCT04549493
View directory record Official record
Conditions
PTSD
Interventions
Exposure Therapy
Behavioral
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 64 Years
Enrollment
134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated May 9, 2024 · Synced Sep 21, 2026, 7:08 AM EDT
Not listed Not applicable Interventional

University of Houston Drug Abuse Research Development Program II

NCT03557632
View directory record Official record
Conditions
Heroin Dependence
Interventions
Virtual Reality Cue Exposure Therapy, Relapse Prevention Drug Education
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 64 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 5, 2018 · Synced Sep 21, 2026, 7:08 AM EDT
Completed Phase 1 Interventional

Immunotherapy With IFx-Hu2.0 Vaccine for Advanced Non-melanoma Skin Cancers

NCT04160065
View directory record Official record
Conditions
Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, Non-Melanoma Skin Cancers
Interventions
IFx-Hu2.0
Biological
Lead sponsor
TuHURA Biosciences, Inc.
Industry
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
4
States / cities
Los Angeles, California • Tampa, Florida • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 22, 2024 · Synced Sep 21, 2026, 7:08 AM EDT
Recruiting Not applicable Interventional

Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center

NCT06210711
View directory record Official record
Conditions
Traumatic Injury, PTSD, Posttraumatic Stress Disorder
Interventions
Treatment as Usual, Brief Prolonged Exposure Therapy
Behavioral
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
3
States / cities
Dallas, Texas • Temple, Texas • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Sep 21, 2026, 7:08 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Cognitive Rehabilitation and Exposure Therapy for Geriatric Hoarding

NCT05254015
View directory record Official record
Conditions
Hoarding Disorder, Obsessive-Compulsive Disorder
Interventions
Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST), Case Management
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
50 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 5, 2023 · Synced Sep 21, 2026, 7:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

tDCS-Augmented Exposure Therapy for Pathological Fear

NCT03095482
View directory record Official record
Conditions
Specific Phobias
Interventions
Transcranial Direct Current Stimulation (tDCS), In vivo exposure therapy
Device · Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Dec 7, 2020 · Synced Sep 21, 2026, 7:08 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (RCT)

NCT07396974
View directory record Official record
Conditions
Trauma, Posttraumatic Stress Disorder
Interventions
Personalized Stepped Care Cognitive Behavioral Therapy for Children after Trauma (pSC-CBT-CT), Treatment as Usual (TAU)
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
7 Years to 14 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 21, 2026, 7:08 AM EDT
Completed Not applicable Interventional

Psychotherapy for PTSD Among Veterans Also Receiving Drug or Alcohol Treatment

NCT04581434
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Substance Use Disorders
Interventions
Prolonged Exposure Therapy, Cognitive Processing Therapy, Present Centered Therapy
Behavioral
Lead sponsor
Center for Veterans Research and Education
Other
Eligibility
18 Years and older
Enrollment
426 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
14
States / cities
San Diego, California • Tampa, Florida • Atlanta, Georgia + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2024 · Synced Sep 21, 2026, 7:08 AM EDT
Active, not recruiting No phase listed Observational

Long - Term Follow Up of Sickle Cell Disease and Beta-thalassemia Subjects Previously Exposed to BIVV003 or ST-400.

NCT05145062
View directory record Official record
Conditions
Blood and Lymphatic Diseases
Interventions
BIVV003, ST-400
Drug
Lead sponsor
Sangamo Therapeutics
Industry
Eligibility
18 Years to 45 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2038
U.S. locations
7
States / cities
Oakland, California • Sacramento, California • Atlanta, Georgia + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Sep 21, 2026, 7:08 AM EDT
Recruiting Not applicable Interventional

Systematic Redesign of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT)

NCT06941428
View directory record Official record
Conditions
Trauma, Psychological, Trauma and Stressor Related Disorders
Interventions
Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), School-Adapted TF-CBT (S-TF)
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
7 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 21, 2026, 7:08 AM EDT
Terminated Not applicable Interventional Results available

Family-Based Interoceptive Exposure for Avoidant Restrictive Food Intake Disorder

NCT06110806
View directory record Official record
Conditions
Avoidant Restrictive Food Intake Disorder
Interventions
MBIE
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
12 Years to 18 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 21, 2026, 7:08 AM EDT
Recruiting Not applicable Interventional

Testing Adaptive Interventions to Improve Posttraumatic Stress Disorder Treatment Outcomes in Federally Qualified Health Centers

