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ClinicalTrials.gov public records Last synced Oct 5, 2026, 2:28 PM EDT

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Showing 73–96 of 169 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Investigational lens Clear all
Active, not recruiting Not applicable Interventional

Acuity 200™ (Fluoroxyfocon A) Orthokeratology Contact Lens for Overnight Wear

NCT06009458
View directory record Official record
Conditions
Myopia
Interventions
Acuity 200™ (fluoroxyfocon A) Orthokeratology Contact Lens for Overnight Wear
Device
Lead sponsor
Acuity Polymers, Inc.
Industry
Eligibility
7 Years and older
Enrollment
387 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
9
States / cities
Mission Viejo, California • Oakland, California • San Francisco, California + 6 more
Source: ClinicalTrials.gov public record
Updated Jan 14, 2025 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Investigational (Frequent Replacement) FRP Lens for Daily Wear

NCT02362724
View directory record Official record
Conditions
Ametropia
Interventions
Sapphire, Pearl
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
6
States / cities
San Diego, California • Torrance, California • Denver, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2020 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Design Validation of Senofilcon A With New UV-blocking Additive

NCT03707821
View directory record Official record
Conditions
Visual Acuity
Interventions
senofilcon A TEST Lens, senofilcon A CONTROL Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 49 Years
Enrollment
253 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
10
States / cities
Cupertino, California • Maitland, Florida • Tallahassee, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2019 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of a Manufacturing Process for a Frequent Replacement Silicone Hydrogel Multifocal Contact Lens

NCT05765227
View directory record Official record
Conditions
Refractive Ametropia
Interventions
Lehfilcon A multifocal contact lenses, Lotrafilcon B multifocal contact lenses, Hydrogen peroxide-based cleaning and disinfection system
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 16, 2024 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

RxSight Light Adjustable Lens and Light Delivery Device New Enrollment Study

NCT05202808
View directory record Official record
Conditions
Aphakia, Cataract
Interventions
Light Adjustable lens (LAL) and Light Delivery Device (LDD), Control IOL
Device
Lead sponsor
RxSight, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
14
States / cities
Fayetteville, Arkansas • Chico, California • Largo, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2025 · Synced Oct 5, 2026, 2:28 PM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Aftobetin-HCl and Fluorescence Detection Measured by Sapphire II to Determine the Number and Timing of Administrations

NCT02928211
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Sapphire II, Aftobetin-HCl, Positron Emission Tomography
Device · Drug · Radiation
Lead sponsor
Cognoptix, Inc.
Industry
Eligibility
25 Years to 90 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Aug 22, 2018 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a Daily Disposable Novel Multifocal Contact Lens in a Hyperopic Population

NCT04567186
View directory record Official record
Conditions
Visual Acuity
Interventions
Investigational senofilcon A C3 Multifocal Lens, delefilcon A Multifocal Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
7
States / cities
Bakersfield, California • Mission Viejo, California • Jacksonville, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 21, 2022 · Synced Oct 5, 2026, 2:28 PM EDT
Completed No phase listed Interventional Accepts healthy volunteers Results available

Clinical Evaluation of an Investigational Lipid Drop in Non-contact Lens Wearing Patients

NCT03995355
View directory record Official record
Conditions
Visual Acuity
Interventions
9618X investigational lipid eye drops, Blink® Tears
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 69 Years
Enrollment
161 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Amarillo, Texas
Source: ClinicalTrials.gov public record
Updated Jul 3, 2023 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Central Corneal Swelling With Silicone Hydrogel Materials

NCT02328937
View directory record Official record
Conditions
Corneal Swelling
Interventions
etafilcon A, lotrafilcon B, comfilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Product Feasibility of a New Silicone Hydrogel Contact Lens

NCT01309100
View directory record Official record
Conditions
Myopia
Interventions
Investigational Lens, Acuvue Oasys Lens, Air Optix Aqua Lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 29, 2014 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Evaluate a New Silicone Hydrogel Contact Lens

NCT01309893
View directory record Official record
Conditions
Myopia
Interventions
Investigational Lens, Air Optix Aqua lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Nov 24, 2014 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Long-Term Evaluation of Approved and Investigational Contact Lenses

