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ClinicalTrials.gov public records Last synced Oct 2, 2026, 2:27 AM EDT

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Showing 25–48 of 292 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Intra-operative Standard of Care Clear all
Recruiting Phase 2 Interventional

Periprosthetic Joint Infection Bubble Study

NCT07599865
View directory record Official record
Conditions
Periprosthetic Joint Infection (PJI)
Interventions
Ultrasound-triggered microbubble destruction with antibiotics
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
3
States / cities
Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 2, 2026, 2:27 AM EDT
Completed Not applicable Interventional Results available

Effect of Epidural Stimulation on Muscle Activation and Sensory Perception

NCT04157400
View directory record Official record
Conditions
Chronic Pain
Interventions
Intraoperative Parameter Testing, Proprioception Testing During Stimulation, Gait Analysis During Stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 15, 2023 · Synced Oct 2, 2026, 2:27 AM EDT
Terminated Not applicable Interventional

Arterial Pulse Waveform Contour Analysis for Intraoperative Goal Directed Therapy in Major Spine Surgery

NCT01124474
View directory record Official record
Conditions
Surgical Procedures, Operative
Interventions
goal directed therapy
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 12, 2012 · Synced Oct 2, 2026, 2:27 AM EDT
Not yet recruiting Not applicable Interventional

PRISM-NLM: Prostatectomy Intraoperative Surgical Margin Assessment With Non-linear Microscopy

NCT07516808
View directory record Official record
Conditions
Prostate Cancer
Interventions
Nonlinear Microscope (NLM)
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older · Male only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 2, 2026, 2:27 AM EDT
Terminated No phase listed Observational Results available

Alloantibodies in Pediatric Heart Transplantation

NCT01005316
View directory record Official record
Conditions
Pediatric Heart Transplantation, Pediatric Heart Transplant Recipients
Interventions
Induction Therapy, Tacrolimus, Mycophenolate Mofetil, Intraoperative plasma exchange/pheresis, Short-term post-operative plasmapheresis, Immunoglobulins, Intravenous, Prednisone
Drug · Procedure
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
Up to 21 Years
Enrollment
290 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
7
States / cities
Boston, Massachusetts • St Louis, Missouri • New York, New York + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Oct 2, 2026, 2:27 AM EDT
Terminated Not applicable Interventional

Optimal Surgical Treatment Of Fulminant Clostridium Difficile Colitis

NCT01441271
View directory record Official record
Conditions
Clostridium Difficile Colitis
Interventions
Ileal diversion and lavage, total abdominal colectomy
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 1, 2015 · Synced Oct 2, 2026, 2:27 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors

NCT05023434
View directory record Official record
Conditions
Brain Tumor, Brain Cancer, Motor Cortex; Lesion
Interventions
Intraoperative Brain Simulation - Alternate Stimulation Parameters
Procedure
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 2, 2026, 2:27 AM EDT
Recruiting Not applicable Interventional

A Study of the Use of 3D Technology to Guide Head and Neck Surgery

NCT06676592
View directory record Official record
Conditions
Surgery, Head and Neck Disorder
Interventions
Preoperative imaging, 3D framework
Diagnostic Test
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 2, 2026, 2:27 AM EDT
Recruiting Phase 3 Interventional

NO During CPB in Neonates to Reduce Risk of AKI

NCT04216927
View directory record Official record
Conditions
AKI, CHD - Congenital Heart Disease, Surgery
Interventions
Nitric Oxide, Oxygen
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
1 Day to 31 Days
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 2, 2026, 2:27 AM EDT
Recruiting Phase 1Phase 2 Interventional

Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery

NCT03510208
View directory record Official record
Conditions
Malignant Brain Neoplasm, Malignant Glioma
Interventions
Near-Infrared Fluorescence Imaging, Panitumumab, Panitumumab-IRDye800, POINPOINT-IR9000
Procedure · Biological · Drug + 1 more
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Oct 2, 2026, 2:27 AM EDT
Active, not recruiting Phase 1 Interventional

Intraoperative Radiation Therapy After Stereotactic Body Radiation Therapy and Chemotherapy in Treatment of Pancreatic Adenocarcinoma

NCT05141513
View directory record Official record
Conditions
Pancreatic Cancer
Interventions
High Dose Rate Brachytherapy (HDR) Intraoperative Radiation Therapy (IORT)
Radiation
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 2, 2026, 2:27 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Enhanced Recovery Pathway for Endoscopy

NCT04983498
View directory record Official record
Conditions
Enhanced Recovery Pathway, Endoscopy
Interventions
Ondansetron 4 MG, Lactated Ringers, Intravenous, Early Mobilization, Early PO Intake
Drug · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 15, 2021 · Synced Oct 2, 2026, 2:27 AM EDT
Terminated Phase 1 Interventional

Distal Radius Steroid

NCT05655130
View directory record Official record
Conditions
Fractures, Bone, Fractures, Closed, Radius Fracture Distal
Interventions
Dexamethasone, Methylprednisolone, Standard of Care
Drug · Other
Lead sponsor
Indiana Hand to Shoulder Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Oct 2, 2026, 2:27 AM EDT
Completed Not applicable Interventional

