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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Invasive mechanical ventilation Clear all
Not listed Not applicable Interventional

The Frequency of Screening and SBT Technique Trial: The FAST Trial

NCT02969226
View directory record Official record
Conditions
Critically Ill
Interventions
Once daily screening, Twice daily screening, PS SBTs, T-piece SBTs
Procedure
Lead sponsor
Unity Health Toronto
Other
Eligibility
16 Years and older
Enrollment
760 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
5
States / cities
Long Beach, California • Los Angeles, California • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2018 · Synced Sep 20, 2026, 7:58 PM EDT
Completed No phase listed Observational

Innovative Approaches to Assessment of Pain Control and Sedation in the NICU

NCT03057782
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Waveguard (TM) EEG cap, Micro Movement Sensor, Pico Movement Sensor, QS Piezostimulator, tactileTM sensory evaluator
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
1 Hour to 6 Months
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Sep 20, 2026, 7:58 PM EDT
Recruiting Not applicable Interventional

Non-Invasive Ventilation Versus Neurally-Adjusted Ventilatory Assistance (NAVA) for the Treatment of Bronchiolitis

NCT06053684
View directory record Official record
Conditions
Bronchiolitis
Interventions
Standard Non-Invasive Mechanical Servo Ventilation, Neurally-Adjusted Ventilatory Assistance (NAVA) Non-Invasive Mechanical Servo Ventilation
Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
0 Years to 2 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Sep 20, 2026, 7:58 PM EDT
Recruiting Not applicable Interventional

Macrophage Programing in Acute Lung Injury: MiniBAL

NCT05767671
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Ventilator Associated Pneumonia
Interventions
Non-Bronchoscopic Mini Bronchoalveolar Lavage
Other
Lead sponsor
William Janssen, MD
Other
Eligibility
18 Years to 99 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 20, 2026, 7:58 PM EDT
Recruiting Not applicable Interventional

Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy

NCT05350332
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Negative Pressure Ventilator, Pulmonary Function Testing (PFT), Transcutaneous Phrenic Nerve Stimulation, Percutaneous Phrenic Nerve Stimulation
Device
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 20, 2026, 7:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ventilatory Strategy for the Prevention of Atelectasis During Bronchoscopy Under General Anesthesia, VESPA Trial

NCT04311723
View directory record Official record
Conditions
Lung Disorder
Interventions
Anesthesia Procedure, Bronchoscopy
Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 21, 2024 · Synced Sep 20, 2026, 7:58 PM EDT
Not listed Not applicable Interventional

Frequency of Screening and SBT Technique Trial

NCT02399267
View directory record Official record
Conditions
Critically Ill
Interventions
Once daily screening, Twice daily screening, PS SBTs, T-piece SBTs
Procedure
Lead sponsor
Unity Health Toronto
Other
Eligibility
16 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
2
States / cities
Long Beach, California • Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 3, 2019 · Synced Sep 20, 2026, 7:58 PM EDT
Terminated Phase 1 Interventional

A Clinical Safety Study on AT-100 in Treating Adults With Severe COVID-19 Infection or Severed Community Acquired Pneumonia

NCT04659122
View directory record Official record
Conditions
COVID-19, Undefined
Interventions
AT-100
Biological
Lead sponsor
Airway Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Sep 20, 2026, 7:58 PM EDT
Active, not recruiting No phase listed Observational

Assessment of PaO2/FiO2 Ratio Pre and POst INTubation

NCT05853068
View directory record Official record
Conditions
Acute Hypoxemic Respiratory Failure
Interventions
Mechanical ventilation
Device
Lead sponsor
Hospital Universitario de Gran Canaria Doctor Negrín
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 25, 2025 · Synced Sep 20, 2026, 7:58 PM EDT
Withdrawn Not applicable Interventional

Early Extubation for Patients With Acute Hypoxemic Respiratory Failure

NCT04349332
View directory record Official record
Conditions
Mechanical Ventilation, Corona Virus Infection
Interventions
Helmet non-invasive ventilation (NIV)
Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 1, 2024 · Synced Sep 20, 2026, 7:58 PM EDT
Recruiting Not applicable Interventional

COMPARE-VENT Feasibility Pilot Study

NCT07656259
View directory record Official record
Conditions
Respiration Failure, Cardio Vascular Disease, Cardiogenic Pulmonary Oedema, Critical Illness, Mechanical Ventilation, Cardiogenic Shock, Cardiopulmonary
Interventions
Volume Controlled Mode, Pressure Controlled Mode
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 9, 2026 · Synced Sep 20, 2026, 7:58 PM EDT
Completed Not applicable Interventional Results available

Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress Syndrome

NCT02582957
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome
Interventions
Sigh breaths
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 89 Years
Enrollment
524 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
15
States / cities
Fresno, California • Los Angeles, California • Sacramento, California + 12 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2024 · Synced Sep 20, 2026, 7:58 PM EDT
Not yet recruiting Not applicable Interventional

WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department

NCT07558265
View directory record Official record
Conditions
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
Interventions
Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
2
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 20, 2026, 7:58 PM EDT
Withdrawn Phase 3 Interventional

