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Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Intracranial Stimulation Clear all
Recruiting Not applicable Interventional

Low Intensity Focused Ultrasound Stimulation in Stroke Patients - Parameter Optimization

NCT07220005
View directory record Official record
Conditions
Stroke, Arm Weakness as a Consequence of Stroke, Upper Extremity Hemiparesis, Upper Extremity Impairments, Upper Extremity Weakness
Interventions
Low intensity focused ultrasound stimulation
Device
Lead sponsor
Duke University
Other
Eligibility
21 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 2, 2026, 7:03 AM EDT
Recruiting Not applicable Interventional

Amygdala Memory Enhancement

NCT05065450
View directory record Official record
Conditions
Brain Diseases, Epilepsy, Memory Disorders, Traumatic Brain Injury, Cognitive Impairment, Post Traumatic Stress Disorder
Interventions
Intracranial Stimulation
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Sep 2, 2026, 7:03 AM EDT
Completed No phase listed Observational

Deciphering Principles of Network Dynamics Underlying Depression Symptom Severity From Multi-day Intracranial Recordings in Patients With Major Depression

NCT06953362
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Direct Neural Electrical Stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
22 Months to 70 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Sep 2, 2026, 7:03 AM EDT
Completed Phase 2 Interventional Results available

RNS® System Feasibility Study

NCT00079781
View directory record Official record
Conditions
Epilepsy
Interventions
RNS® System implantation, RNS® System responsive stimulation
Procedure · Device
Lead sponsor
NeuroPace
Industry
Eligibility
18 Years to 65 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
12
States / cities
Phoenix, Arizona • New Haven, Connecticut • Jacksonville, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2014 · Synced Sep 2, 2026, 7:03 AM EDT
Recruiting Not applicable Interventional

Neurophysiological Mechanisms of Language Comprehension

NCT05283265
View directory record Official record
Conditions
Language Disorders
Interventions
Sentence Type, Direct brain stimulation
Behavioral · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Sep 2, 2026, 7:03 AM EDT
Withdrawn Not applicable Interventional

Neurocognitive Basis of Attention and Eye Movement Guidance in the Real World Scenes

NCT04652856
View directory record Official record
Conditions
Cognition, Attention, Eye Movements
Interventions
Electrical Brain Stimulation, Sham Electrical Brain Stimulation
Device
Lead sponsor
Avniel Ghuman
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 12, 2022 · Synced Sep 2, 2026, 7:03 AM EDT
Recruiting Not applicable Interventional

Intracranial Investigation of Neural Circuity Underlying Human Mood

NCT05871372
View directory record Official record
Conditions
Depression, Epilepsy
Interventions
Brain Stimulation, sEEG Stimulation
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
21 Years to 70 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Sep 2, 2026, 7:03 AM EDT
Enrolling by invitation Not applicable Interventional

Auditory Stimulation Effects on Sleep and Memory in Patients With Epilepsy

NCT04788628
View directory record Official record
Conditions
Epilepsy
Interventions
Baseline, Motor procedural memory task, Motor procedural memory task plus auditory stimulation
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
12 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 16, 2025 · Synced Sep 2, 2026, 7:03 AM EDT
Enrolling by invitation Not applicable Interventional

TMS for iEEG Monitoring Recordings

NCT07518745
View directory record Official record
Conditions
EEG, TMS
Interventions
Single Pulse TMS
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 2, 2026, 7:03 AM EDT
Recruiting Not applicable Interventional

Safety and Feasibility of DBS for Bipolar Depression

NCT07745374
View directory record Official record
Conditions
Bipolar I Disorder, Bipolar Depression
Interventions
Medtronic Percept PC DBS system
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
22 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Sep 2, 2026, 7:03 AM EDT
Recruiting Not applicable Interventional

Subcortical Arousal in Perceptual Awareness

NCT06934356
View directory record Official record
Conditions
Epilepsy
Interventions
EEG, Eye Tracking, Behavioral task, fMRI
Device · Diagnostic Test
Lead sponsor
Yale University
Other
Eligibility
13 Years and older
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
8
States / cities
New Haven, Connecticut • Kansas City, Kansas • Boston, Massachusetts + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 9, 2026 · Synced Sep 2, 2026, 7:03 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Optimizing Brain Excitability in Depression

NCT07242105
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Active Single-Pulse TMS, Sham Single-Pulse TMS, TARGET-optimized TMS, Non-optimized (Open-Loop) TMS, EEG Recording, Intracranial EEG (iEEG) Recording
Device · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
2
States / cities
Iowa City, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 2, 2026, 7:03 AM EDT
Recruiting No phase listed Observational

Baby Brain Recovery Study

NCT05013736
View directory record Official record
Conditions
Perinatal Stroke
Interventions
Magnetic Resonance Imaging, Behavioral Assessments, Non invasive Transcranial Magnetic Stimulation
Device · Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
0 Years to 24 Months
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 2, 2026, 7:03 AM EDT
Not listed Not applicable Interventional

The Effects of Ultrasound on Central Nervous System

NCT04192149
View directory record Official record
Conditions
Focused Ultrasound
Interventions
Focused Ultrasound
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 85 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 9, 2019 · Synced Sep 2, 2026, 7:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Studying the Neuronal Basis of Human Social Cognition

NCT05324579
View directory record Official record
Conditions
Neurosciences
Interventions
Behavioral testing during neuronal recordings
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
Boston, Massachusetts • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 2, 2026, 7:03 AM EDT
Enrolling by invitation Not applicable Interventional

Human Thalamus in Propagation of Temporal Lobe Seizures and Memory Formation

NCT07226908
View directory record Official record
Conditions
Epilepsy
Interventions
Cognitive experiment, Electrical stimulation of the brain
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Sep 2, 2026, 7:03 AM EDT
Enrolling by invitation Not applicable Interventional

Intracranial Recordings to Characterize Action Regulation Mechanisms

NCT06671626
View directory record Official record
Conditions
Parkinson Disease
Interventions
Subcortical Stimulation
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Sep 2, 2026, 7:03 AM EDT
Recruiting Not applicable Interventional

Neural Basis of Human Working Memory

NCT07617506
View directory record Official record
Conditions
Memory Disorders
Interventions
Neurocognitive Tasks, Ripple Neuromed Summit System
Behavioral · Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 2, 2026, 7:03 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Human Intracranial Electrophysiology

NCT05529264
View directory record Official record
Conditions
Epilepsy
Interventions
Memory Tasks, Attention/arousal tasks, Language tasks, Visuospatial tasks, Auditory Tasks, Brain Stimulation, Social Emotional Task, Recording of facial expressions, Judgement/Impulsivity Task
Other · Procedure
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2032
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Sep 2, 2026, 7:03 AM EDT
Recruiting No phase listed Observational

Natural History Study of Patients With Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency

NCT03758521
View directory record Official record
Conditions
Succinic Semialdehyde Dehydrogenase Deficiency
Interventions
Transcranial magnetic stimulation (TMS), Magnetic resonance imaging (MRI), Electroencephalogram (EEG), Bio-specimen Collection
Device · Procedure
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Not listed
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 2, 2026, 7:03 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

K08 VR Fear Conditioning

NCT07216222
View directory record Official record
Conditions
Anxiety and Fear, PTSD, Veteran
Interventions
Deep Brain Stimulation
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 70 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 2, 2026, 7:03 AM EDT
Enrolling by invitation Not applicable Interventional

Intracranial EEG to Test How Noninvasive Stimulation Affects Hippocampal-dependent Memory

NCT07397897
View directory record Official record
Conditions
Memory Performance, Hippocampal Network Activity
Interventions
Transcranial magnetic stimulation (TMS)
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 2, 2026, 7:03 AM EDT
Enrolling by invitation Not applicable Interventional

TMS - Intracranial Electrodes

NCT03702127
View directory record Official record
Conditions
Epilepsy Intractable
Interventions
Transcranial magnetic stimulation
Device
Lead sponsor
Aaron Boes
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Sep 2, 2026, 7:03 AM EDT
Not listed No phase listed Observational

Transcranial Magnetic Stimulation to Measure Cortical Excitability in Dravet Syndrome

NCT04614506
View directory record Official record
Conditions
Dravet Syndrome
Interventions
Transcranial Magnetic Stimulation (TMS), Electroencephalogram (EEG)
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
6 Months to 30 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Sep 2, 2026, 7:03 AM EDT