Molecular Analysis for Precision Surgery in Thyroid Cancer Trial

NCT06235814
View directory record Official record
Conditions
Papillary Thyroid Cancer
Interventions
Molecular Analysis for Thyroid Resection
Procedure
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 2, 2026, 2:27 AM EDT
Completed Phase 3 Interventional Results available

Infrared Coagulator Ablation or Observation in Preventing Anal Cancer in HIV-Positive Patients With Anal Neoplasia

NCT01164722
View directory record Official record
Conditions
Anal Cancer, Neoplasm of Uncertain Malignant Potential, Nonneoplastic Condition, Precancerous Condition
Interventions
clinical observation, infrared photocoagulation therapy
Other · Device
Lead sponsor
AIDS Malignancy Consortium
Network
Eligibility
27 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
7
States / cities
Los Angeles, California • San Francisco, California • Boston, Massachusetts + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2020 · Synced Oct 2, 2026, 2:27 AM EDT
Withdrawn Not applicable Interventional

Intraoperative Brain Microdialysis to Assess Neuroinflammation in Epileptic Tissue Immediately Prior to Surgical Resection.

NCT04531722
View directory record Official record
Conditions
Epilepsy
Interventions
Intraoperative brain microdialysis
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 2, 2026, 2:27 AM EDT
Recruiting Not applicable Interventional

ERAS Protocols in Breast Conserving Surgery

NCT06938581
View directory record Official record
Conditions
Breast Cancer, Postoperative Recovery
Interventions
ERAS Protocol, Standard Perioperative Care
Other
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Oct 2, 2026, 2:27 AM EDT
Active, not recruiting Not applicable Interventional

Efficacy of a Dental Implant System for Immediate Restoration

NCT06651502
View directory record Official record
Conditions
Missing Teeth
Interventions
dental implant placement and immediate provisionalization
Device
Lead sponsor
Harvard Medical School (HMS and HSDM)
Other
Eligibility
20 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Oct 2, 2026, 2:27 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effect of Diastolic Dysfunction on Dynamic Cardiac Monitors

NCT04177225
View directory record Official record
Conditions
Stroke Volume Variation, Diastolic Dysfunction
Interventions
Trans thoracic Ultrasound Examination, Intravenous fluid administration
Procedure · Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2021 · Synced Oct 2, 2026, 2:27 AM EDT
Completed Phase 3 Interventional

Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty

NCT05300685
View directory record Official record
Conditions
Urethral Stricture, Male
Interventions
Standard Buccal Harvest, Basic buccal procedure + Long acting local, Basic buccal procedure + Buccal block
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Male only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
San Francisco, California • Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 2, 2026, 2:27 AM EDT
Not yet recruiting Not applicable Interventional

Feasibility of HISA During TURBT for NMIBC

NCT07817173
View directory record Official record
Conditions
Bladder Cancer, Bladder (Urothelial, Transitional Cell) Cancer Resectable (Pre-Cystectomy), Non-muscle Invasive Bladder Cancer (NMIBC), Non-Muscle Invasive Bladder Neoplasms, Non-muscle Invasive Bladder Cancer, Bladder Cancer (BC), Transurethral Resection of Bladdertumors, Transurethral Resection of the Bladder, Non-Muscle Invasive Bladder Carcinoma
Interventions
HISA
Device
Lead sponsor
CAMC Health System
Other
Eligibility
18 Years to 89 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 2, 2026, 2:27 AM EDT
Completed Phase 4 Interventional

Methylprednisolone Taper After Total Knee Replacement

NCT05859269
View directory record Official record
Conditions
Knee Arthritis
Interventions
Methylprednisolone, Standard of Care
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years to 95 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Atlanta, Georgia • Tucker, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Oct 2, 2026, 2:27 AM EDT
Not yet recruiting Not applicable Interventional

Intraoperative Neuromonitoring of Sacral Reflexes to Predict Post Operative Function in Patients Undergoing Sacrectomy for Pelvic Bone Malignancy or Patients Undergoing Spinal Procedures Without Sacral Root Involvement

NCT07707024
View directory record Official record
Conditions
Bone Neoplasm, Metastatic Malignant Neoplasm in the Bone
Interventions
Intraoperative Nerve Monitoring, Surgical Procedure, Survey Administration
Procedure · Other
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2029
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 2, 2026, 2:27 AM EDT
Active, not recruiting Not applicable Interventional

Perioperative Risk Study

NCT02456389
View directory record Official record
Conditions
Tumors, Primary Neoplasm, Secondary Neoplasm, Surgery
Interventions
Preoperative risk stratification, Postoperative risk stratification, Risk-based, escalating levels of care, Risk-based, escalating levels of monitoring, Risk-based, escalating levels of co-management, Standard postoperative care
Other
Lead sponsor
Fox Chase Cancer Center
Other
Eligibility
18 Years and older
Enrollment
1,456 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 4, 2025 · Synced Oct 2, 2026, 2:27 AM EDT