NCT02625233
View directory record Official record
Conditions
Visual Disorders
Interventions
senofilcon C, comfilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
6
States / cities
Jacksonville, Florida • Longwood, Florida • Bloomington, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2017 · Synced Oct 5, 2026, 2:28 PM EDT
Recruiting Not applicable Interventional

Development of Optical Biometer

NCT07325162
View directory record Official record
Conditions
Cataract and IOL Surgery
Interventions
New Investigational Optical Biometer (Device), Comparator Device A (Cassini Ambient), omparator Device B (Argos)
Device
Lead sponsor
Cassini Technologies
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Hilton Head Island, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

Ocular Comfort and OCT Observation of Post Lens Clearance and Ocular Tissue Compression

NCT01423773
View directory record Official record
Conditions
Ocular Comfort
Interventions
Lotrafilcon A test contact lens, Lotrafilcon A control contact lens, Ultra-High Resolution Optical Coherence Tomographer (OCT)
Device
Lead sponsor
CIBA VISION
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 28, 2013 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

A Study to Evaluate the Product Performance of a Low Add MultiFocal Soft Contact Lens

NCT01539694
View directory record Official record
Conditions
Presbyopia
Interventions
LD118033 contact lens, PureVision multifocal contact lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Short-Term Evaluation of Corneal Staining With Balafilcon A Lenses and Two Multi-Purpose Solutions

NCT01240122
View directory record Official record
Conditions
Corneal Staining
Interventions
Biotrue MPS, Investigational MPS
Device
Lead sponsor
Abbott Medical Optics
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Santa Ana, California
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Contact Lenses With New UV-blocker Manufactured With Different Techniques

NCT03475875
View directory record Official record
Conditions
Correction of Refraction Error, Attenuation of Bright Light
Interventions
senofilcon A TEST Lens, senofilcon A CONTROL Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
5
States / cities
Foster City, California • Jacksonville, Florida • Pickens, South Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2019 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Fitting Investigational Contact Lenses

NCT03150485
View directory record Official record
Conditions
Visual Acuity
Interventions
JJVC Fitting Guides
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 29, 2018 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of the Clinical Performance of Daily Disposable Silicone Hydrogel Multifocal Toric Contact Lenses

NCT06377488
View directory record Official record
Conditions
Visual Acuity
Interventions
JJVC Investigational Multifocal Toric Contact Lens manufactured in Senofilcon A (C3) material with UV blocker / HEV filter
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
176 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
15
States / cities
Jacksonville, Florida • Longwood, Florida • Maitland, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

A Study to Evaluate a Modified Contact Lens

NCT01391364
View directory record Official record
Conditions
Myopia
Interventions
SofLens in investigational solution, SofLens in currently marketed solution
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years to 40 Years
Enrollment
438 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

EYEFILL® C. -US Viscoelastic Clinical Investigation

NCT02024711
View directory record Official record
Conditions
Cataract
Interventions
EYEFILL® C.-US Viscoelastic, Healon® Viscoelastic (CONTROL)
Device
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
22 Years and older
Enrollment
262 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
8
States / cities
Phoenix, Arizona • Redding, California • Cape Coral, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2020 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

Clinical Performance of a Silicone Hydrogel Contact Lens Following Six Nights of Extended Wear

NCT03614130
View directory record Official record
Conditions
Refractive Errors
Interventions
LID011121 contact lens, Comfilcon A contact lens
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
2
States / cities
Johns Creek, Georgia • Brentwood, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 30, 2021 · Synced Oct 5, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

Clinical Performance of a Monthly Replacement Silicone Hydrogel Lens

NCT03586167
View directory record Official record
Conditions
Refractive Errors
Interventions
LID014341 contact lenses, Comfilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
4
States / cities
Maitland, Florida • Johns Creek, Georgia • Bloomington, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Oct 5, 2026, 2:28 PM EDT
Terminated Not applicable Interventional Results available

The Effect of Low-Level Laser Stimulation on Hearing Thresholds

NCT01820416
View directory record Official record
Conditions
Hearing Loss
Interventions
Low-level Laser Therapy, Placebo Comparator: Disabled Laser
Radiation · Other
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 75 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 1, 2017 · Synced Oct 5, 2026, 2:28 PM EDT