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ClinicalTrials.gov public records Last synced Oct 10, 2026, 11:02 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 121–144 of 169 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Investigational lens Clear all
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Etafilcon A Contact Lenses Using a Novel Molding Process

NCT03605303
View directory record Official record
Conditions
Refractive Error Correction
Interventions
Test/Control, Control/Test
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Results available

Vistakon Investigational Contact Lenses Worn for Daily Wear

NCT00717249
View directory record Official record
Conditions
Myopia
Interventions
galyifilcon A control lens, galyfilcon A with a silver additive
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
529 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
20
States / cities
Fresno, California • Mission Viejo, California • Louisville, Colorado + 17 more
Source: ClinicalTrials.gov public record
Updated May 26, 2016 · Synced Oct 10, 2026, 11:02 PM EDT
Terminated No phase listed Interventional Results available

A Clinical Study to Evaluate The Safety and Effectiveness of The RxSight Light Adjustable Lens (LAL) In Subjects Desiring an Extended Depth of Focus

NCT04177771
View directory record Official record
Conditions
Aphakia, Cataract, Presbyopia
Interventions
Light Adjustable lens (LAL) and Light Delivery Device (LDD) - Pre-COVID Population, SofPort LI61AO IOL, Tecnis ZCB00 or ZTC150 IOL
Device
Lead sponsor
RxSight, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Fayetteville, Arkansas
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Results available

Vision Performance Evaluation of TECNIS EYHANCE™ With TECNIS SIMPLICITY™ Compared to TECNIS® 1-piece Intraocular Lenses

NCT05025345
View directory record Official record
Conditions
Cataract
Interventions
Tecnis Eyhance, Tecnis 1 piece IOL
Device
Lead sponsor
Johnson & Johnson Surgical Vision, Inc.
Industry
Eligibility
22 Years and older
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
15
States / cities
Bakersfield, California • Long Beach, California • Sarasota, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 28, 2023 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Daily Disposable Etafilcon A Cosmetic Contact Lenses

NCT04529109
View directory record Official record
Conditions
Visual Acuity
Interventions
etafilcon A investigational cosmetic lens 1, etafilcon A investigational cosmetic lens 2
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 29 Years · Female only
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
2
States / cities
Jacksonville, Florida • Tyler, Texas
Source: ClinicalTrials.gov public record
Updated Nov 24, 2021 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Evaluate the Performance of Two Designs of Soft Toric Lenses

NCT01309867
View directory record Official record
Conditions
Myopia
Interventions
Investigational Toric Lens, PureVision Toric Lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
302 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Prototype Lenses With Experimental UV/HEV Blocker

NCT04885296
View directory record Official record
Conditions
Visual Acuity
Interventions
TRP-200, JJVC Marketed Contact Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
228 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
12
States / cities
Jacksonville, Florida • Orange Park, Florida • Tallahassee, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Sep 1, 2022 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Results available

A Study to Evaluate the Product Performance of a Low Add MultiFocal Soft Contact Lens

NCT01539694
View directory record Official record
Conditions
Presbyopia
Interventions
LD118033 contact lens, PureVision multifocal contact lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Results available

Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Multifocal Toric Contact Lenses

NCT06461455
View directory record Official record
Conditions
Presbyopia, Astigmatism
Interventions
Lehfilcon A multifocal for astigmatism contact lenses, Samfilcon A multifocal for astigmatism contact lenses, CLEAR CARE® Cleaning & Disinfecting Solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
11
States / cities
Oakland, California • San Francisco, California • Maitland, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a New Silicone Hydrogel Contact Lens

NCT01309880
View directory record Official record
Conditions
Myopia
Interventions
Test lens, Air Optix Aqua
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2015 · Synced Oct 10, 2026, 11:02 PM EDT
Not yet recruiting Not applicable Interventional

The Emmetropization Via Accommodation (EVA) - II Study

NCT07838597
View directory record Official record
Conditions
Hyperopia, Farsightedness, Hypermetropia
Interventions
Experimental treatment arm
Combination Product
Lead sponsor
Ohio State University
Other
Eligibility
13 Weeks to 19 Weeks
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2032
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 10, 2026, 11:02 PM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Aftobetin-HCl and Fluorescence Detection Measured by Sapphire II to Determine the Number and Timing of Administrations

NCT02928211
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Sapphire II, Aftobetin-HCl, Positron Emission Tomography
Device · Drug · Radiation
Lead sponsor
Cognoptix, Inc.
Industry
Eligibility
25 Years to 90 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Aug 22, 2018 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessment of Three Basic Progressive Lens Designs

