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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Intermediate nicotine level cigarette Clear all
Completed Phase 2 Interventional Accepts healthy volunteers

Maintaining Abstinence in Chronic Cigarette Smokers - 1

NCT00087880
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Bupropion and NRT
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
407 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Not applicable Interventional

Comparison of Demand and Substitution for Nicotine Pouches as a Function of Nicotine Dosage

NCT07213947
View directory record Official record
Conditions
Tobacco Use, Nicotine Pouch Self-Administration
Interventions
Nicotine Pouch Dosage
Other
Lead sponsor
William Middleton
Other
Eligibility
18 Years and older
Enrollment
1,360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Culturally Targeted & Individually Tailored Smoking Cessation Study: LGBT Smokers

NCT01633567
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Culturally Targeted Cessation Program, Non-Targeted Cessation Program
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 65 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 3, 2017 · Synced Sep 24, 2026, 2:26 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of Short-term Safety and Use Patterns of an Electronic Nicotine Delivery System

NCT01898169
View directory record Official record
Conditions
Nicotine Dependence
Interventions
NJOY King 26 mg nicotine Electronic Nicotine Delivery System
Other
Lead sponsor
LA Clinical Trials
Other
Eligibility
18 Years to 65 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated Jul 11, 2013 · Synced Sep 24, 2026, 2:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparison of Pharmacokinetic Parameters Between Adopters of Electronic Cigarettes and a Historical Sample of Combustible Cigarette Smokers

NCT02730676
View directory record Official record
Conditions
Smoking
Interventions
Electronic Cigarette #1, Electronic Cigarette #2
Other
Lead sponsor
R.J. Reynolds Vapor Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Lakewood, Colorado
Source: ClinicalTrials.gov public record
Updated May 31, 2018 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Comparing NicoBloc to Nicotine Lozenges

NCT03720899
View directory record Official record
Conditions
Smoking Cessation, Nicotine Dependence
Interventions
NicoBloc, Nicotine Lozenge
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 7, 2025 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study

NCT02783768
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, E-cigarettes
Interventions
E-cigarette, Sham, Hyperpolarized 3-Helium, Gadolinium
Device · Other · Drug
Lead sponsor
Columbia University
Other
Eligibility
21 Years to 35 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 21, 2020 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2

NCT05473585
View directory record Official record
Conditions
Smoking, Smoking, Cigarette, E-Cig Use, Nicotine Dependence
Interventions
very low nicotine content cigarettes, normal nicotine content cigarettes, Study e-cigarette
Other
Lead sponsor
Duke University
Other
Eligibility
21 Years and older
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 18, 2023 · Synced Sep 24, 2026, 2:26 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

NCT06372899
View directory record Official record
Conditions
E-cigarette Use, Cigarette Smoking, Harm Reduction, Tobacco Use
Interventions
E-cigarettes, Oral nicotine pouches
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users

NCT02102100
View directory record Official record
Conditions
Nicotine Dependence
Interventions
nicotine, menthol
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 30 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Sep 24, 2026, 2:26 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse Liability

NCT07564648
View directory record Official record
Conditions
Cigarette Addiction, Tobacco Use Disorder
Interventions
Biospecimen Collection, Questionnaire Administration, Cigarette Purchase Task, Cross-Price Elasticity Task, Daily Diary Surveys, Progressive Ratio Task
Behavioral
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 24, 2026, 2:26 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

A RCT to Determine the Effect of ENDS Flavor Availability on Abstinence Within Smokers

NCT07172438
View directory record Official record
Conditions
Smoking, Tobacco
Interventions
P2611222, P2615022, P2615122, P2613422
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 65 Years
Enrollment
668 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
27
States / cities
Chandler, Arizona • Fort Smith, Arkansas • Altamonte Springs, Florida + 21 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 24, 2026, 2:26 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Switch or Quit R01

NCT06373679
View directory record Official record
Conditions
Cigarette Smoking, Smoking Behaviors
Interventions
Switching to E-Cigarette, Switching using Medication
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
225 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Motivation and Skills for Detained Teen Smokers

NCT01387516
View directory record Official record
Conditions
Motivational Intervention, Nicotine Anonymous, Cognitive Behavior Therapy, Relaxation Therapy
Interventions
Motivational Intervention, Relaxation Therapy, Cognitive Behavioral Therapy, Self-Help Programming
Behavioral
Lead sponsor
University of Rhode Island
Other
Eligibility
13 Years to 19 Years
Enrollment
314 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2014
U.S. locations
1
States / cities
Cranston, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Phase 4 Interventional Results available

Identifying Treatments to Motivate Smokers to Quit

NCT01122238
View directory record Official record
Conditions
Smoking, Smoking Cessation, Motivation, Nicotine Dependence
Interventions
Nicotine Patch, Nicotine Gum, Motivational Interviewing, Smoking Reduction, No Intervention, Nicotine Patch + Nicotine Gum
Drug · Behavioral · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
517 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 15, 2015 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers

NCT02989038
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Very Low Nicotine Content Cigarettes, Intermediate Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
Other
Lead sponsor
Duke University
Other
Eligibility
15 Years to 25 Years
Enrollment
182 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Nicotine in Tobacco Smokers

NCT03651869
View directory record Official record
Conditions
Smoking, Tobacco, Smoking (Tobacco) Addiction
Interventions
Cigarette 1, Cigarette 2, Patch 1, Patch 2
Drug
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
221 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 12, 2023 · Synced Sep 24, 2026, 2:26 AM EDT
Withdrawn Not applicable Interventional

Effects of Tobacco Abuse Liability-dependent Taxes in the ETM

NCT07042373
View directory record Official record
Conditions
Cigarette Smoking Behavior
Interventions
Control, Product Category Score, Product Category Rank, Product Tiers
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparing Nicotine Delivery, Subjective Effects, and Sensory Experiences of Tobacco Users Using Oral Nicotine Products and Electronic Cigarettes [ZYN Study]

NCT05030194
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Cigarette Smoking, Smokeless Tobacco Cessation
Interventions
Electronic Cigarette, Oral Nicotine Pouch
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)

NCT04332926
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Tobacco product administration and assessment, own brand cigarettes, Tobacco product administration and assessment, ECIG 30 Watts, 0 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 8 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 15 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 30 mg/ml nicotine
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Phase 4 Interventional Results available

Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking

NCT02995915
View directory record Official record
Conditions
Smoking Cessation, Alcohol Drinking
Interventions
Nicotine Replacement Therapy, Bupropion, Cognitive Behavioral Treatment, Mobile Contingency Management, Mobile Monitoring
Other · Drug · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 80 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals

NCT00308763
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Nicotine Patch, Sustained Release Bupropion
Drug
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 45 Years
Enrollment
594 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated May 20, 2014 · Synced Sep 24, 2026, 2:26 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sex Differences in E-Cigarette Perception

NCT07398976
View directory record Official record
Conditions
Nicotine Dependence, E-cigarette Use
Interventions
Nicotine Level 1 (0mg/ml), Nicotine Level 2 (36mg/ml), Nicotine Level 3 (59mg/ml)
Other
Lead sponsor
Yale University
Other
Eligibility
21 Years to 44 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 24, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Abuse Liability of Reduced Nicotine Content Cigarettes Within a Complex Tobacco Marketplace

NCT02951143
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
SPECTRUM cigarettes, SPECTRUM cigarettes between
Drug
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
305 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 21, 2021 · Synced Sep 24, 2026, 2:26 AM EDT