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Showing 1–24 of 28 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Insufflation pressure Clear all
Completed Not applicable Interventional

Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study

NCT06119087
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis, Chronic Respiratory Failure, Airway Clearance Impairment, Neuromuscular Diseases
Interventions
Mechanical insufflation
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 2, 2026, 5:47 PM EDT
Completed Not applicable Interventional

Veress Entry With/Without Concomitant CO2

NCT02896036
View directory record Official record
Conditions
Laparoscopy, Laparoscopic Surgery, Insufflation, Gynecologic Surgical Procedures
Interventions
Veress needle entry with concomitant CO2, Veress needle entry with subsequent CO2
Procedure
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 70 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Mar 29, 2018 · Synced Sep 2, 2026, 5:47 PM EDT
Terminated Not applicable Interventional

IL-10 Levels and Remote Ischemic Preconditioning in Acute Myocardial Infarction

NCT01532206
View directory record Official record
Conditions
Acute Myocardial Infarction
Interventions
Blood pressure cuff insufflation
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 24, 2016 · Synced Sep 2, 2026, 5:47 PM EDT
Completed Not applicable Interventional

Pneumoperitoneum Management With SurgiQuest AirSeal at Low vs. Higher Pressure ( PRESSURE )

NCT02541448
View directory record Official record
Conditions
Shoulder Pain
Interventions
SurgiQuest AIRSEAL® Insufflation System (AIS)
Device
Lead sponsor
Cynthia Harris
Industry
Eligibility
18 Years to 80 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Nov 12, 2019 · Synced Sep 2, 2026, 5:47 PM EDT
Terminated Not applicable Interventional Results available

Ultralow Versus Standard Pneumoperitoneum Pressure

NCT03630393
View directory record Official record
Conditions
Prostate Cancer
Interventions
Pneumoperitoneum Pressure 6 mmHg, Pneumoperitoneum Pressure 15 mmHg
Other
Lead sponsor
OhioHealth
Other
Eligibility
18 Years and older · Male only
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 17, 2022 · Synced Sep 2, 2026, 5:47 PM EDT
Not yet recruiting Not applicable Interventional

Pneumoperitoneum Management With SurgiQuest AirSeal® at Low vs. Higher Pressure

NCT02837601
View directory record Official record
Conditions
Shoulder Pain
Interventions
AirSeal® Insufflation System (AIS)
Device
Lead sponsor
Akron Children's Hospital
Other
Eligibility
Up to 21 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 12, 2020 · Synced Sep 2, 2026, 5:47 PM EDT
Not listed Not applicable Interventional

Automated Variable Pattern Insufflator Device (AVPI) for the Acute Treatment of Migraine

NCT04584762
View directory record Official record
Conditions
Migraine Headache
Interventions
Automated Variable Pressure Insufflation
Device
Lead sponsor
Nocira, LLC
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
3
States / cities
Scottsdale, Arizona • St. Petersburg, Florida • Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 9, 2022 · Synced Sep 2, 2026, 5:47 PM EDT
Recruiting Not applicable Interventional

Short Title: Standard vs. Lower Pressure Pneumoperitoneum

NCT06338865
View directory record Official record
Conditions
Laparoscopic Surgery
Interventions
Carbon dioxide, Bupivacaine, Oxycodone
Other · Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 9, 2024 · Synced Sep 2, 2026, 5:47 PM EDT
Completed Phase 4 Interventional Results available

Surgical Conditions During Laparoscopic Bariatric Surgery

NCT02703909
View directory record Official record
Conditions
Morbid Obesity
Interventions
Rocuronium, Insufflation pressure
Drug · Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 20, 2018 · Synced Sep 2, 2026, 5:47 PM EDT
Completed Not applicable Interventional Results available

ALS and Airway Clearance (ALSAC) Therapy

NCT04947436
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis, Respiratory Muscle Weakness
Interventions
High Frequency Chest Wall Oscillation, Mechanical insufflation/exsufflation
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
21 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 3, 2021 · Synced Sep 2, 2026, 5:47 PM EDT
Not listed Not applicable Interventional

SurgiQuest AirSeal in Robotic Partial Nephrectomy - (TARPAN Study)

NCT02262884
View directory record Official record
Conditions
Subcutaneous Emphysema
Interventions
SurgiQuest AirSeal Insufflation System (AIS), Conventional Insufflation System (CIS)
Device
Lead sponsor
SurgiQuest, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
189 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
3
States / cities
St Louis, Missouri • Hackensack, New Jersey • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 5, 2016 · Synced Sep 2, 2026, 5:47 PM EDT
Completed Not applicable Interventional Results available

Reducing Operative and Post-operative Morbidity in Living Kidney Donors With the Airseal System

NCT02262039
View directory record Official record
Conditions
Pain
Interventions
Valveless recirculating insufflation (VTI), Conventional pressure
Device
Lead sponsor
Yale University
Other
Eligibility
Not listed
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 16, 2018 · Synced Sep 2, 2026, 5:47 PM EDT
Completed Not applicable Interventional

