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Showing 1–24 of 116 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Intravenous Lidocaine Clear all
Terminated Phase 4 Interventional Results available

High Dose IV Lidocaine vs Hydromorphone for Abdominal Pain in the Emergency Department

NCT04398316
View directory record Official record
Conditions
Abdominal Pain, Renal Colic
Interventions
Lidocaine Iv, HYDROmorphone Injection
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years to 64 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 16, 2024 · Synced Sep 15, 2026, 9:01 AM EDT
Recruiting Phase 2 Interventional

Reducing Pain From Wisdom Molar Extractions

NCT05335070
View directory record Official record
Conditions
Acute Pain
Interventions
Temporo-masseteric Nerve Block
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Sep 15, 2026, 9:01 AM EDT
Completed Phase 4 Interventional Results available

Comparison of Two Techniques of IV Lidocaine on Propofol Injection Pain

NCT03057704
View directory record Official record
Conditions
Injections, Intravenous
Interventions
Lidocaine injection flushed, Lidocaine injection tourniquet
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 9, 2018 · Synced Sep 15, 2026, 9:01 AM EDT
Completed Phase 2 Interventional Results available

Lidocaine Patches Prior to Intravenous Insertion

NCT00552695
View directory record Official record
Conditions
Need for Intravenous Catheter
Interventions
Lidocaine tetracaine, Placebo
Device
Lead sponsor
Stony Brook University
Other
Eligibility
3 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Oct 21, 2012 · Synced Sep 15, 2026, 9:01 AM EDT
Terminated Early Phase 1 Interventional

PVB vs Ketamine/Lidocaine in Rib Fracture Patients

NCT04413799
View directory record Official record
Conditions
Rib Fractures, Rib Trauma, Rib Fracture Multiple, Pain, Acute
Interventions
lidocaine, ketamine intravenous infusion, paravertebral block with ropivicaine
Combination Product · Drug
Lead sponsor
George Washington University
Other
Eligibility
18 Years to 80 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 21, 2025 · Synced Sep 15, 2026, 9:01 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

NCT04814433
View directory record Official record
Conditions
Opioid Pain Medication
Interventions
Tranexamic acid, Aminocaproic acid, Recombinant Human Thrombin, Lidocaine Hydrochloride with Epinephrine, Bupivacaine Hydrochloride with Epinephrine
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 99 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 25, 2024 · Synced Sep 15, 2026, 9:01 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pharmacologic MRI in Cocaine Addiction

NCT01652378
View directory record Official record
Conditions
Cocaine Dependence
Interventions
ondansetron, lidocaine
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 64 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 8, 2019 · Synced Sep 15, 2026, 9:01 AM EDT
Withdrawn Phase 2 Interventional

Effect of Perioperative Intravenous Lidocaine on Postoperative Quality of Recovery in Patients Undergoing Spine Surgery

NCT01930877
View directory record Official record
Conditions
Pain
Interventions
Lidocaine, Placebo (normal saline)
Drug · Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 30, 2015 · Synced Sep 15, 2026, 9:01 AM EDT
Terminated Phase 4 Interventional Results available

Continuous Nerve Block Block vs Combination of Single Block Plus Intravenous Lidocaine for Postoperative Pain.

NCT04208516
View directory record Official record
Conditions
Postoperative Pain
Interventions
Continuous Erector Spinae Plane Nerve Block, Continuous Quadratus Lumborum Nerve Block, Single Erector Spinae Plane Nerve Block, Single Quadratus Lumborum Nerve Block, Lidocaine IV, Ropivacaine 0.5% Injectable Solution, Dexamethasone, Dexmedetomidine, Lidocaine
Procedure · Drug
Lead sponsor
Jeremy Kearns
Other
Eligibility
18 Years to 90 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 12, 2023 · Synced Sep 15, 2026, 9:01 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Pain Control in Colorectal Surgery: Liposomal Bupivacaine Block Versus Intravenous Lidociane

NCT04005859
View directory record Official record
Conditions
Colorectal Disorders
Interventions
Exparel, IV Lidocaine
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 75 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 8, 2022 · Synced Sep 15, 2026, 9:01 AM EDT
Suspended Not applicable Interventional

Insulin Sensitivity in Men With the Metabolic Syndrome

NCT00433173
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
intravenous glucose tolerance test, testosterone, anastrozole, goserelin acetate implant, aerobic capacity (VO2 Max), MRI, muscle biopsy, measurement of resting metabolic rate (energy expenditure), Dual energy x-ray absorptiometry, Fasting oral glucose tolerance test
Procedure · Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
50 Years to 75 Years · Male only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
2
States / cities
Baltimore, Maryland • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 1, 2010 · Synced Sep 15, 2026, 9:01 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