NCT05457985
View directory record Official record
Conditions
PTSD
Interventions
Prolonged Exposure for Primary Care (PE-PC), Full Prolonged Exposure, Clinician Supported PTSD Coach App
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
430 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
13
States / cities
Baldwin, Michigan • Battle Creek, Michigan • Flint, Michigan + 9 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 21, 2026, 7:08 AM EDT
Completed Not applicable Interventional

The Role of Exercise in the Treatment of PTSD Symptoms

NCT02649127
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
imaginal therapy, exercise, self-care
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Fort Hood, Texas
Source: ClinicalTrials.gov public record
Updated Sep 10, 2017 · Synced Sep 21, 2026, 7:08 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Pegasys VR: Integrating Virtual Humans in the Treatment of Child Social Anxiety

NCT02816684
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Pegasys-VR, Social Effectiveness Therapy for Children
Behavioral
Lead sponsor
University of Central Florida
Other
Eligibility
7 Years to 12 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 18, 2018 · Synced Sep 21, 2026, 7:08 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (Pilot)

NCT07396935
View directory record Official record
Conditions
Trauma, Posttraumatic Stress Disorder
Interventions
Personalized Stepped Care Cognitive Behavioral Therapy for Children after Trauma (pSC-CBT-CT)
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
7 Years to 14 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 21, 2026, 7:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

fMRI Predictors of Treatment Response in Posttraumatic Stress Disorder (PTSD)

NCT01576510
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD)
Interventions
Prolonged Exposure (PE)
Behavioral
Lead sponsor
Research Foundation for Mental Hygiene, Inc.
Other
Eligibility
18 Years to 60 Years
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 23, 2014 · Synced Sep 21, 2026, 7:08 AM EDT
Completed Not applicable Interventional

Process and Outcomes in CBT for Anxious and Depressed Youth

NCT03100279
View directory record Official record
Conditions
Anxiety Disorders, Depression
Interventions
Coping Cat/CAT Project, Primary and Secondary Coping Enhancement Therapy
Behavioral
Lead sponsor
Rutgers University
Other
Eligibility
7 Years to 17 Years
Enrollment
247 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2020
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 21, 2026, 7:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cognitive Behavioral Therapy for Anxiety Disorders in Adolescents With Autism

NCT01563003
View directory record Official record
Conditions
Autism, Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified, Generalized Anxiety Disorder, Social Phobia, Separation Anxiety Disorder, Obsessive-compulsive Disorder
Interventions
Cognitive Behavioral Therapy, Treatment as usual
Other
Lead sponsor
University of South Florida
Other
Eligibility
11 Years to 16 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Apr 16, 2015 · Synced Sep 21, 2026, 7:08 AM EDT
Completed Not applicable Interventional Results available

Integrated Treatment for Posttraumatic Stress Disorder and Substance Abuse in Young Adults

NCT02667119
View directory record Official record
Conditions
Substance Use Disorder, Posttraumatic Stress Disorder
Interventions
Prolonged Exposure with Contingency Management, Standard Care
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 25 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
3
States / cities
Farmington, Connecticut • Hartford, Connecticut • New Britain, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Sep 21, 2026, 7:08 AM EDT
Completed Not applicable Interventional Results available

Comparing Virtual Reality Exposure Therapy to Prolonged Exposure

NCT01459705
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic Stress Disorder
Interventions
Prolonged Exposure Therapy (PE), Virtual Reality Exposure Therapy (VRET), Waitlist
Behavioral
Lead sponsor
National Center for Telehealth and Technology
Federal
Eligibility
18 Years to 65 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 13, 2015 · Synced Sep 21, 2026, 7:08 AM EDT
Recruiting Not applicable Interventional

Mechanisms Underlying Efficacy of Prolonged Exposure

NCT05788302
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Prolonged Exposure
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Sep 21, 2026, 7:08 AM EDT
Recruiting Not applicable Interventional

Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication

NCT06088303
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Adjunctive writing to amplify response and engagement (AWARE), Cognitive processing therapy (CPT), Prolonged exposure (PE)
Behavioral
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Sep 21, 2026, 7:08 AM EDT
Recruiting Not applicable Interventional

Mechanisms Underlying the Efficacy of Prolonged Exposure

NCT05663151
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Prolonged Exposure Therapy for Posttraumatic Stress Disorder
Behavioral
Lead sponsor
VA Boston Healthcare System
Federal
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 7, 2025 · Synced Sep 21, 2026, 7:08 AM EDT
Completed Not applicable Interventional

The Effects of Safety Seeking Behaviors During Exposure Therapy for Adults With Spider Phobia

NCT03233113
View directory record Official record
Conditions
Specific Phobia
Interventions
Exposure therapy
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 15, 2018 · Synced Sep 21, 2026, 7:08 AM EDT