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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:39 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 114 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Intervention: Ketamine Clear all

Conditions: Depressive Disorder, Major
Interventions: Cognitive behavioral therapy (CBT) and medication, Psychoeducation and medication; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: PTSD and Trauma-related Symptoms
Interventions: Preparatory Session, Ketamine-assisted Psychotherapy Session #1, Ketamine-assisted Psychotherapy Session #2, Integration Session; Behavioral · Drug
Lead sponsor: Irma Fleming; Other
Eligibility: 18 Years to 65 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Pediatric Burns
Interventions: magnesium sulfate, Normal Saline (0.9% NaCl); Drug
Lead sponsor: Hennepin Healthcare Research Institute; Other
Eligibility: 3 Years to 18 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: PTSD
Interventions: Ketamine, TIMBER Psychotherapy, Placebo (normal saline); Drug · Behavioral
Lead sponsor: Cooper Norcross Health; Other
Eligibility: 21 Years to 60 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2013
U.S. locations: 1
States / cities: Camden, New Jersey

Conditions: Pain Management
Interventions: Bupivacaine alone OR Bupivacaine-Ketorolac-Ketamine (BKK) Combination; Drug
Lead sponsor: Kansas City Heart Rhythm Research Foundation; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 3
States / cities: Loma Linda, California • Overland Park, Kansas

Conditions: Posttraumatic Stress Disorder
Interventions: Ketamine, Midazolam; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 75 Years
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Rattlesnake Envenomation
Interventions: Ketamine, Fentanyl; Drug
Lead sponsor: Meghan Spyres; Other
Eligibility: 18 Years to 100 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Major Depressive Disorder
Interventions: Ketamine, Psychotherapy; Drug · Behavioral
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years to 90 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Posttraumatic Stress Disorder
Interventions: Ketamine, Midazolam; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 70 Years
Enrollment: 350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2031
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Analgesia, Post-Operative Pain, Breakthrough Pain, Colectomy
Interventions: Non-Narcotic ERAS Post-Operative Pain Management; Other
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Administration and Dosage of Ketamine, Endoscopic Sedation
Interventions: Ketamine, Midazolam injection, Fentanyl; Drug
Lead sponsor: Brooke Army Medical Center; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Fort Sam Houston, Texas

Conditions: Burn, Pain, Dissociation, Opioid
Interventions: Ketamine, 0.9% NaCl; Drug
Lead sponsor: University of Tennessee; Other
Eligibility: 18 Years and older
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Healthy Volunteers
Interventions: (2R,6R)-Hydroxynorketamine, Placebo; Drug
Lead sponsor: National Center for Complementary and Integrative Health (NCCIH); NIH
Eligibility: 18 Years to 60 Years
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Post-traumatic Stress Disorder
Interventions: ketamine-enhanced prolonged exposure; Drug
Lead sponsor: Minneapolis Veterans Affairs Medical Center; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Traumatic Injury
Interventions: Ketamine Hydrochloride, Fentanyl Citrate; Drug
Lead sponsor: Jason Sperry; Other
Eligibility: 18 Years and older
Enrollment: 994 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2029
U.S. locations: 11
States / cities: San Diego, California • San Francisco, California • Camden, New Jersey + 7 more

Conditions: Thermal Hyperalgesia, Anxiety, Pain
Interventions: Ketamine, Placebo, Normal Saline; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 89 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Opioid Use
Interventions: NOMO Protocol; Drug
Lead sponsor: Prisma Health-Upstate; Other
Eligibility: 18 Years and older · Female only
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Greenville, South Carolina

Conditions: Abscess, Fracture
Interventions: Ketamine; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 2 Years to 17 Years
Enrollment: 111 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Acute Cholecystitis, Chronic Cholecystitis
Interventions: TIVA - Hypotension, TIVA - Hypertension, TIVA - Bradycardia, TIVA - Tachycardia, INH - Hypotension, INH - Hypertension, INH - Bradycardia, INH - Tachycardia; Procedure
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years to 65 Years
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Depression
Interventions: Intravenous ketamine, Computer-based Cognitive Training; Drug · Behavioral
Lead sponsor: Rebecca Price; Other
Eligibility: 18 Years to 60 Years
Enrollment: 154 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Treatment Resistant Depression, Major Depressive Episode, Major Depression, Major Depressive Disorder, Bipolar Disorder, Bipolar Depression, Obsessive-Compulsive Disorder
Interventions: Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (TMS), Ketamine, Esketamine, Deep Transcranial Magnetic Stimulation (dTMS); Device · Drug
Lead sponsor: Mark Niciu; Other
Eligibility: 18 Years to 99 Years
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2050
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Levodopa-Induced Dyskinesia, Parkinson's Disease
Interventions: Intervention: Ketamine; Drug
Lead sponsor: University of Arizona; Other
Eligibility: 30 Years to 85 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Analgesia
Interventions: Do we speak to them in a way that convinces them to have the dream, Speaking to them as a regualar person; Behavioral
Lead sponsor: CHRISTUS Health; Other
Eligibility: 18 Years and older
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Corpus Christi, Texas

Conditions: Postoperative Delirium, Hemodynamic Instability, Pain, Neurocognitive Dysfunction
Interventions: EEG Monitoring, Ropivacaine, Ketamine, Remifentanil, Dexmedetomidine, Rocuronium, Propofol; Device · Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 60 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Search by objective public record fields.

Cognitive Therapy to Sustain the Antidepressant Effects of Intravenous Ketamine in Treatment-resistant Depression

KALM-B: Ketamine-assisted Psychotherapy (KAP) to Lessen Morbidity After Burn Injury

Magnesium Sulfate in Pediatric Burn Dressing Changes

TIMBER Psychotherapy and Ketamine Single Infusion in Chronic PTSD

Effectiveness of Bupivacaine, Ketorolac, Ketamine, vs Bupivacaine Alone in Reducing Postoperative Pocket Pain

Intensive 7-day Treatment for PTSD Combining Ketamine With Exposure Therapy

Ketamine Pilot Study

Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression

Enhancing Week-long Psychological Treatment for PTSD With Ketamine

A Prospective Pilot Study of a Non-Narcotic Post-Operative Course After Colectomy

Ketamine for Endoscopic Sedation in Outpatient Adult Endoscopy.

Low-Dose Ketamine Infusion During Burn Wound Care

Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers

Ketamine and Prolonged Exposure in PTSD

Prehospital Analgesia INtervention Trial (PAIN)

A Randomized, Double-Blind Study of Placebo vs. Ketamine For Use During Dressing Changes in Critically Ill Burn Patients

Does a Non-Opioid Multimodal Pain (NOMO) Protocol Decrease Narcotic Use

Study to Find the Dose of Rapidly Administered Ketamine for Brief Painful Procedures in Children

Evaluation of Closed-loop TIVA Propofol, Sufentanil and Ketamine Guided by BIS Monitor

Intravenous Ketamine Plus Neurocognitive Training for Depression

University of Iowa Interventional Psychiatry Service Patient Registry

Phase I Open-label Study of Low-dose Ketamine Infusion Treatment in Levodopa-Induced Dyskinesia in Parkinson's Disease

Techniques to Reduce the Severity and Frequency of Emergent Reactions

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies