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ClinicalTrials.gov public records Last synced Oct 7, 2026, 2:32 PM EDT

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Showing 97–120 of 171 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Intravenous Ketamine Clear all
Completed No phase listed Observational Results available

Effects of IV Administration of Ketamine on the Analgesia Nociception Index (ANI) Measured With the PhysioDoloris

NCT01717521
View directory record Official record
Conditions
Monitoring, Intraoperative
Interventions
Not listed
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 5, 2019 · Synced Oct 7, 2026, 2:32 PM EDT
Suspended Early Phase 1 Interventional

Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP)

NCT06378528
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Ketamine, SmartSleep EEG recording headband
Drug · Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
15 Years to 17 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 7, 2026, 2:32 PM EDT
Not yet recruiting Phase 2 Interventional

Electrophysiologic Mechanisms of Ketamine Antidepressant Response

NCT07768618
View directory record Official record
Conditions
Epilepsy, Depressive Symptoms
Interventions
Ketamine
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Ketamine for Treatment of MS Fatigue

NCT03500289
View directory record Official record
Conditions
Multiple Sclerosis, Fatigue
Interventions
Ketamine, Midazolam
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 18, 2020 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Phase 1 Interventional

Cognitive Behavioral Therapy in Prolonging the Antidepressant Effects of Intravenous Ketamine

NCT02289248
View directory record Official record
Conditions
Depression
Interventions
Ketamine, Cognitive Behavioral Therapy (CBT)
Drug · Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 1, 2017 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Phase 2 Interventional Results available

Ketamine for Depression and Suicide Risk

NCT02094898
View directory record Official record
Conditions
Depression, Suicide
Interventions
Ketamine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 11, 2017 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Phase 4 Interventional Results available

Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries

NCT03470675
View directory record Official record
Conditions
Pain, Postpartum Depression
Interventions
Epidural saline + IV saline, Epidural morphine 3 mg + IV saline, Epidural morphine 3 mg + IV ketamine 0.3 mg/kg
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 7, 2026, 2:32 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine

NCT05327699
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Ketamine, Placebo
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Phase 2 Interventional Results available

Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSD

NCT04889664
View directory record Official record
Conditions
PTSD
Interventions
Ketamine, Written Exposure Therapy
Drug · Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 70 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Manhattan, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2024 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Phase 3 Interventional Results available

Ketamine to Prevent PPD After Cesarean

NCT04227704
View directory record Official record
Conditions
Postpartum Depression
Interventions
Ketamine 50 MG/ML, Control
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 26, 2023 · Synced Oct 7, 2026, 2:32 PM EDT
Recruiting Phase 2 Interventional

Intravenous Ketamine for Treatment-Resistant Depression

NCT06668571
View directory record Official record
Conditions
Depressive Disorder, Treatment-Resistant, Treatment Resistant Depression (TRD)
Interventions
Ketamine, Normal Saline
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Phase 4 Interventional Results available

Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia

NCT01325493
View directory record Official record
Conditions
Idiopathic Scoliosis, Spondylolisthesis
Interventions
Ketamine, Normal Saline
Drug
Lead sponsor
Julia Finkel
Other
Eligibility
10 Years to 18 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jan 14, 2016 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Low-Dose Ketamine in Children With ADNP Syndrome

NCT04388774
View directory record Official record
Conditions
ADNP Syndrome
Interventions
Ketamine
Drug
Lead sponsor
Alexander Kolevzon
Other
Eligibility
5 Years to 12 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 7, 2023 · Synced Oct 7, 2026, 2:32 PM EDT
Terminated Phase 2 Interventional Results available

Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression

NCT04011592
View directory record Official record
Conditions
Post Partum Depression
Interventions
Ketamine 0.5 mg/kg, Ketamine 0.2 mg/kg
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 19, 2021 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Phase 3 Interventional

Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents

NCT04592809
View directory record Official record
Conditions
Suicide, Attempted, Suicide and Depression, Suicide Threat
Interventions
Ketamine Hydrochloride, Midazolam Hydrochloride
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
13 Years to 18 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 28, 2025 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

The Effects of Sedatives on Tobacco Use Disorder Version 2

NCT05505630
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Ketamine, Midazolam, Dexmedetomidine, Saline
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Not applicable Interventional Results available

Treatment of Suicidal Ideation With Intravenous Ketamine Infusion

NCT01887990
View directory record Official record
Conditions
Depression, Suicidal Ideation
Interventions
Ketamine, placebo
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 15, 2017 · Synced Oct 7, 2026, 2:32 PM EDT
Recruiting Phase 4 Interventional

Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression

NCT05450432
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Ketamine, Esketamine
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 12, 2025 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Phase 4 Interventional

Reducing Pain With Methadone and Ketamine in Liver Transplant

NCT06868589
View directory record Official record
Conditions
Liver Transplantation
Interventions
Methadone, ketamine, Hydromorphone, fentanyl
Drug
Lead sponsor
Lahey Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Burlington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Sub-dissociative Dose Ketamine Dosing Study

NCT03714620
View directory record Official record
Conditions
Acute Pain
Interventions
Ketamine
Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years to 59 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 9, 2022 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Early Phase 1 Interventional

Ketamine for MS Fatigue

NCT06064162
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
ketamine
Drug
Lead sponsor
Alta Bates Summit Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2025 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Phase 2 Interventional

FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression

NCT06620042
View directory record Official record
Conditions
Bipolar Depression, Treatment Resistant Bipolar Depression
Interventions
Ketamine, Functional magnetic resonance imaging (fMRI)
Drug · Other
Lead sponsor
Brian Barnett
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Cleveland, Ohio • Ohio City, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 7, 2026, 2:32 PM EDT
Completed No phase listed Observational

Endobronchial Ultrasound Guided Transbronchial Needle Aspiration Performed Under General Anesthesia Versus Moderate Sedation

NCT01430962
View directory record Official record
Conditions
Mediastinal Lymphadenopathies, Mediastinal Masses, Hilar Lymphadenopathies
Interventions
Not listed
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2015 · Synced Oct 7, 2026, 2:32 PM EDT
Completed Not applicable Interventional Results available

Effect of Ketamine on Opioid-Induced Hyperalgesia

NCT00833755
View directory record Official record
Conditions
Pain, Chronic Pain, Hyperalgesia
Interventions
Ketamine, Placebos
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 23, 2020 · Synced Oct 7, 2026, 2:32 PM EDT