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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Intervention: Interscalene Block Clear all
Terminated No phase listed Observational Accepts healthy volunteers

Cerebral Blood Flow Evaluation With Trancranial Doppler After Interscalene Nerve Block

NCT04642612
View directory record Official record
Conditions
Regional Anesthesia, Horner Syndrome, Cerebral Blood Flow
Interventions
TCD Measurement
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2021 · Synced Sep 5, 2026, 4:10 AM EDT
Completed No phase listed Interventional Results available

Comparison of Analgesic Efficacy Between of Interscalene Block With Liposomal Bupivacaine With Bupivacaine and Dexamethasone

NCT03969875
View directory record Official record
Conditions
Total Shoulder Arthroplasty, Shoulder Osteoarthritis
Interventions
Interscalene catheter, Liposomal bupivacaine, Dexamethasone, Bupivacaine
Device · Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 80 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Phase 4 Interventional

Measuring Opioid Use After Rotator Cuff Repair: Comparing the Effects of Standard vs. Extended-release Nerve Blocks

NCT05482113
View directory record Official record
Conditions
Rotator Cuff Tears
Interventions
Liposomal bupivacaine, Bupivacaine Hcl 0.25% Inj
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 31, 2022 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Not applicable Interventional

Erector Spinae Plane Versus Interscalene Blocks for Shoulder Surgery

NCT03807505
View directory record Official record
Conditions
Anesthesia, Local, Phrenic Nerve Paralysis, Upper Extremity Injury, Shoulder Injury
Interventions
Interscalene brachial plexus nerve block, Erector spinae plane block
Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 4, 2020 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Not applicable Interventional

Interscalene Block With and Without Liposomal Bupivacaine in Shoulder Surgery

NCT03728946
View directory record Official record
Conditions
Rotator Cuff Tear, Postoperative Pain
Interventions
Liposomal Bupivacaine
Drug
Lead sponsor
Orthopaedic & Neurosurgery Specialists
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
6
States / cities
Greenwich, Connecticut • Stamford, Connecticut • Atlantis, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Sep 5, 2026, 4:10 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Inferior Vena Cava (IVC) Diameters Before & After Interscalene Block

NCT03989076
View directory record Official record
Conditions
IVC - Inferior Vena Cava Abnormality
Interventions
Interscalene Brachial Plexus Block
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 20, 2021 · Synced Sep 5, 2026, 4:10 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Optimal Effective Local Anesthetic Volume for Pain Relief Using Brachial Plexus Block

NCT05868993
View directory record Official record
Conditions
Post Operative Pain
Interventions
Dose of 0.5% Ropivacaine
Drug
Lead sponsor
Benaroya Research Institute
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 21, 2023 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Phase 4 Interventional Results available

Exparel for Total Shoulder Arthroplasty

NCT04364867
View directory record Official record
Conditions
Total Shoulder Arthroplasty
Interventions
Exparel, Pain Pump
Drug
Lead sponsor
Norton Healthcare
Other
Eligibility
18 Years to 70 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 25, 2024 · Synced Sep 5, 2026, 4:10 AM EDT
Terminated Phase 4 Interventional

Shoulder Adhesive Capsulitis and Ambulatory Continuous Interscalene Nerve Blocks

NCT00875862
View directory record Official record
Conditions
Adhesive Capsulitis, Post-operative Pain
Interventions
Interscalene catheter with Ropivicaine or normal saline
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Sep 5, 2026, 4:10 AM EDT
Terminated Phase 4 Interventional

Pain Management After Total Shoulder Arthroplasty

NCT03219983
View directory record Official record
Conditions
Glenohumeral Arthritis, Total Shoulder Arthroplasty
Interventions
Ropivacaine, liposomal bupivacaine
Drug
Lead sponsor
The Christ Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 5, 2017 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Phase 4 Interventional Results available

LIBERATE - LIposomal Bupivacaine vERsus Adjuncts in Total shouldErs

NCT03887650
View directory record Official record
Conditions
Post-operative Pain, Total Shoulder Arthroplasty, Osteoarthritis of the Shoulder, Pain Management
Interventions
Liposomal Bupivicaine 1.3%, Bupivacaine 0.5%
Drug
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 100 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 14, 2023 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Postoperative Pain Control in Total Shoulder Arthroplasty

