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ClinicalTrials.gov public records Last synced Oct 9, 2026, 2:24 AM EDT

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Showing 73–96 of 134 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Investigational contact lens Clear all
Completed Not applicable Interventional Results available

Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Multifocal Toric Contact Lenses

NCT06461455
View directory record Official record
Conditions
Presbyopia, Astigmatism
Interventions
Lehfilcon A multifocal for astigmatism contact lenses, Samfilcon A multifocal for astigmatism contact lenses, CLEAR CARE® Cleaning & Disinfecting Solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
11
States / cities
Oakland, California • San Francisco, California • Maitland, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

Clinical Comparison of DDT2 Contact Lens and a Daily Disposable Contact Lens - Study 2

NCT03888482
View directory record Official record
Conditions
Refractive Error, Myopia
Interventions
Verofilcon A contact lenses, Somofilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
8
States / cities
Jacksonville, Florida • Maitland, Florida • Orlando, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Visual Performance of Senofilcon A With and Without a New UV/HEV-filter

NCT05021081
View directory record Official record
Conditions
Visual Performance
Interventions
TRP-200, ACUVUE Oasys 1-Day
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 26, 2023 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Initial Evaluation of Investigational Lenses Manufactured on a New Production Line

NCT03679741
View directory record Official record
Conditions
Visual Acuity
Interventions
CONTROL Lens, TEST Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 49 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
6
States / cities
San Francisco, California • Jacksonville, Florida • Vestal, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Dec 26, 2019 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Two Daily Disposable Contact Lenses.

NCT01300065
View directory record Official record
Conditions
Myopia
Interventions
Experimental- Soflens, Marketed - Soflens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
15 Years to 40 Years
Enrollment
441 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 6, 2020 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

Effect of FID 114675A on Lens Wettability

NCT01342107
View directory record Official record
Conditions
Contact Lens Wettability
Interventions
FID 114675A multi-purpose disinfecting solution (MPDS), Soft contact lens, Blister pack solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 13, 2012 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of the Feasibility a New Silicone Hydrogel Contact Lens

NCT01309906
View directory record Official record
Conditions
Myopia
Interventions
Investigational lens, Air Optix Aqua lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 22, 2020 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

Effect of an Investigational Multi-Purpose Solution on Lens Moisture

NCT01341990
View directory record Official record
Conditions
Contact Lens Moisture
Interventions
FID 114675A Multi-Purpose Disinfecting Solution (MPDS), ReNu Fresh Lens Comfort Multi-Purpose Solution (MPS), Silicone Hydrogel Contact Lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 13, 2012 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

A Bilateral Dispensing Clinical Trial of an Sapphire Lens Against Senofilcon A Toric for Astigmatism Lens

NCT02555098
View directory record Official record
Conditions
Astigmatism
Interventions
Sapphire contact lenses, senofilcon A contact lenses
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Campbell, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Clinical Investigation of Visual Acuity in Contact Lens Wearers After Instillation of Investigational Lubricating Eye Drops

NCT05814367
View directory record Official record
Conditions
Visual Acuity
Interventions
Blink® Tears eye drops in a multidose bottle, Preservative-free investigational lubricating eye drops in a Novelia® eyedropper
Drug
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 69 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
3
States / cities
Jacksonville, Florida • Maitland, Florida • Tyler, Texas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a Johnson & Johnson Vision Care Investigational Contact Lens Compared to a Marketed Monthly Replacement Contact Lens

NCT02515994
View directory record Official record
Conditions
Refractive Error
Interventions
senofilcon C, comfilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
224 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
10
States / cities
Jacksonville, Florida • Longwood, Florida • Bloomington, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Jul 15, 2016 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

Feasibility of a New Silicone Hydrogel Lens

NCT01131130
View directory record Official record
Conditions
Myopia
Interventions
Investigational contact lens, Acuvue Oasys Contact Lens, Air Optix Aqua
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 30, 2014 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

Vistakon Investigational Lens Worn as a Single Use Daily Wear

NCT01031004
View directory record Official record
Conditions
Myopia
Interventions
narafilcon B, etafilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
3
States / cities
Salt Lake City, Utah • Virginia Beach, Virginia • Laramie, Wyoming
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