NCT05252871
View directory record Official record
Conditions
Presbyopia
Interventions
Progressive Additional Lenses (PAL), pre calibrated and made of polymeric material with anti-reflection coating
Device
Lead sponsor
Western University of Health Sciences
Other
Eligibility
45 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated Aug 15, 2024 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Results available

Effect of FID 114675A on Lens Wettability

NCT01342107
View directory record Official record
Conditions
Contact Lens Wettability
Interventions
FID 114675A multi-purpose disinfecting solution (MPDS), Soft contact lens, Blister pack solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 13, 2012 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety and Efficacy of an Investigational Multi-Purpose Disinfecting Solution

NCT01341977
View directory record Official record
Conditions
Healthy Contact Lens Wearers
Interventions
Alcon MPDS, ReNu Fresh MPS
Device
Lead sponsor
Alcon Research
Industry
Eligibility
Not listed
Enrollment
573 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2020 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Results available

Clinical Performance of a Monthly Replacement Silicone Hydrogel Lens

NCT03586167
View directory record Official record
Conditions
Refractive Errors
Interventions
LID014341 contact lenses, Comfilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
4
States / cities
Maitland, Florida • Johns Creek, Georgia • Bloomington, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Color Correcting Lenses on Color Vision Deficiency

NCT05463016
View directory record Official record
Conditions
Color Blindness, Color Vision Defects, Color Blindness, Green, Color Blindness, Red
Interventions
Experimental Group 1: Color Correcting Lenses, Placebo Group 1: Placebo Lenses, Placebo Group 1 Crosses over to become Experimental Group 2: Color Correcting Lenses, Experimental Group 1 Crosses over to become Placebo Group 2: Placebo Lenses, Color Correcting Lenses in Subjects with Normal Color Vision
Device
Lead sponsor
University of the Incarnate Word
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 3, 2024 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Comparative Evaluation of Corneal Staining With Balafilcon A Lenses and Two Multi-Purpose Solutions

NCT01024855
View directory record Official record
Conditions
Myopia, Hyperopia, Astigmatism
Interventions
RevitaLens OcuTec MPS (Investigational MPS) and Opti-Free RepleniSH MPS (control)
Device
Lead sponsor
Abbott Medical Optics
Industry
Eligibility
18 Years to 99 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Santa Ana, California
Source: ClinicalTrials.gov public record
Updated Oct 20, 2015 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Results available

Pilot Evaluation of a New Galyfilcon A Contact Lens Compared to a Marketed Galyfilcon A Contact Lens

NCT01094730
View directory record Official record
Conditions
Myopia
Interventions
galyfilcon A prototype lens, marketed galyfilcon A lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
9
States / cities
Cupertino, California • Huntington Beach, California • Los Angeles, California + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 10, 2026, 11:02 PM EDT
Recruiting Not applicable Interventional

Comparing Prism Adaptation Training With and Without TENS to Minimize Unilateral Spatial Neglect

NCT07157865
View directory record Official record
Conditions
Unilateral Spatial Neglect, Stroke
Interventions
Prism adaptation training combined with TENS, PAT only
Device · Other
Lead sponsor
Kettering Health Network
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Centerville, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Evaluation of a Monofocal Intraocular Lens

NCT06428955
View directory record Official record
Conditions
Cataract
Interventions
CT LUCIA 621P
Device
Lead sponsor
Carl Zeiss Meditec AG
Industry
Eligibility
50 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
3
States / cities
Indianapolis, Indiana • Lexington, Kentucky • Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a Daily Disposable Silicone Hydrogel Multifocal Contact Lens in Myopes and Hyperopes

NCT05222880
View directory record Official record
Conditions
Visual Acuity
Interventions
JJVC Investigational Multifocal Contact Lenses manufactured in senofilcon A C3
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
12
States / cities
Jacksonville, Florida • Maitland, Florida • Tallahassee, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2023 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a Daily Disposable Novel Multifocal Contact Lens in a Myopic Population

NCT04310566
View directory record Official record
Conditions
Visual Acuity
Interventions
JJVC Investigational Multifocal Contact Lens (senofilcon A c3), Dailies Total 1® Multifocal Contact Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
7
States / cities
Jacksonville, Florida • Maitland, Florida • Pittsburg, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 19, 2022 · Synced Oct 10, 2026, 11:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of the Clinical Performance of Daily Disposable Silicone Hydrogel Multifocal Toric Contact Lenses

NCT06377488
View directory record Official record
Conditions
Visual Acuity
Interventions
JJVC Investigational Multifocal Toric Contact Lens manufactured in Senofilcon A (C3) material with UV blocker / HEV filter
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
176 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
15
States / cities
Jacksonville, Florida • Longwood, Florida • Maitland, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Oct 10, 2026, 11:02 PM EDT