NCT05068960
View directory record Official record
Conditions
Total Shoulder Arthroplasty
Interventions
Liposomal bupivacaine, Bupivacaine
Drug
Lead sponsor
Scripps Clinic
Other
Eligibility
50 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Phase 4 Interventional Results available

Interscalene Block Versus Superior Trunk Block

NCT03272139
View directory record Official record
Conditions
Joint Disease, Pain, Pain, Acute, Pain, Chronic
Interventions
Bupivacaine, Ultrasound
Drug · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Phase 4 Interventional Results available

the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block

NCT02653144
View directory record Official record
Conditions
Opioid Use, Unspecified
Interventions
Ropivacaine, Dexmedetomidine, Dexamethasone
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 21, 2020 · Synced Sep 5, 2026, 4:10 AM EDT
Terminated Not applicable Interventional

Prospective Evaluation of Interscalene Nerve Catheters vs. Single Injection Blocks

NCT01385449
View directory record Official record
Conditions
Pain
Interventions
interscalene catheter, interscalene block
Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 79 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 17, 2019 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine Single-Injection Interscalene Block vs. Continuous Interscalene Block for Primary Total Shoulder Arthroplasty

NCT05005260
View directory record Official record
Conditions
Pain, Postoperative, Brachial Plexus Block
Interventions
Bupivacaine HCl, Liposomal bupivacaine + Bupivacaine Hcl 0.5% Inj
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Sep 5, 2026, 4:10 AM EDT
Recruiting Phase 4 Interventional

Single Shot Exparel vs Catheters in Lower Extremity Trauma

NCT07221019
View directory record Official record
Conditions
Fracture Dislocation of Ankle Joint, Fracture Leg, Fracture Femur, Fracture Lower Leg, Fracture
Interventions
Bupivacaine, Exparel + Bupivacaine
Drug
Lead sponsor
George Washington University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Phase 4 Interventional Results available

Interscalene Block With Low-dose IV vs. Perineural Dexamethasone for Shoulder Arthroscopy

NCT02506660
View directory record Official record
Conditions
Pain, Shoulder Arthroscopy
Interventions
Bupivacaine, Perineural dexamethasone, Intravenous dexamethasone, Intravenous saline, Perineural saline
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 70 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 28, 2018 · Synced Sep 5, 2026, 4:10 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Postoperative Analgesia After Shoulder Replacement

NCT01003860
View directory record Official record
Conditions
Analgesia
Interventions
Not listed
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 28, 2009 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine Interscalene Blocks for Rotator Cuff Repair

NCT03587584
View directory record Official record
Conditions
Acute Pain
Interventions
liposomal bupivacaine, Bupivacaine
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Sep 5, 2026, 4:10 AM EDT
Not listed Not applicable Interventional

Indwelling Interscalene Nerve Catheters in Surgical Management of Idiopathic Adhesive Capsulitis

NCT01606332
View directory record Official record
Conditions
Frozen Shoulder
Interventions
Interscalene block with nerve catheter
Procedure
Lead sponsor
OAD Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Warrenville, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 10, 2013 · Synced Sep 5, 2026, 4:10 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Trial on the Effects of Ultrasound Probe Position on Ultrasound-guided Nerve Blocks

NCT01690156
View directory record Official record
Conditions
In-plane Ultrasound-guided Regional Anesthesia Performance
Interventions
Not listed
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years to 55 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Sep 5, 2026, 4:10 AM EDT
Terminated Not applicable Interventional

Out of Plane Approach for Interscalene

NCT03785392
View directory record Official record
Conditions
Acute Pain, Brachial Plexus Block
Interventions
Group 1 In-plane, Group 2 out of plane
Procedure
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
2
States / cities
Galveston, Texas • League City, Texas
Source: ClinicalTrials.gov public record
Updated Dec 2, 2020 · Synced Sep 5, 2026, 4:10 AM EDT
Completed No phase listed Observational

Preoperative Maximum Inspiratory Pressure and Outcomes After Interscalene Block in Obese Patients

NCT06549244
View directory record Official record
Conditions
Dyspnea After Interscalene Nerve Block
Interventions
Maximum Inspiratory Pressure monitoring
Diagnostic Test
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 11, 2024 · Synced Sep 5, 2026, 4:10 AM EDT