PROPER Trial of Pain and Inflammation After Knee Arthroscopy

NCT05149287
View directory record Official record
Conditions
Meniscus Tear, Meniscus Lesion, Cartilage Injury
Interventions
Ceftriaxone, Placebo
Drug · Other
Lead sponsor
Austin V Stone
Other
Eligibility
18 Years to 55 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 4, 2023 · Synced Sep 15, 2026, 9:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Intravenous Lidocaine on Normal Sensation and Pain in Healthy Volunteers

NCT00657358
View directory record Official record
Conditions
Pain
Interventions
Lidocaine
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 16, 2017 · Synced Sep 15, 2026, 9:01 AM EDT
Active, not recruiting Early Phase 1 Interventional

Hematoma Block Versus Bier Block for Closed Fracture Reduction

NCT05086224
View directory record Official record
Conditions
Distal Radius Fractures
Interventions
Hematoma Local Anesthetic Block Procedure with 1% Lidocaine, Bier Anesthetic Block Procedure with 1% Lidocaine
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 80 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 15, 2026, 9:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Jet Lidocaine for Pain Relief During Needle Insertion in a Pediatric Emergency Department

NCT00681902
View directory record Official record
Conditions
Pain
Interventions
Lidocaine, Placebo
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
5 Years to 19 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 5, 2009 · Synced Sep 15, 2026, 9:01 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of Second Esmarch Application on Intravenous Regional Anesthesia Effectiveness

NCT03702387
View directory record Official record
Conditions
Hand Injuries and Disorders, Anesthesia, Local, Upper Extremity Injury
Interventions
standard intravenous regional anesthesia (IVRA) with reapplication of esmach
Procedure
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 100 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Sep 15, 2026, 9:01 AM EDT
Not listed Phase 4 Interventional

Pain Relief After Hiatal Hernia Repair Surgery

NCT04936711
View directory record Official record
Conditions
Shoulder Pain, Hiatal Hernia
Interventions
Resteck Shiatsu Neck and Back Massager, Marcaine
Device · Drug
Lead sponsor
Norton Thoracic Institute
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 22, 2021 · Synced Sep 15, 2026, 9:01 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Intralipid® 20% for Reversal of Local Anesthetics

NCT03968822
View directory record Official record
Conditions
Anesthesia, Local
Interventions
Lidocaine 2%, Lidocaine 1%, Bupivacaine 0.25%, Bupivacaine 0.5%, Intralipid, 20% Intravenous, Saline intravenously, Saline
Drug · Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 7, 2025 · Synced Sep 15, 2026, 9:01 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Neural Correlates of Lidocaine Analgesia

NCT05501600
View directory record Official record
Conditions
Anesthesia, Pain
Interventions
Peripheral Nerve Stimulation, Lidocaine IV
Device · Drug
Lead sponsor
Keith M Vogt
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 23, 2024 · Synced Sep 15, 2026, 9:01 AM EDT
Completed Not applicable Interventional

Anesthetics in Rhytidoplasty - A Comparison Study

NCT02410460
View directory record Official record
Conditions
Rhytidoplasty
Interventions
clonidine, glycopyrrolate, propofol, ketamine, marcaine, scopolamine, midazolam, ondansetron, metoclopramide, lidocaine, famotidine, desflurane, sevoflurane
Drug · Device
Lead sponsor
Mercy Facial Plastic Surgery Center
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Sep 15, 2026, 9:01 AM EDT
Withdrawn Phase 4 Interventional

Lidocaine Infusions for Rib Fractures

NCT03571919
View directory record Official record
Conditions
Rib Fracture Multiple, Trauma Chest, Pain, Acute
Interventions
Lidocaine infusion, Saline infusion
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jun 27, 2021 · Synced Sep 15, 2026, 9:01 AM EDT
Completed Not applicable Interventional Results available

Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair

NCT01500109
View directory record Official record
Conditions
Cleft Palate
Interventions
Oral acetaminophen, Ofirmev®, Opioid only
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
5 Months to 5 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2021 · Synced Sep 15, 2026, 9:01 AM EDT
Terminated Not applicable Interventional

Determining if the Buzzy® Personal Pain Relief Device Reduces Injection Pain of Propofol as Much as Intravenous Lidocaine in Children

NCT07770581
View directory record Official record
Conditions
Propofol Injection Pain in Children
Interventions
Buzzy device, Intravenous lidocaine
Device · Drug
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
12 Years to 17 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 15, 2026, 9:01 AM EDT
Terminated Phase 1Phase 2 Interventional

Effect of Intravenous Lidocaine, Used to Attenuate Pain With Propofol Injection, on Defibrillation Threshold Testing

NCT03117166
View directory record Official record
Conditions
Pain
Interventions
lidocaine, Placebo
Drug
Lead sponsor
Drexel University College of Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 8, 2017 · Synced Sep 15, 2026, 9:01 AM EDT