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ClinicalTrials.gov public records Last synced Oct 21, 2026, 4:09 AM EDT

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Showing 1–24 of 117 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Induced hypothermia Clear all
Terminated Phase 3 Interventional

Hypothermia in Children After Trauma

NCT00222742
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
induced moderate hypothermia
Procedure
Lead sponsor
Phoenix Children's Hospital
Other
Eligibility
Up to 17 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
17
States / cities
Phoenix, Arizona • Sacramento, California • Washington D.C., District of Columbia + 14 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2012 · Synced Oct 21, 2026, 4:09 AM EDT
Completed No phase listed Observational

Neuroprognostication Using Optic Nerve Sheath Diameter

NCT03195881
View directory record Official record
Conditions
Heart Arrest, Intracranial Pressure Increase
Interventions
Ocular ultrasound
Other
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Results available

Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery

NCT03111875
View directory record Official record
Conditions
Perioperative Care, Surgery--Complications, Hypothermia; Anesthesia, Myocardial Injury
Interventions
aggressive warming, routine thermal management
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
45 Years and older
Enrollment
5,056 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional

Study of Endorectal Cooling During RARP to Minimize Trauma and Promote Earlier Return to Continence

NCT01920035
View directory record Official record
Conditions
Incontinence
Interventions
UroCool (Local cooling/hypothermia)
Device
Lead sponsor
ZOLL Circulation, Inc., USA
Industry
Eligibility
18 Years and older · Male only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
2
States / cities
Duarte, California • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 20, 2020 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO)

NCT01913340
View directory record Official record
Conditions
Hypoxic-ischemic Encephalopathy, Neonatal Encephalopathy, Birth Asphyxia
Interventions
Erythropoietin, Normal saline
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
30 Minutes to 24 Hours
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
7
States / cities
Little Rock, Arkansas • Palo Alto, California • San Francisco, California + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Oct 21, 2026, 4:09 AM EDT
Recruiting No phase listed Observational

Cool Prime Comparative Effectiveness Study for Mild HIE

NCT04621279
View directory record Official record
Conditions
Mild Hypoxic Ischemic Encephalopathy of Newborn
Interventions
Normothermia, Whole body therapeutic hypothermia
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
36 Weeks and older
Enrollment
460 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Results available

Telemedicine to Improve Use of Therapeutic Hypothermia in Rural Settings

NCT03706417
View directory record Official record
Conditions
Neonatal Encephalopathy
Interventions
Telemedicine consult
Diagnostic Test
Lead sponsor
MaineHealth
Other
Eligibility
Up to 6 Hours
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Sep 12, 2025 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

OMT to Improve Feeding After Hypothermia

NCT03380013
View directory record Official record
Conditions
Neonatal Encephalopathy, Feeding; Difficult, Newborn
Interventions
Osteopathic Manipulative Treatment (OMT)
Procedure
Lead sponsor
MaineHealth
Other
Eligibility
37 Weeks and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated May 31, 2019 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Results available

Breast/Evaluation of Cryotherapy and TRPA1 Receptors in Chemotherapy Induced Neuropathy

NCT03329131
View directory record Official record
Conditions
Peripheral Neuropathies
Interventions
Cryotherapy
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional

Pro-2-Cool Device Clinical Study

NCT03511339
View directory record Official record
Conditions
Mild Traumatic Brain Injury
Interventions
TecTraum device
Device
Lead sponsor
TecTraum Inc.
Industry
Eligibility
12 Years to 21 Years
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
5
States / cities
Ann Arbor, Michigan • Akron, Ohio • Boardman, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated May 3, 2023 · Synced Oct 21, 2026, 4:09 AM EDT
Not listed Phase 2 Interventional

Prevention of Paclitaxel Neuropathy With Cryotherapy

NCT02230319
View directory record Official record
Conditions
Breast Cancer
Interventions
Cryotherapy, Paclitaxel
Other · Drug
Lead sponsor
Medical Oncology & Hematology Associates of Northern Virginia
Other
Eligibility
18 Years and older · Female only
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Fairfax, Virginia • Reston, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 1, 2015 · Synced Oct 21, 2026, 4:09 AM EDT
Withdrawn Not applicable Interventional

Mild Hypothermia for COVID-19 ARDS

NCT04570462
View directory record Official record
Conditions
COVID19 ARDS
Interventions
Hypothermia Via Cooling Machine- Arctic Sun 5000
Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Oct 21, 2026, 4:09 AM EDT
Terminated Not applicable Interventional Results available

Impact of Fever Prevention in Brain Injured Patients

NCT02996266
View directory record Official record
Conditions
Fever, Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
Interventions
Targeted Temperature Management, Standard Care
Device · Other
Lead sponsor
C. R. Bard
Industry
Eligibility
21 Years to 85 Years
Enrollment
686 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
28
States / cities
Los Angeles, California • Palo Alto, California • Aurora, Colorado + 23 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Results available