Aralast NP With Antiviral Treatment and Standard of Care Versus Antiviral Treatment With Standard of Care in Hospitalized Patients With Pneumonia and COVID-19 Infection

NCT04675086
View directory record Official record
Conditions
Covid19, Pneumonia, Viral
Interventions
alpha1-proteinase inhibitor, Antiviral Agents
Drug
Lead sponsor
Blessing Corporate Services, Inc
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Hannibal, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 20, 2020 · Synced Sep 20, 2026, 7:58 PM EDT
Recruiting Not applicable Interventional

Telehealth-Enabled, Real-time Audit and Feedback for Clinician AdHerence (TEACH)

NCT05141396
View directory record Official record
Conditions
Respiration, Artificial
Interventions
Telehealth- enabled support for SAT/SBT adherence, Usual audit and feedback for SAT/SBT adherence
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
16 Years and older
Enrollment
13,400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
11
States / cities
American Fork, Utah • Cedar City, Utah • Layton, Utah + 8 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Sep 20, 2026, 7:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of PEEP on TRJV in Mechanically Intubated Pediatric Patients

NCT06229886
View directory record Official record
Conditions
Tricuspid Regurgitation, Mechanical Ventilation Pressure High, Pediatric Respiratory Diseases
Interventions
Application of positive-end-expiratory pressure
Other
Lead sponsor
Northwell Health
Other
Eligibility
3 Months to 18 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
New Hyde Park, New York
Source: ClinicalTrials.gov public record
Updated Sep 25, 2024 · Synced Sep 20, 2026, 7:58 PM EDT
Completed No phase listed Observational

Respiratory Supports and COVID-19 Mortality

NCT04832061
View directory record Official record
Conditions
COVID-19
Interventions
Respiratory supports
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
2,300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 12, 2021 · Synced Sep 20, 2026, 7:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

MusculRA: The Effects of Rheumatoid Arthritis on Skeletal Muscle Biomechanics

NCT04226131
View directory record Official record
Conditions
Rheumatoid Arthritis, Healthy Controls
Interventions
Blood Draw, Disease Activity (DAS-28) Assessment, Skeletal Muscle Mitochondrial Respiratory Capacity, Muscle Biopsy, Body Composition, Cardiopulmonary Exercise Test (CPET), Strength Testing, Questionnaires, Skeletal Muscle Biomechanical Property Assessment
Other
Lead sponsor
Duke University
Other
Eligibility
25 Years to 75 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 12, 2023 · Synced Sep 20, 2026, 7:58 PM EDT
Recruiting No phase listed Observational

Lung Function Monitoring During Hypoxemia Episodes

NCT06535074
View directory record Official record
Conditions
Hypoxemia of Newborn
Interventions
Detecting changes in lung volume with hypoxemia episodes
Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
Not listed
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 20, 2026, 7:58 PM EDT
Completed Not applicable Interventional Results available

Non-Invasive Ventilation Via a Helmet Device for Patients Respiratory Failure

NCT01680783
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Shock, Ventilatory Failure, Cardiogenic Pulmonary Edema
Interventions
Non invasive ventilation using a helmet hyperbaric device, Noninvasive ventilation via facemask
Device · Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 100 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Sep 20, 2026, 7:58 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Software Enhancements to the Respironics BiPAP autoSV Device Compared to BiPAP S/T Device

NCT01241604
View directory record Official record
Conditions
Sleep Disordered Breathing
Interventions
BiPAP S/T, BiPAP Auto SV3
Device
Lead sponsor
Philips Respironics
Industry
Eligibility
21 Years to 80 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 8, 2019 · Synced Sep 20, 2026, 7:58 PM EDT
Completed Not applicable Interventional

Impact of Nebulized Dornase Alpha on Mechanically Ventilated Patients

NCT01095276
View directory record Official record
Conditions
Atelectasis, Ventilation, Mechanical
Interventions
Pulmozyme (nebulized dornase alpha), Saline
Drug
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 29, 2010 · Synced Sep 20, 2026, 7:58 PM EDT
Recruiting Phase 4 Interventional

International Care Bundle Evaluation in Cerebral Hemorrhage Research

NCT06429332
View directory record Official record
Conditions
Intracerebral Hemorrhage, Intracerebral Haemorrhage, Intraventricular Hemorrhage, Stroke, Cerebrovascular Disease
Interventions
Reversal of Oral anticoagulation within 30 minutes, Early intensive blood pressure lowering, Treatment of pyrexia, Hyperglycemia treatment, Do-not-resuscitate (DNR) or withdrawal of care, Referral to Intensive Care, Referral to Neurosurgery, Repeat brain imaging, Standard care
Other · Diagnostic Test
Lead sponsor
Region Skane
Other
Eligibility
18 Years and older
Enrollment
3,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 20, 2026, 7:58 PM EDT
Completed No phase listed Observational

Imputation of PaO2 From SaO2

NCT02598492
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
arterial blood gas
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
646 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 7, 2022 · Synced Sep 20, 2026, 7:58 PM EDT