A Study to Evaluate a Modified Contact Lens

NCT01391364
View directory record Official record
Conditions
Myopia
Interventions
SofLens in investigational solution, SofLens in currently marketed solution
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years to 40 Years
Enrollment
438 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effectiveness of Orthokeratology in Myopia Control

NCT03465748
View directory record Official record
Conditions
Myopia
Interventions
OrthoK
Device
Lead sponsor
Illinois College of Optometry
Other
Eligibility
6 Years to 13 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Daily Disposable Etafilcon A Cosmetic Contact Lenses

NCT04529109
View directory record Official record
Conditions
Visual Acuity
Interventions
etafilcon A investigational cosmetic lens 1, etafilcon A investigational cosmetic lens 2
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 29 Years · Female only
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
2
States / cities
Jacksonville, Florida • Tyler, Texas
Source: ClinicalTrials.gov public record
Updated Nov 24, 2021 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

Clinical Performance of a Silicone Hydrogel Contact Lens Following Six Nights of Extended Wear

NCT03614130
View directory record Official record
Conditions
Refractive Errors
Interventions
LID011121 contact lens, Comfilcon A contact lens
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
2
States / cities
Johns Creek, Georgia • Brentwood, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 30, 2021 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

A Study to Evaluate the Product Performance of a Low Add MultiFocal Soft Contact Lens

NCT01539694
View directory record Official record
Conditions
Presbyopia
Interventions
LD118033 contact lens, PureVision multifocal contact lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

Clinical Assessment of Two Daily Wear Monthly Replacement Soft Silicone Hydrogel Contact Lenses

NCT04980456
View directory record Official record
Conditions
Myopia
Interventions
Lehfilcon A contact lenses, Comfilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
257 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
14
States / cities
Los Angeles, California • Oakland, California • San Francisco, California + 11 more
Source: ClinicalTrials.gov public record
Updated Jan 6, 2023 · Synced Oct 9, 2026, 2:24 AM EDT
Recruiting No phase listed Observational

Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy

NCT04310241
View directory record Official record
Conditions
Amblyopia, Strabismus
Interventions
Patching therapy, Glasses
Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
6 Months to 90 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

Assessing the Clinical Performance of Two Frequent Replacement Silicone Hydrogel Multifocal Toric Contact Lenses

NCT05886907
View directory record Official record
Conditions
Refractive Errors, Presbyopia, Astigmatism
Interventions
Lehfilcon A multifocal toric contact lenses, Samfilcon A multifocal toric contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 31, 2024 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

Vistakon Investigational Contact Lenses Worn for Daily Wear

NCT00717249
View directory record Official record
Conditions
Myopia
Interventions
galyifilcon A control lens, galyfilcon A with a silver additive
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
529 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
20
States / cities
Fresno, California • Mission Viejo, California • Louisville, Colorado + 17 more
Source: ClinicalTrials.gov public record
Updated May 26, 2016 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a Daily Disposable Novel Multifocal Contact Lens in a Myopic Population; Part 2

NCT04615507
View directory record Official record
Conditions
Visual Acuity
Interventions
JJVC Investigational Multifocal Contact Lens, Dailies Total 1® Multifocal Contact Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
6
States / cities
Jacksonville, Florida • Roswell, Georgia • Raytown, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2022 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Daily Disposable Toric Soft Lenses Manufactured With an Alternative Hydration Process

NCT06967129
View directory record Official record
Conditions
Astigmatism
Interventions
Investigational daily disposable, soft, toric lenses manufactured on 4th Generation Technology (4GT) lines with extended mini-stack hydration using propylene glycol (PG) as the hydration solvent., ACUVUE® Oasys 1-Day for Astigmatism (AO1DfA) soft contact lenses manufactured on 3rd Generation Technology (3GT) legacy lines using isopropyl alcohol (IPA) as the hydration solvent.
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
281 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
20
States / cities
Mission Viejo, California • San Diego, California • Jacksonville, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 9, 2026, 2:24 AM EDT