California Transport Cooling Trial

NCT01683383
View directory record Official record
Conditions
Hypoxic Ischemic Encephalopathy
Interventions
Device (servo-regulated cooling), Control (standard practice)
Device · Other
Lead sponsor
Stanford University
Other
Eligibility
Up to 6 Hours
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
9
States / cities
Loma Linda, California • Madera, California • Oakland, California + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 8, 2014 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Results available

Delayed Rewarming for Neuroprotection in Infants Following Cardiopulmonary Bypass Surgery

NCT03036072
View directory record Official record
Conditions
Post-Op Complication
Interventions
Strict normothermia, Delayed Rewarming
Other · Device
Lead sponsor
Alexa Craig
Other
Eligibility
Up to 6 Months
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Oct 21, 2026, 4:09 AM EDT
Terminated Not applicable Interventional

Helping Stroke Patients With ThermoSuit Cooling

NCT02453373
View directory record Official record
Conditions
Stroke, Brain Ischemia
Interventions
ThermoSuit Cooling Induction, Magnesium Sulfate, tPA, Propofol, Etomidate, Neurothrombectomy
Device · Drug · Procedure
Lead sponsor
Life Recovery Systems
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
4
States / cities
New Orleans, Louisiana • Danville, Pennsylvania • Wilkes-Barre, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 6, 2023 · Synced Oct 21, 2026, 4:09 AM EDT
Not listed Phase 2 Interventional

Targeted Temperature Management After Intracerebral Hemorrhage

NCT01866384
View directory record Official record
Conditions
Cerebral Hemorrhage, Hypothermia
Interventions
mild induced hypothermia, Normal Temperature
Procedure · Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 18, 2014 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness, Safety and Ease of Application of Excel Cryo Cooling Collar to Rapidly Reduce Core Brain Temperature

NCT02703675
View directory record Official record
Conditions
Stroke
Interventions
Excel Cryo Cooling Collar
Device
Lead sponsor
Michel Torbey
Other
Eligibility
18 Years to 60 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 2, 2018 · Synced Oct 21, 2026, 4:09 AM EDT
Recruiting Not applicable Interventional

Comparing Hypothermic Temperatures During Hemiarch Surgery

NCT02860364
View directory record Official record
Conditions
Thoracic Aortic Disease
Interventions
Hypothermic circulatory arrest
Procedure
Lead sponsor
Ottawa Heart Institute Research Corporation
Other
Eligibility
18 Years and older
Enrollment
282 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2030
U.S. locations
3
States / cities
Boston, Massachusetts • Ridgewood, New Jersey • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 24, 2025 · Synced Oct 21, 2026, 4:09 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor

NCT06293638
View directory record Official record
Conditions
Essential Tremor
Interventions
Alcohol, Alprazolam, Cold Therapy, Peripheral Nerve Stimulation
Drug · Device · Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
30 Years to 80 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 21, 2026, 4:09 AM EDT
Recruiting Not applicable Interventional

Cold and Compression Post TKA

NCT07023185
View directory record Official record
Conditions
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Interventions
Cold and Compression, SOC (Standard of care)
Device · Other
Lead sponsor
Ochsner Health System
Other
Eligibility
50 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Phase 2 Interventional Results available

Amantadine to Speed Awakening After Cardiac Arrest

NCT02486211
View directory record Official record
Conditions
Coma, Heart Arrest, Anoxia
Interventions
Amantadine, Placebo
Drug
Lead sponsor
Jon Rittenberger, MD
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
4
States / cities
Portland, Maine • Boston, Massachusetts • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 4, 2019 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Results available

Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial

NCT00880087
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Therapeutic Hypothermia, Therapeutic Normothermia
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
48 Hours to 18 Years
Enrollment
329 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
25
States / cities
Birmingham, Alabama • Phoenix, Arizona • Loma Linda, California + 21 more
Source: ClinicalTrials.gov public record
Updated Jun 15, 2018 · Synced Oct 21, 2026, 4:09 AM EDT
Not listed Not applicable Interventional

TIME Study: Therapeutic Hypothermia for Infants With Mild Encephalopathy

NCT04176471
View directory record Official record
Conditions
Hypoxic-Ischemic Encephalopathy Mild, Neonatal Encephalopathy
Interventions
Therapeutic Hypothermia, Normothermia
Other
Lead sponsor
Stanford University
Other
Eligibility
Up to 6 Hours
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
5
States / cities
Loma Linda, California • Oakland, California • Orange, California + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Oct 21, 2026, 4:09 AM EDT