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ClinicalTrials.gov public records Last synced Oct 19, 2026, 1:10 PM EDT

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Showing 1–24 of 99 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Isoflavone Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Isoflavones for Promoting Calcium Absorption and Preventing Bone Loss in Post Menopausal Women

NCT00244907
View directory record Official record
Conditions
Osteoporosis, Osteopenia
Interventions
Genistein vs Risedronate
Dietary Supplement
Lead sponsor
Purdue University
Other
Eligibility
Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated May 4, 2018 · Synced Oct 19, 2026, 1:10 PM EDT
Completed Phase 2 Interventional Results available

Efficacy and Safety of S-equol on Vasomotor Symptoms in Menopausal Patients

NCT00962585
View directory record Official record
Conditions
Menopause
Interventions
Placebo, S-equol
Drug
Lead sponsor
Ausio Pharmaceuticals, LLC
Industry
Eligibility
Female only
Enrollment
169 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
5
States / cities
Louisville, Kentucky • Cincinnati, Ohio • Cleveland, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2014 · Synced Oct 19, 2026, 1:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Soy Nuts and Cardiovascular Risk in Postmenopausal Women

NCT01740076
View directory record Official record
Conditions
Postmenopausal Women
Interventions
soy nuts
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
21 Years and older · Female only
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Oct 19, 2026, 1:10 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis)

NCT00590538
View directory record Official record
Conditions
Cystic Fibrosis
Interventions
Sodium 4-Phenylbutyrate, Genistein (Unconjugated Isoflavones 100), Placebo
Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 30, 2011 · Synced Oct 19, 2026, 1:10 PM EDT
Not listed Phase 1Phase 2 Interventional Accepts healthy volunteers

A Novel Combination Oral Agent to Treat Acne Vulgaris

NCT01301586
View directory record Official record
Conditions
ACNE VULGARIS
Interventions
Doxycycline and S-equol, Doxycycline
Drug
Lead sponsor
Nexgen Dermatologics, Inc.
Industry
Eligibility
13 Years to 60 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
2
States / cities
Rolling Hills Estates, California • Boynton Beach, Florida
Source: ClinicalTrials.gov public record
Updated Feb 23, 2011 · Synced Oct 19, 2026, 1:10 PM EDT
Completed Phase 2 Interventional

Alkontrol-herbal Effects on Alcohol Drinking

NCT03099590
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Use Disorder, Alcohol Abstinence
Interventions
kudzu extract, puerarin, Placebo control
Dietary Supplement
Lead sponsor
Mclean Hospital
Other
Eligibility
21 Years to 60 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 29, 2020 · Synced Oct 19, 2026, 1:10 PM EDT
Completed Not applicable Interventional

Clinical Study Examining Use of an Over-the-Counter Supplement for the Prevention of Menstrually-Associated Migraine Headache

NCT00203255
View directory record Official record
Conditions
Migraine Headache
Interventions
Soy Isoflavones
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
Female only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 23, 2009 · Synced Oct 19, 2026, 1:10 PM EDT
Terminated Phase 2 Interventional Results available

Genistein Supplementation to Mitigate Cardiometabolic Dysfunction in Patients Undergoing Androgen Deprivation Therapy for Prostate Cancer

NCT02766478
View directory record Official record
Conditions
Prostate Cancer
Interventions
Genistein, Placebo
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years and older · Male only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Oct 19, 2026, 1:10 PM EDT
Completed Phase 2 Interventional

Soy Protein Supplement In Treating Hot Flashes in Postmenopausal Women Receiving Tamoxifen for Breast Disease

NCT00031720
View directory record Official record
Conditions
Breast Cancer, Hot Flashes, Hot Flushes
Interventions
soy protein, isoflavones, Tamoxifen, Placebo
Dietary Supplement · Drug · Other
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
18 Years and older · Female only
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2013
U.S. locations
14
States / cities
Rockford, Illinois • Elkhart, Indiana • Kokomo, Indiana + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2016 · Synced Oct 19, 2026, 1:10 PM EDT
Terminated Phase 3 Interventional Results available

Soy Protein/Effexor Hormone Therapy for Prostate Cancer

NCT00354432
View directory record Official record
Conditions
Hot Flashes, Prostate Cancer
Interventions
oral soy protein/isoflavones powder, Venlafaxine, Placebo Powder, Placebo Pill
Dietary Supplement · Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older · Male only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
20
States / cities
Newark, Delaware • Chicago, Illinois • Decatur, Illinois + 15 more
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Oct 19, 2026, 1:10 PM EDT
Recruiting Phase 1Phase 2 Interventional

Soy Tomato Juice to Improve Outcomes in Pancreatitis

NCT07447687
View directory record Official record
Conditions
Recurrent Acute Pancreatitis, Chronic Pancreatitis
Interventions
Soy-tomato juice product, Will include a soy-tomato juice product to be consumed during the 4 week intervention phase. A total of about 12 ounces (administered in two small cans) of the juice will be consumed
Dietary Supplement
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 80 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Oct 19, 2026, 1:10 PM EDT
Active, not recruiting Phase 2 Interventional Accepts healthy volunteers

Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers

NCT05741060
View directory record Official record
Conditions
Arterial Stiffness, White Matter Lesions, Cognitive Decline
Interventions
S-equol, Placebo
Drug
Lead sponsor
Akira Sekikawa
Other
Eligibility
65 Years to 85 Years
Enrollment
369 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
3
States / cities
Atlanta, Georgia • Winston-Salem, North Carolina • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 19, 2026, 1:10 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effect of Soy on Cognition and Hot Flashes in Men With Prostate Cancer Undergoing Testosterone Suppression Therapy

NCT00245518
View directory record Official record
Conditions
Hot Flashes
Interventions
Isoflavone, Placebos
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years and older · Male only
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 13, 2017 · Synced Oct 19, 2026, 1:10 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Soy Isoflavones For Inner City Infants At Risk For Asthma (SIRA) Study

NCT05667701
View directory record Official record
Conditions
Wheezing, Asthma in Children
Interventions
Soy isoflavone, matching placebo
Drug
Lead sponsor
Rajesh Kumar
Other
Eligibility
2 Months to 12 Months
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 21, 2025 · Synced Oct 19, 2026, 1:10 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Soy Supplementation and Gestational Diabetes

NCT02806739
View directory record Official record
Conditions
Gestational Diabetes
Interventions
Soy Group (Soy Protein + Isoflavones), Control Group (Minimize Soy Intake)
Dietary Supplement
Lead sponsor
University of Massachusetts, Boston
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 27, 2016 · Synced Oct 19, 2026, 1:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Soy Isoflavones on Bone Mineral Density and Physical Performance Indices

NCT00661856
View directory record Official record
Conditions
Osteoporosis
Interventions
Soy protein
Dietary Supplement
Lead sponsor
Creighton University
Other
Eligibility
55 Years to 72 Years · Female only
Enrollment
203 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2004
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Apr 21, 2008 · Synced Oct 19, 2026, 1:10 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Effects of Soy Compounds on Breast Cancer, Prostate Cancer, and Bone Health

NCT00200824
View directory record Official record
Conditions
Breast Cancer, Prostate Cancer
Interventions
Soy Isoflavone Nutritional Supplements
Drug
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2005
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 12, 2009 · Synced Oct 19, 2026, 1:10 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Women's Isoflavone Soy Health (WISH) Trial

NCT00118846
View directory record Official record
Conditions
Atherosclerosis
Interventions
25 gm soy protein supplement, Placebo
Dietary Supplement · Other
Lead sponsor
University of Southern California
Other
Eligibility
30 Years and older · Female only
Enrollment
350 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 6, 2023 · Synced Oct 19, 2026, 1:10 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Soy Isoflavone Tablets: Effects on Sleep, Quality of Life, Symptoms and Cognitive Function in Menopausal Women

NCT01401946
View directory record Official record
Conditions
Hot Flashes
Interventions
soy isoflavones, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
Female only
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2001
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 26, 2011 · Synced Oct 19, 2026, 1:10 PM EDT
Completed Phase 1Phase 2 Interventional Results available

S-Equol in Alzheimer's Disease 2 Trial

NCT03101085
View directory record Official record
Conditions
Alzheimer Disease
Interventions
S-equol and Placebo, Placebo and S-equol
Drug
Lead sponsor
Russell Swerdlow
Other
Eligibility
50 Years to 90 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
2
States / cities
Fairway, Kansas • Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jul 25, 2024 · Synced Oct 19, 2026, 1:10 PM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Genes, Soy Isoflavones, and Virus

NCT07828405
View directory record Official record
Conditions
Wheezing
Interventions
Soy Isoflavone Nutritional Supplements
Drug
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
4 Months to 24 Months
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 19, 2026, 1:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Effectiveness of Soy Phytoestrogens to Prevent Bone Loss

NCT00665860
View directory record Official record
Conditions
Osteoporosis
Interventions
Placebo, Soy isoflavones
Dietary Supplement
Lead sponsor
Baylor College of Medicine
Other
Eligibility
40 Years to 60 Years · Female only
Enrollment
403 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2006
U.S. locations
3
States / cities
Davis, California • Athens, Georgia • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 27, 2020 · Synced Oct 19, 2026, 1:10 PM EDT
Completed Phase 2 Interventional

Examination of a Soy-Based Supplement for Major Depression

NCT00042380
View directory record Official record
Conditions
Depression
Interventions
Novasoy
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 19, 2026, 1:10 PM EDT
Terminated Not applicable Interventional

Isoflavones in Treating Women Who Have Breast Cancer and Are Planning to Undergo Mastectomy or Lumpectomy

NCT00036686
View directory record Official record
Conditions
Breast Cancer
Interventions
Soy protein isolate, Placebo
Dietary Supplement · Other
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2003
U.S. locations
7
States / cities
Phoenix, Arizona • Tampa, Florida • Savannah, Georgia + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 24, 2012 · Synced Oct 19, 2026, 1:10 PM EDT