Single Port Insufflation RCT

NCT06990750
View directory record Official record
Conditions
Postoperative Pain Score
Interventions
15 mmHg, 12 mmHg
Procedure
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 2, 2026, 5:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Pneumoinsufflation Modes and Pressure Settings in Gynecology

NCT02853591
View directory record Official record
Conditions
Pain, Pneumoperitoneum, Inflammation, Quality of Life
Interventions
Pneumoinsufflator mode and setting
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Weston, Florida
Source: ClinicalTrials.gov public record
Updated Mar 7, 2023 · Synced Sep 2, 2026, 5:47 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Prospective Randomized Trial of Moderate vs Deep Neuromuscular Blockade During Laparoscopic Ventral Hernia Repair

NCT03201744
View directory record Official record
Conditions
Hernia, Ventral, Neuromuscular Blockade, Pneumoperitoneum
Interventions
Patients will be randomized to moderate (TOF 1-2) or deep (post tetanic count 1-2) relaxation. Low pressure insufflation (start pressure set at 8 mm Hg)
Procedure
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Sep 2, 2026, 5:47 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Prolonged Manual Ventilation Simulation

NCT06805838
View directory record Official record
Conditions
Manual Ventilation
Interventions
Sotair
Device
Lead sponsor
SafeBVM
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Sep 2, 2026, 5:47 PM EDT
Terminated Not applicable Interventional

Feasibility of Using a Mobile Device Controlled Micro-pressure Pulse Insufflator for Acute Migraine Relief

NCT03263897
View directory record Official record
Conditions
Migraine
Interventions
insufflation, placebo insufflation
Device
Lead sponsor
Caps Research Network
Other
Eligibility
20 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
Prescott, Arizona • Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 20, 2022 · Synced Sep 2, 2026, 5:47 PM EDT
Completed Phase 2 Interventional

Preventing Pneumonia and Other Respiratory Problems in Persons With Spinal Cord Injury

NCT00448045
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Manual and mechanical assisted cough, Incentive spirometry
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 70 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 14, 2013 · Synced Sep 2, 2026, 5:47 PM EDT
Active, not recruiting Phase 2 Interventional Results available

The Effect of Deep Versus Moderate Muscle Relaxants in Men During and After Robotic Surgery for Prostate Cancer

NCT03808077
View directory record Official record
Conditions
Prostate Cancer
Interventions
Rocuronium 0.3mg/kg/hr, Rocuronium 1.5mg/kg/hr
Drug
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years to 80 Years · Male only
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Sep 2, 2026, 5:47 PM EDT
Terminated Not applicable Interventional Results available

Evaluation of Ability to Detect Bowel Gas During Laparoscopic Right Colectomy With Intracorporeal Anastomosis

NCT04964297
View directory record Official record
Conditions
Crohn's Disease of Large Intestine, Malignant Neoplasm of Colon
Interventions
Obtaining bowel gas samples
Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Sep 2, 2026, 5:47 PM EDT
Not yet recruiting Not applicable Interventional

Gastrectomy at Low Pressure Trial - (GALPT)

NCT07313930
View directory record Official record
Conditions
Pain, Postoperative
Interventions
AirSeal® Insufflation System (AIS), Lexicon AP 50/30 Insufflator
Device
Lead sponsor
SurgiQuest, Inc.
Industry
Eligibility
22 Years to 65 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Stamford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 1, 2026 · Synced Sep 2, 2026, 5:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Stabilization of Hypercapnia: NIPPV v HVNI

NCT04709562
View directory record Official record
Conditions
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Dyspnea, Hypercapnic Acidosis
Interventions
High Velocity Nasal Insufflation (HVNI), Noninvasive Positive Pressure Ventilation (NIPPV)
Device
Lead sponsor
Vapotherm, Inc.
Industry
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
7
States / cities
Los Angeles, California • Oxnard, California • Washington D.C., District of Columbia + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 8, 2024 · Synced Sep 2, 2026, 5:47 PM EDT
Completed Not applicable Interventional

Prospective Randomized Controlled Trial Comparing Water and Air Colonoscopy in a Community Based Setting

NCT01729416
View directory record Official record
Conditions
Tubular Adenoma, Colon Cancer, Hyperplastic Polyp
Interventions
Water Exchange Colonoscopy, Air Colonoscopy
Other
Lead sponsor
University of California, Davis
Other
Eligibility
50 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Elk Grove, California
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Sep 2, 2026, 5:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

AirSeal®Insufflation Trocar/CO2 Absorption Study

NCT02654808
View directory record Official record
Conditions
Gynecologic Diseases
Interventions
AirSeal trocar, Standard trocar
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 15, 2021 · Synced Sep 2, 2026, 5:47 PM EDT